• Title/Summary/Keyword: analytical correction

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Determination of Fermentation Specific Carcinogen, Ethyl Carbamate, in Kimchi (김치에서 발효 식품의 고유 발암원 Ethyl Carbamate 검출)

  • Koh, Eun-Mi;Kwon, Hoon-Jeong
    • Korean Journal of Food Science and Technology
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    • v.28 no.3
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    • pp.421-427
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    • 1996
  • Ethyl carbamate is an animal carcinogen and a suspected human carcinogen found in fermented foods and beverages. For the determination of ethyl carbamate in typical Korean diet, an analytical method was established for the food as complex as Kimchi. Kimchi samples collected from various locations in the country were homogenized and extracted four times with ethyl acelate. Following concentration and reconstitution with water, the extract was loaded onto $C_{18}$ column. Fraction containing ethyl carbamate was eluted with methanol, while most of the red pigment of the sample was retained on the column. The eluent was further purified with alumina, followed by Florisil column. The final eluent was analyzed by gas chromatography mass spectrometry in the selected ion monitoring mode. None of the twenty Kimchi samples showed ethyl carbamate level higher than 4.6 ppb without correction for the recovery. The concentration of ethyl carbamate in Kimchi increased as pH decreased, suggesting fermentation dependent formation of ethyl carbamate.

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HPLC Determination and Pharmacokinetics of Endogenous Acetyl-L-Carnitine (ALC) in Human Volunteers Orally Administered a Single Dose of ALC

  • Kwon, Oh-Seung;Chung, Youn-Bok
    • Archives of Pharmacal Research
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    • v.27 no.6
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    • pp.676-681
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    • 2004
  • Acetyl-L-camitine (ALC), a naturally occurring endogenous compound, has been shown to improve the cognitive performance of patients with senile dementia Alzheimer's type, and to be involved in cholinergic neurotransmission. Because ALC is an endogenous compound, valida-tion of the analytical methods of ALC in the biological fluids is very important and difficult. This study was presented validation and correction for plasma ALC concentrations and pharmacok-inetics after oral administration of ALC to human volunteers. ALC concentrations in human plasma were corrected by subtracting the concentration of blank plasma from each sample. Precision and accuracy (bias %) for uncorrected ALC concentrations were below 2.6 and 6.5% for intra-days, and 4.0 and 9.4% for inter-days, respectively. Precision and accuracy (bias %)for corrected ALC concentrations were below 10.9 and 6.0% for intra-days, and 10.5 and 16.9% for inter-days, respectively. Quantitation limit was $0.1{\;}\mu\textrm{g}/mL$. After oral administration of a 500 mg ALC tablet to 8 healthy volunteers, the principle pharmacokinetic parameters were 4.2 h of the half-life$ (t_{1/2},{\beta})$, the area under the curve $(AUC_{0{\rightarrow}8){\;}of{\;}9.88{\;}\mu\textrm{g}{\cdot}h/mL$, and 3.1 h of the time ($T_{max}$) to reach $C_{max}$. This study first describes the pharmacokinetic study after oral admin-istration of a single dose of ALC in human volunteers.

Geometric Region Reconstruction of Steel-tube Computed Radiography Using Nonlinear Structural Analysis (비선형 구도해석에 의한 강관 CR영상의 기하학적 영역복원)

  • Hwang, Jae-Ho
    • Journal of the Institute of Electronics Engineers of Korea SP
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    • v.46 no.6
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    • pp.146-152
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    • 2009
  • The steel-tube is exposed to a radiation from X-ray source. The transmitted radiation is detected by a detector, usually film or more recently an imaging plate(IP) of Computed Radiography(CR). The detected radiation overlaps the region of both sides of the object. The radiographic images reflect the projections of the rays, passing twice through both external and internal tube material. Nonlinear distortion due to the radioactive transmission and geometric disposition also appears on images. In this paper, an analytical approach is presented to achieve image reconstruction from the steel-tube CR images. Parameters related to radiation and measuring structure, such as intensities, absorption in material and geometric specifications linked with the collimating components, are calculated and identified in order to construct the renoval images for twofold regions of circle-type steel tubes. A correction procedure for region recovery most similar to the true tube is designed. The application of this approach on CR images is shown and reconstructed results are discussed.

