• 대한간호학회지
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• 제49권6호
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• pp.690-700
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• 2019

Purpose: The purpose of this study was to examine the awareness of alcohol use during pregnancy and factors influencing the intention to abstain from alcohol during pregnancy by drinking levels. Methods: Utilizing a comparative descriptive design, a total of 359 female college students were recruited. Measurements were Theory of Planned Behavior (TPB) variables related awareness of alcohol use during pregnancy, Korean Version of the Alcohol Use Disorders Identification Test, knowledge about alcohol use during pregnancy, and socio-demographic factors. Main variables were compared by drinking levels. The factors influencing the intention to abstain from alcohol during pregnancy were identified using hierarchical regression analysis. Results: Non-problematic alcohol behavior group (n=185) had higher the intention to abstain from alcohol during pregnancy than problematic alcohol behavior group (n=174) (t=3.13, p=.002). The significant TPB variables influencing the intention to abstain from alcohol during pregnancy were that attitudes (β =-.44, p<.001), subjective norms (β =.14, p=.026), and perceived behavior control (β =.19, p=.002) in non-problematic alcohol behavior group, whereas the corresponding variables in the problematic alcohol behavior group were attitudes (β =-.51, p<.001) and subjective norms (β =.21, p=.006). Conclusion: It is necessary to increase the intention to abstain from alcohol during pregnancy for the female college students having problematic alcohol behavior. The following strategies are recommended for them; decreasing acceptable attitudes toward alcohol use during pregnancy and reinforcing the influence of social pressure toward to abstain from alcohol during pregnancy.

• Toxicological Research
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• 제14권4호
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• pp.557-562
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• 1998

Allyl alcohol is metabolized in the liver through two steps, first to reactive acrolein by alcohol dehydrogenase (ADH), subsequently to acrylic acid by aldehyde dehydrogenase (ALDH). Since ethanol could compete the same enzymes to be metabolized in the liver, we have determined the plasma concentrations of allyl alcohol and ethanol followed by combined treatment. Pretreatment of rats with 2g/kg ethanol followed by ip administration of 40mg/kg allyl alcohol increased the lethality significantly. Determination of in vivo blood concentrations revealed that ethanol pretreatment caused the apparent decrease in allyl alcohol clearance, whereas acetaldehyde level in blood increased significantly by allyl alcohol treatment, as determined by head space GC analysis. Treatment of 4-methylpyrazole, an inhibitor of ADH, delayed allyl alcohol elimination significantly and reduced its lethality. Collectively, these findings suggested that reduction of allyl alcohol clearance in the presence oj ethanol was mediated through ADH competitive inhibition.

• Preventive Nutrition and Food Science
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• 제6권1호
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• pp.62-65
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• 2001

Persimmon has been known to help alcohol intoxication in Korea for a long time and is prepared as a processed food. The effect of dried persimmon snacks on alcohol metabolism was determined in vivo. Eight Korean men (25~27 years old) were administered 3.5 mL/kg of alcohol (22.5%, w/v) with or without a dried persimmon snack (2g/kg). The levels of alcohol in the blood and of acetaldehyde in the blood and the urine were determined by alcoholmeter and assay using alcohol dehydrogenase and HPLC, respectively. All subjects showed decreased levels of alcohol in blood, and six subjects showed a decrease of alcohol in urine after consumption of ethanol with dried persimmon snacks. Concentration of acetaldehyde in the blood an urine decreased significantly in three and five of the eight subjects, respectively. Reduction was more significant for alcohol than for alcohol than for acetaldehyde with administration of ethanol and dried persimmon snacks. This in vivo result suggests that dried persimmon snacks are effective in decreasing th concentration of alcohol after alcohol intake.

• 여성건강간호학회지
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• 제18권4호
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• pp.279-289
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• 2012

Purpose: The purpose of this study was to explore the influence in a planned pregnancy of alcohol related family variables, knowledge and recognition of the effects of alcohol use during pregnancy on actual alcohol use during pregnancy. Methods: The participants were 284 women who had experienced a pregnancy at some time in their lives. The data were collected from December 2011 to January 2012 and the method of data collection was self-report questionnaires. The instruments for this study were AUDIT-K, Knowledge of alcohol use during pregnancy, and Recognition of alcohol use during pregnancy. Results: There were higher incidences of alcohol use during pregnancy when alcohol consumption was a problem, when there was a family member with an alcohol problem, or after having had an artificial abortion. There was no correlation in alcohol use during pregnancy with knowledge, but a correlation with recognition was found. Conclusion: The results of this study suggest that the main factor in alcohol use during pregnancy is recognition of the effects of alcohol use during pregnancy.

