• Journal of Applied Biological Chemistry
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• 제62권2호
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• pp.123-127
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• 2019

핑크왐피는 피부병, 말라리아, 복통, 이질 및 장염 치료를 위한 약용 식물로 사용되고 있다. 본 연구의 목적은 핑크왐피의 안전성을 확인하기 위하여, 수컷 ICR 마우스를 이용하여 핑크왐피를 3주 반복 경구 투여하여 최대무독성용량을 평가했다. 핑크왐피를 100, 250, 500, 1000, 및 2000 mg/kg으로 투여한 결과, 모든 시험물질 투여군에서 이상이 관찰되지 않았다. 사망률, 임상 증상, 체중 변화, 혈액 학적 검사 및 혈청 생화학 검사에서 유의적인 차이는 없었고, 경미한 변동은 핑크왐피의 투여로 인한 영향이 아닌 정상 범위 내에서의 변화로 간주 되어진다. 결과적으로, 핑크왐피는 모든 시험물질 투여군에서 독성 영향을 미치지 않았으며, 핑크왐피의 최대무독성용량은 2000 mg/kg 이상으로 간주되었다.

• Geomechanics and Engineering
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• 제33권5호
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• pp.519-528
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• 2023

In this paper, we present the results of an experimental study on the effect of polymer support fluid on shaft resistance of offshore bored piles. A series of pullout tests were performed on bored piles installed under various boundary conditions considering different types of grounds and support fluids, and a range of support fluid exposure times. Contrary to previous studies concerning onshore bored piles, a time dependent effect of polymer fluid on shaft resistance was observed in all ground types. The adverse effect of polymer support fluid on the shaft resistance, however, was considerably less than bentonite support fluid for a given exposure time. No significant reduction in shaft resistance was evident when limiting the exposure time of the polymer support fluid to the side wall of the borehole within 2-3 hours. The degree to which the polymer fluid affects shaft resistance seemed to vary with the ground type. A proper consideration should be given to the time dependent effect of polymer fluid on shaft resistance of bored piles installed in offshore construction environment to limit its adverse effect on the pile performance. The practical implications of the findings are discussed.

• 한국병원경영학회지
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• 제23권2호
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• pp.42-53
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• 2018

Purpose: this study investigates the effect of private health insurance on healthcare utilization. Methodology: For the analysis, we employed the three level nested two part model. Findings: the private health insurance adoption was associated with higher health care utilization. In particular, indemnity and fixed insurances adoption was associated with higher probability of outpatient visit, the number of outpatient visit and outpatient cost. While indemnity insurance adoption was associated with higher inpatient admission probability and inpatient days, fixed insurance adoption was associated only with higher inpatient admission probability. Practical Implications: indemnity and fixed insurance adoption were related with the adverse selection as well as moral hazard.

• Korean Chemical Engineering Research
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• 제60권3호
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• pp.468-471
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• 2022

헬리컬 리본 임펠러 교반조의 중심축과 헬리컬 리본을 지지하는 스트럿의 영향을 실험과 가시화를 통하여 검토한 결과, 액위 변화에 따른 불완전 혼합부의 발생 등 혼합성능에 크게 악영향을 미치는 것은 종 방향의 중심축이 아니라 횡 방향의 스트럿임을 밝혔다.

• Tuberculosis and Respiratory Diseases
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• 제78권4호
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• pp.321-325
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• 2015

