• Title/Summary/Keyword: adverse reaction

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Synbiotic Synthesis of Oligosaccharides During Milk Fermentation by Addition of Leuconostoc Starter and Sugars

  • Seo, Dong-Mi;Kim, So-Young;Eom, Hyun-Ju;Han, Nam-Soo
    • Journal of Microbiology and Biotechnology
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    • v.17 no.11
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    • pp.1758-1764
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    • 2007
  • Synthesis of oligosaccharides during milk fermentation was attempted by inoculating Leuconostoc citreum with Lactobacillus casei, Lb. delbrueckii subsp. bulgaricus, and Streptococcus thermophilus as starters. Dextransucrase of Ln. citreum worked as a catalyst for the transglycosylation reaction of sugars; sucrose was added as the glucose donor, and lactose or maltose acted as the acceptor compound for the reaction. When 4% sucrose was added in milk, glucosyl-lactose was synthesized (about 1%, w/v) after 1-2 days of fermentation at 15 or $25^{\circ}C$. Alternatively, when sucrose and maltose (2% each, w/v) were added, panose (about 1 %, w/v) and other isomaltooligosaccharides were made in a day at $15-35^{\circ}C$. Growth patterns of lactobacilli and streptococci starters were not affected by the coculture of leuconostoc starter, but the rate of acid synthesis was slightly slowed at every temperature. Addition of sugars in milk did not give any adverse effect on the lactate fermentation. Accordingly, the use of leuconostoc starter and addition of sugars in milk allowed the production of oligosaccharides-containing fermented milk, and application of this method will facilitate the extensive development of synbiotic lactate foods.

Study for Association between Adverse Drug Reactions and Causative Drugs in the Elderly Using Data-mining Analysis (데이터마이닝 분석을 이용한 노인약물유해반응과 원인약물의 연관성연구)

  • Lee, Mee Woo;Lee, Jeong Seon;Han, Ok Yeon;Choi, In Young;Jeong, Seung Hee;Yim, Hyeon Woo;Lee, Dong Gun;La, Hyen O;Park, Young Min
    • Korean Journal of Clinical Pharmacy
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    • v.24 no.1
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    • pp.39-44
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    • 2014
  • Purpose: To investigate adverse drug reactions (ADR) and causative drugs in the elderly 65 years of age or older, using Korean spontaneous reporting adverse events reporting database from June 2009 to December 2010. Methods: We estimated the association between ADRs and implicated medications by calculating a proportional reporting ratio (PRR), reporting odds ratio (ROR), and information component (IC). We reexamined the most frequently implicated medications and ADRs, and the seriousness of ADRs. Then, we assessed reports and concordant rate of ADRs due to medications designated as "high-risk" in elderly by 2012 healthcare effectiveness data and information set (HEDIS) or "potentially inappropriate" by 2012 American Geriatrics Society updated Beers criteria for potentially inappropriate medications (PIMs). Results: Among 15,484 elderly reports, data-mining analysis by PRR, ROR and IC showed that 421 drug-ADR pairs were detected as signals (3,189). The most frequently reported ADR and causative drug were urticaria (470) and contrast media agents (647), respectively. One hundred eighty nine ADR cases were graded as serious. Twenty-two kinds of high-risk medications were shown to be implicated in only 0.9% of ADRs. Only thirty-nine cases were consistent with 2012 Beers criteria or HEDIS. Conclusion: These results suggest that management of the other medications including contrast media agents as well as close monitoring of PIMs are necessary for reducing ADRs in the elderly.

The Impact of Collective Guilt on the Preference for Japanese Products (집체범죄감대경향일본산품적영향(集体犯罪感对倾向日本产品的影响))

