• 약학회지
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• 제58권3호
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• pp.190-199
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• 2014

The Korean Pharmaceutical Codex (KPC) analytical method of ambroxol hydrochloride and clenbuterol hydrochloride formulation is complicated and needed to carry out multiple processes during the test. To improve the low efficiency of analytical procedure that makes pharmaceutical laboratory consume much time and high cost to conduct the test of this formulation, this study was performed for simplifying the pretreatment process and optimizing conditions of the HPLC assay. The analytical procedure using HPLC was developed to establish analytical specification for ambroxol hydrochloride and clenbuterol hydrochloride formulations. The newly developed analytical method has good linearity ($R^2$ >0.999), specificity, precision (RSD<1.0%) and the recovery ranges of 98.50~101.84% for ambroxol, 98.29~101.35% for clenbuterol syrup and 98.66~101.71% for clenbuterol tablets. The LOQs were 0.204 ${\mu}g/ml$ for ambroxol, 0.021 ${\mu}g/ml$ for clenbuterol syrup and 0.073 ${\mu}g/ml$ for clenbuterol tablets. The new method was performed with commercially available samples to confirm analytical conditions and validated to be suitable for saving time and cost to control the quality of routine manufactured products. This analytical method will be used for revising the monograph of ambroxol hydrochloride and clenbuterol hydrochloride formulation in next supplement of KPC.

• Structural Engineering and Mechanics
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• 제22권3호
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• pp.263-278
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• 2006

Starting with the geometrically non-linear formulation and the subsequent linearization, this paper presents a consistent formulation of the exact mechanical analysis of geometrically and materially linear three-layer continuous planar beams. Each layer of the beam is described by the geometrically linear beam theory. Constitutive laws of layer materials and relationships between interlayer slips and shear stresses at the interface are assumed to be linear elastic. The formulation is first applied in the analysis of a three-layer simply supported beam. The results are compared to those of Goodman and Popov (1968) and to those obtained from the formulation of the European code for timber structures, Eurocode 5 (1993). Comparisons show that the present and the Goodman and Popov (1968) results agree completely, while the Eurocode 5 (1993) results differ to a certain degree. Next, the analytical solution is used in formulating a general procedure for the analysis of layered continuous beams. The applications show the qualitative and quantitative effects of the layer and the interlayer slip stiffnesses on internal forces, stresses and deflections of composite continuous beams.

• Steel and Composite Structures
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• 제38권4호
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• pp.463-476
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• 2021

The concept of using Steel-concrete (SC) composite walls as retaining walls has recently been introduced by the authors and their effectiveness of resisting out-of-plane loads has also been demonstrated. In this paper, an improved analytical formulation based on partial interaction theory, which has previously been developed by the authors, is presented. The improved formulation considers a new loading condition and also accounts for cracking in concrete to simulate the real conditions. Due to a limited number of test specimens, further finite element (FE)simulations are performed in order to verify the analytical procedure in more detail. It is observed that the results from the improved analytical procedure are in excellent agreement with both experimental and numerical results. Moreover, a detailed parametric study is conducted using the developed FE model to investigate effects of different parameters, such as distance between shear connectors, shear connector length, concrete strength, steel plate thickness, concrete cover thickness, wall's width to thickness ratio, and wall's height to thickness ratio, on the behavior of SC composite walls subjected to out-of-plane loads.

• Structural Engineering and Mechanics
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• 제19권4호
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• pp.413-423
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• 2005

This paper presents the solution of large static deflection due to uniformly distributed self weight and the critical or maximum applied uniform loading that a simply supported beam with variable-arc-length can resist. Two analytical approaches are presented and validated experimentally. The first approach is a finite-element discretization of the span length based on the variational formulation, which gives the solution of large static sag deflections for the stable equilibrium case. The second approach is the shooting method based on an elastica theory formulation. This method gives the results of the stable and unstable equilibrium configurations, and the critical uniform loading. Experimental studies were conducted to complement the analytical results for the stable equilibrium case. The measured large static configurations are found to be in good agreement with the two analytical approaches, and the critical uniform self weight obtained experimentally also shows good correlation with the shooting method.

• 분석과학
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• 제31권5호
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• pp.179-184
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• 2018

Diphencyprone (DPCP) is frequently used as a compounded preparation in dermatology for the treatment of alopecia and recalcitrant warts based on the immune reaction of skin allergy. However, DPCP is a non-recognized agent in Pharmacopoeia, because there are no criteria or analytical method for quality control of its powder and formulation. DPCP is unstable under light irradiation because as it easily decomposes to diphenylacetylene (DPA). This study aims to develop a simultaneous HPLC analytical method for analyzing DPCP and DPA in the raw materials and compounded preparation. The method required a C18 column ($250{\times}4.6mm$, $5{\mu}m$) at $40^{\circ}C$ with a mobile phase of (A) 0.01 M phosphoric acid in water and (B) acetonitrile at UV 220 nm. DPA conversion to DPCP in the powder and compounded preparations was accelerated after light exposure for 60 min. In addition, this resulted in different patterns depending on the wavelength of light and the formulation. That is, DPCP in compounded preparation was more unstable than that in the powder. However, the DPCP formulation in amber bottles was observed to remain stable, although the measured concentrations of DPCP were somewhat different from the nominal concentration of the compounded preparations. The control of the exact concentration is required for effective disease treatment, depending on the state of the patient. In conclusion, these results will be useful for the recognition of DPCP in Pharmacopoeia and new DPCP formulation development to prevent photodecomposition.

