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http://dx.doi.org/10.5478/MSL.2022.13.4.95

Mass Spectrometry-Based Analytical Methods of Amatoxins in Biological Fluids to Monitor Amatoxin-Induced Mushroom Poisoning  

Choi, Jin-Sung (College of Pharmacy, The Catholic University of Korea)
Lee, Hye Suk (College of Pharmacy, The Catholic University of Korea)
Publication Information
Mass Spectrometry Letters / v.13, no.4, 2022 , pp. 95-105 More about this Journal
Abstract
Amatoxin-induced mushroom poisoning starts with nonspecific symptoms of toxicity but hepatic damage may follow, resulting in the rapid development of liver insufficiency and, ultimately, coma and death. Accurate detection of amatoxins, such as α-, β-, and γ-amanitin, within the first few hours after presentation is necessary to improve the therapeutic outcomes of patients. Therefore, analytical methods for the identification and quantification of α-, β-, and γ-amanitin in biological samples are necessary for clinical and forensic toxicology. This study presents a literature review of the analytical techniques available for amatoxin detection in biological matrices, and established an inventory of liquid chromatography (LC) techniques with mass spectrometry (MS), ultraviolet (UV) detection, and electrochemical detection (ECD). LC-MS methods using quadrupole tandem mass spectrometry, time-of-flight mass spectrometry, and orbitrap MS are powerful analytical techniques for the identification and determination of amatoxins in plasma, urine, serum, and tissue samples, with high sensitivity, specificity, and reproducibility compared to LC with UV and ECD, enzyme-linked immunoassay, and capillary electrophoresis methods.
Keywords
amatoxin-induced mushroom poisoning; ${\alpha}$-amanitin; ${\beta}$-amanitin; ${\gamma}$-amanitin; LC-MS/MS; biological samples;
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