• KSII Transactions on Internet and Information Systems (TIIS)
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• v.3 no.5
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• pp.527-547
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• 2009

Moving object management is widely used in traffic, logistic and data mining applications in ubiquitous environments. It is required to analyze spatio-temporal data and trajectories for moving object management. In this paper, we proposed a novel index structure for spatio-temporal aggregation of trajectory in a constrained network, named aCN-RB-tree. It manages aggregation values of trajectories using a constraint network-based index and it also supports direction of trajectory. An aCN-RB-tree consists of an aR-tree in its center and an extended B-tree. In this structure, an aR-tree is similar to a Min/Max R-tree, which stores the child nodes' max aggregation value in the parent node. Also, the proposed index structure is based on a constrained network structure such as a FNR-tree, so that it can decrease the dead space of index nodes. Each leaf node of an aR-tree has an extended B-tree which can store timestamp-based aggregation values. As it considers the direction of trajectory, the extended B-tree has a structure with direction. So this kind of aCN-RB-tree index can support efficient search for trajectory and traffic zone. The aCN-RB-tree can find a moving object trajectory in a given time interval efficiently. It can support traffic management systems and mining systems in ubiquitous environments.

• The KIPS Transactions:PartC
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• v.17C no.6
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• pp.485-490
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• 2010

IEEE 802.11n supports two frame aggregation schemes, aggregation for MAC service data unit (A-MSDU) and aggregation for MAC protocol data unit (A-MPDU), to improve throughput at the MAC layer. In this paper, we propose a cooperative frame aggregation (CoFA), which can recover erroneous frames in a cooperative manner based on A-MPDU. Specifically, CoFA receive multiple frames from direct and relay paths, and combined multiple frames jointly. Numerical results show that CoFA outperforms direct transmission and relay transmission over diverse channel conditions.

• The Transactions of the Korea Information Processing Society
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• v.5 no.10
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• pp.2584-2590
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• 1998

In the existing fuzzy aggregation method, the operators such as t-norm, t conorm, mean operator, Yafer's operator and $\gamma$ operator are used to aggregate the values of membership functions. However, these methods have problems in that they do not reflect the decision situation properlyin the decision process. In order to solve these problems we suggest a situation assessment model(SAM) to reflect the decision situation in the decision proess. In the fuzzy decision environment, we propose a new aggregation method to reflect the decision situation using the result of SAM. We call it the aggregation based on situation assessment (ASA) method. It makes the stepwise aggregation with derection according to the decision situation. Moreover, we compare ASA method with the existing aggregation methods.

• Biomedical Science Letters
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• v.15 no.4
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• pp.273-279
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• 2009

Cordycepin (3'-deoxyadenosine) is an adenosine analogue isolated from Cordyceps militaris, and it has been used as an anti-cancer and anti-inflammation ingredient in traditional Chinese medicine. We investigated the effects of cordycepin on human platelet aggregation induced by thapsigargin, and determined the cytosolic free $Ca^{2+}$ levels ($[Ca^{2+}]_i$), an aggregation-stimulating factor. Cordycepin significantly inhibited thapsigargin-induced platelet aggregation. Its inhibitory effect was continually sustained at the maximal aggregation concentration of thapsigargin. The thapsigargin-induced $[Ca^{2+}]_i$ were clearly reduced by cordycepin in the presence of exogenous $CaCl_2$ or extracellular $Ca^{2+}$-chelator (EDTA). These results suggest that cordycepin inhibited thapsigargin-induced $Ca^{2+}$-influx from extracellular domain and thapsigargin-induced $Ca^{2+}$-mobilization from intracellular $Ca^{2+}$ storage. Accordingly, our data demonstrated that cordycepin may have a beneficial effect on platelet aggregation-mediated thrombotic diseases by inhibiting a $[Ca^{2+}]_i$-elevation.

• Biomedical Science Letters
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• v.20 no.3
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• pp.129-138
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• 2014

In this study, we investigated the effect of water extract from rice bran (RB) on ADP ($20{\mu}M$)-stimulated platelet aggregation. RB dose-dependently inhibited ADP-induced platelet aggregation, and its $IC_{50}$ value was $224.0{\mu}g/mL$, which was increased by adenylate cyclase inhibitor SQ22536 and cAMP-dependent protein kinase (A-kinase) inhibitor Rp-8-Br-cAMPS. RB elevated the phosphorylation of VASP ($Ser^{157}$) which was also inhibited by SQ22536 and Rp-8-Br-cAMPS. It is thought that RB-elevated cAMP contributed to the phosphorylation of VASP ($Ser^{157}$) to inhibit ADP-induced platelet aggregation. Therefore, we demonstrate that RB has an antiplatelet effect via cAMP-dependent phosphorylation of VASP ($Ser^{157}$), and RB may have preventive or therapeutic potential for platelet aggregation-mediated diseases, such as thrombosis, myocardial infarction, atherosclerosis, and ischemic cerebrovascular disease.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.9 no.12
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• pp.5189-5208
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• 2015

