• YAKHAK HOEJI
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• v.46 no.5
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• pp.337-342
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• 2002

Propofol(2,6-diisopropyl phenol) is a phenol derivative that is chemically distinct from other intravenous sedative hypnotics. It has been extensively used as a short term anesthetic agent, because of the rapid onset and short duration of action. Propofol microemulsion system was prepared with different concentrations of ethyl oleate, $Solutol^{(R)}$ HS 15 and $Kollidon^{(R)}$ 17 PF. Propofol microemulsions were studied by transmittance, viscosity, particle size, in vitro release and pharmacokinetics. The range of transmittance of A group with 4% ethyl oleate and that of B group with 5% ethyl oleate were 92.6~95.1 and 91.3~94.2%, respectively. Transmittance 1~2% decreased as concentration of $Kollidon^{(R)}$ 17 PF was increased and increased 0.8~3.3% when 10 times diluted with normal saline. The viscosity of A and B group were in the range of 3.9~4.1 mPaㆍsec and 4.4~5.3 mPaㆍsec, respectively. The particle sizes of A and B group increased as amount of $Kollidon^{(R)}$ 17 PF. Also, release of propofol was slowly increased as the amount of $Kollidon^{(R)}$ 17 PF was increased. Propofol plasma concentration by i.v injection showed 2-compartment model. Pharmacokinetics of A-5 was similar to that of commercial emuision(POFOL).

• YAKHAK HOEJI
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• v.55 no.3
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• pp.234-239
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• 2011

Glycycoumarin, a 3-arylcoumarine isolated from Glycyrrhizae radix (a family of Leguminosae), is reported to have anti-bacterial activity. However, its antifungal activity is still unknown. In this present study, the antifungal activity of glycycoumarin (GLM) against Candida albicans, a polymorphic fungus was investigated. Possible mechanism such as blocking of the hyphal induction was also analyzed. By the in-vitro susceptibility analysis, GLM showed anticandidal activity, resulting in an almost complete inhibition of the fungal growth at a concentration of 320 ${\mu}g/ml$, which was equivalent to the efficacy of fluconazole at the same dose. In the murine model of disseminated candidiasis GLM enhanced resistance of mice against the disseminated disease (P<0.05), resulting in 60% protection of GLM-treated mice group during a period of 21-day observation. As for its mechanism of the antifungal activity, GLM blocked hyphal production, one of the important of virulence factors by the fungus, from the yeast form of C. albicans (P<0.01). These data indicate that GLM may contribute to the perspectives that focus on the development of a novel agent with antifungal activity specific for C. albicans infection.

• Journal of the Korea Society for Simulation
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• v.23 no.2
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• pp.25-33
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• 2014

In this study, the border security problem of the ROK Army is examined by applying the agent-based modeling and simulation (ABMS) concept as well as its platform, MANA. Based on the approximately optimized behavior of the infiltrator obtained using genetic algorithm (GA), we evaluate the GOP border security system which consists of human resources, surveillance, as well as command and control (C2) systems. We use four measures of effectiveness (MOEs) to evaluate its performance, and we apply a near optimal latin hypercube (NOLH) design to deal with the large number of factors of interest in our model. By using a NOLH design, our simulation runs are implemented efficiently. We hope the results of this study provide valuable data for deciding the configuration of the border security system structure and the number of soldiers assigned in the platoon.

• The Journal of Society for e-Business Studies
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• v.7 no.2
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• pp.55-68
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• 2002

Internet group buying systems have been widely used recently. In those systems, because the reserve price is provided by the buyer, the success rate can be decreased if the reserve price is set too low compared with the normal price. Otherwise, an unsuitable successful bid can be made if the reserve price is set too high based on inaccurate information. Likewise, the seller's providing too high a bid price can deteriorate his/her own successful bid rate, whereas a successful bid with too low a price may make no profit in the sale. Therefore, pricing agents that recommend adequate prices based on the past buying and selling history data can be helpful. In this paper, we propose two kinds of agents. One suggests reserve prices to buyers based on the past buying history database of the system. The other recommends bid prices to a seller based on the past bidding history data of the company using the cost accounting theory. Through performance experiments, we show that the successful bid rate can increase by preventing buyers from making unreasonable reserve prices. Also, we show that, for the seller, the rate of successful bids with appropriate profits can increase. Using the pricing agents, we design and implement an XML-based group buying system.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2004.10a
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• pp.68-98
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• 2004

Although the internet is useful for transferring information, Internet auction environments make fraud more attractive to offenders because the chance of detection and punishment are decreased. One of fraud is phantom transaction which is a colluding transaction by the buyer and seller to commit illegal discounting of credit card. They pretend to fulfill the transaction paid by credit card, without actual selling products, and the seller receives cash from credit card corporations. Then seller lends it out buyer with quite high interest rate whose credit score is so bad that he cannot borrow money from anywhere. The purpose of this study is to empirically investigate the factors to detect of the phantom transaction in online auction. Based up on the studies that explored behaviors of buyers and sellers in online auction, bidding numbers, bid increments, sellers' credit, auction length, and starting bids were suggested as independent variables. We developed an Internet-based data collection software agent and collect data on transactions of notebook computers each of which winning bid was over 1,000,000 won. Data analysis with logistic regression model revealed that starting bids, sellers' credit, and auction length were significant in detecting the phantom transaction.

