• Journal of Korean Foot and Ankle Society
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• v.24 no.2
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• pp.87-93
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• 2020

Purpose: This study evaluated the clinical results of surgical treatment with minimally invasive plate osteosynthesis for treating displaced intra-articular fractures of the calcaneus in comparison with conventional lateral extensile approach plate osteosynthesis. Materials and Methods: Of 79 cases of Sanders type II or III calcaneus fractures, 15 cases treated with the minimally invasive calcaneal plate (group M) and 64 cases treated with lateral extensile approach calcaneal plate (group E) were identified. After successful propensity score matching considering age, sex, diabetes mellitus history, and Sanders type (1:3 ratio), 15 cases (group M) and 45 cases (group E) were matched and the demographic, radiologic, and clinical outcomes were compared between the two groups. Results: The median time of surgery from injury was 2.0 days in group M and 6.0 days in group E (p=0.014). At the six months follow-up, group M showed results comparable with those of group E in radiographic outcomes. In the clinical outcomes, group M showed better postoperative American Orthopaedic Foot and Ankle Society (AOFAS) and visual analogue scale (VAS) scores than did group E (p=0.001, p=0.008). A greater range of subtalar motion was achieved at the six months follow-up in group M (inversion 20.0° vs. 10.0°, p=0.002; eversion 10.0° vs. 5.0°, p=0.025). Although there were no significant differences in complications between the two groups (1 [6.7%] vs. 7 [15.6%], group M vs. group E; p=0.661), there was only one sural nerve injury and no wound dehiscence and deep infection in group M. Conclusion: Minimally invasive plate osteosynthesis showed superior clinical outcomes compared with that of the conventional lateral extensile approach plate osteosynthesis in Sanders type II or III calcaneus fractures. We suggest applying minimally invasive plate osteosynthesis in Sanders type II or III calcaneus fractures.

• Journal of Physiology & Pathology in Korean Medicine
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• v.16 no.4
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• pp.788-800
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• 2002

Aging is characterized by an age-dependent reduction in bone density. Pronounced bone loss by postmenopausal estrogen deficiency induces a bad effect on dynamic balance of bone metabolism. When the bone density is reduced to the level below the fracture threshold, the risk for fracture is greatly increased. The purpose of this study is to examine what are the effects of the Yuklinzu(YLZ: 毓麟珠) on the ovariectomized rat model of postmenopausal osteoporosis. The results of the experiment are as follows: Body weight in control group showed significant increase in comparison with sham, but that in YLZ-treated showed no change in comparison with control. The level of serum albumin in control group showed significant decrease in comparison with sham. That in YLZ-treated was slightly decreased in comparison with control. The level of serum ALP activity in control group showed significant increase in comparison with sham, but that in YLZ-treated was significantly decreased in comparison with control. The level of serum phosphorous in control group showed significant increase in comparison with sham, but that in YLZ-treated showed no change in comparison with control. The level of serum calcium in control group showed no change in comparison with sham, but that in YLZ-treated was significantly decreased in comparison with control. The level of serum GOT in control group showed no change in comparison with sham, but that in YLZ-treated was significantly decreased in comparison with control. The level of serum GPT did not significant change among the three groups. The level of serum estrogen in control group showed slightly increased in comparison with sham, but that in YLZ-treated showed no change in comparison with control. The level of serum T3 in control group showed no change in comparison with sham, and that in YLZ-treated showed no change in comparison with control. The level of serum T4 in control group showed significant increase in comparison with sham, but that in YLZ-treated was significantly decreased in comparison with control. Mechanical strength of the femur neck in control group showed significant decrease in comparison with sham. That in YLZ-treated showed slightly increased in comparison with control. Trabecular bone area as well as trabecular thickness in control group showed significant decrease in comparison with sham. Those in YLZ-treated showed significant increase in comparison with control. Trabecular number and did not significant change among the three groups. Trabecular separation only in YLZ-treated showed significant decrease in comparison with control. Osteoclast number and oseoblast surface in control group showed significant increase in comparison with sham. Those in YLZ-treated showed slightly decreased in comparison with control. According to the above these results, YLZ has shown to be capable of preventing and curing osteoporosis caused by old-aged and postmenopause.

