• Journal of Biomedical Engineering Research
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• v.21 no.4
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• pp.411-417
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• 2000

This paper describes the analysis of the oscillometric method based on the shape of arterial pressure and proposal of a new algorithm for estimating the blood pressure by computer simulation. In the first step, the arterial pressure model which is able to control the shape of arterial pressure was designed and then we simulated the oscillometric model using both the existing exponential model showing the static arterial pressure-volume relation and the designed arterial pressure model. By analyzing the correlation of characteristic ratio based on the shape of arterial pressure, we could find that the characteristic ratio was not the only standard parameter for estimating systolic and diastolic pressure. We were able to estimate the shape of arterial pressure by computing the correlation of arterial pressure shape with oscillation shape. Finally, we proposed an algorithm which is able to estimate systolic and diastolic pressure according to pressure(Pp) table constructed from the relation of maximum amplitude of oscillation and arterial pressure shape. We tested 60 arterial pressure waveforms having various arterial pressure shape and pulse. As a results, the absolute deviation average values of the estimation of systolic, diastolic and mean pressure were 1.62%, 2.40% and 2.20%, respectively. In conclusions, the proposed algorithm showed the possibility of usefullness in estimating the blood pressure.

• Journal of the Korean GEO-environmental Society
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• v.16 no.7
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• pp.35-42
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• 2015

Grouting method has been widely used for the ground improvement and stabilization: mostly to block or control the ground water in the early years and to improve the ground, repair the structure in recent years, ever increasing its use. Despite many advantages so far, the existing grouting method also has some shortcomings including uncertain permeation of grouting with gravity type if the voids between the soil particles are narrow, and problems due to the relaxation of the neighboring ground when injected using injection pressure. As an alternative, a vibration injection method with constant amplitude and frequency has been developed in recent years, with the vibration grouting being reported to have a permeability increasing effect of grout material compared with the positive pressure injection type. Accordingly, the purpose of this study is to investigate the improvement effect of the vibration grouting that applies short-period vibration energy by varying vibration cycle, vibration time and ground conditions to evaluate the strength enhancing effect of grouting materials, expansion effect of grouting body, ground improvement effect of the grouting and the penetration characteristics of the rock joint. The findings of this study show the improved compressive strength of grout, expansion of grouting body and increased penetration rate, according to the vibration compared with non-vibration under the loose soil condition.

• Journal of Pharmacopuncture
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• v.22 no.3
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• pp.166-170
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• 2019

Objectives: Attentional and memory functions are important aspects of neural plasticity that, theoretically, should be amenable to pharmacopuncture treatments. A previous study from our laboratory suggested that quantitative electroencephalographic (qEEG) measurements of theta/beta ratio (TBR), an index of attentional control, may be indicative of academic performance in a first-semester medical school course. The present study expands our prior report by extracting and analyzing data on frontal theta and beta asymmetries. We test the hypothesis that the amount of frontal theta and beta asymmetries (fTA, fBA), are correlated with TBR and academic performance, thereby providing novel targets for pharmacopuncture treatments to improve cognitive performance. Methods: Ten healthy male volunteers were subjected to 5-10 min of qEEG measurements under eyes-closed conditions. The qEEG measurements were performed 3 days before each of first two block examinations in anatomy-physiology, separated by five weeks. Amplitudes of the theta and beta waveforms, expressed in ${\mu}V$, were used to compute TBR, fTA and fBA. Significance of changes in theta and beta EEG wave amplitude was assessed by ANOVA with post-hoc t-testing. Correlations between TBR, fTA, fBA and the raw examination scores were evaluated by Pearson's product-moment coefficients and linear regression analysis. Results: fTA and fBA were found to be negatively correlated with TBR (P<0.03, P<0.05, respectively) and were positively correlated with the second examination score (P<0.03, P=0.1, respectively). Conclusion: Smaller fTA and fBA were associated with lower academic performance in the second of two first-semester medical school anatomy-physiology block examination. Future studies should determine whether these qEEG metrics are useful for monitoring changes associated with the brain's cognitive adaptations to academic challenges, for predicting academic performance and for targeting phamacopuncture treatments to improve cognitive performance.