Background: The adverse effects of the phosphodiesterase-4 inhibitor roflumilast, appear to be more frequent in clinical practice than what was observed in chronic obstructive pulmonary disease (COPD) clinical trials. Thus, we designed this study to determine whether adverse effects could be reduced by starting roflumilast at half the dose, and then increasing a few weeks later to $500{\mu}g$ daily. Methods: We retrospectively investigated 85 patients with COPD who had taken either $500{\mu}g$ roflumilast, or a starting dose of $250{\mu}g$ and then increased to $500{\mu}g$. We analyzed all adverse events and assessed differences between patients who continued taking the drug after dose escalation and those who had stopped. Results: Adverse events were reported by 22 of the 85 patients (25.9%). The most common adverse event was diarrhea (10.6%). Of the 52 patients who had increased from a starting dose of $250{\mu}g$ roflumilast to $500{\mu}g$, 43 (82.7%) successfully maintained the $500{\mu}g$ roflumilast dose. No difference in factors likely to affect the risk of adverse effects, was detected between the dose-escalated and the discontinued groups. Of the 26 patients who started with the $500{\mu}g$ roflumilast regimen, seven (26.9%) discontinued because of adverse effects. There was no statistically significant difference in discontinuation rate between the dose-escalated and the control groups (p=0.22). Conclusion: Escalating the roflumilast dose may reduce treatment-related adverse effects and improve tolerance to the full dose. This study suggests that the dose-escalated regimen reduced the rate of discontinuation. However, longer-term and larger-scale studies are needed to support the full benefit of a dose escalation strategy.

• 한국초지조사료학회지
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• 제37권2호
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• pp.108-115
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• 2017

The aim of this study was to evaluate different herbicides in corn-soybean intercropping for optimum growth, yield and nutritive value of forage under Korean environment conditions. Herbicidal treatments were randomly applied over five plots, viz. (1) Control treatment: no herbicide; (2) Alachlor; (3) Simazine; (4) Pendimethalin and (5) Mixture of alachlor and simazine herbicides in RCBD have three replications. Results depicted that treated herbicides exhibited significant effect over control of weeds. Simazine herbicide alone or mixed with alachlor had adverse effects on soybean but enhanced (p<0.05) corn production in terms of survivability, dry matter and digestible nutrients yield. Corn-soybean coupling and total dry matter yield were greater (p<0.05) in pendimethalin. Simazine-alachlor mixture reduced (p<0.05) soybean height. Conclusively, simazine could not be suitable for corn soybean intercropping because of having an adverse effect on soybean component. Pendimethalin could maintain growth and yield of corn and soybean both components. Effect of alachlor was comparable to that of pendimethalin.

• 한국임상약학회지
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• 제30권1호
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• pp.11-18
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• 2020

Background: Nivolumab and pembrolizumab are antagonists of the programmed death-ligand 1 (PD-L1) receptor that function as immuno-oncological agents. This study aimed to evaluate the safety and efficacy of nivolumab and pembrolizumab in elderly patients in outpatient settings. Methods: The safety and efficacy of nivolumab and pembrolizumab were compared retrospectively among patients at the Veterans Health Service (VHS) Medical Center in Seoul, South Korea, from September 1, 2017 to August 25, 2018. Results: Eighty-seven patients were selected for the study. The median progression-free survival was 63 days for nivolumab (95% confidence interval (CI), [14 to 282]) vs. 243 days for pembrolizumab (95% CI, [22 to 348]) (p =0.04). The objective response rate (ORR) was 0% in the nivolumab group vs 5.6% in the pembrolizumab group (p =0.310). All the patients exhibited treatment-related adverse effects. More than 89% of the patients exhibited diseases of the gastrointestinal (GI) tract. Pneumonia, of grades three or higher, was the most common adverse effect, followed by weakness and anorexia. Conclusions: There was no statistically significant difference between the nivolumab group and the pembrolizumab group with respect to the ORR. The incidence and severity of the adverse effects in this study were higher than those of previous studies; however, these adverse effects are generally manageable in a real-world clinical setting. Further randomized controlled studies will be necessary to confirm these results in elderly patients.

