• 보건의료산업학회지
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• 제14권1호
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• pp.137-146
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• 2020

Objectives: The aim of this study was to investigate cognitive function decline by socio-demographic and health-related characteristics (health behaviors and health status) using 5th Korean Longitudinal Study of Aging panel data. Methods: The subjects were 4,440 community-dwelling people aged over 57 years. The data were analyzed with descriptive statistics, frequency analysis, χ²-test, and binary logistic regression analysis using SPSS ver. 25.0. Results: The findings revealed that socio-demographic characteristics (gender, age, area of residence, educational level, marital status, number of children, number of grand-children) and health-related characteristics (smoking, drinking, regular exercise, weight category by body mass index, hypertension and diabetes mellitus) were factors that influenced cognitive function decline (p<.05). Conclusions: Cognitive function decline was closely related to health behaviors and disease types. Future studies must examine related constructs to accurately determine these relationships among various populations. The present study could be used as a tool for the development and implementation of health promotion and prevention strategies.

• Environmental Engineering Research
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• 제23권4호
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• pp.406-419
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• 2018

In planning public service systems such as waterworks, the design population is very important factor. Owing to the limitations of the indirect method, two new models, which take into consideration urban characteristics, were developed to accurately predict external migration rate (EMR), which is an essential component in estimating reliably the design population. The root mean square error (RMSE) between the model values and observed values were 10.12 and 15.58 for the metropolitan cities and counties respectively and were lower compared to RMSE values of 27.31 and 28.79 obtained by the indirect method. Thus, the developed models provide a more accurate estimate of EMR than the indirect method. In addition, the major influencing factors for external migration in counties were development type, ageing index, number of businesses. On the other hand, the major influencing migration factors for cities were project scale, distance to city center, manufacturing size, population growth rate and residential environment. Future medium and long-term studies would be done to identify emerging trends to appropriately inform policy making.

• Journal of Animal Science and Technology
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• 제65권4호
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• pp.865-877
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• 2023

Thirty Hanwoo cattle including bulls, cows, and steers (n = 10 each) were slaughtered and investigated for carcass traits (weight, meat color, fat color, yield index, maturity, marbling score, back-fat thickness, and firmness) and meat quality. The meat quality such as: pH, color, cooking loss, fatty acid, thiobarbituric acid reactive substance, warner-bratzler shear force, tensile tests, and texture profiles were analyzed on longissimus lumborum (LL) muscles of the carcasses at different aging times (3 d and 21 d). The results showed that steers and cows had higher back-fat thickness and marbling score, and a lower firmness (p < 0.001) than bulls. Bulls exhibited a lower meat quality indicating by higher cooking loss, thiobarbituric acid reactive substance content, warner-bratzler shear force and tensile test values (p < 0.01). Regarding the sensory property, the bull meat also had higher hardness, and lower tenderness, juiciness and flavor scores than the cow or steer meat (p < 0.01). Additionally, the bull meat had a higher polyunsaturated fatty acid and a lower monounsaturated fatty acid contents (p < 0.01). With increased aging time, the meat tenderness was improved in all the genders. Taken together, the present study demonstrated that the gender and aging time affected the carcass traits, fatty acid and sensory quality of beef. Postmortem aging could improve the meat tenderness of all genders especially bulls.

• 한국축산식품학회지
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• 제32권5호
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• pp.591-597
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• 2012

This study was conducted to compare meat quality traits related to the tenderness of longissimus muscles obtained from domestic and imported steers. A total of 12 steers from three breeds were slaughtered, and were graded as quality grade 2. They were composed of 4 Hanwoo and 4 Holstein steers (domestic) as well as 4 Angus steers (imported from Australia and gained for six months in Korea until slaughtered). The longissimus lumborum muscles were separated and were stored at $4^{\circ}C$ for 7 and 14 d. Sarcomere length of Hanwoo was significantly shorter than Holstein and Angus at storage day 14 (p<0.05). The myofibrillar index was significantly lower on Hanwoo than Angus at ageing day 7, and was significantly lower than Holstein and Angus steers at storage day 14 (p<0.05). Total collagen contents of Hanwoo and Angus steers were significantly higher than Holstein on storage day 7 (p<0.05), whereas soluble collagen contents of Holstein were significantly higher than Hanwoo and Angus on storage days 7 and 14 (p<0.05). There was no significant difference in the fatty acid composition of the three breeds (p>0.05). Glutamic acid contents of Hanwoo and Angus steers were higher than those of Holstein steers at ageing day 7 and 14 (p<0.05). The results of this study have shown that there were no dramatic differences between beef from the three breeds that were fattened for 6 months under equal conditions.