• Journal of the Korea Convergence Society
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• v.13 no.5
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• pp.9-19
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• 2022

In this study, a systematic review was conducted to analyze the method of applying sEMG to evaluate the swallowing function of the elderly at each stage of swallowing, and to help objectively measure the swallowing stage of the older adults in clinical practice. From 2011 to 2021, 7 studies that met the selection criteria were selected using Pubmed, Scopus, and Web of Science (WoS). As a result of this study, the older adults and adults were divided into an experimental group and a control group and the swallowing phase was analyzed using sEMG only for the older adults. sEMG was used to evaluate swallowing in the oral and pharyngeal stages, and the sEMG attachment site was attached to the swallowing muscle involved in each stage. The collected sEMG data were filtered using a bandpass-filter and a notch-filter, and were analyzed using RMS, amplitude, and maximum spontaneous contraction. In this study, it was found that sEMG can be used as a tool to objectively and quantitatively evaluate the swallowing function in stages. Therefore, it is expected that this study will activate various studies that incorporate sEMG to evaluate the swallowing function in stages.

• Journal of Chest Surgery
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• v.30 no.7
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• pp.677-685
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• 1997

Thromboelastography(TEG) is the unique measure that gives rapid information about the whole clotting process. Simplifying the diagnosis of coagulopathy during operations, TEG can provide an adequate therapy for postoperative bleeding. Remarkable improvement in hemostasis after cardiopulmonary bypass(CPB) has been achieved by the treatment with proteinase inhibitor aprotinin, but the hemostatic mechanism of aprotinin during CPB is still unclear. This study was designed to evaluate the effects of aprotinin on coagulation system during CPB by using TEG. Forty patients who underwent CPB were divided into two groups: aprotinin(2u 106 kallikrein inhibition units, as a single dose into the cardiopulmonary bypass priming solution) treatment group(male 14, female 8, mean age=50.Byears) and no aprotinin treatment(control) group(male 10, female 8, mean age=53.4 years). TEG, activated clotting time, prothrombin time, activated partial thromboplastin time, platelet counts, fibrinogen an (ibrinogen degradation product(FDP) concentrations were checked before and after CPB(30 minutes after neutralization of heparin effect by protamine sulfate). There was no significant difference in other conventional coagulation tests of two groups except postcardiopulmonary bypass FDP concentration in control group, which was significantly increased compared to that in aprotinin group(p<0.05). In TEG variables of both groups, clot formation time(K) and alpha $angle(\alpha^{\circ})$ were significantly increased and decreased, respectively, after CPB(p<0.05), but fibrinolytic index(LYS60) was not changed during CPB. In aprotinin group, reaction time(R) was decreased significantly after CPB(p<0.05) but maximum amplitude(MA) was not changed(p>0.05). On the contrary, R was not changed markedly but MA was decreased significantly in control group after CPB(p<0.05). This result shows that main change in coagulation system during CPB is not hyperfibrinolysis but cecrease in clot strength by platelet dys unction, and the main effect of aprotinin during cardiopulmonary bypass is the maintenance of clot strength to the pre-CPB level by the preservation of platelet function.

• Progress in Medical Physics
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• v.23 no.2
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• pp.91-98
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• 2012

