• 약학회지
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• 제35권4호
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• pp.264-270
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• 1991

An efficient synthetic route to carbocycle is described. 1, 1, 2-Trisubstituted cycloheptane has been synthesized from allylic carbonate by Pd(0) catalzyed cyclization.

• 약학회지
• /
• 제34권5호
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• pp.287-290
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• 1990

An efficient stereoselective synthetic route to carbocycle is described. 1,1,2-Trisubstituted cyclopentane was synthesized from allylic carbonate by Pd(0) catalyzed cyclization.

• 약학회지
• /
• 제39권1호
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• pp.41-47
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• 1995

An efficient and stereoselective synthetic route to the trisubstituted hydroxy cyclopentane as an useful synthetic intermediate for carbaprostacyclin is described. Pd(0)-mediated intramolecular alkylation of allylic carbonate has been employed as a key reaction.

• 약학회지
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• 제34권3호
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• pp.166-170
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• 1990

An efficient synthetic route to macrolide is described. Eight-membered lactone was synthesized via palladium catalyzed intramolecular alkylation of allylic carbonate in high yield.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1994년도 춘계학술대회 and 제3회 신약개발 연구발표회
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• pp.215-215
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• 1994

PGI$_2$ 안정한 구조를 갖는 carbaprostacyclin 및 그 structural analog들을 입체 선택적으로 합성하고, 혈관 순환 개선제로 발전시키고자 중요한 합성 중간체이며 광학활성을 갖는 5-ethenyl-3-hydroxy cyclopentane carboxylate를 합성하였다. 반응의 핵심 단계는 butyrolactone moiety를 갖는 allylic carbonate를 Pd(0)촉매하에서 환화시킨 후, 정교한desulfonation에 이온 lactone의 개열 단계를포함한다.