Analytical investigation of bending response of FGM plate using a new quasi 3D shear deformation theory: Effect of the micromechanical models

  • Bouiadjra, Rabbab Bachir;Mahmoudi, Abdelkader;Benyoucef, Samir;Tounsi, Abdelouahed;Bernard, Fabrice
    • Structural Engineering and Mechanics
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    • v.66 no.3
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    • pp.317-328
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    • 2018
  • In this paper, a new refined quasi-three-dimensional (3D) shear deformation theory for the bending analysis of functionally graded plate is presented. The number of unknown functions involved in this theory is only four against five or more in the case of the other shear and normal deformation theories. Due to its quasi-3D nature, the stretching effect is taken into account in the formulation of governing equations. In addition, the effect of different micromechanical models on the bending response of these plates is studied. Various micromechanical models are used to evaluate the mechanical characteristics of the FG plates whose properties vary continuously across the thickness according to a simple power law. The present theory accounts for both shear deformation and thickness stretching effects by a parabolic variation of displacements across the thickness, and the zero traction boundary conditions on the top and bottom surfaces of the plate without using shear correction factors. The problem is solved for a plate simply supported on its edges and the Navier solution is used. The results of the present method are compared with others from the literature where a good agreement has been found. A detailed parametric study is presented to show the effect of different micromechanical models on the flexural response of a simply supported FG plates.

Bending behaviour of FGM plates via a simple quasi-3D and 2D shear deformation theories

  • Youcef, Ali;Bourada, Mohamed;Draiche, Kada;Boucham, Belhadj;Bourada, Fouad;Addou, Farouk Yahia
    • Coupled systems mechanics
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    • v.9 no.3
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    • pp.237-264
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    • 2020
  • This article investigates the static behaviour of functionally graded (FG) plates sometimes declared as advanced composite plates by using a simple and accurate quasi-3D and 2D hyperbolic higher-order shear deformation theories. The properties of functionally graded materials (FGMs) are assumed to vary continuously through the thickness direction according to exponential law distribution (E-FGM). The kinematics of the present theories is modeled with an undetermined integral component and satisfies the free transverse shear stress conditions on the top and bottom surfaces of the plate; therefore, it does not require the shear correction factor. The fundamental governing differential equations and boundary conditions of exponentially graded plates are derived by employing the static version of principle of virtual work. Analytical solutions for bending of EG plates subjected to sinusoidal distributed load are obtained for simply supported boundary conditions using Navier'is solution procedure developed in the double Fourier trigonometric series. The results for the displacements and stresses of geometrically different EG plates are presented and compared with 3D exact solution and with other quasi-3D and 2D higher-order shear deformation theories to verify the accuracy of the present theory.

Implementation of the Equalization Circuits for High Bandwidth Visible Light Communications Using Phosphorescent White LED (인광성 백색 LED의 가시광 통신 변조 대역폭 향상을 위한 등화기 구현)

  • Sohn, Kyung-Rak
    • Journal of Advanced Marine Engineering and Technology
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    • v.39 no.4
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    • pp.473-477
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    • 2015
  • In this paper, a commercial phosphorescent white light-emitting diode (WLED) visible light communication (VLC) system with an equalization circuit to achieve the high modulation bandwidth was designed and demonstrated. An analytical method to examine the performance of the equalizer was carried out using a general circuit-simulator, PSpice. The equalization circuit was composed of two passive filters with resisters and a capacitor and an active filter with an op-amp. Utilizing our post-equalization technology, the ~3.5 MHz bandwidth of phosphor WLED could be extended to ~25 MHz without using an optical blue-filter. In this VLC system with a single round-type WLED and a single PIN photo-diode, ASK data transmission up to 35 Mbps at a 1m free space distance was obtained. The resulting bit-error-rate was $7.6{\times}10^{-4}$, which is less than the forward error correction (FEC) limit of $3.8{\times}10^{-3}$.

