• Transactions of the Korean Society of Mechanical Engineers B
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• v.40 no.11
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• pp.727-736
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• 2016

In this study, a high-pressure multistage pump used in the combined cycle power plants is analyzed. The pump performance characteristics (differential head and efficiency) are numerically analyzed for different shapes of the radial diffuser. The design variables selected for the radial diffuser are, number of vanes, diameter ratio ($D_4/D_3$), return channel outlet angle(${\alpha}_6$), and pressure recovery factor ($C_p$). The numerical analysis results showed that the differential head and efficiency are the highest when the diameter ratio is the highest. Further, it was observed that the differential head was lower when the return channel outlet angle was $60^{\circ}$ than when it was $90^{\circ}$, because of pre-swirl at the diffuser outlet.

• Biomolecules & Therapeutics
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• v.16 no.3
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• pp.219-225
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• 2008

Taurine is the most abundant amino acid in many tissues and is found to be enhancing the bone tissue formation or inhibits the bone loss. Although it is reported that taurine reduces the alveolar bone loss through inhibiting the bone resorption, its functions of taurine and expression of taurine transporter (TauT) in bone have not been identified yet. The purpose of this study is to clarify the uptake mechanism of taurine in osteoblast using mouse osteoblast cell lines. In this study, mouse stromal ST2 cells and mouse osteoblast-like MC3T3-E1 cells as osteoblast cell lines were used. The activity of taurine uptake was assessed by measuring the uptake of [$^3H$]taurine in the presence or absence of inhibitors. TauT mRNA was detected in ST2 and MC3T3-E1 cells. [$^3H$]Taurine uptake by these cells was dependent on the presence of extracellular calcium ion. The [$^3H$]taurine uptake in ST2 cells treated with 4 mM calcium was increased by 1.7-fold of the control which was a significant change. In contrast, in $Ca^{++}$-free condition and L-type calcium channel blockers (CCBs), taurine transport to osteocyte was significantly inhibited. In oxidative stress conditions, [$^3H$]taurine uptake was decreased by TNF-$\alpha$ and $H_2O_2$. Under the hyperosmotic conditions, taurine uptake was increased, but inhibited by CCBs in hyperosmotic condition. These results suggest that, in mouse osteoblast cell lines, taurine uptake by TauT was increased by the presence of extracellular calcium, whereas decreased by CCBs and oxidative stresses, such as TNF-$\alpha$ and $H_2O_2$.

• Journal of Distribution Science
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• v.14 no.11
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• pp.129-138
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• 2016

Purpose - The ICT(information and communications technologies) development is affecting consumer behaviors on selecting channel or distribution system. This study aims to advance our knowledge about the factors influencing omni-channel behaviors. This study considers the positive brand experience as the moderating variable into the relationship between omini-channel use intention and consumer brand relation. Also, the effect of positive brand experience on consumer-brand relation is researched. Research design, data, and methodology - This study conducted an empirical test with the subject as customers who purchase goods or service through on-off cross channel simultaneously. The research model is developed from prior literatures about influencing variables on channel selection. The structure of this study is designed to identify causal relationships between the variables. 268 survey data from the questionnaire survey which is conducted to target customers who use online and offline channels, is used for empirical analysis. This study validates generality with descriptive statistics and data reliability with Cronbach's alpha value. The exploratory factor analysis is used for value purification. Then, the confirmatory factor analysis is conducted for structural equation modeling. Finally, the execute structural equation modeling is analyzed to confirm the hypotheses Results - First, the two causal influences between perceived performance risk and the propensity of omni-channel and between price consciousness and the propensity of omni-channel are verified through the empirical test. Second, the result identifies that the propensity of omni-channel is influenced on consumer-brand relationship. Third, the AMOS analysis proves that the moderating variable, positive brand experience, has significant positive impact on consumer-brand relationship. This significant relationship is highly supported by the regression analysis between brand experience and propensity of omni-channel because it results that positive brand experience has positive impact on the propensity of omni-channel. All hypotheses are verified to be true. Conclusions - Based on the empirical result, this study confirms that perceived performance risk and price consciousness are the important factors influencing propensity of omni-channel. According to the additional analysis, the moderating variable and positive brand experience plays important role between the propensity of omni-channel and consumer-brand relationship. Furthermore, positive brand experience influences more on consumer-brand relationship than non-positive brand experience.

