• 한국식품영양과학회지
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• 제23권4호
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• pp.561-567
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• 1994

This study was designed to evaluate the effects of dietary vitamin E and caffeine on the activities of lipid peroxidation related enzymes in rat liver . Male Sprague-Dawley rats were fed on diets containing three level of vitamin E (37.5, 750 or 1,5oomg/kg diet) and with or without 0.3% caffeine. The rats were sacrificed after 5 and 10 weeks of feeding. Results obtained from this study were as follows ; The content of cytochrome P450 tended to increase as dietary vitamin E level was raised. The activity of xanthine oxidase increased in the caffeine groups, but it decreased by the increasing level of vitamin E. Superoxide dismutase and catalase activity were slightly elevated by dietary supplementation of vitamin E. And there was a tendency of higher these enzyme activity of caffeine groups. The activity of glutathione perxidase tended to decrease as dietary vitamin E level increased. But it was raised by caffeine supplementation . Liver glutathione content was not affected by dietary supplementation of vitamin E, but it showed a decreasing tendency in caffeine groups. There was a tendency of more lipid peroxide content of caffeine groups than that of the only vitamin E supplemented group. But the degree of increment of this decreased as dietary vitamin E level increased.

• Korea Journal of Cosmetic Science
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• 제1권1호
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• pp.11-18
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• 2019

Caffeine is widely used in cosmetics and hair care products. Although its efficacy in stimulating hair growth has been confirmed in recent studies, its mechanism of action remains unelucidated. The present study aimed to determine the effects of caffeine on hair growth, with a focus on intracellular hair follicle activity. Experiments included in vitro and ex vivo tests, and a clinical study. Caffeine enhanced the cellular activity and potassium channel opening. It also promoted human hair follicle elongation. Immunohistochemical staining showed that the Ki-67 signal was significantly higher in cells treated with caffeine. These efficacies of caffeine were comprehensively demonstrated in clinical results, wherein caffeine-containing shampoo improved hair density after 24 weeks of testing. Collectively, the results of this study demonstrated that caffeine promoted hair growth and inhibited the progression of hair loss by enhancing intracellular activity of hair follicles.

• Journal of Pharmaceutical Investigation
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• 제17권4호
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• pp.189-195
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• 1987

The effects of cimetidine or ranitidine pretreatment on the intestinal absorption, plasma and urine level of caffeine, gastric acidity of mouse, and sleeping time by hexobarbital sodium were investigated pharmacokinetically. Cimetidine and ranitidine pretreatments were found to increase both the rate and extent of absorption of caffeine in rats. Cimetidine pretreatment increased blood level of caffeine and decreased urine level, while ranitidine pretreatment had no effect on urine level of caffeine. Ranitidine pretreatment inhibited gastric secretion due to caffeine more than cimetidine pretreatment. Cimetidine pretreatment increased the action of caffeine and showed shorter sleeping time by hexobarbital sodium, comparing with ranitidine pretreatment.

• 한국직업건강간호학회지
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• 제29권4호
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• pp.306-315
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• 2020

Purpose: This study was conducted to identify the effects of caffeine intake by shift workers on sleep, considering various variable related to the sleep health of shift workers. Methods: A descriptive survey study was conducted with 128 employees who worked shifts. Respondents were surveyed on their of caffeine intake behavior, schedule type, quality of sleep, health promotion behavior, and occupational stress. Differences in their quality of sleep were assessed using the t-test and analysis of variance, while factors influencing the effect of caffeine intake on the quality of sleep were analyzed using hierarchical logistic regression. Results: The average Pittsburgh Sleep Index, Korean Version score of those surveyed was 7.3±3.25, indicating that their quality of sleep was low. On the other hand, their aveage daily intake of caffeine was 1.6±0.99 cups (1 cup =150 mL) and 116.4±77.58 mg/dL of caffeine. When the various variables that could have affected the quality of sleep were corrected, an increase in the amount of caffeine consumed was found to lead to a decrease in the quality of sleep (p=.015). Conclusion: Caffeine intake by shift workers has a significant bearing on their quality of sleep; therefore, such intake should be adjusted to improve their sleep health.

• Bulletin of the Korean Chemical Society
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• 제16권5호
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• pp.432-436
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• 1995

The solubility of caffeine in compressed carbon dioxide has been measured to determine its fugacity coefficient between 330 and 410 K up to 500 bar. The result allows the calculation of the thermodynamic excess functions such as the molar excess enthalpy, the molar excess free energy, and the molar excess entropy. The pressure variations of the molar excess functions of caffeine in the caffeine-CO2 mixture were discussed and also compared them with those in the caffeine-NH3 mixture.

• 한국환경과학회지
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• 제21권7호
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• pp.837-843
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• 2012

The aims of this study were to investigated the occurrence of caffeine and carbamazepine in Nakdong river basin (8 mainstreams and 2 tributaries) and the behavior of caffeine and carbamazepine under drinking water treatment processes (conventional and advanced processes). The examination results showed that caffeine was detected at all sampling sites (5.4~558.5 ng/L), but carbamazepine was detected at five sampling sites (5.1~79.4 ng/L). The highest concentration level of caffeine and carbamazepine in the mainstream and tributaries in Nakdong river were Goryeong and Jinchun-cheon, respectively. These pharmaceutical products were completely removed when they were subject to conventional plus advanced processes of drinking water treatment processes. Conventional processes of coagulation, sedimentation and sand-filtration were not effective for their removal, while advanced processes of ozonation and biological activated carbon (BAC) filtration were effective. Among these pharmaceuticals, carbamazeoine was more subject to ozonation than caffeine.