A Study on Step Up-Down AC-DC Converter with DCM-ZVS of High Performance (고성능 DCM-ZVS 스텝 업-다운 AC-DC 컨버터에 관한 연구)

  • Kwak, Dong-Kurl
    • Journal of IKEEE
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    • v.16 no.4
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    • pp.335-342
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    • 2012
  • This paper is studied on a new DCM-ZVS step up-down AC-DC converter of high performance, that is, high system efficiency and power factor correction (PFC). The switching devices in the proposed converter are operated by soft switching technique using a new quasi-resonant circuit, and are driven with discontinuous conduction mode (DCM) according to pulse width modulation (PWM). The quasi-resonant circuit uses a step up-down inductor and a loss-less snubber capacitor. The proposed converter with DCM also simplifies the requirement of control circuits and reduces the number of control components. The input AC current waveform in the proposed converter becomes a quasi-sinusoidal waveform proportional to the magnitude of input AC voltage under constant switching frequency. As a result, the proposed converter obtains low switching power loss and high efficiency, and its input power factor is nearly in unity. The validity of the analytical findings is confirmed by some computer simulation results and experimental results.

An efficient shear deformation theory with stretching effect for bending stress analysis of laminated composite plates

  • Abbas, Soufiane;Benguediab, Soumia;Draiche, Kada;Bakora, Ahmed;Benguediab, Mohamed
    • Structural Engineering and Mechanics
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    • v.74 no.3
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    • pp.365-380
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    • 2020
  • The focus of this paper is to develop an analytical approach based on an efficient shear deformation theory with stretching effect for bending stress analysis of cross-ply laminated composite plates subjected to transverse parabolic load and line load by using a new kinematic model, in which the axial displacements involve an undetermined integral component in order to reduce the number of unknowns and a sinusoidal function in terms of the thickness coordinate to include the effect of transverse shear deformation. The present theory contains only five unknowns and satisfies the zero shear stress conditions on the top and bottom surfaces of the plate without using any shear correction factors. The governing differential equations and its boundary conditions are derived by employing the static version of principle of virtual work. Closed-form solutions for simply supported cross-ply laminated plates are obtained applying Navier's solution technique, and the numerical case studies are compared with the theoretical results to verify the utility of the proposed model. Lastly, it can be seen that the present outlined theory is more accurate and useful than some higher-order shear deformation theories developed previously to study the static flexure of laminated composite plates.

Application of Satellite Data on Geomorphological Study of the Tidal Flats near Kum River Estuary (위성자료의 한국 금강 하구부근 조간대 지형 연구에 대한 응용)

  • 안충현;이용국;유흥룡;오재경
    • Korean Journal of Remote Sensing
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    • v.5 no.1
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    • pp.1-12
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    • 1989
  • The objective of this study is to develop the application techniques, such as geometrical correction, image overlapping etc., of LANDSAT Thematic Mapper image data especially useful to the geomorphological study of tidal flats. The developed processing techniques were applied to the Kum river estuary. The results of this study are as follows. 1) According to the analysis of the distribution and topographical profiles of the tidal flats, the geomorphological characteristics of the study area seem to be different depending on their location. 2) Even though the geomorphological changes were not always observable on the satellite images, several areas of undoubtful short-term deposition could be detected on the analytical map-image which compares two different situations of tidal flats. 3) Even though a further ditailed study is necessary, the distribution and dispersal patterns of suspended materials and sea surface temperature distribution patterns due to tidal and other meteorological conditions were analyzed by LANDSAT TM channel 3 and 6.

Effect of tapered-end shape of FRP sheets on stress concentration in strengthened beams under thermal load

  • El Mahi, Benaoumeur;Kouider Halim, Benrahou;Sofiane, Amziane;Khalil, Belakhdar;Abdelouahed, Tounsi;Adda Bedia, El Abbes
    • Steel and Composite Structures
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    • v.17 no.5
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    • pp.601-621
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    • 2014
  • Repairing and strengthening structural members by bonding composite materials have received a considerable attention in recent years. The major problem when using bonded FRP or steel plates to strengthen existing structures is the high interfacial stresses that may be built up near the plate ends which lead to premature failure of the structure. As a result, many researchers have developed several analytical methods to predict the interface performance of bonded repairs under various types of loading. In this paper, a numerical solution using finite - difference method (FDM) is used to calculate the interfacial stress distribution in beams strengthened with FRP plate having a tapered ends under thermal loading. Different thinning profiles are investigated since the later can significantly reduce the stress concentration. In the present theoretical analysis, the adherend shear deformations are taken into account by assuming a parabolic shear stress through the thickness of both beam and bonded plate. The shear correction factor for I-section beams is also included in the solution. Numerical results from the present analysis are presented to demonstrate the advantages of use the tapers in design of strengthened beams.