• Journal of Preventive Medicine and Public Health
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• 제42권5호
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• pp.275-282
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• 2009

Objectives : This study aimed to verify the association between wealth or income level and health status after adjusting for other socio-economic position (SEP) indicators among Korean adults aged 45 and over. Methods : Data were obtained from the 1st wave of Korean Longitudinal Study of Ageing (households: 6,171, persons: 10,254). We used self-rated health status and activities of daily living (ADLs) as dependent variables. Explanatory variables included both net wealth measured by savings, immovables, the other valuated assets and total income including pay, transfer, property and so on. Binary logistic regression was conducted to examine the relationships. Also, in order to determine the relative health inequality across economic groups, we estimated the relative index of inequality (RII). Results : The inequality of health status was evident among various wealth and income groups. The wealthiest group (5th quintile) was much healthier than the poorest group, and this differential increased with age. Likewise, higher income was associated with better health status among the elderly. However, these effects, as measured by the odds ratio and RII, showed that wealth was more important in determining health status of elderly people. Conclusions : This study suggests that economic capability plays a significant role in determining the health status and other health-related problems among the elderly. Particularly, our results show that health status of the aged is related more closely to the individual s wealth than income.

• Reproductive and Developmental Biology
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• 제37권4호
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• pp.281-287
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• 2013

In mammal, unfertilized oocytes remain in the oviduct or under in vitro culture, which is called "oocyte aging". This asynchrony negatively affects fertilization in pre- and post-implantation embryo development. Caffeine a phosphodiesterase inhibitor is known to rescue oocyte aging in several species. The objective of this study is to determine the cytoskeleton distribution in aged oocytes and the embryo developmental ability of aged oocytes in the present or absence of caffeine during maturation. Caffeine treatment increased the incidence of normal spindle assembly of aged oocytes (treatment, $67.57{\pm}4.11%$ aging, $44.61{\pm}6.4%$) and no significant differences compared to control group. Fluorescence values were compared using ROS (Reactive oxidation species) stain. Fluorescence values appear of control group intensity rate ($51.53.{\pm}3.80$), aging group ($68.10{\pm}5.54$) and treatment of caffeine ($45.04{\pm}2.98$). Aged oocytes that were derived from addition of caffeine to the IVM (in vitro maturation) medium had significantly increased 2-cell that developed to the blastocyst stage compared to the aging group. Blastocysts, derived from caffeine treatment group, significantly increased the total cell number compare aging ($90.44{\pm}10.18$ VS $67.88{\pm}7.72$). Apoptotic fragments of genomic DNA were measured in individual embryo using TUNEL assay. Blastocyst derived from caffeine treatment group decreased significantly the apoptotic index compared to blastocyst derived from aging group. In conclusion, we inferred that the caffeine treatment during oocyte aging can improve the developmental rate and quality in bovine embryos developing in vitro.

• 보건행정학회지
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• 제29권3호
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• pp.303-311
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• 2019

Background: Cerebrovascular disease is included in four major diseases and is a disease that has high rates of prevalence and mortality around the world. Moreover, it is a disease that requires a high cost for long-term hospitalization and treatment. This study aims to figure out the correlation between grip strength, which was presented as a simple, cost-effective, and relevant predictor of cerebrovascular disease, and cerebrovascular disease based on the results of a prior study. And furthermore, our study compared model suitability of the model to measuring grip strength and relative grip strength as a predictor of cerebrovascular disease to improve the quality of cerebrovascular disease's predictor. Methods: This study conducted an analysis based on the generalized linear mixed model using the data from the Korea Longitudinal Study of Ageing from 2006 to 2016. The research subjects consisted of 9,132 middle old age people aged 45 years or older at baseline with no missing information of education level, gender, marital status, residential region, type of national health insurance, self-related health, smoking status, alcohol use, and economic activity. The grip strength was calculated the average which measured 4 times (both hands twice), and the relative grip force was divided by the body mass index as a variable considering the anthropometric figure that affects the cerebrovascular disease and the grip strength. Cerebrovascular diseases, a dependent variable, were investigated based on experiences diagnosed by doctors. Results: An analysis of the association between grip strength and found that about 0.972 (odds ratio [OR], 0.972; 95% confidence interval [CI], 0.963-0.981) was the incidence of cerebral vascular disease as grip strength increased by one unit increase and the association between relative grip strength and cerebrovascular disease found that about 0.418 (OR, 0.418; 95% CI, 0.342-0.511) was the incidence of cerebral vascular disease as relative grip strength increased by unit. In addition, the model suitability of the model for each grip strength and relative grip strength was 11,193 and 11,156, which means relative grip strength is the better application to the predictor of cerebrovascular diseases, irrespective of other variables. Conclusion: The results of this study need to be carefully examined and validated in applying relative grip strength to improve the quality of predictors of cerebrovascular diseases affecting high mortality and prevalence.

