• 생체재료학회지
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• 제22권4호
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• pp.290-302
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• 2018

Background: The main purpose of drug delivery systems is to deliver the drugs at the appropriate concentration to the precise target site. Recently, the application of a thin film in the field of drug delivery has gained increasing interest because of its ability to safely load drugs and to release the drug in a controlled manner, which improves drug efficacy. Drug loading by the thin film can be done in various ways, depending on type of the drug, the area of exposure, and the purpose of drug delivery. Main text: This review summarizes the various methods used for preparing thin films with drugs via Layer-by-layer (LbL) assembly. Furthermore, additional functionalities of thin films using surface modification in drug delivery are briefly discussed. There are three types of methods for preparing a drug-carrying multilayered film using LbL assembly. First methods include approaches for direct loading of the drug into the pre-fabricated multilayer film. Second methods are preparing thin films using drugs as building blocks. Thirdly, the drugs are incorporated in the cargo so that the cargo itself can be used as the materials of the film. Conclusion: The appropriate designs of the drug-loaded film were produced in consideration of the release amounts and site of the desired drug. Furthermore, additional surface modification using the LbL technique enabled the preparation of effective drug delivery carriers with improved targeting effect. Therefore, the multilayer thin films fabricated by the LbL technique are a promising candidate for an ideal drug delivery system and the development possibilities of this technology are infinite.

• Tribology and Lubricants
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• 제38권6호
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• pp.267-273
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• 2022

Surface texturing is the latest technology for processing grooves or dimples on the friction surface of a machine. When appropriately applied, it can reduce friction and significantly increase durability. Despite many studies over the past 20 years, most are isothermal (ISO) analyses in which the viscosity of the lubricant is constant. In practice, the viscosity changes significantly owing to the heat generated by the viscous shear of the lubricant and film-temperature boundary condition (FTBC). Although many thermohydrodynamic (THD) analyses have been performed on various sliding bearings, only few results for surface-textured bearings have been reported. This study investigates the effects of the FTBC and groove number on the THD lubrication characteristics of a surface-textured parallel thrust bearing with multiple rectangular grooves. The continuity, Navier-Stokes, and energy equations with temperature-viscosity-density relations are numerically analyzed using a commercial computational fluid dynamics code, FLUENT. The results show the pressure and temperature distributions, variations of load-carrying capacity (LCC), and friction force with four FTBCs. The FTBCs greatly influence the lubrication characteristics of surface-textured parallel thrust bearings. A groove number that maximizes the LCC exists, which depends on the FTBC. ISO analysis overestimates the LCC but underestimates friction reduction. Additional analysis of various temperature boundary conditions is required for practical applications.

• 상하수도학회지
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• 제26권1호
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• pp.47-54
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• 2012

This study analyzed influence factors and the correlation among pollutants which affect occurrence of leaked pollution based on the long-term runoff flow and water quality investigation results to understand the characteristics of highway rainfall runoff pollution load. According to the result of correlation analysis on TSS (Total Suspended Solid) concentration, anteceded dry days, rainfall intensity, traffic volume and etc. as major influence factors of highway rainfall runoff pollution loads, the correlations were weak or scarce in most items. These results might be attributed that runoff pollutant concentration changes vary severely on changes of rainfall intensity and rainfall duration within rainfall and it is affected by disturbances of vehicles and street cleaning and etc. as characteristics of the highway. While Cu, Fe and Zn which are discharged with high concentrations out of heavy metals showed high correlation with particulate matter, organic matter(COD), nutrient(TN, TP), Ni and Pb showed relatively low correlation in a correlation evaluation by pollutant. Significant correlation with traffic volumes was not shown and TSS concentration even decreased in accordance with increase of the traffic volume. In the comparison with precedent studies, it was considered necessary additional analysis of the effects of rainfall section analysis, road type, disturbances of surface contaminants by vehicles, rainfall and climate conditions, surrounding terrains etc.

• International Journal of Aeronautical and Space Sciences
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• 제5권2호
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• pp.54-61
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• 2004

In this paper we carried out a design study for an unmanned Mars missionsuitable for Republic of Korea. The mission will use a KSLV series launch system,which is to place a one tonne payload into the LEO. We calculated the velocityincrements(AV) required for departure from Earth and insertion into the orbitaround Mars based on the mission opportunity data provided by NASA. Two typesof Mars modules - entry type and orbiter type - were considered in this studyWe calculated the mass of TPS(therma1 protection system) for the entry tvpe Marsmodule based on the heat transfer rate and heat load from the Mars atmosphere tothe surface of the TPS. The heat transfer rate and heat load were obtained throughan entry trajectory calculation. For the orbiter type Mars module, we calcuIated themass breakdown of the additional spacecraft which is to insert the Mars moduleinto the orbit around Mars. Other mass items were determined by proportioningfrom the existing Mars modules. This paper finally proposes the payload capacitiesfor each types of Mars modules.

