• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.13 no.3
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• pp.56-63
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• 1999

In power system, substation facilities have become too complex and large according to extended power system. Also, some facilities becorre old and often break down unexpectedly. In order to improve the sectrity of transformer out of substation facilities, the development of diagnosis technique to transformer is very needed. In this paper, we developed a method to be analysis the origin and degree of aging by KSOM based on the dissolved gases in power transfonrer. KSOM can do topological mapping for the multi-dimensional pattern based on the dissolved gases to two dimensional plane. And potential possibility and degree of aging for nonna1 transfonrer are presented using the proposed quantitative criterion. Furtherrrore, the aging process of transfonrer is analyzed based on the proposed criterion to special transfonrer. To demonstrate the validity of peoposed method, case study is performed and its results are presented.sented.

• The Journal of Korean Obstetrics and Gynecology
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• v.25 no.4
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• pp.46-55
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• 2012

Objectives: It is well known that genetic factors and environmental factors play major role in aging skin. In general, son and daughter take after their parents in appearance. But comparability of skin properties in Korean family has not been well estimated. So we evaluated the correlation of skin properties in Korean mother-daughter pairs. Methods: 10 couples of mother and daughter pair(n=20) participate in this study. Mothers and daughters were aged $50.6{\pm}2.459$ and $23.8{\pm}2.15$ years, respectively. Skin moisture, sebum, skin color and elasticity is measured using non-invasive method : Corneometer CM825, Sebumeter(MPA580), Mexameter MX18, Cutometer MPA580. Statistical analysis program we used is Minitab 14 Korea. Results: The Skin moisture of mother group was significantly higher than daughter group. And skin elasticity(R2) of the daughter group was significantly higher than mother group. In the results of correlation analysis between mother and daughter pairs, skin elasticity(R2) had high positive correlation(r=0.729, p=0.026). But skin moisture, sebum, melanin index, erythema index and skin elasticity(R5) did not be confirmed a significant correlation. Conclusions: Skin elasticity(R2) is the only factor that showed high positive correlation significantly in mother and daughter pairs. Mother and daughter share the genetic factors and environmental factors that influence skin aging. So, mother's aging pattern will be a good guide for anti-aging of daughters.

• BMB Reports
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• v.52 no.6
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• pp.403-408
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• 2019

Dorsoventral patterning of body axis in vertebrate embryo is tightly controlled by a complex regulatory network of transcription factors. Ventx1.1 is known as a transcriptional repressor to inhibit dorsal mesoderm formation and neural differentiation in Xenopus. In an attempt to identify, using chromatin immunoprecipitation (ChIP)-Seq, genome-wide binding pattern of Ventx1.1 in Xenopus gastrulae, we observed that Ventx1.1 associates with its own 5'-flanking sequence. In this study, we present evidence that Ventx1.1 binds a cis-acting Ventx1.1 response element (VRE) in its own promoter, leading to repression of its own transcription. Site-directed mutagenesis of the VRE in the Ventx1.1 promoter significantly abrogated this inhibitory autoregulation of Ventx1.1 transcription. Notably, Ventx1.1 and Xcad2, an activator of Ventx1.1 transcription, competitively co-occupied the VRE in the Ventx1.1 promoter. In support of this, mutation of the VRE down-regulated basal and Xcad2-induced levels of Ventx1.1 promoter activity. In addition, overexpression of Ventx1.1 prevented Xcad2 from binding to the Ventx1.1 promoter, and vice versa. Taken together, these results suggest that Ventx1.1 negatively regulates its own transcription in competition with Xcad2, thereby fine-tuning its own expression levels during dorsoventral patterning of Xenopus early embryo.

• Journal of dental hygiene science
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• v.23 no.4
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• pp.264-270
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• 2023

Background: Resin-based dental materials release residual monomers or other substances from incomplete polymerization into the oral cavity, thereby causing adverse biological effects on oral tissue. 10-Methacryloyloxydecyl dihydrogen phosphate (10-MDP), an acidic monomer containing dihydrogen phosphate and methacrylate groups, is the most commonly used component of resin-based dental materials, such as restorative composite resins, dentin adhesives, and resin cements. Although previous studies have reported the cytotoxicity and biocompatibility in various cultured cells, the effects of resin monomers on cellular aging have not been reported to date. Therefore, this study aimed to investigate the effects of the resin monomer 10-MDP on cellular senescence and inflamm-aging in vitro. Methods: After stimulation with 10-MDP, MC3T3-E1 osteoblast-like cells were examined for cell viability by WST-8 assay and reactive oxygen species (ROS) production by flow cytometry. The protein and mRNA levels of molecular markers of aging were determined by western blotting and RT-PCR analysis, respectively. Results: Treatment with 0.05 to 1 mM 10-MDP for 24 hours reduced the survival of MC3T3-E1 cells in a concentration-dependent manner. The intracellular ROS levels in the 10-MDP-treated experimental group were significantly higher than those in the control group. 10-MDP at a concentration of 0.1 mM increased p53, p16, and p21 protein levels. Additionally, an aging pattern was observed with blue staining due to intracellular senescence-associated beta-galactosidase activity. Treatment with 10-MDP increased the levels of tumor necrosis factor-α, interleukin (IL)-1β, IL-6 and IL-8, however their expression was decreased by mitogen-activated-protein-kinase (MAPK) inhibitors. Conclusion: Taken together, these results suggest that the exposure of osteoblast-like cells to the dental resin monomer 10-MDP, increases the level of cellular senescence and the inflammatory response is mediated by the MAPK pathway.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.14 no.1
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• pp.464-469
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• 2013