• 한국노년학
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• 제29권4호
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• pp.1479-1500
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• 2009

노인들의 체질량지수는 노후 삶의 질을 결정할 수 있는 중요한 변수임에도 불구하고 어떤 요인 들이 이와 관련되어 있는가에 대한 연구는 상대적으로 부족하다. 따라서 본 연구는 미국, 일본, 한국 노인들의 체질량 지수의 분포가 어떻게 다른지 고찰하는데 일차적인 목적을 두었다. 더 나아가, 세 국가 노인들의 체질량지수에 영향을 미치는 요인들이 무엇인지 살펴보고 그 관계가 세 국가에서 어떻게 다르게 나타나는지 살펴보고자 한다. 자료는 미국 (LSOA II, N=8,589), 일본 (NUJLSOA, N=2,888), 그리고 한국의 고령화연구패널 (KLoSA, N=2,397)을 사용하였으며, 기술적인 분석과 체질량지수를 종속변수로 하는 다중회귀분석을 사용하였다. 일본과 한국 노인들의 체질량지수 분포는 매우 유사했지만, 일본 노인들의 체질량지수가 한국 노인들의 그것에 비교하여 좀 더 가벼웠으며 분포의 오른쪽 상단인 비만에 해당하는 부분에서 더 낮은 비율을 보였다. 한국과 일본의 체질량 지수 분포는 미국에 비해서 상대적으로 좌측에 위치하고 있으며, 최빈값에서 덜 퍼져있음이 밝혀졌다. 체질량지수와 사회경제적인 변인의 관계는 한국 노인들에 비해서 미국과 일본 노인들에게서 더 강하게 나타났으며, 한국의 경우 기존연구와 달리 교육 수준이 높을수록 체질량지수가 높은 것으로 나타났다. 한국은 사회경제적 변인이나 건강행태보다 인구학적 변수들이 체질량지수에 좀 더 유의미한 영향을 미쳤으며 일본의 경우 세 가지 건강행태가 모두 체질량지수를 예측할 수 있는 중요한 요인인 것으로 밝혀졌다. 따라서 미국, 일본, 한국에서 노인의 체질량지수에 영향을 미치는 요인들과 그 관계의 방향성은 다르다고 결론지을 수 있다. 본 연구 결과는 상이한 국가에서 노인들과 현장에서 마주하게 되는 노인병 의사, 간호사, 양로원의 책임자, 사회복지사 등이 노인들로 하여금 적절하게 몸무게를 조절하게 하기 위해서는 어떤 요인이 중요한지 파악할 수 있게 해주고 구체적으로 도움을 줄 수 있다는데 그 정책적인 함의가 있다.

• 대한치위생과학회지
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• 제7권1호
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• pp.1-15
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• 2024

