• 대한한방부인과학회지
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• 제22권4호
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• pp.83-92
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• 2009

Purpose: The aim of this study was to review systemically journals on the studies for complementary and alternative medicine in the treatment of endometriosis. Methods: Through medical websites, foreign clinical literatures about complementary and alternative medicines of endometriosis were searched. The cite used was http://www.Pubmed.gov. And then they were divided into three groups. In vitro, in vivo, clinical studies. Results: 1. We researched 2 papers about in vitro. Both were used extract of herbal mixture. And they used CCL5, SE-1, COUP-TF, 17-$\beta$-HSD1, 17-$\beta$-HSD2 which were not commonly used in Korea. 2. We researched 8 papers about in vivo. Most of them used blood-activating stasis-dispelling medicine, just few used tonic medicine. And they used acupuncture which were not used in Korea. Most of Korean paper also used blood-activating stasis-dispelling medicine and rarely used tonic medicine. 3. We researched 19 papers about clinical studies. They had much more cases(average=60) than Korean paper. They were also used western medicine randomized sham-controlled trial. Conclusion: Afterward we need to study for comparing western medicine and herb medicine. And we concern about acupuncture therapy.

• Toxicological Research
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• 제30권3호
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• pp.159-168
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• 2014

Pesticides have provided significant benefits including plant disease control and increased crop yields since people developed and utilized them. However, pesticide use is associated with many adverse effects, which necessitate precise toxicological tests and risk assessment. Most of these methods are based on animal studies, but considerations of animal welfare and ethics require the development of alternative methods for the evaluation of pesticide toxicity. Although the usage of laboratory animals is inevitable in scientific evaluation and alternative approaches have limitations in the whole coverage, continuous effort is necessary to minimize animal use and to develop reliable alternative tests for pesticide evaluation. This review discusses alternative approaches for pesticide toxicity tests and hazard evaluation that have been used in peer-reviewed reports and could be applied in future studies based on the critical animal research principles of reduction, replacement, and refinement.

• Asian Pacific Journal of Cancer Prevention
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• 제14권6호
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• pp.3469-3472
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• 2013

Extract of Lentinula edodes mycelia (LEM) is currently utilized as an oral biological response modifier (BRM) medicine for cancer patients. However, its effectiveness for breast cancer patients with postoperative adjuvant hormone therapy has not yet been scientifically verified. In this study, we investigated the influence of LEM on the quality of life (QOL) and immune response in breast cancer patients undergoing postoperative adjuvant hormone therapy. Twenty patients were studied in total. They received only hormone therapy in the first 4 weeks followed by hormone therapy and LEM during the next 8 weeks. Laboratory tests, QOL score and peripheral blood cytokine production levels were evaluated during the study period. No changes in QOL or cytokines were noted after the first 4 weeks. In contrast, during the following combined therapy period, improvements were noted in QOL and cytokine levels. Although a future large-scale investigation is necessary to confirm these results, these data suggest that the concomitant use of LEM with postoperative adjuvant hormone therapy improves the QOL and immune function of patients.

• 생약학회지
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• 제43권1호
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• pp.66-71
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• 2012

Cirsium japonicum var. ussuriense is often used in treatment of human disease such as hemorrhage, blood congestion and inflammation. This study was accomplished to evaluate the antioxidant properties of the leaf (CLE) and flower (CFE) extracts of C. japonicum var. ussuriense to protect normal human red blood cells (RBC) and plasma samples against oxidative damage in vitro. CLE and CFE were prepared by extracting with hot water. In red blood cells and plasma, oxidative hemolysis and lipid peroxidation induced by the aqueous peroxyl radical generator [2,2'-azobis (2-amidinopropane) dihydrochloride, AAPH] were significantly suppressed by CLE or CFE in a dose-dependent manner at the same time. CLE and CFE also prevented the depletion of cytosolic antioxidant glutathione (GSH) in RBC. These results suggest that the leaves and flowers of C. japonicum var. ussuriense may have the antioxidant properties.