• The Journal of Engineering Geology
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• v.8 no.2
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• pp.175-188
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• 1998

This paper describes the internal structures and K-Ar ages of fault gouges collected from the Dongnae fault zone. This fault zone is internally zoned and occurs in the multiple fault cores. A fault core consists of thin gouge and narrow cataclastic zones that are bounded by a much thicker damage zone. Intensity of deformation and alteration increases from damage zone through cataclastic zone to gouge zone. It is thought that cataclasis of brittle deformation was the dominant strain-accomodation mechanism in the early stage of deformation to form the gouge zone and that crushed materials in the regions of maximum localization of fault slip subsequently moved by cataclastic flow. Deformation mechanism drastically changed from brittle processes to fluid-assisted flow along the gouge zone as the high porosity and permeability of pulverzied materials during faulting facilitated the influx of the hydrothermal fluids. Subsequently, the fluids reacted with gouge materials to form clay minerals. Fracturing and alteration could have repeatedly taken place in the gouge zone by elevated fluid pressures generated from the reduction of pore volume due to the formation of clay minerals and precipitation of other materials. XRD analysis revealed that the most common clay minerals of the gouge zones are illite and smectite with minor zeolite and kaolinite. Most of illites are composed of 1Md polytype, indicating the products of hydrothermal alteration. The major activities of the Dongnae fault can be divided into two periods based upon K-Ar age data of the fault gouges : 51.4∼57.5Ma and 40.3∼43.6Ma. Judging from the enviromental condition of clay mineral formation, it is inferred that the hydrothermal alteration of older period occured at higher temperature than that of younger period.

• Journal of Korean Institute of Industrial Engineers
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• v.41 no.2
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• pp.121-127
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• 2015

A reduction of motor performance due to brain disorders can be screened by evaluating force tracking capabilities (FTCs). Existing studies have examined FTCs mainly using simple sinusoidal waves, of which repeated profiles have a critical limitation due to a learning effect in force tracking. The present study examined the effects of personal factors (age and gender) and sinusoidal wave factors (central force and complexity) on FTCs of healthy adults using composite sinusoidal wave profiles (CSWPs). FTCs were measured using Finger $Touch^{TM}$ for 30 seconds and quantified in terms of time within the target range (TWR, accuracy measure) and relative RMSE (RRMSE, variability measure). A total of 90 healthy adults in 20s to 70s with the equal gender ratio participated in the experiment consisting of combinations of 2 central force levels (6 N and 10 N) and 2 complexity levels (approximate entropy, ApEn = 0.03 and 0.06) of CSWPs. Significantly decreased FTCs (lower TWR and higher RRMSE) were found in aged adults, females, the low central force, and the high complexity. The detailed FTC decrements include a 43% reduced TWR and a 85% increased RRMSE of older adults in 70s as compared to those in 20s, a 17% reduced TWR and a 17% increased RRMSE of female as compared to those of male, a 30% reduced TWR and a 108% increased RRMSE at central force = 6N when compared to those at central force = 10N, and a 19% reduced TWR and a 30% increased RRMSE at ApEn = 0.06 as compared to those at ApEn = 0.03. The characteristics of FTCs for CSWPs can be of use in establishing an assessment protocol of motor performance for screening brain disorders.

• Asian-Australasian Journal of Animal Sciences
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• v.15 no.3
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• pp.357-365
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• 2002