After city of Busan has been entered to the aging society in 2000, the city has the highest aging rate among 7 representative cities in 2011. Moreover, while entire population and number of average household are decreasing, over 65 years old of elderly population is rapidly increasing. So, it is possible to enter the super-aged society, where aging rate would be about 20% after 2020. The purpose of this study is that older housing-related analysis is consisted of dong-unit, and this led microscopic analysis has become necessary. Surveys from 2000 through 2010, census aggregate (output area) unit of spatial analysis was conducted. Take advantages of this, aging population and area, soaring area, high-density areas, such as the region of interest were primary extracted, and microscopic location and spatial distribution patterns were analyzed. Upon analysis, aging population is concentrated in the city and adjacent area, the highlands, and 10 years of increasing rate was more than 30 times in certain aggregate. Regarding the characteristic of these areas, the original city center, Busan, especially concentrated and intensified in aging population. Also, 2000 to 2010, the overall distribution pattern of Busan has identified aging population that is increasingly being distributed. This is the result, which is confronted with previous research result. Entering a super aged-society for the future is accordance with migration of social costs and improve the quality of life of elderly. And this could be the basic information to use the spatial dimension for the corresponding.

• Proceedings of the PSK Conference
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• 2002.10a
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• pp.359.1-359.1
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• 2002

In mammalian species, CpG dinucleotides are highly methylated with 60-90% methylation at the 5-position of cytosine. The pattern of DNA methylation in a cell dramatically affects the function of the DNA by switching genes on or off. Abnormal methylation events occur during aging and in the development of many cancers. Methylated CpG was reported recently to affect the reactivity of agents (mitomycin C and benzo ［a］pyrenediolepoxide) that can fromguanine adducts in DNA. (omitted)

• Electrical & Electronic Materials
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• v.10 no.3
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• pp.247-254
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• 1997

Internal voids in insulators give rise to partial discharge, which causes a local breakdown and even entire insulation breakdown. Recently, the necessity of establishing the way to diagnose the aging of insulation materials and to predict of insulation breakdown become important. The purpose of our work are to investigate the treeing phenomena with an artificial needle shaped void by the charge of discharge and acoustic emission pulse in each phase angle area at the same time. We analyzed the .PHI.-QA-t pattern and .PHI.-AEA-t pattern using statistic operators such as pulse magnitude, pulse number, skewness, kurtosis. Therefore, the relation between the charge of discharge and acoustic emission pulse will be helpful to predict the breakdown just before the breakdown occur.

• Proceedings of the KIEE Conference
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• 2002.07c
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• pp.1685-1687
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• 2002

High voltage(H.V.) induction motors have been applied to various industrial applications. But aging and failure of induction motors are initiated by electrical, mechanical, thermal and chemical processes during manufacturing or in-service. These detects reduce locally the dielectric strength of the insulation. At such defects partial discharges can occur, which cause further degradation of the insulation and reduce the life time of the H.V induction motors. Consequently in this paper, we studied the partial discharge pattern analysis of H.V. induction motor for on-site applications.

• Proceedings of the Korean Institute of Building Construction Conference
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• 2016.05a
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• pp.257-258
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• 2016

Construction of Multi-Family Housing(MFH) was rapidly spread in the 1990s, it has been mostly passed more than 20 years and it is faced to aging time. Remodeling has emerged a major issue in the construction industry as an alternative of improvement and recovery the initial performance of the deteriorated MFH. But, Many decision-makers are struggling to determine whether to conduct a remodeling because of profitability. In this context, this research was conducted as the following steps to achieve this research goal, i) remodeled MFH cases and comparative cases were collected, ii) the price information based on three time frames (i.e., before remodeling, after remodeling, and present) was collected, and iii) the relative price variation of the remodeled cases was analyzed and finally it is revealed that there are four patterns of price variation.

• The Journal of Korean Obstetrics and Gynecology
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• v.31 no.2
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• pp.68-79
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• 2018

Objectives: The aim of this study is the development of the questionnaire for pattern identification of Liver-qi stagnation infertility. Methods: We conducted a literature review and retrieved the symptoms and diagnosis from Korean and Chinese literatures which mentioned pattern identification of Liver-qi stagnation infertility. Based on the findings, We conducted three times expert Delphi surveys on selection of question items and determination of weight. Results: 12 questionnaire items for subjects and 4 questionnaire items for researchers were selected from 19 references. From expert delphi surveys, we finally determined 14 questionnaire items (10 items for subjects, 4 items for researchers) which are clinically significant and obtained weight of question items. Conclusions: Questionnaire for pattern identification of Liver-qi stagnation infertility was developed through experts' discussion. Further study is required to identify the validity and reliability of this pattern identification instrument for Liver-qi stagnation infertility.