• 한국농공학회지
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• 제12권4호
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• pp.2078-2083
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• 1970

The purpose of this study is to give the data neccesary for improving the planning of drainage structures, specially inverted siphons, in irrigation channels. With the samples of 15 drainage inlets, one drainage flume, 16 drainage inverted siphons and 6 drainage culverts in the 3 lines of irrigation channel under Chong-Won Irrigation Association, author abtained the following results. 1. It is presumed that design drainage discharge should be determined with some additional reserves, on the basis of the maximum rainfall intensity in local area and the size of drainage area on the topographical map, avoiding the way of eye measure. 2. Location of drainage inlet should be kept away from the place where topography can make lots of wash load, but when unavoidably allowing the inflow into irrigation channel, wash load outlet with even the purpose of drainage, or drainage flume in stead of drainage inlet should be taken account of. 3. It is presumed that drainage flume may be the structure which can perform its function from a structural point of view as far as topography permits. 4. Drainage inverted siphon should be avoided at any place as much as possible; a) In case that location of the siphon would be permitted only at paddy field, drainage area hauing the amount of discharge which requires more than 90cm in diameter could only be allowed. b) In this case, crest elevation of the tank of both inlet and outlet, at least, should not be lower than the surface level of paddy field. c) As far as topography and stratum permit, ratio of depth of outlet tank to head drop should be decreased as much as possible so that discharging efficiency of wash load could increase. d) In case of avoiding the setting of the siphon, irrigation aqueduct, irrigation inverted siphon, or drainage flume should be recommended in accordance with topography. 5. Discharging capability of wash load by drainage culvert appeared to depend hardly upon the diameter of the culvert, but greatly upon the location, specially near village, for there stones and dirts dumped may considerably be piled up. So, a counter plan for that is required.

• 한국기계가공학회지
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• 제18권11호
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• pp.9-17
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• 2019

Interest in renewable energy is rapidly growing around the world. One of the most popular renewable energy sources is solar power, and photovoltaic (PV) systems are the most representative route for generating solar energy. However, with the growing adoption of solar power systems, the demand for land on which to install these systems has increased, which has caused environmental degradation. Recently, floating PV systems have been designed to utilize idle water surface areas of dams, rivers, and oceans. Because floating PV systems will be exposed to harsh environmental stresses, the safety of such systems should be secured before installation. In this study, the structural robustness of a floating PV system was analyzed by conducting numerical simulation to investigate whether the system can withstand harsh environmental stresses, such as wind and wave loads. Additionally, conventional wind and wave load predictions based on the design method and the simulation results were compared. The comparison revealed that the design method overestimated wind and wave loads. The total drag of the PV system was significantly overestimated by the conventional design criteria, which would increase the cost of the mooring system. The simulation offers additional advantages in terms of identifying the robustness of the floating PV system because it considers real-world environmental factors.

• Steel and Composite Structures
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• 제17권1호
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• pp.105-121
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• 2014

A fundamental limitation of steel structures is the decrease in their load-bearing capacity at high temperatures in fire situations such that structural members may require some additional treatment for fire resistance. In this regard, this paper evaluates the structural stability of fire-resistant steel, introduced in the late 1999s, through tensile coupon tests and proposes some experimental equations for the yield stress, the elastic modulus, and specific heat. The surface temperature, deflection, and maximum stress of fire-resistant steel H-section columns were calculated using their own mechanical and thermal properties. According to a comparison of mechanical properties between fire-resistant steel and Eurocode 3, the former outperformed the latter, and based on a comparison of structural performance between fire-resistant steel and ordinary structural steel of equivalent mechanical properties at room temperature, the former had greater structural stability than the latter through $900^{\circ}C$.

• 한국공작기계학회:학술대회논문집
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• 한국공작기계학회 1999년도 추계학술대회 논문집 - 한국공작기계학회
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• pp.525-529
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• 1999

A cone shape drum polisher was developed to make up for the demerits of conventional CMP apparatus. The developed equipment has several superiorities. First of all, it can achieve uniform velocity profile on all the contact line because of its shape and easy to control the amount of slurry at the position of use. The whole area of wafer surface is exposed to the visual area except the contact line between wafer and drum, hence we can detect polishing end point more easily than any other polishing equipments. Also it has additional merits such as small foot print and polishing load. Polishing characteristics were investigated by developed equipment.

• International Journal of Railway
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• 제5권2호
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• pp.71-76
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• 2012

Recently, axle load, operating speed and traffic density on railroads have had a tendency to increase and thereby cause additional pressure applied on used track. These operating conditions frequently result in service failure due to wear caused by wheel-rail contact and fatigue damage under cyclic loading. Among rail defects, the transverse crack, which has been the most dangerous type of fatigue damages, is developed from the subsurface crack near the rail running face and grows perpendicular to the rail surface. Therefore, it is necessary to investigate systematically the growth behavior of transverse crack for rail steel under mixed mode. In this study, the fatigue crack growth behavior of the transverse crack in rail steel was experimentally investigated under mixed-mode variable amplitude loadings.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 2005년도 봄학술 발표회 논문집(I)
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• pp.503-506
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• 2005

The purpose of this study was the Development of Retrofit Method for Beam Using Steel Plate Reinforced by Fiber Sheet.1. Additional reinforcements are not needed in the joining area of slab and beam web.2. Beam using carbon fiber reinforced plastic displays low effects in shearing effect.3. Beams reinforced steel plate by epoxy effect the capacities of strength. But the capacities of strength are rapidly reduced when adhesive surface be omitted. Thus details are needed in this case.4.Retrofit method for beam using steel plate reinforced by fiber sheet with epoxy rosin improves the capacities of strength and the initial stiffness, shows a large transformation since the maximum load likewise may be excellent to the shearing reinforcement.