• Genomics & Informatics
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• 제20권4호
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• pp.46.1-46.7
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• 2022

Influenza A virus (IAV) is the most widespread pathogen causing human respiratory infections. Although polymerase chain reaction (PCR)-based methods are currently the most commonly used tools for IAV detection, PCR is not ideal for point-of-care testing. In this study, we aimed to develop a more rapid and sensitive method than PCR-based tools to detect IAV using loop-mediated isothermal amplification (LAMP) technology. We designed reverse-transcriptional (RT)-LAMP primers targeting the hemagglutinin gene. RNAs from reference H1N1 and H3N2 showed specific RT-LAMP signals with the designed primers. We optimized the reaction conditions and developed universal reaction conditions for both LAMP assays. Under these conditions, the detection limit was 50 copies for both RT-LAMP assays. There was no non-specific signal to 19 non-IAV respiratory viruses, such as influenza B virus, coronaviruses, and respiratory syncytial viruses. Regarding the reaction time, a positive signal was detected within 25 min after starting the reaction. In conclusion, our RT-LAMP assay has high sensitivity and specificity for the detection of the H1 and H3 subtypes, making it suitable for point-of-care IAV testing.

• 여성건강간호학회지
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• 제2권1호
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• pp.68-87
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• 1996

The purpose of this study was to investigate the effects of breast-feeding education program on the promotion of mothers's feeding compliance during the 4 months after childbirth. A nonequivalent control group posttest design was used. Eighty-nine pregnant women at their 32 more weeks of gestation receiving antenatal care at the Chonnam University Hospital Obstetrics Clinic were assigned to the experimental group. Control group was ninety-nine pregnant women over 32wks of gestation receiving antenatal care at the Kwangju Christianity Hospital Obstetric Clinic during the same period. Breast-feeding education program was introduced to the experimental group from antepartal visit to 4 months after childbirth. Data were collected primarily via telephone interview on the 7th day, the end of 1 month and the 4 months after childbirth respectively. The results showed that 1) the frequency of breast-feeding continuation promoting behaviors was higher in the experimental group than in the control group. 2) The rates of mothers' compliance during the 4 months after childbirth in the experimental group demonstrated a significant difference ; much higher rate of mothers' compliance than control group. Conclusively, the breast-feeding education program increase the rate of mothers' compliance and duration of breast-feeding.

• Tuberculosis and Respiratory Diseases
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• 제53권4호
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• pp.431-438
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• 2002

배 경 :기체역학적 실험을 기반으로 새로 개발된 Natural 스텐트(N-Stent)의 유효성과 안전성을 기존의 Dumon 스텐트와 비교하고자, Nd-YAG Laser를 이용한 한국산 잡견 기관협착 동물모델에서 연구를 시행하였다. 방 법 : 한국산 잡견 12마리를 Nd-YAG 레이저를 이용하여 기관협착을 유도한 후, 무작위로 선정한 6마리에게는 Dumon 스텐트를, 6마리에게는 Natural 스텐트를 삽입하였다. 실험동물은 매 1주마다 4주 동안 기관지내시경으로 스텐트 위치변동과 점액저류 정도를 반정량적으로 기록하였고, 삽입 4주후에 스텐트를 제거하였다. 스텐트 제거 1주 후, 기관협착 정도를 조사하였다. 결 과 : Natural 스텐트를 삽입한 동물에서 스텐트의 위치 변동의 정도($2.0{\pm}l.0$)는 Dumon 스텐트 삽입동물($3.0{\pm}0.8$)과 차이를 보이지 않았으며, 점액저류의 정도($1.5{\pm}0.6$)도 Dumon 스텐트 삽입동물($1.7{\pm}0.5$)과 차이를 보이지 않았다. 스텐트 제거 1주 후의 협착의 정도도 Dumon 스텐트 삽입통물($1.5{\pm}0.5$)에 비해 Natural 스텐트 삽입동물($1.0{\pm}0.4$)에서 차이를 보이지 않았으며, 협착의 정도는 두군에서 모두 2.0 이하로 관찰되어, 설정한 기도확장의 기준을 만족시켰다. 결 론 : 새로 개발한 Natural 스텐트가 잡견을 이용한 기관협착 동물모델에서, Dumon 스텐트와 비교하여 동일한 유효성과 안전성을 지난 것으로 입증되었다. 향후 인체에서의 유효성과 안전성을 입증하기 위해, 기도협착 환자를 대상으로 한 임상시험이 필요할 것으로 사료된다.