To address the contradiction between data aggregation and data security in wireless sensor networks, a Recoverable Privacy-preserving Integrity-assured Data Aggregation (RPIDA) scheme is proposed based on privacy homomorphism and aggregate message authentication code. The proposed scheme provides both end-to-end privacy and data integrity for data aggregation in WSNs. In our scheme, the base station can recover each sensing data collected by all sensors even if these data have been aggregated by aggregators, thus can verify the integrity of all sensing data. Besides, with these individual sensing data, base station is able to perform any further operations on them, which means RPIDA is not limited in types of aggregation functions. The security analysis indicates that our proposal is resilient against typical security attacks; besides, it can detect and locate the malicious nodes in a certain range. The performance analysis shows that the proposed scheme has remarkable advantage over other asymmetric schemes in terms of computation and communication overhead. In order to evaluate the performance and the feasibility of our proposal, the prototype implementation is presented based on the TinyOS platform. The experiment results demonstrate that RPIDA is feasible and efficient for resource-constrained sensor nodes.

• Journal of Korea Multimedia Society
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• v.7 no.11
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• pp.1556-1563
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• 2004

In this paper, we propose an efficient full mesh topology aggregation method in PNNI networks. The proposed scheme can search multi-links efficiently using the depth priority method based on hop count instead of searching the all links. To do this, we propose a modified line segment algorithm using two line segment method that represents two points which consist of delay-bandwidth pair to reduce topology information and provide a flexibility to the multiple-links aggregation. And we apply it to current full mesh topology aggregation. To evaluate performance of the proposed scheme, we compare/analyze the current method with the proposed scheme with respect to call success rate, access time and crank back rate. The result is that the proposed scheme is better than the current scheme in performance.

• Korea-Australia Rheology Journal
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• v.20 no.4
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• pp.253-260
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• 2008

A method based on transient shear flow dynamics of red cell aggregates was developed to investigate reversible re-aggregation processes with decreasing shear flow. In the microchannel-flow aggregometry, the aggregated red blood cells that are subjected to continuously decreasing shear stress in microchannel flow were measured with the use of a laser-scattering technique. Both the laser-backscattered intensity and pressure were simultaneously measured with respect to time, resulting in shear stress ranging from $0{\sim}35\;Pa$ for a time period of less than 30 seconds. The time dependent recording of the backscattered light intensity (syllectogram) yielded an upward convex curve with a peak point, which reflected the transition threshold of aggregation in the RBC suspensions. Critical-time and critical-shear stress corresponding to the peak point were examined by varying the initial pressure-differential and the micro channel depth, and these results showed good potential for being used as new aggregation indices. In the present study, these newly proposed indices were also validated by differentiating the effect of fibrinogen on RBC aggregation and then these indices were compared to the conventional indices that were measured by a rotational aggregometer.

• Natural Product Sciences
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• v.2 no.1
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• pp.37-42
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• 1996

Several species and varieties of Allium spp. grown in Indonesia were screened for their in vitro antiplatelet aggregation activities. The extracts were also analyzed by GC for their volatile sulfur-containing compounds, and measured for their Volatile Reducing Substances (VRS) contents. Antiplatelet aggregation potencies of Allium spp. were varied among the species and varieties studied. Garlic extracts showed the greatest ability to inhibit platelet aggregation followed by extract of shallot, chive, yellow onion, and green onion. The 'Jawi' and 'local Padang' variety of garlic showed high activities with $IC_{50}$ values of 9.1 and $9.8\;{\mu}g/ml$, respectively. The local Kupang variety of shallot showed the highest antiplatelet activity among the shallot varieties evaluated, with an $IC_{50}$ value of $111\;{\mu}g/ml$. Antiplatelet aggregation activities of Allium extracts showed a positive correlation with the level of volatile compounds.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1998.11a
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• pp.177-177
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• 1998

In the previous report, tetrandrine (TET) and fangchinoline (FAN) showed antithrombotic and antiplatelet aggregation activities. The present study was undertaken to investigate the effects of tetrandrine and fangchinoline on human platelet aggregation, formation of thromboxane B$_2$ and coagulation of platelet poor plasma. TET and FAN inhibited platelet activating factor (PAF) induced human platelet aggregation, but didn't inhibit the specific binding of PAF to its receptor. Meanwhile, TET and FAN also inhibited PAF, thrombin and arachidonic acid induced thromboxane B$_2$ formation in human washed platelets. In addition, neither TET nor FAN showed any anticoagulation activities in the measurement of the activated partial thromboplastin time (APTT), prothrombin time (PT) and thrombin time (TT) using human platelet poor plasma. These results suggest that antithrombotic effects of TET and FAN in mice may be mainly related to the antiplatelet aggregation activities, and the antiplatelet aggregation effects may be related to the intracellular messenger system such as TXA$_2$ formation etc., but not to the binding of PAF to PAF-receptor on the platelet membrane directly.