  • Maher, Amro A.;Singhapakdi, Anusorn;Park, Hyun-Soo;Auh, Sei-Gyoung
    • Journal of Global Scholars of Marketing Science
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    • v.20 no.2
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    • pp.135-148
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    • 2010
  • Arab boycotts of Danish products, Australian boycotts of French products and Chinese consumer aversion toward Japanese products are all examples of how adverse actions at the country level might impact consumers' behavior. The animosity literature has examined how consumers react to the adverse actions of other countries, and how such animosity impacts consumers' attitudes and preferences for products from the transgressing country. For example, Chinese consumers are less likely to buy Japanese products because of Japanese atrocities during World War II and the unjust economic dealings of the Japanese (Klein, Ettenson and Morris 1998). The marketing literature, however, has not examined how consumers react to adverse actions committed by their own country against other countries, and whether such actions affect their attitudes towards purchasing products that originated from the adversely affected country. The social psychology literature argues that consumers will experience a feeling called collective guilt, in response to such adverse actions. Collective guilt stems from the distress experienced by group members when they accept that their group is responsible for actions that have harmed another group (Branscombe, Slugoski, and Kappenn 2004). Examples include Americans feeling guilty about the atrocities committed by the U.S. military at Abu Ghraib prison (Iyer, Schamder and Lickel 2007), and the Dutch about their occupation of Indonesia in the past (Doosje et al. 1998). The primary aim of this study is to examine consumers' perceptions of adverse actions by members of one's own country against another country and whether such perceptions affected their attitudes towards products originating from the country transgressed against. More specifically, one objective of this study is to examine the perceptual antecedents of collective guilt, an emotional reaction to adverse actions performed by members of one's country against another country. Another objective is to examine the impact of collective guilt on consumers' perceptions of, and preference for, products originating from the country transgressed against by the consumers' own country. If collective guilt emerges as a significant predictor, companies originating from countries that have been transgressed against might be able to capitalize on such unfortunate events. This research utilizes the animosity model introduced by Klein, Ettenson and Morris (1998) and later expanded on by Klein (2002). Klein finds that U.S. consumers harbor animosity toward the Japanese. This animosity is experienced in response to events that occurred during World War II (i.e., the bombing of Pearl Harbor) and more recently the perceived economic threat from Japan. Thus this study argues that the events of Word War II (i.e., bombing of Hiroshima and Nagasaki) might lead U.S. consumers to experience collective guilt. A series of three hypotheses were introduced. The first hypothesis deals with the antecedents of collective guilt. Previous research argues that collective guilt is experienced when consumers perceive that the harm following a transgression is illegitimate and that the country from which the transgressors originate should be responsible for the adverse actions. (Wohl, Branscombe, and Klar 2006). Therefore the following hypothesis was offered: H1a. Higher levels of perceived illegitimacy for the harm committed will result in higher levels of collective guilt. H1b. Higher levels of responsibility will be positively associated with higher levels of collective guilt. The second and third hypotheses deal with the impact of collective guilt on the preferences for Japanese products. Klein (2002) found that higher levels of animosity toward Japan resulted in a lower preference for a Japanese product relative to a South Korean product but not a lower preference for a Japanese product relative to a U.S. product. These results therefore indicate that the experience of collective guilt will lead to a higher preference for a Japanese product if consumers are contemplating a choice that inv olves a decision to buy Japanese versus South Korean product but not if the choice involves a decision to buy a Japanese versus a U.S. product. H2. Collective guilt will be positively related to the preference for a Japanese product over a South Korean product, but will not be related to the preference for a Japanese product over a U.S. product. H3. Collective guilt will be positively related to the preference for a Japanese product over a South Korean product, holding constant product judgments and animosity. An experiment was conducted to test the hypotheses. The illegitimacy of the harm and responsibility were manipulated by exposing respondents to a description of adverse events occurring during World War II. Data were collected using an online consumer panel in the United States. Subjects were randomly assigned to either the low levels of responsibility and illegitimacy condition (n=259) or the high levels of responsibility and illigitemacy (n=268) condition. Latent Variable Structural Equation Modeling (LVSEM) was used to test the hypothesized relationships. The first hypothesis is supported as both the illegitimacy of the harm and responsibility assigned to the Americans for the harm committed against the Japanese during WWII have a positive impact on collective guilt. The second hypothesis is also supported as collective guilt is positively related to preference for a Japanese product over a South Korean product but is not related to preference for a Japanese product over a U.S. product. Finally there is support for the third hypothesis, since collective guilt is positively related to the preference for a Japanese product over a South Korean product while controlling for the effect of product judgments about Japanese products and animosity. The results of these studies lead to several conclusions. First, the illegitimacy of harm and responsibility can be manipulated and that they are antecedents of collective guilt. Second, collective guilt has an impact on a consumers' decision when they face a choice set that includes a product from the country that was the target of the adverse action and a product from another foreign country. This impact however disappears from a consumers' decision when they face a choice set that includes a product from the country that was the target of the adverse action and a domestic product. This result suggests that collective guilt might be a viable factor for company originating from the country transgressed against if its competitors are foreign but not if they are local.

