• Journal of the Korean Society of Physical Medicine
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• v.13 no.1
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• pp.63-72
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• 2018

PURPOSE: The aim of this study was to compare the effect of whole body vibration stimulation on ankle instability, ankle range of motion, and balance ability in adult with chronic ankle instability. METHODS: Forty-five adult with chronic ankle instability were randomly equally allocated the I group (whole body vibration stimulated at 10 Hz), or the II group (20 Hz), or the III group (25 Hz). All the participants (male:13/female: 32, age: $26.64{\pm}3.14$) in this study received whole body vibration therapy for an additional 15 minutes after hot pack and ultrasound three times a week for four weeks. Outcome were measured before and after 4 weeks training. RESULTS: All the three groups showed significant differences in AII and CAIT after intervention (p<.05). I group showed the most significant difference (p<.05). All the three groups also showed significant increase in ankle dorsiflexion and plantar flexion after training (p<.05). I group showed greater increase than the other groups in ankle dorsiflexion (p<.05). The X-axis, Y-axis, and fluctuation speed were significantly decreased in the three groups (p<.05), but there was no significant difference between the three groups after the intervention. CONCLUSION: The findings suggest that the whole body vibration stimulation according to various frequencies is effective for improve ankle instability, ankle range of motion and balance ability in adult with chronic ankle instability. 10 Hz whole body vibration stimulation could help improve ankle instability and ankle range more effectively than other frequencies.

• Radiation Oncology Journal
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• v.7 no.1
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• pp.1-13
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• 1989

Effects of ionizing radiation alone and combined with chemotherapy on tumor growth and it's clonal specificity monitored by changes in distribution of chromosome number were studies in A549 ceil line originated from human adenocarcinoma of the lung. Radiation (300 rad, 600 rad and 900 rad) were delivered with or without 5-FU. Forty eight hours later, 57.5% of growth inhibition of cell w8s seen in cells treated with 5-FU concentration of $0.4{\mu}g/ml$ for 24hr exposure. Cell survival curves after radiation with and without 5-FU were made. Chromosomal analysis of cells in metaphase in control, and in cells treated with 300 rad of radiation, or $0.4{\mu}g/ml$ of 5-FU treatment, and combined treatment of both were done to examine the changes in ploidy and number of chromosome. Radiation combined with S-FU enhanced growth inhibition of A549 cells. However, no evidence of synergegic effects in growth. inhibition was observed in the cells treated with the combination therapy. Pattern of chromosomal distribution of survived cells were shifted from hyperploidy to hypoploidy by single dose of radiation (300 rad). As radiation dose increased a large number of hypoploidy cells were observed. Following treatment of cells with 5-FU, chomosomal distribution of survived cells were also shifted to hypodiploidy which were seen in cells treated with radiation, The ceil treated with 5-FU and fellowed by radiation within 24 hrs had cell with increased number of hypodiploidy cells. Almost same type of chromosomal changes were reproduced in cells treated with combined treatment with radiation and 5-FU. Minor differences were that cells with fewer number of chromosome were more frequent in cells treated with combined therapy. Further increase in cells of hypoploidy (93%) having 1-10 chromosome were induced by additional radiation. Therefore, the enhanced therapeutic effect of 5-FU combined with radiation of A549 cells appeared to be additive rather than synergistic.

• Radiation Oncology Journal
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• v.34 no.3
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• pp.168-176
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• 2016

Purpose: The purpose of current study is to evaluate the response of the patients with portal vein thrombosis (PVT) or hepatic vein thrombosis (HVT) in hepatocellular carcinoma (HCC) treated with three-dimensional conformal radiation therapy (3D-CRT). In addition, survival of patients and potential prognostic factors of the survival was evaluated. Materials and Methods: Forty-seven patients with PVT or HVT in HCC, referred to our department for radiotherapy, were retrospectively reviewed. For 3D-CRT plans, a gross tumor volume (GTV) was defined as a hypodense filling defect area in the portal vein (PV) or hepatic vein (HV). Survival of patients, and response to radiation therapy (RT) were analyzed. Potential prognostic factors for survival and response to RT were evaluated. Results: The median survival time of 47 patients was 8 months, with 1-year survival rate of 15% and response rate of 40%. Changes in Child-Pugh score, response to RT, Eastern cooperative oncology group performance status (ECOG PS), hepatitis C antibody (HCVAb) positivity, and additional post RT treatment were statistically significant prognostic factors for survival in univariate analysis (p = 0.000, p = 0.018, p = 0.000, p = 0.013, and p = 0.047, respectively). Of these factors, changes in Child-Pugh score, and response to RT were significant for patients' prognosis in multivariate analysis (p = 0.001 and p = 0.035, respectively). Conclusion: RT could constitute a reasonable treatment option for patients with PVT or HVT in HCC with acceptable toxicity. Changes in Child-Pugh score, and response to RT were statistically significant factors of survival of patients.