• 대한임상독성학회지
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• 제14권2호
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• pp.100-106
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• 2016

Purpose: Beta blocker (BB) has been prescribed for anxiety and panic disorder. Patients intoxicated by psychiatric drugs have often been exposed to BB. Moreover, BB overdose has adverse effects including cardiovascular effects, which can be life-threatening. This study was conducted to identify the characteristics of BB intoxication with psychiatric drugs and the adverse effects on the cardiovascular system. Methods: A single center, retrospective study was performed from January 2010 to December 2015. A total of 4,192 patients visited the emergency department (ED) with intoxication, and 69 with BB intoxication were enrolled. Results: Overall, 64 patients (92.8%) of enrolled patients were intoxicated with drugs prescribed for the purpose of psychiatric disorders. Propranolol was the most common BB (62 cases, 96.2%), and the median dose was 140.0 mg (25%-75% 80.0-260.0). Twenty-four patients (37.5%) had experienced cardiovascular events, and these patients tended to have decreased mentality, hypotension and coingestion with quetiapine. An initial mean arterial pressure (MAP) below 65 mmHg (odds ratio 10.069, 95% confidence interval 1.572-64.481, p=0.015) was identified as a factor of cardiovascular event upon multiple logistic regression analysis. Conclusion: Initial MAP below 65 mmHg was a factor of cardiovascular adverse effect in patients of BB intoxication with psychiatric drugs.

• 한국항공우주학회지
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• 제48권5호
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• pp.335-342
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• 2020

스텔스 성능을 향상시키기 위해 꼬리날개를 제거한 무미익 항공기는 러더(rudder)를 대체하여 스포일러(spoiler)를 활용하여 방향조종을 수행한다. 짧은 시간에 스포일러 작동을 반복하는 경우 비정상적(unsteady)이고 비선형적인 공력특성이 발생하여 항공기 비행성능에 역효과(adverse effect)를 초래할 수 있다. 본 연구에서는 dynamic mesh 기법을 적용한 전산해석을 통하여 스포일러 전개에 따른 에어포일의 비정상 공력 특성을 해석하였다. 스포일러 전개 속도, 장착 위치, 전개 스케줄(deployment scheduling) 변화에 따른 공력특성을 분석하여 스포일러의 동적 작동에 따른 역효과를 감소시킬 수 있는 방안을 검토하였다. 스포일러 장착위치 및 전개 방식의 적절한 선정을 통해 스포일러 동적 역효과를 감소시킬 수 있음을 확인하였으며, 에어포일 형상최적화를 통한 역효과 감소방안에 대한 추가적인 연구가 필요한 것으로 판단된다. 이러한 동적 공력 데이터는 향후 무미익 형태의 항공기 개발에 기초자료로 활용될 수 있을 것이다.

• 한국콘텐츠학회논문지
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• 제16권11호
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• pp.103-115
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• 2016

본 연구는 보호관찰 청소년을 대상으로 성장과정에서의 부정적 경험과 불안이 인터넷중독 위험성에 미치는 구조적 관계를 확인하였다. 서울소재 보호관찰소 1개 곳의 협조를 받아 보호관찰소를 방문한 청소년 200명에게 구조화된 자기기입식 설문을 실시하였고, 197명의 자료를 분석하였다. 분석방법은 성장기 부정적 경험, 불안, 인터넷중독의 구조적 관계검증을 위해 경로분석을 사용하였다. 분석결과, 성장기 부정적 경험이 인터넷중독에 미치는 영향은 ${\beta}=.284$(p<.01)이었고, 불안이 인터넷중독에 미치는 영향은 ${\beta}=.396$(p<.05)로 성장기 부정적 경험이 많을수록, 불안수준이 높을수록 인터넷중독 위험성이 높아짐을 확인하였다. 또한 성장기 부정적 경험이 불안에 미치는 영향은 ${\beta}=.131$(p<.01)이었으며, 성장기 부정적 경험과 인터넷중독의 관계에서 불안의 매개효과는 통계적으로 유의미하였다. 본 연구는 보호관찰 청소년을 대상으로 성장과정에서의 부정적 경험과 불안이 인터넷중독에 미치는 구조적 관계를 확인함으로써 인터넷중독 예방 및 보호관찰제도에 대한 실천적 정책적 제언을 하였다.