A survey was under taken of six district of Northern India viz. Bareilly, Pilibhit, Udham Singh Nagar, Nainital, Almora and Rampur. The age, breed, sex and physiological status recorded. A total number of 854 cattle examined out of which lactating (274 cases), non lactating (302 cases) heifers (128 cases), calves (82 cases) and adult male (68 cases) were examined. An incidence of 4.92 percent (42) of microfilarisis was recorded. The highest prevalence was observed in Rudrapur District of Udham Singh Nagar (33.33%, 4/12), followed by Lalkaun in Nanital District (21.74%, 10/46), Rampur (12.50%, 2/16), Bareilly (8.16%, 8/98) and Pilibhit (1.22%, 1/82). No infection was observed in Almora region. Amongst 854 cattle of different group incidence was highest in adult male (12.20%, 10/82), followed by non lactating (3.82%, 12/314) and lactating (2.70%, 2/74), (7.64%, 12/157) was found in Heifers. For haemeto-biochemical, serum minerals estimations and therapeutic study 32 animals suffering from filariasis and 18 healthy animals were taken. 16 animals were treated with ivermectin $@200{\mu}g/kg $ body weight. Effect of this disease on production has also been estimated for which body weight and milk production was observed. The main clinical manifestations observed were anaemia, loss of appetite, debility, oedematous swelling especially in the abdominal region, increased heart rate, and respiration rate. Haematological changes indicated decrease in hemoglobin, total erythrocyte count, packed cell volume, erthrocyte fragility and neutrophil, whereas there was significant increase in erythrocytes sedimentation rate (ESR), total leukocyte count (TLC), lymphocyte and eosinophils. Biochemical changes showed significant reduction in the values of serum albumin, A : G ratio, where as there was significant increase in blood glucose, blood urea nitrogen (BUN), globulin, total lipid, total cholesterol, phospholipids, serum bilirubin. Serum mineral profile also altered markedly, which indicate a significant decrease in Ca, Cu, Fe, Zn, and Mn with increase value of Na and Cl. There was no significant change in P and K values. Enzyme pattern in micro filaria infected animal indicated increased level of AST, ALT, alkaline phosphatase, ornithine carbamyl transferase, sorbitol dehydrogenase, glutamate dehydrogenase, isocitric dehydrogenase and lactate dehydrogenase. In blood gas values and acid/base balance, there was an increase in $PVCo_2$ and $PVo_2$. It has been observed that microfilaria infected cattle showed decrease in body weight and milk production. Animal treated with ivermectin showed the return of these above values toward normalcy.

• The Journal of the Korea Contents Association
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• v.9 no.8
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• pp.360-366
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• 2009

The purpose of this research was to study of the lower body obesity control with female university students, particularly has been done meridian message and aroma therapy, The data included in the remainder of this research was gathered from the experimental groups consisted of eighteen female students for tested group and compared group over 8 weeks. By the observation of tested group and compared group, we could see the measurement of thigh and calf sizing down overall, but they still show some differences depend on physical constitutions of each members who has been tested. This meant that the result could be changed by the will and persistent endurance of experimented ones Both of tested group and compared group's body mass index shrinked but still there were some exceptions, this result showed the difference of each participants' willingness as well as the age gap. We could find the reduction of Total Cholesterol, LDL, neutral fat and blood sugar in both tested group and compared group. However in case of HDL the measurement increased which means wrong method of controlling obesity can show some abnormal figures

• Journal of Nutrition and Health
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• v.40 no.7
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• pp.639-649
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• 2007

This study was performed to investigate the effects of very low calorie diet (VLCD) using meal replacements that contain the wild grass extracts based on Samul-tang ingredients on psychological factors and quality of life in the obese women $(BMI{\geq}25kg/m^2)$ for four weeks. Seventy five women $(20{\leq}age<26)$ participated in this experiment. Subjects were randomly classified three groups: 1) General diet group (GD roup, n=27) consumed 3 regular meals within 600 kcal/day 2) Meal replacements group (MR group, n=27) consumed 1 regular meal and 2 meal replacements within 600 kcal/day 3) Herbal Meal replacements group (HMR group, n=27) consumed 1 regular meal and 2 meal replacements within 600 kcal/day. Physical factors (weight, BMI, fat (%)) of the HMR group significantly decreased more than those of GD and MR groups. Moreover, binge eating habit and environmental factors (surrounding support, emotional reaction, expression of opinion) of the HMR group significantly decreased more than those of GD and MR groups. Psychological factor and quality of life were no significant differences among three groups during the experimental period, because both were significantly decreased in all groups after 4 weeks. Therefore, very low calorie diet using meal replacements that contain the wild grass extracts based on Samul-tang ingredients for 4 weeks was effective on improvement of psychological factor and quality of life as well as weight reduction in the obese premenopausal women.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.6
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• pp.2355-2359
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• 2015