• 한국수정란이식학회지
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• 제14권1호
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• pp.59-67
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• 1999

To make up the medium for quantitative selection of capacitated-sperm through sucrose layer, the effects of BSA, caffeine, heparin and progesterone on sperm swim-up migration and movement were examined. And the results obtained were as follows; 1. BSA of 4mg/ml in bMSS stimulated sperm migration and movement, and attracted capacitated-sperm. 2. Caffeine of 5mM in bMSS containing 4mg/ml BSA stimulated sperm movement and attracted capacitated-sperm. 3. Heparin of 20$\mu\textrm{g}$/ml in bMAA containing both 4mg/ml BSA and 5mM caffeine stimulated movement and capacitation of sperm. 4. Progesterone of 50$\mu\textrm{g}$/ml in bMSS containing all 4mg/ml BSA, 5mM caffeine and 20$\mu\textrm{g}$/ml heparin (BCHP-MSS) attracted capacitated-sperm. 5. Effect of BCHP-MSS on sperm on sperm attraction was not different from effect of 10% follicular fluid solution (FF-MSS) on sperm swim-up separation. In conclusion, bMSS with 4mg/ml BSA, 5mM caffeine, 20$\mu\textrm{g}$/ml heparin and 50$\mu\textrm{g}$/ml progesterone(BCHP-MSS) was a optimal condition for selection of capacitated-sperm through sucrose layer.

• BMB Reports
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• 제46권4호
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• pp.207-212
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• 2013

The main purpose of this study is to examine the effect of caffeine on lipid accumulation in human hepatoma HepG2 cells. Significant decreases in the accumulation of hepatic lipids, such as triglyceride (TG), and cholesterol were observed when HepG2 cells were treated with caffeine as indicated. Caffeine decreased the mRNA level of lipogenesis-associated genes (SREBP1c, SREBP2, FAS, SCD1, HMGR and LDLR). In contrast, mRNA level of CD36, which is responsible for lipid uptake and catabolism, was increased. Next, the effect of caffeine on AMP-activated protein kinase (AMPK) signaling pathway was examined. Phosphorylation of AMPK and acetyl-CoA carboxylase were evidently increased when the cells were treated with caffeine as indicated for 24 h. These effects were all reversed in the presence of compound C, an AMPK inhibitor. In summary, these data indicate that caffeine effectively depleted TG and cholesterol levels by inhibition of lipogenesis and stimulation of lipolysis through modulating AMPK-SREBP signaling pathways.

• 운동영양학회지
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• 제15권4호
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• pp.183-189
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• 2011

Caffeine and capsaicin increase resting energy metabolism. However, most measurements have been conducted in short-term studies. Therefore, we investigated the effects of caffeine and capsaicin on energy expenditure and energy substrate utilization in resting rats for 6 h. The caffeine (Experiment 1) experiment included four male rats aged 5 weeks and measured the effects of oral administration of caffeine (10 or 50 mg/kg) on respiratory gas, energy expenditure, and energy substrate oxidation for 6 h. Experiment 2 included four male rats aged 6 weeks to measure the effects of capsaicin (10 mg/kg) using the same method as in Experiment 1. The results of Experiment 1 indicated that O₂ uptake and carbohydrate oxidation after caffeine administration for 2 h was higher in the 10 mg trial than that in the 50 mg or placebo trials (P < 0.05). However fat oxidation was not significantly different. In contrast, capsaicin (Experiment 2) observed no differences between the placebo and the capsaicin trials. In conclusion, caffeine initially increased the resting energy consumption for 2 h, and this energy expenditure was due to carbohydrate oxidation. Capsaicin did not change oxygen uptake, respiratory exchange ratio, fat oxidation, or carbohydrate oxidation.

• Biomolecules & Therapeutics
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• 제23권3호
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• pp.268-274
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• 2015

${\gamma}$-Aminobutyric acid (GABA), a major inhibitory neurotransmitter in the mammalian central nervous system, is involved in sleep physiology. Caffeine is widely used psychoactive substance known to induce wakefulness and insomnia to its consumers. This study was performed to examine whether GABA extracts from fermented rice germ ameliorates caffeine-induced sleep disturbance in mice, without affecting spontaneous locomotor activity and motor coordination. Indeed, caffeine (10 mg/kg, i.p.) delayed sleep onset and reduced sleep duration of mice. Conversely, rice germ ferment extracts-GABA treatment (10, 30, or 100 mg/kg, p.o.), especially at 100 mg/kg, normalized the sleep disturbance induced by caffeine. In locomotor tests, rice germ ferment extracts-GABA slightly but not significantly reduced the caffeine-induced increase in locomotor activity without affecting motor coordination. Additionally, rice germ ferment extracts-GABA per se did not affect the spontaneous locomotor activity and motor coordination of mice. In conclusion, rice germ ferment extracts-GABA supplementation can counter the sleep disturbance induced by caffeine, without affecting the general locomotor activities of mice.