Verification of internal organ motion during treatment and its feedback is essential to accurate dose delivery to the moving target. We developed an offline based internal organ motion verification system (IMVS) using cine EPID images and evaluated its accuracy and availability through phantom study. For verification of organ motion using live cine EPID images, a pattern matching algorithm using an internal surrogate, which is very distinguishable and represents organ motion in the treatment field, like diaphragm, was employed in the self-developed analysis software. For the system performance test, we developed a linear motion phantom, which consists of a human body shaped phantom with a fake tumor in the lung, linear motion cart, and control software. The phantom was operated with a motion of 2 cm at 4 sec per cycle and cine EPID images were obtained at a rate of 3.3 and 6.6 frames per sec (2 MU/frame) with $1,024{\times}768$ pixel counts in a linear accelerator (10 MVX). Organ motion of the target was tracked using self-developed analysis software. Results were compared with planned data of the motion phantom and data from the video image based tracking system (RPM, Varian, USA) using an external surrogate in order to evaluate its accuracy. For quantitative analysis, we analyzed correlation between two data sets in terms of average cycle (peak to peak), amplitude, and pattern (RMS, root mean square) of motion. Averages for the cycle of motion from IMVS and RPM system were $3.98{\pm}0.11$ (IMVS 3.3 fps), $4.005{\pm}0.001$ (IMVS 6.6 fps), and $3.95{\pm}0.02$ (RPM), respectively, and showed good agreement on real value (4 sec/cycle). Average of the amplitude of motion tracked by our system showed $1.85{\pm}0.02$ cm (3.3 fps) and $1.94{\pm}0.02$ cm (6.6 fps) as showed a slightly different value, 0.15 (7.5% error) and 0.06 (3% error) cm, respectively, compared with the actual value (2 cm), due to time resolution for image acquisition. In analysis of pattern of motion, the value of the RMS from the cine EPID image in 3.3 fps (0.1044) grew slightly compared with data from 6.6 fps (0.0480). The organ motion verification system using sequential cine EPID images with an internal surrogate showed good representation of its motion within 3% error in a preliminary phantom study. The system can be implemented for clinical purposes, which include organ motion verification during treatment, compared with 4D treatment planning data, and its feedback for accurate dose delivery to the moving target.

• Journal of Yeungnam Medical Science
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• v.22 no.1
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• pp.96-103
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• 2005

The motor recovery mechanism of a 21-year-old male monoparetic patient with cerebral palsy, who had complained of a mild weakness on his right hand since infancy, was examined using functional Magnetic Resonance Imaging (fMRI) and Transcranial Magnetic Stimulation (TMS). The patient showed mild motor impairment on the right hand. MRI located the main lesion on the left precentral knob of the brain. fMRI was performed on this patient as well as 8 control subjects using the Blood Oxygen Level Dependent technique at 1.5 T with a standard head coil. The motor activation task consisted of finger flexionextension exercises at 1 Hz cycles. TMS was carried out using a round coil. The anterior portion of the coil was applied tangentially to the scalp at a 1.0 cm separation. Magnetic stimulation was carried out with the maximal output. The Motor Evoked Potentials (MEPs) from both Abductor Pollicis Brevis muscles (APB) were obtained simultaneously. fMRI revealed that the unaffected (right) primary sensori-motor cortex (SM1), which was centered on precentral knob, was activated by the hand movements of the control subjects as well as by the unaffected (left) hand movements of the patient. However, the affected(right) hand movements of the patient activated the medial portion of the injured precentral knob of the left SM1. The optimal scalp site for the affected (right) APB was located at 1 cm medial to that of the unaffected (left) APB. When the optimal scalp site was stimulated, the MEP characteristics from the affected (right) APB showed a delayed latency, lower amplitude, and a distorted figure compared with that of the unaffected (left) APB. Therefore, the motor function of the affected (right) hand was shown to be reorganized in the medial portion of the injured precentral knob.

• Journal of Embryo Transfer
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• v.16 no.2
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• pp.79-89
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• 2001

Steroid hormones control the expression of many cellular regulators, and a role thor estrogen in mouse oocytes has been well documented. The preovulatory $E_2$increment is generally accepted as the endocrine process regulating induction of in vivo oocyte maturation To address whether the activity of the T-type $Ca^{2+}$ channel is altered by 17 beta-estradiol ( $E_2$), we examined the actions of $E_2$on the calcium channel of mouse oocytes and early embryos. Oocrtes were collected from the oviduct of mice treated with pregnant mare's serum gonadotropin (PMSG) and human choronic gonadotropin (hCG). Whole cell voltage clamp technique and confocal microscopy were used to examine that $E_2$increase intracellular $Ca^{2+}$ concentration ([C $a^{2+}$]$_{i}$ ) via voltage dependent $Ca^{2+}$ channel (VDC) and estrogen receptor (FSR), and $E_2$concentration by the use of radioimmunoassay (RIA) were examined in mouse. The results obtained were as follows: The peak of $Ca^{2+}$ current induced by $E_2$increased 122% to 1.50$\pm$0.03 nA from 1.23$\pm$0.21 nA (n=15) in the presence of 5 mM extracellular $Ca^{2+}$ concentration ([C $a^{2+}$]$_{o}$ ). The increased $Ca^{2+}$ current was temporally associated with $Ca^{2+}$ transients. The intracellular $Ca^{2+}$ level increased 207%~30 s following the addition of 1${\mu}{\textrm}{m}$ $E_2$(relative fluorescence intensity: 836.4$\pm$131.2 for control, n=10, 1736.4$\pm$192.0 in the presence of $E_2$, n=10). $E_2$increased amplitude of $Ca^{2+}$ current and [C $a^{2+}$]$_{i}$ . $E_2$-induced $Ca^{2+}$ current and $E_2$concentration in blood were showed difference on the stage of embryo. These results suggest that $E_2$modulate $Ca^{2+}$ channel to increase $Ca^{2+}$ influx.$Ca^{2+}$ influx.