• 한국융합학회논문지
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• 제11권4호
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• pp.265-275
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• 2020

본 연구는 내러티브 탐구를 활용하여 정신과 낮병원 이용 환자들의 경험을 연구하였다. 연구자들은 낮병원 이용경험이 있는 정신과 환자 4명을 대상으로 3회 이상 심층면담을 실시하였으며 낮병원 퇴원 후 외래 진료 과정에서 추가 면담을 실시하여 자료를 수집했다. 연구 참여자들의 낮병원 이용 경험의 의미는 '세상과 끊어진 줄을 다시 묶다.', '힘이 되는 마음의 안식처.', '삶에 대한 방향성을 찾다.' 세 가지 주제로 나타났다. 본 연구는 정신과 낮병원 이용 당사자들의 이야기를 깊이 있게 다루었다는 점에서 의의가 있다. 연구 결과를 바탕으로 정신과 환자의 고립 해소를 위한 제도적 지원, 다양한 지지체계 활성화 노력, 프로그램 개발 활성화의 정책적 제안을 한다.

• 대한간호학회지
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• 제35권7호
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• pp.1277-1284
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• 2005

Objectives: This study was designed to investigate the effect of delivery nursing care using essential oils on labor stress response, labor anxiety and postpartum status anxiety for primipara. Methods: This study used nonequivalent control group pretest-posttest design. The subjects of this experiment consisted of forty eight primipara with single gestation, full term, & uncomplicated pregnancies. Twenty four primipra were in the experimental and control group each. Their mean age was 27.9 years old, their mean gestation period 279.9 days. As a treatment, delivery nursing care using essential oils was applied by nurses. Data collected epinephrine, norepinephrine, anxiety during labor. In the 24 hours after birth, the data for the postpartum mother's status anxiety was collected. Data was analyzed by t-test, repeated measures ANOVA, Mann-Whitney U test, & Wilcoxon signed ranks test with SPSS Program. Results : Plasma epinephrine, norepinephrine were significantly low in the experimental group (P=0.001, P=0.033, respectively). There was no significant difference between the two groups in anxiety during labor and postpartum mother's status anxiety. Conclusion : These findings indicate that delivery nursing care using essential oils could be effective in decreasing plasma epinephrine, norepinephrine. But, that could not be verified in decreasing mother's anxiety.

• 대한한의학원전학회지
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• 제21권1호
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• pp.43-62
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• 2008

After parturition, woman in childbed's health can grow worse. Because when woman in childbed gives birth, Genital organ can be damaged, and lost a lot of blood, and also consume a lot of physical strengths. So, after parturition, woman in childbed is easy to fall in disease if do not take care in health specially. So after parturition, woman in childbed should be careful in stress, sleep, food etc. This thesis described Postpartum Spasm[痙病], Oppressive Feeling and Dizziness[鬱冒], Constipation[便秘], Abdominal Pain[腹痛], Diarrhea[下利], Annoyance[煩亂] and Vomitting Sickness[嘔逆]. Postpartum Spasm[痙病]'s major symptom is rigided body. This disease corresponds to Tetanus in modem medicine, and bacterial infection is assumed for cause. By Oriental medicine, after parturition, when blood is lacking, if patient takes wind, this disease breaks out. Oppressive Feeling and Dizziness[鬱冒]'s major symptom is dizzy head and gloomy eye. After parturition, when blood is lacking, if patient sweats too much and take cold, this disease breaks out. After parturition, if patient consumes a lot of resins of human body, Constipation[使秘] breaks out. There are four causes to Abdominal pain[腹痛]. First, due to deficiency and cold treats by Danggwisaenggangyangyuktang(當歸牛薑羊肉湯). Second, due to stagnation of Gi(氣) treats by Jisiljakyaksan(枳實芍藥散). Third, due to blood stasis treats by Ha-eohyeoltang(下瘀血湯). Fourth, due to lochiorrhea treats by Daeseunggitang(大承氣湯). After parturition, Annoyance[煩亂] and Vomitting Sickness[嘔逆] due to fever of difficiency treat by Jukpidaehwan(竹皮大丸). After parturition, Febrile diarrhea[熱性下利] treats by Baekduonggagamchoagyotang(白頭翁加甘草阿膠湯). This disease is similar with present Bacillary Dysentery. After parturition, Exteroceptive disease due to taking wind treats by Yangdaltang. Due to wind and fever treats by Jukyeoptang(竹葉湯).