• 한국사회복지학
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• 제44권
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• pp.91-116
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• 2001

The purposes of this study were to compare middle school students' alcohol expectancies with high school students' alcohol expectancies and to identify factors (family history of alcohol problems, television advertisements, age, gender, drinking experience, alcohol prevention education) related to their alcohol expectancies. A total of 1,164 middle school students in seven metropolitan areas in Korea participated in this study. The major finding of this study was that the respondents scored higher on negative alcohol expectancies than high school adolescents. As found in previous studies, factors related to adolescents' alcohol expectancies were also significantly related to respondents' alcohol expectancies in this study. Respondents who had family histories of alcohol problems, had drinking experiences, and were older expect drinking in a more positive manner. This study also found that alcohol advertising affected respondents' alcohol expectancies. However, this study found that current substance abuse prevention programs did not affect respondents' alcohol expectancies at all. This finding may suggest that some changes on current prevention programs should be needed in order to be more effective. Finally the result on the relationship gender and alcohol expectancies in this study was different from previous studies. Female respondents expected drinking more positively than male counterparts. This study suggests that further studies on this issue are necessary.

• Journal of health informatics and statistics
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• 제42권2호
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• pp.192-198
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• 2017

Objectives: This study was designed to construct and test the structural equation model for the alcohol-related problem of alcohol use disorders. Methods: Data were collected by structured self-questionnaires from 229 male subjects who received > 8 (greater than 8) score on Alcohol Use Disorder Identification Test (AUDIT). The Data were analyzed by SPSS 21.0 and AMOS 21.0. Results: The model fit indices for the modified hypothetical model showed Q = 2.50, GFI = 0.90, and CFI = 0.94. As a result, Life position, parent's drinking problem, and alcohol expectancy had significantly direct effect on alcohol-related problem. Alcohol expectancy also had mediator effect between life position and alcohol-related problem. Conclusions: Consequently, the more positive life position, the less alcohol-related problem occurred. It is necessary to change their life position, which is individual factor, to prevent or reduce the alcohol related problem of alcohol use disorders.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1994년도 춘계학술대회 and 제3회 신약개발 연구발표회
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• pp.323-323
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• 1994

Allyl alcohol은 간에서 두 단계의 효소 반응을 거쳐 대사되는데, 먼저, alcohol dehydrogenase (ADH)에 의해 독성 활성체인 acrolein으로 바뀌고, 이후 계속하여 aldehyde dehydrogenase (ALDH)에 의해 acrylic acid로 무독화되어 배설된다. Ethanol 역시 간에서 대사되는데 있어 같은 효소들을 공유하므로 allyl alcohol과 경쟁적으로 반응할 것이다. 따라서, 본 실험에서는 ethanol에 의한 대사 효소 경쟁반응에 의해 allyl alcohol 의 간독성이 어떻게 변화하는지를 연구하였다. 우선 ethanol과 allyl alcohol을 동시 투여할 경우 5시간째에 allyl alcohol에 의해 증가된 ALT level을 낮춘다는 보고를 확인하고자 ethanol 2 g/kg과 allyl alcohol 40 mg/kg을 동시투여했으나 오히려 치사율이 증가했고, ethanol을 2시간 전처리한 군에서도 역시 치사율이 증가되고, 간의 glutathione 양은 allyl alcohol 단독 처리군에 비해 현저히 감소되는 양상을 보였다.