• Proceedings of the Korean Institute of Communication Sciences Conference
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• 1991.10a
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• pp.205-209
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• 1991

The conventional modeling equations for planar MOSFET can not be directly used for zero or minus junction depth concave MOSFET. In this paper, we suggest a new model which can simulate the electrical characteristics of concave MOSFET. The threshold voltage modeling was achieved using the charge sharing method considering the relative difference of source and drain depletion widths. To analyze the ID-VDS characteristics, the conventional expressions for planar MOSFET were employed with the electrical channel length as an effective channel length and the channel length modulation factor as ${\alpha}$ΔL. By comparing the proposed model with experimental results, we could get reasonably similar curves and we proposed a concave MOSFET conditiion which shows no short channel effect of threshold voltage(V${\gamma}$).

• ETRI Journal
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• v.38 no.6
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• pp.1031-1041
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• 2016

This paper presents millimeter-wave (mmWave) propagation characteristics and channel model parameters including path loss, delay, and angular properties based on 28 GHz and 38 GHz field measurement data. We conducted measurement campaigns in both outdoor and indoor at the best potential hotspots. In particular, the model parameters are compared to sub-6 GHz parameters, and system design issues are considered for mmWave 5G Giga communications. For path loss modeling, we derived parameters for both the close-in free space model and the alpha-beta-gamma model. For multipath models, we extracted delay and angular dispersion characteristics including clustering results.

• The Korean Journal of Pharmacology
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• v.32 no.2
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• pp.189-199
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• 1996

Myocardial ${\alpha}_1-adrenoceptors$ have been shown to mediate a biphaslc inotropic response that was characterized by a transient decline followed by a sustained increasing phase in guinea pig ventricular muscle. Recently one group reported that an ${\alpha}_1-adrenoceptors-induced$ intracellular $Na^+$ decrease is linked to fast $Na^+$ channel inhibition and another group reported that it is linked to $Na^+$-$K^+$ pump activation by ${\alpha}_{1b}-adrenoceptors$. But until now, its mechanism is not clear. Therefore, to see whether the $Na^+$channel or $Na^+-K^+$ pump is related to a decrease in intracellular $Na^+$ activity and/or the negative inotropic response, and which ${\alpha}_1-adrenoceptor$ subtype was involved in the decrease in intracellular $Na^+$activity by phenylephrine, we used conventional and sodium selective microelectrodes, and tension transducer to determine the effects of ${\alpha}_1-adrenergic$ stimulation on membrane potential, intracellular $Na^+$ activity, and twitch force in guinea pig ventricular muscles. $10^{-5}$ M Phenylephrine produced a slight hyperpolarization of the diastolic membrane potential, a decrease or increase in $a_N^i_a$, and a biphasic inotropic response. The negative inotropic response accompanied by a decrease in intracellular $Na^+$activity, whereas in muscles showing a remarkable positive inotropic response without initial negative inotropic effect was accompanied by an increase in intracellular $Na^+$ activity. The decrease in intracellular $Na^+$ activity was apparently inhibited by WB4101, an antagonist of the ${\alpha}_{1a}-adrenoceptors$. The decrease in intracellular $Na^+$ activity caused by phenylephrine was not abolished or reduced by a block of the fast $Na^+$ channels. $V_{max}$ also was not affected by phenylephrine. Phenylephrine produced an increase in intracellular $Na^+$ activity in the presence of a high concentration of extracellular $Ca^{2+}$ (in quiescent muscle) or phorbol dibutyrate, a protein kinase C activator(in beating muscle). These suggest that the ${\alpha}_{1a}-adrenoceptors-mediated$ decrease in intracellular $Na^+$ activity may be related to the protein kinase C.

• Molecules and Cells
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• v.27 no.5
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• pp.591-599
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• 2009