Implementation of Film Type Sensor for Synthetic Lube Oil and High Pressure Hydraulic Fluid Leak Detection (합성 윤활유 및 고압 작동유 누출감지 필름형 센서의 구현)

  • Park, No-Jin;Yu, Dong-Kuen;Yu, Hong-Kuen
    • Journal of Sensor Science and Technology
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    • v.23 no.4
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    • pp.266-271
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    • 2014
  • Chemical sensors are used in various industrial facilities such high-risk and prevent the leakage of substances, important in life and environmental protection and the safe use of industry, used for management. In particular, high-temperature environments such as power generation equipment of the rotating part due to leakage generated by the various oil, power plants Shut Down, fire, work environment (exposure to various chemical solution and gas leak) and various water, air and soil pollution causes. Thus, over the long term through various channels such as crops and groundwater contamination caused by the slow, serious adverse effect on the ecosystem. In this paper, synthetic lube oil and high pressure hydraulic fluid leakage and immediately detect a new Printed Electronic implementation of technology-based film-type sensors, and its performance test. Thus, industrial accidents and environmental pollution and for early detection of problems, large accidents can be prevented. Experimental results of the synthetic lube oil and high pressure hydraulic fluid solution after the contact time depending on the experiment and the oil solution of the sensor material of the conductive porous PE resistance value by a chemical reaction could be confirmed that rapid increase. Also implemented in the film-type oil sensor electrical resistance change over time of the reaction rate and the synthetic lube oil is about 2 minutes or less, the high pressure hydraulic fluid is less than about 1 minute was. Therefore, more high-pressure hydraulic fluid such as a low volatility synthetic lube oils are the resistance change and the reaction rate was confirmed to be the slowest.

A Study on the Installation of Rupture Disk for Emergency Discharge of Dangerous Substances in Case of Styrene Monomer Runaway Reaction (스티렌모노머 폭주반응 시 위험물 비상 배출을 위한 파열판 적정 크기 선정에 관한 연구)

  • Sang Ryung Kim;Jae Min Ryu;Hyang Nam Choi;Jong Su Hyun;Hyung Sik Byun
    • Journal of the Korean Institute of Gas
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    • v.28 no.2
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    • pp.24-31
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    • 2024
  • In the chemical industry, fires and explosions constantly occur due to runaway reactions during the production of various chemical products. To prevent this, much research has been conducted, and the possibility of runaway reactions for each substance is reviewed and interlocking devices are installed to prepare for adverse reactions to prepare for fires and explosions. However, despite legal and technical safety measures, accidents due to runaway reactions still occur every year. Accordingly, in this study, based on cases of fire and explosion accidents in styrene monomer reactors, the discharge capacity during runaway reactions was examined through experiments and graphs. Unlike the commonly calculated fire equation, in the case of a runaway reaction where pressure and temperature increase rapidly, discharge is made in two phases rather than a single phase, so the size of the rupture disk must also increase, and the orientation must be adjusted before the rupture disk is installed at the top of the pressure vessel. It was found that position adjustment was necessary.

A Study on Perception and Reaction of Ground Effect during Landing of Large Airplanes (대형기 착륙과정의 지면효과에 대한 인식과 대응에 관한 연구)

  • Moon, Bong-Sup;Choi, Youn-Chul
    • Journal of the Korean Society for Aviation and Aeronautics
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    • v.26 no.1
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    • pp.1-9
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    • 2018
  • Ground effect includes a reduction of induced drag, increase of lift, and nose-down moment during landing. These phenomena, occurring late in the landing maneuver, are considered to be of little significance because they tend to counteract and/or compensate in this respect. Even though it is unlikely to affect any flare profile variations appreciably, some pilots have reversed perception about such phenomenon and overestimate during landing. It is becoming a negative factor and is making an adverse effect on landing maneuver. This study examines the perception of ground effect of large aircraft pilots, reviews literature regarding ground effect, and makes suggestions that pilots can correctly recognize and respond to the effect during landing flare maneuvers.

