• 대한물리의학회지
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• 제11권1호
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• pp.11-21
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• 2016

PURPOSE: This study was examined the effects of aerobic exercise using a step box and lower extremity strengthening exercise with an elastic band on the balance ability and lower extremity muscular strength in elderly subjects. METHODS: Forty-one healthy adults were randomly divided into experimental group 1 (Exp 1, n=14), experimental group 2 (Exp 2, n=14), and a control group (n=13). The Exp 1 conducted lower limb strengthening exercise using an elastic band and the Exp 2 performed aerobic exercise with a step box 50 minutes per day, twice per week, for eight weeks. RESULTS: There was significant increase in the Exp 1 and Exp 2 in comparison of the change of lower limb muscle strength according to measurement time (p<.05). But there was no significant difference according to intervention methods. In one-leg standing test change among the three groups after the intervention, the Exp 1 and Exp 2 saw significant improvement compared to the control group (p<.05) but there was no significant difference according to intervention methods. The change of the functional reaching test results, the Exp 1 and Exp 2 saw significant improvement according to the time of measurement. In the change of the Timed Up and Go test, there was significant improvement in the Exp 1 and Exp 2 compared to the control group (p<.01), but there was no significant difference according to intervention methods. CONCLUSION: Exercise to lower extremity strengthening program accompanied with aerobic exercise is considered more effective in dynamical balance and ability to walk.

• 한국생활과학회지
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• 제17권1호
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• pp.171-179
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• 2008

This study focuses on 130 estheticians currently working in and around Daegu and Gyeongbuk region, in order to find out the current state of affairs and side effects related to aromatherapy. This paper is based on a survey. SPSS win 11.0 program was used for the analysis of descriptive statistics and independent t-test. According to the result of analysis, about 33% of the estheticians have had allergy experience. And in terms of installation of an air ventilation fan, which is the most important facility in an treatment room, more than half (50.8%) replied they did not have one. There was a statistically significant difference between those estheticians suffering from allergy and those who did not, in symptoms of stuffy nose/rhinitis (P<0.01) and dry skin/itchiness (P<0.5). (Allergy symptoms from the 33% of estheticians were limited to those which occurred after he or she began career) On work related symptoms, those who had work history at hospitals/clinics or apothecaries were compared. A statistically relevant difference was confirmed between those estheticians with therapy experience and those who had none, in all symptoms except headaches and drowsiness/weariness. In other words, there was difference in symptoms such as dryness of skin/itchiness (P<0.01), stuffy nose/rhinitis, dry throat, tension/nervousness, dizziness, tired eyes(P<0.5), nausea, having trouble with focusing, and fatigue(P<0.1). Those estheticians who had a history of treatment especially suffered most from dryness of skin and itchiness. The rate of regular check-ups and the use of masks, employed for self protection, was lower than average (amounting to 5 points), with the use of masks especially having the lowest average (1.7) points.

• 한국정보통신학회논문지
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• 제20권4호
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• pp.857-865
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• 2016

방위사업 원가산정 업무를 민간 용역기관에 아웃소싱한지 4년이 경과되었다. 객관성과 신뢰성이 다소 향상되었지만, 용역기관이 원가산정한 결과를 공무원이 다시 검토하는 등 시간과 비용만 더 든다는 부정적 시각도 일부 존재하였다. 따라서 본 연구를 통해 방위사업 원가산정 아웃소싱 수행간 발생할 수 있는 리스크 요인을 식별하여 중요도 우선순위를 분석해 중요도에 따른 리스크 대응방안을 강구하고자 한다. 향후 원가산정 아웃소싱간 사전 리스크 관리를 함으로써 적정 원가산정으로 원활한 군수품 조달로 군 전투력 향상, 방산업체 적정 이윤 보장 및 국방 예산절감에 기여하기 위함이다.