• Structural Engineering and Mechanics
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• 제82권3호
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• pp.401-416
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• 2022

The aim of this study is to examine the frictionless double receding contact problem for two functionally graded (FG) layers pressed with a uniformly distributed load and resting on a homogeneous half plane (HP) using analytical and numerical methods. The FG layers are made of a non-homogeneous material with an isotropic stress-strain law with exponentially varying properties. It is assumed that the contact at the FG layers and FG layer-HP interface is frictionless. The body force of the FG layers and homogeneous HP are ignored in the study. Firstly, an analytical solution for the contact problem has been realized using the theory of elasticity and the Fourier integral transform techniques. Then, the problem modeled and two-dimensional analysis was carried out by using the ANSYS package program based on FEM. Numerical results for contact lengths and contact pressures between FG layers and FG layer-HP were provided for various dimensionless quantities including material inhomogeneity, distributed load width, the shear module ratio, and the heights of the FG layers for both methods. The results obtained using FEM were compared with the results found using the analytical formulation. It was found that the results obtained from analytical formulation were in perfect agreement with the FEM study.

• 대한조선학회지
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• 제12권1호
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• pp.77-82
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• 1975

An analytical formulation of obtaining propeller sections for a given vortex system of radial and chordwise distribution is given as an indirect problem of tracing the propeller surface. The formulation satisfies the boundary condition of potential flow exactly rather than previous approximate use of induced streamline curvatures at the zero camber line.

• Structural Engineering and Mechanics
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• 제26권6호
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• pp.725-739
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• 2007

In recent years there are many plate bending elements that emerged for solving both thin and thick plates. The main features of these elements are that they are based on mix formulation interpolation with discrete collocation constraints. These elements passed the patch test for mix formulation and performed well for linear analysis of thin and thick plates. In this paper a member of this family of elements, namely, the Discrete Reissner-Mindlin (DRM) is further extended and developed to analyze both thin and thick plates with geometric nonlinearity. The Von K$\acute{a}$rm$\acute{a}$n's large displacement plate theory based on Lagrangian coordinate system is used. The Hu-Washizu variational principle is employed to formulate the stiffness matrix of the geometrically Nonlinear Discrete Reissner-Mindlin (NDRM). An iterative-incremental procedure is implemented to solve the nonlinear equations. The element is then tested for plates with simply supported and clamped edges under uniformly distributed transverse loads. The results obtained using the geometrically NDRM element is then compared with the results of available analytical solutions. It has been observed that the NDRM results agreed well with the analytical solutions results. Therefore, it is concluded that the NDRM element is both reliable and efficient in analyzing thin and thick plates with geometric non-linearity.

• 분석과학
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• 제36권1호
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• pp.32-43
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• 2023

This study reports for the first time about a stability indicating RP-HPLC method for qualitative and quantitative determination of acalabrutinib in bulk and dosage form and in presence its impurities 1, 2 and 3. The chromatographic separation was carried on Zorbax XDB-C18 (250×4.6 mm; 5 µ id) as stationary phase, Phosphate buffer pH 6.4 and methanol 80:20 (v/v) as mobile phase at a flow rate of 1.0 mL/min, UV detection was carried at wavelength of 238 nm and the analysis was completed with a run time of 15 min. In these conditions the retention time of acalabrutinib and its impurities 1, 2 and 3 was observed to be 3.50, 4.83, 8.40 and 9.93 min respectively. The method was validated for system suitability, range of analysis, precision, specificity, stability and robustness. Spiked recovery at 50 %, 100 % and 150 % was carried for both standard and impurities and the acceptable % recovery of 98-102 was observed for acalabrutinib and both impurities studied and the % RSD in each spiked level was found to be less than 2. Stability tests were done through exposure of the analyte solution to five different stress conditions i.e expose to 1N hydrochloric acid, 1 N sodium hydroxide, 3 % peroxide, 80 ℃ temperature and UV radiation at 254 nm. In all the degradation condition, standard drug acalabrutinib was detected along with both the impurities studied and the degradation products were successfully separated. In the formulation analysis there is no other chromatographic detection of other impurities and formulation excipients. Hence the developed method was found to be suitable for the quantification of acalabrutinib and can separate and analyse impurities 1 and 2.

• Structural Engineering and Mechanics
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• 제36권5호
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• pp.575-598
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• 2010

The shape and size of the plastic zone around the crack tip are analyzed under pure mode I, pure mode II and mixed mode (I+II) loading for small scale yielding and for both plane stress and plane strain conditions. A new analytical formulation is presented to determine the radius of the plastic zone in a non-dimensional form. In particular, the effect of T-stress on the plastic zone around the crack tip is studied. The results of this investigation indicate that the stress field with a T-stress always yields a larger plastic zone than the field without a T-stress. It is found that under predominantly mode I loading, the effect of a negative T-stress on the size of the plastic zone is more dramatic than a positive T-stress. However, when mode II portion of loading is dominating the effect of both positive and negative T-stresses on the size of the plastic zone is almost equal. For validating the analytical results, several finite element analyses were performed. It is shown that the results obtained by the proposed analytical formulation are in very good agreements with those obtained from the finite element analyses.