연구배경: 본 연구는 노인을 대상으로 경제활동 여부에 따라 구강건강상태로써 잔존치아수와 구강건강관련 삶의 질의 관련성을 확인하고자 한다. 연구방법: 제9차 고령화연구 패널조사자료를 사용하여 59세 이상 노인 6,004명을 분석대상으로 하였다. 잔존치아수는 20개 미만, 20개 이상으로 이분화 하였으며, 노인의 구강건강관련 삶의 질은 노인구강건강평가지수(GOHAI)를 사용하였다. 경제활동 상태에 따른 인구·경제·사회학적 특성 및 건강특성과 GOHAI의 평균을 확인하기 위해 독립표본 t-test를 실시하였으며, ANOVA 분석을 실시한 경우 Scheffe's post hoc 분석을 실시하여 집단간의 통계적 유의미함을 확인하였다. 경제활동 상태에 따라 잔존치아수가 GOHAI에 미치는 영향력을 확인하고자 선형회귀분석을 실시하였다. 연구 결과: 본 연구대상자 중 경제활동을 하고 있는 경우가 33.9%로 나타나 비경제활동을 하고 있는 경우보다 약 2배 정도 낮았다. 경제활동을 하고 있는 경우와 비경제활동을 하고 있는 경우에서 잔존치아수가 20개 이상일 때 GOHAI의 평균은 각각 43.32점, 40.15점으로 나타났다(p<0.001). 단순선형회귀분석결과 경제활동을 하는 경우와 비경제활동을 하는 경우에서 잔존치아수가 20개 이상인 경우는 20개 미만인 경우에 비해 GOHAI가 각각 약 4.56배, 4.92배 높아지는 것이 통계적으로 유의하게 확인되었다(p<0.001). 인구·경제·사회학적 특성 및 건강특성을 보정한 다중선형회귀분석결과 경제활동을 하는 경우와 비경제활동을 하는 경우에서 잔존치아수가 20개 이상인 경우는 20개 미만인 경우에 비해 GOHAI가 각각 약 3.62배, 2.97배 높아지는 것이 통계적으로 유의하게 확인되었다(p<0.001). 결론: 본 연구는 노인의 구강건강 상태를 확인할 수 있는 지표로써 잔존치아수를 활용하여 노인의 구강건강관련 삶의 질을 증진시킬 수 있는 다양한 방안 중 하나로 경제활동을 고려하였다. 노인의 사회경제적 환경의 개선방안으로 경제활동 지원을 통해 구강건강 뿐만 아니라 구강건강관련 삶의 질도 높일 수 있다면, 노인의 경제활동 활성화를 통한 경제적 불평등의 완화와 같은 정책적 개입은 긍정적인 효과를 거둘 수 있을 것으로 사료된다.

• 한국생물정보학회:학술대회논문집
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• 한국생물정보시스템생물학회 2003년도 제2차 연례학술대회 발표논문집
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• pp.26-51
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• 2003

Large scale protein interaction maps provide a new, global perspective with which to analyse protein function. PSIMAP, the Protein Structural Interactome Map, is a database of all the structurally observed interactions between superfamilies of protein domains with known three-dimensional structure in thePDB. PSIMAP incorporates both functional and evolutionary information into a single network. It makes it possible to age protein domains in terms of taxonomic diversity, interaction and function. One consequence of it is to predict the most important protein domain structure in evolution. We present a global analysis of PSIMAP using several distinct network measures relating to centrality, interactivity, fault-tolerance, and taxonomic diversity. We found the following results: ${\bullet}$ Centrality: we show that the center and barycenter of PSIMAP do not coincide, and that the superfamilies forming the barycenter relate to very general functions, while those constituting the center relate to enzymatic activity. ${\bullet}$ Interactivity: we identify the P-loop and immunoglobulin superfamilies as the most highly interactive. We successfully use connectivity and cluster index, which characterise the connectivity of a superfamily's neighbourhood, to discover superfamilies of complex I and II. This is particularly significant as the structure of complex I is not yet solved. ${\bullet}$ Taxonomic diversity: we found that highly interactive superfamilies are in general taxonomically very diverse and are thus amongst the oldest. This led to the prediction of the oldest and most important protein domain in evolution of lift. ${\bullet}$ Fault-tolerance: we found that the network is very robust as for the majority of superfamilies removal from the network will not break up the network. Overall, we can single out the P-loop containing nucleotide triphosphate hydrolases superfamily as it is the most highly connected and has the highest taxonomic diversity. In addition, this superfamily has the highest interaction rank, is the barycenter of the network (it has the shortest average path to every other superfamily in the network), and is an articulation vertex, whose removal will disconnect the network. More generally, we conclude that the graph-theoretic and taxonomic analysis of PSIMAP is an important step towards the understanding of protein function and could be an important tool for tracing the evolution of life at the molecular level.