• 한국전문물리치료학회지
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• 제22권1호
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• pp.58-68
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• 2015

This study aimed to determine the effect of lower trapezius muscle strengthening exercises on pain, neck disability index (NDI), cervical range of motion (ROM), and lower trapezius muscle strength in patients with unilateral neck pain. Following baseline measurements, the subjects (N=40) with unilateral neck pain were randomized into one of two 5 weeks exercise intervention groups: a experimental group (EG, $n_1=20$) that received strength training of the lower trapezius muscles or a control group (CG, $n_2=20$) that received routine physical therapy program. Each group participated in the intervention for 30 minutes, 3 times a week, for 5 weeks. All participants performed 2 repetitions of each intervention per day. The numeric pain rating scale for pain, NDI, ROM, and lower trapezius strength were recorded both pre- and post-intervention for both groups. Paired t-tests were used to determine significant changes post-intervention compared with pre-intervention and independent t-tests were used to analyze differences in the dependent variables between the 2 groups. After the 5-weeks intervention, both groups experienced significantly decreased pain and disability level (p<.05) and significantly increased cervical flexion, extension, lateral flexion, and rotation ROM (p<.05). The EG that received strength training of the lower trapezius muscles showed greater improvements in pain and functional disability level, cervical rotation, and lower trapezius strength than the CG (p<.05). These results suggest that a lower trapezius strengthening exercises reduce neck pain and neck disability level and enhance cervical ROM and lower trapezius strength level in patients with unilateral neck pain.

• BMB Reports
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• 제49권4호
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• pp.220-225
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• 2016

Cancer cells have different characteristics due to the genetic differences where these unique features may strongly influence the effectiveness of therapeutic interventions. Here, we show that the spontaneous reactivation of extracellular signalregulated kinase (ERK), distinct from conventional ERK activation, represents a potent mechanism for cancer cell survival. We studied ERK1/2 activation in vitro in SW480 colorectal cancer cells. Although ERK signaling tends to be transiently activated, we observed the delayed reactivation of ERK1/2 in epidermal growth factor (EGF)-stimulated SW480 cells. This effect was observed even after EGF withdrawal. While phosphorylated ERK1/2 translocated into the nucleus following its primary activation, it remained in the cytoplasm during late-phase activation. The inhibition of primary ERK1/2 activation or protein trafficking, blocked reactivation and concurrently increased caspase 3 activity. Our results suggest that the biphasic activation of ERK1/2 plays a role in cancer cell survival; thus, regulation of ERK1/2 activation may improve the efficacy of cancer therapies that target ERK signaling.

• 대한기계학회논문집A
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• 제35권5호
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• pp.555-559
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• 2011

본 연구는 유압 피스톤 펌프 재료로 사용되고 있는 SACM645소재를 사용하여 모재, QT(quenching & tempering) 시험편 및 QT 질화시험편의 피로특성을 조사하였다. 피로특성 조사결과는 다음과 같다. QT 질화시험편은 피로한도가 인장강도의 80%로 나타나 아주 높은 값을 나타내었다. 이것은 시험편 표면에 단단한 질화처리를 실시하여 피로균열의 발생을 지연시켰고, 피로균열이 발생하더라고 소재가 단단하여 균열진전속도가 늦었다고 판단된다. 파면 관찰결과 피로균열진전 영역에서는 모두 스트라이에이션이 관찰되었고, 피로균열진전 이외의 영역에서 QT 시험편은 벽개파괴의 양상을, 모재와 Qt 질화시험편은 딤플 파괴의 양상을 나타내었다.

• 재활치료과학
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• 제1권2호
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• pp.35-40
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• 2012

본 연구에서는 가상현실 치료가 뇌졸중 환자의 뇌 가소성을 동반한 상지기능 향상에 미치는 영향을 알아보고 강도 높은 가상현실 훈련이 뇌졸중 환자의 상지기능 향상을 위한 집중치료로써 임상적으로 유용한 훈련인지 알아보고자 하였다. 뇌졸중 환자에게 있어 사용-의존성 즉 운동 강도와 반복은 마비 측 사지의 운동 기능향상에 중요한 치료적 요소이다. 최근에는 상지의 지속적 사용을 통한 뇌-가소성에 기반한 변화를 유도할 수 있는 치료방법으로 가상현실 치료가 대두되었다. 가상현실 치료는 재활 임상환경에서 운동기능 향상을 위한 훈련강도와 반복을 제공할 수 있는 기술적 방법으로 채택되기 시작하였다. 특히 뇌졸중 환자의 상지 기능을 향상시키기 위한 치료적 유용성 측면에서는 강도 높은 반복적 훈련이 가능하다는 것과 게임 같은 형식으로 높은 동기부여가 가능하다는 것, 실제 수행을 통한 다중감각적 피드백 제공, 상호작용이 가능한 과제지향적 치료가 가능하다는 장점을 가지고 있다. 임상 환경에서 작업치료와 더불어 부가적으로 가상현실 치료를 실시하는 것은 뇌졸중 환자의 상지 기능회복을 더욱 촉진할 것이다.