Comparison of Chromotropic Acid Method and DNPH-HPLC Method for the Measurement of Formaldehyde in the Air (공기 중 포름알데히드 측정을 위한 크로모트로핀산법과 DNPH/HPLC방법의 비교.평가)

  • Hwang, Yun-Jeong;Park, Sang-Gon;Baek, Seong-Ok
    • Journal of Korean Society for Atmospheric Environment
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    • v.14 no.5
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    • pp.519-524
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    • 1998
  • Formaldehyde is known to have adverse health effects, and is also found to be a product of atmospheric. photochemical reaction%. Several methods have been employed for the measurement of formaldehyde. Among them, two common methods are comparatively evaluated in this study, i.e. the chromotropic acid method and the HPLC method coupled with 2,4- dinitrophenylhydrazine (DNPH) derivatization of carbonyl compounds. Method evaluation and validation were performed with respect to repeatability, linearity, collection efficiency, and recovery efficiency. Comparison of formaldehyde concentrations measured simultaneously in the field using the two (n=20) and 35.8%, respectively. Overall, the measured levels by chromotropic acid method appeared to ice significantly higher than those by DNPH-HPLC method, indicating a positive interference due to the other aldehydes collected together with formaldehyde.

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A Study on Development of Electronic Blood Pressure Depressor of Meridian Point Discrimination Type

  • Kim, Jung-Ho;Lee, Jin-Woo;Son, Joon-Ho;Kim, Soon-Taek;Lee, Kwon-Soon
    • 제어로봇시스템학회:학술대회논문집
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    • 2002.10a
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    • pp.57.6-57
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    • 2002
  • Recently, the seriousness of the high blood pressure appearing in the whole world as well as Korea. Therefore, the methods to treat this disease proposing. For exam pie, there are the medicinal therapy and the dietetic treatment, etc. But these are uncertain and produce an adverse reaction. Thereupon, we studied effectively and financially to execute the treatment of the high blood pressure based on oriental medicine. Oriental medicine includes many treatments. We used Meridian Theory, the Meridian point, and Acupuncture that are a part of oriental medicine and treatments. And actualizing the above explained treatment into electronic technique, we produced the same effect without the help of...

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New Concepts on Vaccine Development for the Poultry Diseases

  • Han, M.G.
    • Korean Journal of Poultry Science
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    • v.28 no.2
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    • pp.165-172
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    • 2001
  • Vaccination is one of the most important and cost-effective methods of preventing infectious diseases. Over the past decade, scientific in molecular biology and immunology have improved understanding of many diseases and led to the development of novel strategies for vaccination. An ideal vaccine would induce effective immunity specific for the type of infection, have long duration, require minimal or no boosters, have safety, would not induce adverse reaction, and be easy to administer. The desire to meet these criteria has resulted in the development of vaccines that do not depend on the use of the viable disease agent. It is not the intent of this review to give an extensive review of the field of vaccinology, but rather to address characteristics of conventional and genetically engineered vaccines.

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Association between periodontitis and preterm birth and low birth weight (임부의 치주염이 조산 및 저체중아 출산에 미치는 영향)

  • Ha, Jung-Eun
    • Journal of Korean society of Dental Hygiene
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    • v.16 no.2
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    • pp.155-163
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    • 2016
  • The purpose of the review article is to investigate the influence of periodontal diseases on preterm birth(PTB) and low birth weight(LBW). PTB and LBW are the main risk factors of infant mortality and a major public health problem. PTB is defined as delivery at less than 37 weeks and LBW is less than 2,500 grams. Over Approximately 60 percent of perinatal mortality results from PTB or LBW. Although the causes of PTB and LBW are not fully understood, infection is the leading cause of PTB and LBW. Periodontal diseases are serious disease burdens because they are caused by bacterial endotoxin, inflammatory reaction, and cytokine. The periodontal diseases are the predisposing factors of cerebrovascular and cardiovascular diseases including atherosclerosis. Over the past 15 years, previous studies revealed that periodontitis had adverse outcomes including PTB and LBW in pregnancy.