• Journal of Radiopharmaceuticals and Molecular Probes
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• v.1 no.1
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• pp.62-73
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• 2015

We developed an evans blue-indocyanine green-$^{99m}Tc$-human serum albumin conjugate for sentinel lymph node mapping and we describe its unique potential usage for clinical implications. This conjugate has combined the strengths of visible blue dye, near-infrared fluorescence and radioisotope into one single conjugate without any additional weakness/disadvantage. All the components of evans blue-indocyanine green-$^{99m}Tc$-human serum albumin are safe and of low cost, and they have already been clinically used. This conjugate was stable in the serum, it showed a long retention time in the lymphatic system and the lymph nodes showed a much higher signal-to-noise ratio after the conjugate was injected intradermally into the paw of mice. Both the single-photon emission computed tomography and near-infrared fluorescent images of the mice were successfully obtained at the same time as the excised sentinel lymph nodes showed blue color. The visual color, near-infrared fluorescence and gamma ray from this agent could be complementary for each other in all the steps of sentinel lymph node sampling: exploring and planning sentinel lymph node before excision with visualization of the exact sentinel lymph node location during an operation. Therefore, the triple modal agent will possibly be very ideal for sentinel lymph node mapping because of the high signal-to-noise ratio for non-invasive imaging and its complementary multimodal nature, easy preparation and safety. It is promising for clinical applications and it may have great advantages over the traditional single modal methods.

• Journal of The Korean Society of Integrative Medicine
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• v.6 no.2
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• pp.99-106
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• 2018

Purpose : Various studies effects of mental practice. However, there is a lack of research on the effects of practice on postural alignment. Therefore this study to the effect of ankle exercise combined with mental practice on postural alignment of legs. Method : Subjects were randomly assigned to mental practice group (experimental group n=15) and general exercise group (control group n=15). Postural alignment was the hip, knee, and ankle joints. When viewed from the side, an arbitrary point in front of the malleolus makes a straight line with the plumb line. Exercise was performed a week for weeks. Exercise programs included muscle strengthening, relaxation, and proprioception exercise. The experimental group mental practice. Result : Both groups showed significant differences in postural alignment ankle joint, knee joint, and hip joint. In particular, the experimental group showed a larger change than the control group. However, significant difference in postural alignment change only the knee joint (p<0.05), and there was no significant difference the hip joint (experimental group=$0.77{\pm}0.81$, control group=$0.87{\pm}1.13$) and ankle joint (experimental group=$0.52{\pm}0.63$, control group=$0.48{\pm}0.41$). Conclusion : This study suggests that mental practice is effective as an exercise method postural alignment. Mental practice also expected to be musculoskeletal disorders. Therefore, additional studies should be conducted to verify the effect of mental practice on the alignment of various parts.

• Journal of the Korean Society of Physical Medicine
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• v.2 no.2
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• pp.243-250
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• 2007

Purpose : Shoulder subluxation is a very common problem in patients with hemiplegia with stroke. Prevention of the low tone subluxed shoulder has been an issue for physical therapists working with neurological patients for many years. Methods : This study reviewed the literature to definite the management and a cause of shoulder subluxation with hemiplegia patients after stroke. Various modalities have been suggested for realigning the glenohumeral joint, but their use is controversial. The purpose of this paper is to review critically the evidence base in order to inform the clinical decision-making process for physiotherapists working in neurology. Results : Literature has identified supports, strapping and functional electrical stimulation(FES) in the management of low tone shoulders. Following review of this evidence it is suggested that there is a lack of reliable and valid research evidence on which to base conclusions. The modalities with the best supporting evidence for realigning the low tone subluxed glenohumeral joint are the triangular sling, Harris hemi sling and the Rolyan humeral cuff used in a standing position and the lap board and arm trough while the patient is sitting. However, due to soft tissue adaptation with associated lack of movement, over-correction and the need for careful patient positioning these supports need to be evaluated for each patient and should be used only in appropriate situations. Conclusion : Similarly, there is a lack of evidence on the effects of long-term use to this equipment. Electrical stimulation is also thought to have potential in the treatment to subluxed low tone shoulders but additional research is required to clarify the parameters for use and the long-term effects of these forms of management.

