• 제목/요약/키워드: amines

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Retention of Configuration; Mechanism Studies on the Reaction of Chlorosulfonyl Isocyanate with Ethers

  • Kim, Ji-Duck;Jung, Young-Hoon
    • Proceedings of the PSK Conference
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    • 2003.04a
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    • pp.242.2-243
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    • 2003
  • We have developed the novel one-pot synthetic method for regioselective N-protected amines, carbamates as a protective group of amines, through the reaction of various ethers with chlorosulfonyl isocyanate (CSJ). This synthetic method provides a simple and convenient alternative for the formation of carbamates, such as -NHMoc, -NHPoc. -NHCbz, -NHPnz, -NHTroc and -NHAloc, by varying the alkyl moiety of ethers. (omitted)

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Ligand Exchange Studies with an Iminodiacetic Acid Ion Exchange Resin (Iminodiacetic Acid 이온 교환수지를 사용한 Ligand Exchange 에 대한 연구)

  • CHONG MIN BAK
    • Journal of the Korean Chemical Society
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    • v.11 no.2
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    • pp.56-59
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    • 1967
  • Mixtures of amines can be separated by elution chromatography on a chelating resin, Dowex A-1 loaded with nickel ions based on ligand exchange. Aqueous ammonia is used as the eluent. The method has proved particulary effective for separating aromatic amines.

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Syntheses and Central Nervous Depressant Activities of Piperine Derivatives (V) (피페린 유도체의 합성 및 중추 억제작용에 관한 연구(V) -Methylenedioxyphenylalkenoic Acid Amide 유도체-)

  • 도경삼;임중기;우경식;이은방
    • YAKHAK HOEJI
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    • v.30 no.4
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    • pp.163-168
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    • 1986
  • Thirteen compounds were synthesized by condensing the N-heterocyclic amines (piperidine, pyrrolidine, morpholine) and secondary aliphatic amines (dimethylamine, diethylamine) with 3,4-methylenedioxyphenylalkenoic acid chlorides for developing CNS depressants. Among them, N, N-diethyl-3,4-methylenedioxycinnamamide (IX) and N, N-dimethyl-5-(3,4-methylenedioxyphenyl)-2, 4-pentadienoic acid amicle (XII) exhibited strong activity in antagonism against pentylenetetrazole-induced convulsion, strychnine-induced convulsion and maximal electroshock seizure. N, N-Dimethyl-3, 4-methylenedioxycinnamide (VIII) showed more potent activity in antagonism against strychnine-induced convulsion and maximal electroshock seizure and in the prolongation of hexobarbital sleeping time.

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Formation of Nitrosamines from Sodium Nitroprusside and Physiological Amines

  • Park, Jeen-Woo
    • Archives of Pharmacal Research
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    • v.12 no.4
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    • pp.239-242
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    • 1989
  • Several physiological components containing a secondary amino group were capable of reacting sodium nitroprusside to form potentially carcinogenic nitrosamines under physiological conditions (pH 7.3, 37). In each case the products were identical to those produced upon reaction with nitrous acid at much lower pH values. Reaction rates measured with proline were shown to reflect a first order dependence on both amine and nitroprusside concentrations. The strong influences of pH on the reactions of sodium nitro prusside with amines were also observed. These results show sodium nitroprusside could be a very potent nitrosation agent under physiological conditions.

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Mild and Efficient Tris(pentafluorophenyl)borane-catalyzed Sakurai Allylation of N-Benzyloxycarbonylamino p-Tolylsulfone with Allyltrimethylsilane

  • Thirupathi, Ponnaboina;Neupane, Lok Nath;Lee, Keun-Hyeung
    • Bulletin of the Korean Chemical Society
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    • v.33 no.4
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    • pp.1275-1278
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    • 2012
  • Tris(pentafluorophenyl)borane, $B(C_6F_5)_3$, was found to be an efficient catalyst for synthesis of N-Cbzhomoallylic amines using Sakurai allylation of N-benzyloxycarbonyl-amino p-tolylsulfones with allyltrimethylsilane.

Convenient Synthesis of N-Sulfinylamines Catalytic Effects of Tertiary Amines

  • Park, Koon-Ha;Park, Myeong-Soon
    • Bulletin of the Korean Chemical Society
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    • v.11 no.6
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    • pp.494-496
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    • 1990
  • Catalytic effects of tertiary amines on N-sulfinylation of p-toluenesulfonamide, p-toluidine, and p-toluamide have been investigated by proton NMR studies. Though the catalytic effects were dependent on the substrates, 4-dimethylaminopyridine, pyridine and triethylamine exerted stronger catalytic effects than imidazole and N,N-dimethylaniline. Among the substrates employed, p-toluenesulfonamide turned out to be catalyzed greater than p-toluidine and p-toluamide.

Ruthenium Catalyzed Synthesis of 1-Substituted Perhydroazocines from Primary Amines and 1,7-Heptanediol

  • Shim, Sang-Chul;Doh, Chil-Hoon;Yoon, Jeum-Ho;Lee, Dong-Yub;Youn, Young-Zoo
    • Bulletin of the Korean Chemical Society
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    • v.12 no.6
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    • pp.649-652
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    • 1991
  • The reaction of primary aromatic amines with 1,7-heptanediol in the presence of a catalytic amount of ruthenium complex in dioxane at $180^{\circ}C$ for 24 hours gave the corresponding 1-substituted perhydroazocines in moderate yield.

Catalytic Hydrogenation of Aromatic Nitro Compounds over Borohydride Exchange Resin Supported Pd (BER-Pd) Catalyst

  • Yoon, Nung-Min;Lee, Hyang-Won;Choi, Jae-Sung;Lee, Hyun-Ju
    • Bulletin of the Korean Chemical Society
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    • v.14 no.2
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    • pp.281-283
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    • 1993
  • Aromatic nitro compounds are selectively hydrogenated to the corresponding amines in high yields at room temperature and atmospheric pressure using BER-Pd catalyst without affecting ketone, ether, ester, nitrile or chloro groups also present. Especially the nitro group in 4-nitrobenzyl alcohol, methyl 4-nitrobenzyl ether and N-N-dimethyl 4-nitrobenzylamine is selectively hydrogenated with this catalyst to give the corresponding amines without hydrogenolysis of benzylic groups. And aromatic nitro compound can be reduced selectively in the presence of aliphatic nitro compound.

INHIBITION OF THE FORMATION AND ACTION OF HETEROCYCLIC AROMATIC AMINES

  • Weisburger, John H.
    • Proceedings of the Korean Society of Toxicology Conference
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    • 2001.10a
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    • pp.45-45
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    • 2001
  • Heterocyclic aromatic amines (HCAs) are established genotoxic human cancer risks, that display their activity also in a number of animal models and in vitro. They are formed during the trying or broiling of creatinine-containing foods, mainly fish or meat. We established that mixing soy protein with ground meat blocks the formation of HCAs. we also observed that coating the surface of meat with polyphenols green or from black tea gives a dose - related reduction of the formation of HCAs.(omitted)

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