• 대한간호학회지
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• 제31권1호
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• pp.7-19
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• 2001

In our country, patients with diabetes mellitus are searching for complementary treatments to recover from illness, while they received treatments from the doctor. However, have been evaluated or investigated systematically. This study was carried out to explore application of complementary treatments for patients with DM. For this survey, questionnaires were developed by researchers and the data was collected from July to October of 1999. Among the 223 subjects, there is one general hospital, one oriental hospital, 15 area C.H.P, ahd 2 area health centers. The results were as follows: 1. The total number of cases was 223 and the average age was 62.85 years old and average duration of DM was 8.1 years. The number of patients who had experience with alternative therapies was 145 (65%). The number of those who have not undergone treatments was 78 (35%). 2. The 43.5% of experienced CAM were advised family and relatives. Only 30.3% approved the effect of CAM and 52.5% said that If another a new CAM is introduced, they will try it. 4. Ninety three kinds of complementary treatments were used. Among the used items, 63.7% was various types of plants, 21.6% was animal material and 14.7% was the mixed group. As a single item, Bombyx Mori (Silkworm) was the most frequently used (10.5%) followed by the bean, mushroom, Morus bombycis (mulberry), Ginseng, Commelina Communis (Dalgaebi), Chinese medicine, root of Rosa rugosa (Haedangwha). 5. Among the used items, Trichosanthes kirilowii Max. Eucommia ulmoides Oliver, Commelina Communis, Aralia elata, pine needle, mulberry fruit, root of Rosa rugosa. Ginseng, Lycii Fructus, Dioscorea radix, Polygonatum odoratum, Cassia tora L, Bombyx Mori, loach, Crucian carp were based upon the pharmacological function of effect for control of diabetes mellitus symptom. 6. In the analysis of the relationships between the general characters of the patients with new complementary alternative medicine try and hospital treatment; 1) The shorter group suffered from DM (p=.038), poor Self-MBG (p=.037) and wanted to try new complementary alternative medicine. 2) The group of DM education experience were carried out hospital treatment well (p=.045). In conclusion, further study will be required for the patients experience using alternative therapies as the D-M in terms of holistic view of patients.

• The Korean Journal of Pain
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• 제25권3호
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• pp.183-187
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• 2012

The use of fluoroscopy guidance together with the loss of resistance technique during epidural injections has been advocated lately; moreover, epidural injections in the absence of fluoroscopic guidance have a high rate of inaccurate needle-tip placement during the injections. However, the approach to the lower cervical and upper thoracic epidural space may be challenging due to its obscure lateral fluoroscopic views from overlying normal tissue structures. In this case, we report an alternative oblique C-arm fluoroscopy guided view approach to supplement the standard anterior-posterior and lateral fluoroscopic views to facilitate successful needle placement and precise anatomical localization of the epidural space.

• 한국의사학회지
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• 제21권2호
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• pp.95-113
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• 2008

Unsatisfied with the modern medicine's treatment of diabetes, patients diagnosed with the disease turn to alternative medicine for treatment. A look at the percentage of people using alternative medicine marked 72.8% in the United States and more than 60% in Korea in 2006. The most preferred form of alternative medicine turned out to be usage of dietary supplements and herbal medicine. Most of the dietary supplements and herbs that diabetic patients use largely originated from their usage in East Asian Traditional Medicine. As Western Medicine made its way into East Asia in late 18th century, excessive efforts were made to translate Western medical terminology into traditional medical terminology equivalents. In the process of doing so, wasting-thirst became a concept equivalent to diabetes. Theories regarding the pathogenic outbreak and transmission of wasting-thirst has been supplemented and progressed according to needs and even showed new tendencies. Profound understanding of wasting-thirst achieved through historical research is expected to lead to proper application of wasting-thirst treatment methods in treating modern diabetes.