• 한국식품영양과학회지
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• 제23권2호
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• pp.181-186
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• 1994

The present study was undertaken to clarify the effect of Puffer fish skin extract (PF) on the hepatic alcohol metabolism in rats. It was observed that alcohol concentration in blood had been markedly decreased by the pretreatment of PF for two weeks. Activities of alcohol dehydrogenase (ADH) and microsomal ethanol-oxidizing system (MEOS) were significantly incrased (more than 20% of control) by pretreatment of PF for two weeks and acute alcohol intoxication (5 g/kg) on final day. When rats were fed with subacute toxic state by alcohol (25v/v % , once a day for six weeks), activities of ADH and MEOS were significantly increased by additional treatments of PF for final two weeks. But the catalase activity was not affected by any of both case. And also activities of ADH and MEOS in vitro were not changed . These results suggest that PF treatemnt prompted the recovery from alcohol intoxication.

• 한국환경보건학회지
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• 제46권1호
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• pp.65-77
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• 2020

Objectives: This study investigated the average number of drinkers in Korea, the number of high-risk drinkers, the average amount of alcohol consumed by high-risk drinkers, and the types of alcohol consumed according to the characteristics of the group of dependent drinkers. Methods: The results were obtained by analyzing the following data: The Global Status Report on Alcohol and Health; Country Profile 2014; WHO Country Profile 2014; Korea National Health and Nutrition Examination Survey 2014, Korean Statistical Information Service; National Tax Statistics-Liquor Tax; Gallup Drinking Frequency Survey 2015 Results: This study found that a large proportion of drinkers in Korea are already high-risk drinkers, and even among drinkers, alcohol consumption was highly biased. It was reported that 49.8% of men in the problem, abuse, and dependence groups accounted for 92.4% of total alcohol consumption among the male population. Notably, the 9.6% of men making up the dependent group consumed more than 30% of the alcohol ingested among males. Women had significant variations within groups that were considered high-risk and exhibited a large share of alcohol consumption in the problem (10.0% of the female population), abuse (1.8% of the female population), and dependence (1.5% of the female population) groups, constituting 72.8% of total alcohol consumption. The average amount of alcohol consumed by drinkers in Korea seems to have exceeded the level of intake by high-risk groups. Alcohol-dependent groups consumed 900.7 mL of soju, 405.2 mL of table wine, and 2,043.8 mL of beer, which is very similar to the consumption average of 2,031 mL of beer and 895.2 mL of soju in the drinking group. Conclusion: It has been shown that men's dependence on alcohol is serious, and it is possible to infer that alcohol consumption in some vulnerable groups is very high. As the average alcohol intake among alcohol-dependent groups and ordinary drinkers is very similar, it is highly likely that the drinker is an alcohol-dependent consumer in Korea.

• Journal of Trauma and Injury
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• 제22권2호
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• pp.233-241
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• 2009

Purpose: Alcohol is a major risk factor for injuries, but little is known about the relationship between chronic drinking pattern and injuries. The purpose of this study was to evaluate the incidence of alcohol-related injuries and the differences in the characteristics of the injuries between Alcohol Use Disorder Identification Test (AUDIT) categories. Methods: Among a representative sample of the third Korea National Health and Nutrition Examination Survey. 7,697 adults answered questions about injuries, drinking patterns, and socioeconomic status. Incidences of alcohol-related injuries and of non-alcohol-related injuries were calculated, and the relative ratio of injuries between AUDIT categories was analyzed. Results: The incidences of all injuries and alcohol-related injuries were 69.2 and 6.8 per 1000 person-year. After adjustment, the incidences of non-alcohol-related injuries showed no differences between AUDIT categories. But the adjusted relative ratios (RRs) of alcohol-related injuries were 3.73 (95% CI: 1.54~8.99) and 7.70 (95% CI: 3.61~16.44) for risk drinkers and for alcohol-dependent drinkers respectively. No specific body part could be identified as being frequently injured in cases of risk drinkers and alcohol-dependent drinkers. In contrast, the adjusted RRs of fractures, bruises, and open wounds were 1.76 (95% CI: 1.03~3.02), 1.73 (95% CI: 1.15~2.61), and 1.85 (95% CI: 1.17~2.93) for alcohol-dependent drinkers. Assaults occurred 4.66 times more frequently in alcohol-dependent drinkers. Conclusion: Alcohol-related injuries occur more frequently as the person becomes more dependent on alcohol. Fractures, Bruises, open wounds, and assaults occur more frequently in alcohol-dependent drinker. This study suggests that efforts should be carried out in the ED to screen and treat alcohol-use disorders associated with patients injured after drinking.