Background: Combination chemotherapy of 5 fluorouracil (5-FU) and leucovorin (LV) with oxaliplatin, mainly FOLFOX regimens, has shown considerable antitumor activity and a tolerable toxicity profile in gastric cancer. The goal of this study was to retrospectively compare the efficacy and toxicity of modified FOLFOX-6 (mFOLFOX6) regimen in advanced gastric cancer (AGC) patients with good and poor performance status (PS). Materials and Methods: AGC patients receiving the mFOLFOX6 regimen including oxaliplatin $85mg/m^2$, bolus of 5-FU $400mg/m^2$ and LV $400mg/m^2$ on the first day, followed by $2400mg/m^2$ of 5- FU as a continious infusion over 46 hour for first-line treatment were eligible for the study. Results: A total 58 patients with a median age of 59.5 (32-81) were included. The median follow up of the study was 9.2 months. Thirty patients (51.7%) with an ECOG PS 0-1 were assigned to the good PS arm, while 28 patients (48.3%) with ECOG PS 2 were in the poor PS arm. Overall response rates were 36.6 and 28.8%, respectively (p=0.91). Median PFS was 6.7 and 6.3 months in good PS and poor PS arms (p=0.50) and median OS was 9.6 and 10.4 months (p=0.55). As compared with good PS arm, poor PS arm was associated with more grade 3-4 neutropenia and anemia. Dose reduction and dose delays were also significantly higher. Conclusions: In this study, mFOLFOX6 was similarly effective in both arms. Although hematologic toxicity was significantly higher in patients with poor PS, it remained manageable. Our results suggest that this regimen may be an effective treatment option for AGC patients with poor PS.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.12
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• pp.4765-4771
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• 2014

Background: Patients with chronic liver diseases (CLD) may have compromised health related quality of life (HRQoL). Hepatitis B virus (HBV) infection has long been the leading cause of CLD including liver cancer and cirrhosis. Knowledge on different symptom profiles of CLD should help in development of comprehensive treatment and patient care plans. Objective: To access the facets of HRQoL in chronic liver diseases throughout their spectrum of severity. Materials and Methods: A cross-sectional study was conducted in the First Affiliated Hospital of Kunming Medical University in Yunnan Province of China. Both out- and inpatients undergoing treatment protocols for different HBV related liver disease states were consecutively collected from December 2012 to June 2013. ANOVA was used to compare the mean scores of EQ-5D and chronic liver disease questionnaire (CLDQ) among 5 disease groups. The relationship between demographic variables predicting global CLDQ scores and the domains of CLDQ was analysed. Results: A total of 1040 patients including 520 without complications, 91 with compensated cirrhosis, 198 with decompensated cirrhosis, 131 with HCC and 100 with liver failure were recruited. All domains of CLDQ, the means of EQ-5D value and EQ VAS exhibited significant decline with worsening of disease severity from uncomplicated HBV to liver failure. The multivariate regression demonstrated the reduction of mean scores of CLDQ domain at advanced stage. Patients with liver failure and HCC had more HRQoL impairment than other disease states. No effect of patient gender was found. Patient age was associated with 'fatigue' and 'worry' domains (p=0.006; p=0.004) but not with other domains and global scores of CLDQ and ED-5D. Conclusions: The HRQoL in chronic hepatitis B patients is greatly affected by disease states. Care for HBV-related diseases should consider not only the outcomes of treatment strategies but also improvement in patient wellbeing.

• Journal of Korean Ophthalmic Optics Society
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• v.18 no.4
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• pp.465-471
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• 2013

Purpose: This study was conducted to research effects of influence factors on stereopsis of induced aniseikonia in emmetropia. Methods: 20 college students (a mean age of $22.50{\pm}2.72$ years, 14 males, 6 females) were selected as subjects and all of them had no ocular disease or systemic disease, the refractive correction of spherical equivalent within ${\pm}0.50$ D, the corrected visual acuity of 1.0 or better and the aniseikonia values less than 1% by AWAYA. Subject's dominant eye was checked by Hole in card method and contact lenses of -7.00 ~ +7.00D were fitted to cause anisometropia in dominant eye or non-dominant eye, respectively. And then aniseikonia was induced with spectacles to correct refractive error by contact lenses. Stereopsis was measured by Random Dot Stereo Acuity Test with LEA symbols$^{(R)}$ (Vision Assessment Corporation$^{TM}$, USA). Results: Stereopsis was remarkably reduced by inducing aniseikonia, with induced aniseikonia in dominant eye, with higher diopter of wearing contact lenses to induce anisometropia, with spectacles lenses correction of minus power after fitting contact lenses with plus power and in case of men. Conclusions: It should be considered to correct anisometropia that aniseikonia could cause reduction of stereopsis.