• Archives of Pharmacal Research
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• 제29권6호
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• pp.459-463
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• 2006

Previous studies on the anticonvulsant activity of $N-Cbz-{\alpha}-aminoglutarmides$ have shown that the derivatives of $N-Cbz-{\alpha}-amino-N-alkoxy$ glutarimide have significant anticonvulsant activity. In addition, their anticonvulsant activities are dependent on the presence of N-alkoxy groups. Based on these results, a series of $N-Cbz-{\alpha}-amino-glutarimidooxy$ carboxylates derivatives (3a-e) were synthesized in moderate yield using a known synthetic procedure. Their anticonvulsant activities were evaluated using the maximal electroshock seizure (MES) test, the pentylene tetrazole induced seizure (PTZ) test, and the strychinine (Str) threshold test with the ultimate aim of developing more active anticonvulsants. None of the compounds (3a-e) tested showed anticonvulsant activity in the MES and PTZ test. However, all the compounds tested exhibited significant anticonvulsant activity in the Str. test. The most active compound in the Str. test was the methyl ester of $N-Cbz-{\alpha}-amino-glutarimidooxy$ acetic acid 3a $(ED_{50}\;=\;42.9\;mg/kg)$.

• 한국전기전자재료학회논문지
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• 제29권1호
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• pp.35-39
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• 2016

In this research, we focused on the improvement of cy3 dye's characteristics for LCD color filter. Solubility and thermal stability are main characteristics of dyes for LCD color filter. We performed experiment to change counter cation of cy3 dyes with alkoxy substituent for these purposes. These cy3 dyes (1b~5b) were prepared through the synthetic procedure of three steps. The synthesized new cy3 dyes were charaterized by using NMR, FT-IR, UV/Vis spectroscopy, and TGA. These cy3 dyes showed purple color and maximum absorption wavelength (${\lambda}_{max}$) in the range of 578~590 nm in UV/Vis spectrum. We confirmed that solubility and thermal stability of cy3 dyes were dependent on the structure of counter cation. Cy3 dyes with alkoxy substituent have good solubility in organic solvents such as dichloromethane, methanol, and acetone. Especially, Cy3 dye with 4-nitrobenzyl counter cation (5b) gave excellent solubility characteristics.

• 청정기술
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• 제20권4호
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• pp.415-424
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• 2014

본 연구는 전자주개 물질인 phenothiazine 유도체와 전자받개 물질로 quinoxaline 유도체를 Suzuki coupling reaction으로 push-pull 구조의 고분자(PPQX-2hdPTZ (P1), POPQX-2hdPTZ (P2))를 합성하였다. 용해도 향상을 위해 기본 골격에 alkoxy 사슬을 도입하였고, 반응시간을 단축시키고 중합도를 높이기 위해 마이크로웨이브 합성 반응기를 이용하여 중합시켰다. 합성된 고분자는 물리적, 열적, 광학적 및 전기화학적 특성을 확인하였다. 두 고분자의 초기분해온도는 $323-328^{\circ}C$로서 열 안정성이 우수함을 확인하였고, 추가로 alkoxy 사슬을 도입한 P2의 중합도가 더 높았다. 전기화학적 특성을 분석한 결과 두 고분자의 HOMO에너지 레벨은 유사하였다. 합성된 고분자는 ITO/PEDOT:PSS/active layer/$BaF_2$/Al 구조로 소자를 제작하여 유기박막태양전지로의 특성을 확인하였다. 각 소자는 박막의 두께를 다르게 하여 이에 따른 효율의 변화를 확인하였고, 박막의 두께가 얇아질수록 높은 효율을 나타내었다($PCE_{max}:P1=1.0%$, P2 = 1.1%).

• 약학회지
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• 제44권1호
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• pp.9-15
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• 2000

Four 3-alkoxy-6-allylthiopyridazines and 3-chloro-6-allylthiopyridazine were synthesized and their protective effects against oxidative stress and UV-C irradiation were tested. 3-Methoxy-6-allylthiopyridazine and 3-ethoxy-6-allylthiopyridazine did not show protective effect on the oxidative stress but showed the strongest protective effect on UV-C irradiation among the tested compounds. Especially 500 $\mu\textrm{g}$/$m\ell$ of the two compounds was the most effective concentration.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1994년도 춘계학술대회 and 제3회 신약개발 연구발표회
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• pp.224-224
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• 1994

N-arylsulfonylimidazolenes를 항암효과가 우수한 화합물로 설정하여 이들 유도체를 합성하고 이들의 세포독성을 측정한바 있다. 그 이유는 2번 위치의 alkoxy기에 의하여 alkylating agent로서 작용할 수 있다는 개념과 생체 반응 후 생성될 것으로 예상되는 N-arylsulfonylimidazolidinone이 sulofenur와 유사한 작용을 갖을 것으로 기대 되었기 때문이다. 이에따라 N-arylsulfonylimidazolidinone 유도체의 항암효과의 측정이 관심의 대상이 됨에 따라 이들 유도체를 합성하고 이들의 세포독성을 관찰함으로써N-arylsulfonylimidazolidinone 유도체들의 구조 활성 상관관계를 관찰하고자 하였다. 합성은 출발물질을 N-arylsulfonyl-2-alkoxyimidazoline에서 시작 몇단계를 거쳐 목적하는 화합물을 합성 하였다.

• 대한화학회지
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• 제41권7호
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• pp.366-370
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• 1997

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1993년도 제2회 신약개발 연구발표회 초록집
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• pp.39-39
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• 1993

To find out the novel anticancer agent for the treatment of solid tumors, 1-arylsulfonyl-2-alkoxy-4-arylimidazolines were designed and prepared from substituted styrenes through three steps. Compared to 5-fluorouracil, these analogues exhibit moderate cytotoxicity against human solid tumor cell lines, A-549(lung carcinoma) and SK-Mel-2(malignant melanoma). The structure-activity relationship indicates the high potential of this series for the development of novel antineoplastic agent.

• Archives of Pharmacal Research
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• 제22권5호
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• pp.502-506
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• 1999

Different 2-(8,12 dimethyl-5-oxa-7(E), 11-tridecadienyl)-alkyl phenyl ethers, their mono oxirane and thirane derivatives were synthesized and tested on Culex pipiens quinquefasciatus Say for their juvenile hormone activity.

• Bulletin of the Korean Chemical Society
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• 제33권1호
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• pp.33-34
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• 2012

• 한국세라믹학회지
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• 제28권12호
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• pp.975-980
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• 1991

Chelated titanium alkoxides are hydrolysed showly and stable enough to prepare multicomponent gels of titania without its precipitation due to the fast hydrolysis of Ti alkoxide. The alkoxy groups of chelated titanium alkoxide are hydrolysed as fast as that of titanium alkoxide but the chelating groups are stable even in aqueous solution. The chelating groups showed different rates of hydrolysis in aqueous ammonia solution and water added one. Those rates were monitored with UV-VIS spectrophotometer by using their unique absorption bands before and after hydrolysis.