• 한국병원경영학회지
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• 제7권2호
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• pp.37-51
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• 2002

It has been 2 years since the implementation of the separation of prescription and drug dispensing policy. This study analyzes the effects of the policy on the job contents and personnel structure of hospital pharmacy. The main purposes of the analysis are to determine if the policy has causes the increase of professional activities of pharmacists in hospital and to investigate whether the hospital pharmacy is equipped with enough manpower to provide high quality pharmaceutical service as intended by the policy. The level of professionality of pharmacists' activities is measured by the number of activities of direct involvement in inpatient care such as participation in patient rounding, medication consultation, the number of hospital committee the pharmacists involved and the number of continuous education pharmacists took. The adequacy of personnel structure to provide high quality pharmaceutical care is measured by the level of compliance to the governmental standard of hospital pharmacy personnel. In order to collect the data, surveys were performed for two periods: year 1999 (before the implementation of the policy) and year 2001 (after the implementation of the policy). The results show that the pharmacists' participation in inpatient rounding decreased and that the inpatient medication history management activities, operation of ward pharmacy, participation in hospital committee increased. In personnel structure, the average number of pharmacist per hospital decreased and the number of prescription processing per pharmacist increased. Based on the results this study concludes that the professional activities of hospital pharmacists has increased a little and there were structural changes in hospital pharmacy service activities to increase the professionalism in providing care. However, the pharmacy departments were understaffed hampering the strive to increase the provision of professional pharmaceutical service in hospitals.

• 재활간호학회지
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• 제3권2호
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• pp.169-181
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• 2000

The purpose of this study was to identify the effect of follow-up care for stroke survivors on primary caregivers' quality of life. Quasi-experimental research was conducted in which an experimental group and a control group-each of 15 stroke survivors and their primary caregivers-were consecutively sampled. Data collected from July to September, 1999 by interview using a structured questionnaire with both the experimental and the control groups. After a month, the two groups were given the same questionnaire. The experimental group was also given a telephone follow-up every week for a month, as well as a home visit. The survey instruments used in this study were Saha and Cooper's "Modified Barthel Index" (11 items) for checking the stroke survivors' level of activities of daily living, and a modified form of Jeong's "Quality of life" (18 items) for primary caregivers' QOL level. The obtained data were analyzed by percentage, t-test, $X^2$-test, Kruscal-Wallis test, Spearman correlation coefficient by SAS/PC program. The results were as follows: 1. There was no significant difference in the stroke survivors' ADL level, though the level of the experimental group was higher than that of the control group. 2. There was a statistical difference in the before and after treatment of the primary caregivers' QOL level. In conclusion, the follow-up care program had a useful effect on the quality of life of primary caregivers.

• Physical Therapy Rehabilitation Science
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• 제8권2호
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• pp.67-73
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• 2019

Objective: The purpose of this study was to compare the differences in the length of hospital stay between hemorrhage stroke survivors with health insurance and those with medical care after controlling all factors except for the type of medical insurance by using the propensity score matching (PSM) method. Design: Retrospective cohort study. Methods: Data from the Korean National Centers for Disease Control and Prevention's In-Depth Discharge Injury Survey between the years 2006 and 2012 were used for analysis. A total of 4,538 cases were defined as persons with hemorrhagic stroke (I60-I62) based on the block of categories in the International Classification of Diseases (10th). In order to analyze the inpatient period differences depending on the type of health care, which reflects one's socio-economic level, the chi-square and t-test was conducted. Results: Frequency and percentage were presented, and regression analysis was used to determine the factors affecting the inpatient period. Age, severity of disease, treatment outcome, and post-discharge status were no longer statistically significant after matching. The inpatient period of the persons receiving medical aid benefits was found to be significantly longer than those with national health insurance (p<0.05). Conclusions: The factors influencing the inpatient period of hemorrhagic stroke survivors were treatment outcomes, severity of disease, hospital admission process, and the type of health care. It is necessary for systematic and comprehensive governmental management for persons with hemorrhagic stroke to be transferred to long-term care facilities.

• 중환자간호학회지
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• 제16권1호
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• pp.56-70
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• 2023

Purpose : This study aimed to identify the effects of a multifaceted pediatric delirium education program for pediatric intensive care unit (PICU) nurses on their delirium knowledge, confidence in delirium nursing, and delirium evaluation accuracy. Methods : This study used a one-group pretest-posttest design. The participants were 50 nurses in two units of the PICU at S General Hospital in Seoul. All participants took a 1-hour lecture with case-based practice for the first two weeks, and received feedback as they applied the program to clinical practice over the next two weeks. Test measures were completed before and after the four week intervention period for all participants. The delirium evaluation accuracy was measured using the Korean version of the Cornell Assessment of Pediatric Delirium. Data were analyzed using the chi-square and paired t-tests. Results : After the Pediatric Delirium Education Program, nurses' delirium knowledge (x²=11.65, p =.001), confidence in delirium nursing (t=9.71, p<.001), and delirium evaluation accuracy (t=6.07, p<.001) improved significantly. Conclusions : Pediatric delirium education programs for PICU nurses were effective. For active application of the program in clinical practice in the future, various cases of childhood delirium and specific strategies for each subject must be developed. To achieve this, long-term intervention and research for multiple organizations are required.