Nicotinic acetylcholine receptors (nAChRs) play important roles in nervous system functions and are involved in a variety of diseases. We previously demonstrated that ginsenosides, the active ingredients of Panax ginseng, inhibit subsets of nAChR channel currents, but not ${\alpha}7$, expressed in Xenopus laevis oocytes. Mutation of the highly conserved Leu247 to Thr247 in the transmembrane domain 2 (TM2) channel pore region of ${\alpha}7$ nAChR induces alterations in channel gating properties and converts ${\alpha}7$ nAChR antagonists into agonists. In the present study, we assessed how point mutations in the Leu247 residue leading to various amino acids affect 20(S)-ginsenoside $Rg_3$ ($Rg_3$) activity against the ${\alpha}7$ nAChR. Mutation of L247 to L247A, L247D, L247E, L247I, L247S, and L247T, but not L247K, rendered mutant receptors sensitive to $Rg_3$. We further characterized $Rg_3$ regulation of L247T receptors. We found that $Rg_3$ inhibition of mutant ${\alpha}7$ nAChR channel currents was reversible and concentration-dependent. $Rg_3$ inhibition was strongly voltage-dependent and noncompetitive manner. These results indicate that the interaction between $Rg_3$ and mutant receptors might differ from its interaction with the wild-type receptor. To identify differences in $Rg_3$ interactions between wild-type and L247T receptors, we utilized docked modeling. This modeling revealed that $Rg_3$ forms hydrogen bonds with amino acids, such as Ser240 of subunit I and Thr244 of subunit II and V at the channel pore, whereas $Rg_3$ localizes at the interface of the two wild-type receptor subunits. These results indicate that mutation of Leu247 to Thr247 induces conformational changes in the wild-type receptor and provides a binding pocket for $Rg_3$ at the channel pore.

• The Journal of the Korea Contents Association
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• v.8 no.1
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• pp.272-281
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• 2008

A layer channel, which can express effects on 3D image, is inserted to use it on application rendering effectively. The current method of effect rendering requires individual sources in storage and image processing, because it uses individual and mixed management of images and effects. However, we can save costs and improve results in images processing by processing both image and layer channels together. By changing image format to insert a layer channel in image and adding a hide function to conceal the layer channel and control to make it possible to approach image and layer channels simultaneously during loading image and techniques hiding the layer channel by changing image format with simple techniques, like alpha blending, etc., it is developed to improve reusability and be able to be used in all programs by combining the layer channel and image together, so that images in changed format can be viewed in general image viewers. With the configuration, we can improve processing speed by introducing image and layer channels simultaneously during loading images, and reduce the size of source storage space for layer channel images by inserting a layer channel in 3D images. Also, it allows managing images in 3D image and layer channels simultaneously, enabling effective expressions, and we can expect to use it effectively in multimedia image used in practical applications.

• Science of Emotion and Sensibility
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• v.16 no.1
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• pp.75-84
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• 2013

The underlying changes in biological processes that are associated with reported changes in mental and physical health in response to yoga breathing ($pr{\bar{a}}n{\bar{a}}y{\bar{a}}ma$) have not been systematically explored yet. In this study, the effects of a yoga breathing program on prefrontal EEG were tested with middle-aged women. Participants were collected as volunteers and controlled into two groups. Two channel EEG was recorded in the prefrontal region (Fp1, Fp2) from the yoga breathing group (n=17) and control group (n=17). QEEG quotients were transformed from the EEGs and analyzed by the ANOVAs on gain scores. As a result, ${\alpha}/{\delta}$ (left, right) and CQ (correlation quotient) for yoga breathing participants were significantly decreased compared to control group (p<.05). ${\alpha}/{\beta}_H+{\alpha}/{\delta}$ (left, right) were increased significantly (p<.05). For those significantly changed QEEG quotients, the interaction effects of Group x prefrontal alpha (${\alpha}$) and beta (${\beta}$) asymmetry were tested. Only the ${\alpha}$ asymmetry showed main effect on the gain score of ${\alpha}/{\beta}_H+{\alpha}/{\delta}$ (right) with F (1, 34)＝5.694 (p<.05). Pearson's correlation coefficient between ${\alpha}$ asymmetry and gain score of ${\alpha}/{\beta}_H+{\alpha}/{\delta}$ (right) was .374 (p<.05). The gain score of ${\alpha}/{\beta}_H+{\alpha}/{\delta}$ (right) was increased for the right ${\alpha}$ dominance of yoga breathing group. On the contrary it was decreased for the left ${\alpha}$ dominance of yoga breathing group as well as the control regardless of the dominance. The result of this study implies that yoga breathing increases stress resistance and is effective in the management of physical stress. Emotionally relaxed people may have greater instantaneous stress reduction after yoga breathing. Moreover, yoga breathing could be also beneficial for depressed who may be more vulnerable to stress.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 1999.11a
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• pp.586-589
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• 1999

Organic semiconductors based on conjugated thiophene oligomer have great potential to be utilized as an active layer far electronic and optoelectronic devices. In this study, $\alpha$ -sexithiophene($\alpha$-6T) thin films and various electrode materials were deposited by Organic Molecular Beam Deposition(OMBD) and vacuum evaporation respectively. Those films were photolithographically patterned fur measurements. Electrical characterization of the thin film transistor with various channel length were measured, and field effect mobility is calculated by formula.