• Archives of Reconstructive Microsurgery
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• v.25 no.2
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• pp.29-36
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• 2016

Purpose: Skin grafting is used for the transfer of cutaneous tissue from one site of the body to another. To improve graft survival, close contact between the graft and the wound bed is essential for vessels to grow across the gap. Here, we introduce an easy and efficient dressing method to improve graft survival. Materials and Methods: A retrospective chart review was performed to identify patients who underwent split thickness skin graft and negative pressure wound therapy (NPWT) or conventional treatment between January 2007 and April 2015. Overall, 25 consecutive patients were included in the NPWT group and 49 were included in the conventional dressing group to compare the outcome of the procedure. The data were obtained from medical records, including age, sex, cause of the skin defect, size of graft, time for healing, wound preparation time, and complications. Results: Of the NPWT group, the average wound size was $147.04{\pm}146.74cm^2$ (range, $9{\sim}900cm^2$). With the exception of one patient, all wounds healed without the need for further procedure. The average duration of time required for the NPWT group, which was defined as removal of stitches (or staples) and no need for additional active dressing, was $6.4{\pm}1.97days$ (range, 5~15 days). The average time for the conventional dressing group was $10.78{\pm}2.38days$ (range, 5~15 days). Conclusion: NPWT can be used to cover regions in which wound healing does not occur fully or when neither tie-over nor compressive dressings are applicable. This treatment also reduced wound healing time and allowed earlier patient mobilization and hospital discharge.

• Radiation Oncology Journal
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• v.36 no.4
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• pp.332-340
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• 2018

Purpose: To retrospectively analyze dosimetric parameters of volumetric-modulated arc therapy (VMAT) and three-dimensional conformal radiotherapy (3D-CRT) delivered to extranodal marginal zone B-cell lymphomas of mucosa-associated lymphoid tissue in the stomach (gastric MALT lymphoma) to find out advantages of VMAT and conditions for definite benefits of VMAT. Materials and Methods: Fifty patients with stage I-II gastric MALT lymphoma received VMAT (n = 14) or 3D-CRT (n = 36) between December 2005 and April 2018. Twenty-seven patients were categorized according to whether the planning target volume (PTV) overlaps kidney(s). Dosimetric parameters were analyzed by dose-volume histogram. Results: Radiation dose to the liver was definitely lower with VMAT in terms of mean dose (p = 0.026) and V₁₅ (p = 0.008). The V₁₅ of the left kidney was lower with VMAT (p = 0.065). For those with PTV overlapping kidney(s), the left kidney V₁₅ was significantly lower with VMAT. Furthermore, the closer the distance between the PTV and kidneys, the less the left kidney V₁₅ with VMAT (p = 0.037). Delineation of kidney(s) by integrating all respiratory phases had no additional benefit. Conclusions: VMAT significantly increased monitor units, reduced treatment time and radiation dose to the liver and kidneys. The benefit of VMAT was definite in reducing the left kidney V₁₅, especially in geometrically challenging conditions of overlap or close separation between PTV and kidney(s).

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.29 no.2
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• pp.142-148
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• 2016

Objectives : The objective of this study was to report the efficacy of the Crucial Incision Acupuncture Therapy(CIAT) for removing melanocytic nevi. Methods : CIAT is penetration acupuncture to remove a lesion by sticking needles like cross-shape. We used the CIAT for treating one patient with melanocytic nevi, and then we investigated efficacy and side effect for about 5 months. Results : In 16 melanocytic nevuses treated with CIAT, one of the nevuses recurred after about 3 months. And hyperpigmentation lasted for about 2-5 months was caused after the CIAT. Conclusions : In Korean medicine, the CIAT might be used for treating melanocytic nevi. But additional studies might be needed for improvement of treatment effect.

• The Journal of Korean Physical Therapy
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• v.19 no.4
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• pp.53-64
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• 2007

Purpose: We investigated the effects of music on pain, blood pressure, and pulse in patients with chronic back pain. We tried to find some change of satisfaction of treatment and a sense. Method: We recruited total 30 patients with chronic back pain, who had pain from lumbago for more than six months. Subjects received electrotherapy and electrotherapy with music one at a time during me test, and subjects received one in the morning and the other one in the afternoon. We compared the test results between the electrotherapy and electrotherapy with music. Visual Analogue Scale was used to check the effect on pain. Blood pressure and pulse were checked, too. The gathered informatio was analyzed by t-test, independent sample t-test, and chi-square test. Results: There was statistically not significant difference between electrotherapy and electrotherapy with the music in VAS(Visual Analogue Scale)(p>0.05). There were statistically some significant differences between two groups in systolic pressure, diastolic pressure, and the pulse(p<0.05). Subject group showed statistically higher scores of satisfaction(p<0.05). There was significant difference between two groups(p<0.05) in the tingling and vibration sense. Conclusion: we found that the lumbago patients who are treated by electrotherapy with the music did not have additional difference in relief of pain, but electrotherapy with music can get better effects on their blood pressure, the pulse, satisfaction, and tingling-vibration sense. This means that the patients receive their treatment comfortably with rest. Therefore, We consider that it is desirable to play music to lumbago patients to offer the better treatment service to the patients.