• YAKHAK HOEJI
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• v.32 no.1
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• pp.26-39
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• 1988

Eudragit $RS^{\circledR}$ polymer was used as a wall material for the microencapsulation of aspirin by a phase separation method from chloroform-cyclohexane system with 5% polyisobutylene (PIB) in cyclohexane, and microcapsules obtained were evaluated by particle size analysis, scanning electron microscopy (SEM), drug release and drug stability test. With PIB as a coacervation inducing agent, smooth and tight microcapsules with less aggregation were obtained. Below 1 : 0.3 core-wall ratio, it was possible to coat individual particle. Variation of production conditions showed that increasing the proportion of wall material, particle size and wall thickness of microcapsules and the concentration of paraffin wax in cyclohexane as a sealant sustained drug release rates effectively. SEM confirmed that larger microcapsules after drug release did not rupture into smaller particles but contained a few small pores on the surface. Aspirin release from Eudragit $RS^{\circledR}$ coated microcapsules was independent of the pH of medium, and the mechanism of drug release from non-sealed and sealed microcapsules appeared to fit Higuchi matrix model kinetics. Aspirin in the mixture of aspirin microcapsules and sodium bicarbonate was by far more stable than that in the mixture of pure aspirin and sodium bicarbonate.

• Annual Conference of KIPS
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• 2003.05c
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• pp.1805-1808
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• 2003

웹 서비스의 위치와 컨텐츠에 대한 정보를 제공하는 UDDI 는 현재 IBM, Microsoft 그리고 SAP 에서 공용 UDDI 레지스트리 서비스 형태로 제공되고 있다. 기존의 UDDI 레지스트리 서비스는 웹 서비스 사용자 입장에서 볼 때 이용이 어렵고, 제공업체에 따른 UDDI 의 검색 도구와 방식의 차이로 인한 혼란이 있으며, 검색 효율도 만족스럽지 못한 실정이다. 이에 본 논문에서는 이러한 문제를 보완하기 위해 UDDI 레지스트리 서비스 중 검색을 위한 에이전트 개념 모델을 제안한다 UDDI 검색 에이전트는 사용자와 공용 UDDI 레지스트리 서비스 사이에 위치하며, UDDI 서비스 이용의 편의를 위해 사용자의 정보를 관리하는 UDDI 브라우저, 필요 시 검색 과정의 각 상황에 대한 정보 및 해결책을 제공하는 Help Desk, 사용자의 UDDI 레지스트리 검색 성향을 분석하는 패턴 분석기, 그리고 이전에 검색한 웹 서비스 정보 검색 경로를 기록한 Search Map으로 구성된다. 이 외에 Search Map을 작성하기 위한 Search Map Building Engine 또한 사용된다 이러한 UDDI 검색 에이전트 개념 모델의 구성요소들은 서로 메시지를 주고받으며 유기적으로 협력해, 사용자 입장에서 보다 더 쉽고, 용이하고, 효율적인 UDDI 검색 서비스를 제공한다.

• Annual Conference of KIPS
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• 2003.05c
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• pp.2177-2180
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• 2003

현재 이동 에이전트 및 이의 전송과 실행을 위한 이동 에이전트 시스템의 구현에 Java가 많이 사용되고 있지만 Java의 기본적인 보안 모델은 이동 로드의 기능 확장성에 제한을 주는 문제점이 있다. 본 논문에서는 전자서명을 Java 기반의 이동 에이전트에 적용함으로써 시스템의 보안을 유지하면서 이동 에이전트의 기능 확장성을 보장할 수 있음을 보였다. 또한 이동 에이전트의 전자서명과 이의 망 관리로의 적응을 위해서는 망 관리국(NMS:Network Management Station)에서의 서명자 관리나 공개키 관리 등 전자서명과 관련된 기능 외에 망 관리 이동 에이전트의 등록과 전송, 실행 및 실행 관리를 위한 구성이 필요하다. 따라서 이를 위해 작성한 망 관리국과 관리 대상 시스템의 구성 모델을 보였으며, 제안한 구성방식의 동작을 검증하기 위해 망 관리 응용 예를 작성하고 평가하였다. 제안한 구성 방식을 사용하면 전자서명 처리로 인한 속도 저하의 문제가 있지만, 이동 에이전트의 사용으로 인해 얻어지는 부하 분산과 실시간 관리, 망 확장성 증대의 장점 이외에도 관리 기능 및 서비스 추가가 용이한 장점이 있다.

• Convergence Security Journal
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• v.8 no.4
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• pp.167-179
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• 2008

As ubiquitous technology develops, there are many studies to provide various contents proper to users through a mobile device. However, there is a limit of information provision due to a small user interface of a mobile device. This study proposes a system that can solve a problem and provide an intelligent agent model appropriate to a mobile environment and job information positively that an individual user is interested. It is composed of a personalization engine to monitor users' behavior patterns and a learning algorithm to provide information to a mobile device. Analysis shows that preferred job items are different by sex, age and education, while a region affects job searching significantly.

• Biomedical Science Letters
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• v.24 no.3
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• pp.168-174
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• 2018

Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by abdominal pain, rectal bleeding and diarrhea. Gastrodia elata Blume (GE) has been used for the treatment of various diseases including neurodegenerative diseases and inflammatory disease. However, there has been no information on whether GE regulates intestinal inflammation. The aim of this study is to elucidate whether GE can protect against dextran sulfate sodium (DSS)-induced colitis in a mouse model. The colitis mice were induced by drinking water containing 5% DSS for 7 days. Body weight, colon length and clinical score were assessed to determine the effects on colitis. The levels of inflammatory cytokines, tumor necrosis factor $(TNF)-{\alpha}$ and interleukin (IL)-6 in colitis tissue were also measured. The results showed that mice administrated with DSS showed clinical signs including weight loss and reduced colon length. GE inhibited the DSS-induced loss of body weight and shortening of colon and increased Disease activity index score. Additionally, we observed that GE suppressed the levels of $TNF-{\alpha}$ and IL-6 in DSS-treated colon tissues. Collectively, these findings provide experimental evidence that GE might be a useful therapeutic agent for patients with UC.