• Journal of Bio-Environment Control
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• v.24 no.2
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• pp.85-92
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• 2015

This study examined the settlement of a 1-2W type greenhouse using a timber pile, which was recently established on Gyehwa-do reclaimed land, in order to obtain base data for the construction of a greenhouse on reclaimed land. The results of this study are as follows. foundation and timber pile increased over time, irrespective of the interior and exterior of the upon investigation of the ground, it was confirmed that there was no soft rock stratum (bedrock), and that a sedimentary stratum existed under the fill deposit, which is estimated to have been reclaimed during the site renovation. It was also found that a weathered zone was located under the fill deposit and sedimentary stratum, and that the soil texture of the entire ground floor consisted of clay mixed with sand, silty clay, and granite gneiss, in that order, regardless of boreholes. In addition, the underground water level was 0.3m below ground, regardless of boreholes. Despite a slight difference, the settlement of the greenhouse or measurement sites (channels). With regard to the pillar inside the greenhouse, except in the case of CH-2, the data at a site located on the side wall of the greenhouse (wind barrier side) indicated vibrations of relatively larger amplitude. Moreover, the settlement showed a significant increase during a certain period, which was subsequently somewhat reversed. Based on these phenomena, it was verified that the settlement range of each site in the interior and exterior of the greenhouse was between 1.0 and 7.5mm at this time, except in the case of CH-1. The results of the regression analysis indicated good correlation, with the coefficient of determination by site ranging between 0.6362 and 0.9340. Furthermore, the coefficient of determination ranged between 0.6046 and 0.8822 on the exterior of the greenhouse, which is lower than inside the greenhouse, but still indicates significant correlation.

• Journal of the Korean Geophysical Society
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• v.2 no.1
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• pp.39-44
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• 1999

High-resolution images are drawn from existing seismic data which were originally obtained by Korea Ocean Research & Development Institute (KORDI) during 1994-1997 for deep seismic studies on the East Sea of Korea. These images are analyzed for mapping Quaternary faults and near-bottom gas pockets. First 12 channels are selected from shot gathers for reprocessing. The processing sequence adopted for high-resolution seismic images comprises data copy, trace editing, true amplitude recovery, common-midpoint sorting, initial muting, prestack deconvolution, bandpass filtering, stacking, highpass filtering, poststack deconvolution, f-x migration, and automatic gain control (AGC). Among these processing steps, predictive deconvolution, highpass filtering, and short window AGC are the most significant in enhancement of resolution. More than 200 Quaternanry faults are interpreted on the migrated sections in the shallow depths beneath the seafloor. Although numerous faults are found mostly at the western continental slope and boundaries of the Ulleung Basin, significant amount of the faults are also indicated within the basin. Many of these faults are believed to be formed with reactivation of basement, from geotectonic activities including volcanism, and often originated in Tertiary, indicating that the tectonic regime of the East Sea might be unstable. Existence of shallow gas pockets casts real hazardous warnings to deep-sea drillings and/or to underwater constructions such as inter-island cables and gas pipelines. On the other hand, discovery of these gas pockets heightens the interests in developing natural resources in the East Sea. Reprocessed seismic sections, however, show no typical seismic characteristics for gas hydrates such as bottom-simulating reflectors in the western continental slope and ocean floor.