• 한국대기환경학회지
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• 제34권1호
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• pp.120-143
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• 2018

The analytical methods and their ambient levels of organic nitrogenous compounds such as nitrosamines, nitramines (nitroamines), imines, amides and nitro-polycyclic aromatic hydrocarbons (nitro-PAHs) in the atmosphere are summarized and discussed. Sampling for the analysis of organic nitrogenous compounds was mostly conducted using high volume air sampler. The direct liquid extraction (DLE) using sonification and the pressurized liquid extraction (PLE) using the accelerated solvent extraction (ASE) have been frequently employed for the extraction of organic nitrogenous compounds in the atmospheric samples. After extraction, clean-up via filtration and the solid phase extraction (SPE) and concentrations using nitrogen and rotary evaporator have been generally conducted but in some studies the clean-up and concentration steps have been omitted to prevent the loss of analyte and improve the recovery rate of the analytical procedure. Instrumental analysis was mainly carried out using gas chromatography (GC) or the high performance liquid chromatography (HPLC) coupled with the single quadrupole mass spectrometer or tandem mass spectrometer in the electron ionization (EI), positive chemical ionization (PCI) and negative chemical ionization (NCI) mode and analysis sensitivity of nitrosamines and nitramines were higher in NCI mode. Desirable sampling and analysis methods for analyzing particulate organic nitrogenous compounds are suggested.

• Mass Spectrometry Letters
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• 제13권4호
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• pp.95-105
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• 2022

Amatoxin-induced mushroom poisoning starts with nonspecific symptoms of toxicity but hepatic damage may follow, resulting in the rapid development of liver insufficiency and, ultimately, coma and death. Accurate detection of amatoxins, such as α-, β-, and γ-amanitin, within the first few hours after presentation is necessary to improve the therapeutic outcomes of patients. Therefore, analytical methods for the identification and quantification of α-, β-, and γ-amanitin in biological samples are necessary for clinical and forensic toxicology. This study presents a literature review of the analytical techniques available for amatoxin detection in biological matrices, and established an inventory of liquid chromatography (LC) techniques with mass spectrometry (MS), ultraviolet (UV) detection, and electrochemical detection (ECD). LC-MS methods using quadrupole tandem mass spectrometry, time-of-flight mass spectrometry, and orbitrap MS are powerful analytical techniques for the identification and determination of amatoxins in plasma, urine, serum, and tissue samples, with high sensitivity, specificity, and reproducibility compared to LC with UV and ECD, enzyme-linked immunoassay, and capillary electrophoresis methods.

• 분석과학
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• 제36권2호
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• pp.89-98
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• 2023

Analytical methods for detecting atranol, chloroatranol, evernic acid, (+)-usnic acid, and atranorin in sanitary napkins and mouthwashes were developed using ultrahigh performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). UHPLC-MS/MS conditions were optimized for rapid, sensitive, and simultaneous analysis of the five allergenic compounds. The methods were validated by assessing their specificity, matrix effects, limit of detection (LOD), limit of quantification (LOQ), linearity, accuracy, and precision. Good linearity was achieved with a determination coefficient of ≥0.99. The LOD and LOQ were 2.1-9.8 and 6.4-29.6 ng/g for sanitary napkins and 0.29-0.48 and 0.87-1.45 ng/mL for mouthwashes, respectively. The accuracy and precision were within an acceptable range according to the criteria reported in the European SANTE/11813/2017 guidelines (70-120 % recovery, <20 % relative standard deviation). Therefore, these methods can be used to analyze atranol, chloroatranol, evernic acid, (+)-usnic acid, and atranorin in sanitary napkins and mouthwashes.

• 분석과학
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• 제28권3호
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• pp.139-159
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• 2015

• 분석과학
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• 제14권5호
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• pp.1083-1108
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• 2001

• 분석과학
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• 제17권3호
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• pp.1001-1027
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• 2004

• 분석과학
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• 제18권3호
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• pp.173-187
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• 2005

• 분석과학
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• 제16권1호
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• pp.1015-1027
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• 2003

• 분석과학
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• 제16권1호
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• pp.1001-1014
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• 2003

• Geomechanics and Engineering
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• 제12권6호
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• pp.1003-1020
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• 2017

Estimation of groundwater inflow into underground opening is of critical importance for the design and construction of underground structures. Groundwater inflow into a pilot underground storage facility in China was estimated using analytical equations, numerical modeling and field measurement. The applicability of analytical and numerical methods was examined by comparing the estimated and measured results. Field geological investigation indicated that in local scale the high groundwater inflows are associated with the appearance of open joints, fractured zone or dykes induced by shear and/or tensile tectonic stresses. It was found that 8 groundwater inflow spots with high inflow rates account for about 82% of the total rate for the 9 caverns. On the prediction of the magnitude of groundwater inflow rate, it was found that could both (Finite Element Method) FEM and (Discrete Element Method) DEM perform better than analytical equations, due to the fact that in analytical equations simplified assumptions were adopted. However, on the prediction of the spatial distribution estimation of groundwater inflow, both analytical and numerical methods failed to predict at the present state. Nevertheless, numerical simulations would prevail over analytical methods to predict the distribution if more details in the simulations were taken into consideration.