• 대한물리의학회지
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• 제11권4호
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• pp.127-137
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• 2016

PURPOSE: This study aimed to compare the effects of side-lying hip abduction exercise with and without vibration on pain, disability, strength and balance in individuals with low back pain. METHODS: 30 participants enrolled in this study were randomly assigned to an experimental group (EG, n=15) for side-lying hip abduction with vibration and a control group (CG, n=15) for side-lying hip abduction without vibration. Both groups were treated 3 times per week for 4 weeks. Pain (Numeric Rating Scale), disability (Korean Oswestry Disability Index), hip abductor muscle strength, and static balance were measured in both groups before and after the program. Results were analyzed using paired t-test for comparing the difference within the group and independent t-test for comparing the difference between two groups. RESULTS: Compared to the CG, the EG showed significantly greater reductions in pain and disability (p<.05). There was a significant difference in all balance categories of both the painful and non-painful sides within the EG (p<.05). Balance showed a significant decrease except the envelope area (ENV) on the non-painful side within the CG (p<.05). There was a significant increase in all balance categories except ENV of non-painful side between the two groups (p<.05). Balance increased on both the painful and non-painful sides in the EG. Balance improved on the painful side in the CG, but significantly decreased on the non-painful side (p<.05). CONCLUSION: Side-lying hip abduction exercise with vibration is considered an effective treatment for pain, disability and balance in individuals with low back pain.

• Asian-Australasian Journal of Animal Sciences
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• 제33권4호
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• pp.670-677
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• 2020

Objective: Interleukin-6 (IL-6) is a T cell-derived B cell stimulating factor which plays an important role in inflammatory diseases. In this study, the pharmacokinetic properties of LMT-28 including physicochemical property, in vitro liver microsomal stability and an in vivo pharmacokinetic study using BALB/c mice were characterized. Methods: LMT-28 has been synthesized and is being developed as a novel therapeutic IL-6 inhibitor. The physicochemical properties and in vitro pharmacokinetic profiles such as liver microsomal stability and Madin-Darby canine kidney (MDCK) cell permeability assay were examined. For in vivo pharmacokinetic studies, pharmacokinetic parameters using BALB/c mice were calculated. Results: The logarithm of the partition coefficient value (LogP; 3.65) and the apparent permeability coefficient values (P_app; 9.7×10^-6 cm/s) showed that LMT-28 possesses a moderate-high cell permeability property across MDCK cell monolayers. The plasma protein binding rate of LMT-28 was 92.4% and mostly bound to serum albumin. The metabolic half-life (t_1/2) values of LMT-28 were 15.3 min for rat and 21.9 min for human at the concentration 1 μM. The area under the plasma drug concentration-time curve and C_max after oral administration (5 mg/kg) of LMT-28 were 302±209 h·ng/mL and 137±100 ng/mL, respectively. Conclusion: These data suggest that LMT-28 may have good physicochemical and pharmacokinetic properties and may be a novel oral drug candidate as the first synthetic IL-6 inhibitor to ameliorate mammalian inflammation.

• 한국융합학회논문지
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• 제2권2호
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• pp.57-65
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• 2011

이 연구는 김천대학교 보건계열의 의료봉사 교과목의 운영과 보건복지 임상센터의 물적 인적자원의 효율을 높일 수 있는 방안을 제시하여 의료봉사를 체계적이며 예측가능하게 운영하는데 기여하고자 시도하였다. 이러한 연구결과로부터 얻은 결론은 아래와 같다. 1) 사회봉사 교과목의 운영은 1학점 이상을 교양필수 또는 전공필수로 2학년에 개설하여 학습과 봉사의 혼합 형태로 개설 운영하여야 한다. 2) 의료봉사 활동대상은 독거노인, 고아원 아동, 독거 장애인, 소년소녀가장, 양노원 노인 등이어야 한다. 3) 다양한 프로그램 개발과 봉사학생에 대한 인센티브 제공이 필요하며, 보건복지임상센터는 주 1회 지역소외 계층을 대상으로 운영하여야 한다.