• 대한한방내과학회지
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• 제30권4호
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• pp.732-745
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• 2009

Objectives : This study analyzed the contents of research papers of complementary and alternative medicine (CAM) concerning chronic obstructive pulmonary disease (COPD) published in PubMed during the last 5 years. This study was conducted to help clinical studies for treating COPD with Oriental medicine. Materials and Methods : We inspected 31 theses and scrutinized their objectives, periods, participants, materials and methods, methods of assessment, results and Jadad score. Results : The treatments in the studies were supplements, physical training, acupuncture, acu-TENS, Bojungikgi-tang (Buzhongyiqi-tang), counseling, breathing training, osteopathic manipulative treatment, reflexology, and distractive auditory stimuli. The aims of treatment were improvement of exercise capacity, lung function, quality of life, oxidative status, nutrient status, systemic inflammation, and cessation of smoking. The median for treatment period of study was 8 weeks, the median number of participants was 35 and the differences between mean $FEV_1$ from groups were less than 10% in 22 studies. The methods of assessment were lung function test, exercise capacity test, muscle strength test, questionnaire of QoL, laboratory studies, and measurement of nutrient state. The mean of Jadad score was $2.4\;{\pm}\;1.03$, and 24 treatment were assessed as effective. Conclusion : Recent CAM studies of COPD have focused on various topics in alternative and complementary medicine, and it is necessary to provide objective studies for treatment of this disease with Oriental medicines.

• Journal of Rheumatic Diseases
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• 제24권4호
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• pp.227-235
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• 2017

Objective. Failure of first-line anti-tumor necrosis factor (TNF) agents in in rheumatoid arthritis patients leads to decisions among second-line biologic agents. To better inform these decisions, the therapeutic effectiveness of rituximab is compared with other second-line biologic agents in this observational study. Methods. Between November 2011 and December 2014, study subjects were observed for 12 month periods. Patients with an inadequate response to initial anti-TNF agent received either rituximab or alternative anti-TNF agents (adalimumab/etanercept/infliximab) based on the preference of patients and physicians. The efficacy end point of this study was the change in 28-joint count Disease Activity Score (DAS28) at six and 12 months from baseline. Safety data were also collected. Results. Ninety patients were enrolled in the study. DAS28 at six months did not change significantly whether the patients were treated with rituximab or alternative anti-TNF agents in intention-to-treat analysis (n=34, $-1.63{\pm}0.30$ vs. n=31, $-2.05{\pm}0.34$) and standard population set analysis (n=31, $-1.51{\pm}0.29$ vs. n=24, $-2.21{\pm}0.34$). Similarly, the change in DAS28 at 12 months did not reach statistical significance ($-1.82{\pm}0.35$ in the rituximab vs. $-2.34{\pm}0.44$ in the alternative anti-TNF agents, p=0.2390). Furthermore, the incidences of adverse events were similar between two groups (23.5% for rituximab group vs. 25.8% for alternative anti-TNF agents group, p=0.7851). Conclusion. Despite the limitations of our study, switching to rituximab or alternative anti-TNF agents after failure of the initial TNF antagonist showed no significant therapeutic difference in DAS28 reduction.

• 대한암한의학회지
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• 제14권1호
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• pp.1-11
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• 2009

Objectives: Many countries have been using Complementary and alternative medicine (CAM) for treating cancer and it has been given more weight than before. This study aimed to look into its current status and perspective way to suggest the way which Korean oriental medicine goes to. Methods: We searched internet web sites that are relative with CAM in oncology parts and made lists for this study. We downloaded the essays in the form of electronic files in that web sites and copied the originals consulting to each libraries and relative institution. Results: North America was processing the standardization of CAM based evidences and China was making their traditional medicine representative medicine of CAM. India was developing their traditional medicine because of their domestic need and its results were recognized by National Cancer Institute (NCI). CAM was regulated and studied legally in Europe. Japan was using mushroom for immune therapy clinically. Mexico had a large scale of medical valley in Tijuana area and made it international. Conclusions: The efforts to develop and study CAM for treating cancer are increasing in the world. We need to know the current status of CAM in the world, and make our way that Korean oriental medicine goes to.