• Geomechanics and Engineering
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• v.28 no.5
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• pp.505-520
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• 2022

In recent years, geotextile-encased gravel columns (usually called stone columns) have become a popular method to increasing soil shear strength, decreasing the settlement, acceleration of the rate of consolidation, reducing the liquefaction potential and increasing the bearing capacity of foundations. The behavior of improved loose base-soil with gravel columns under shear loading and the shear stress-horizontal displacement curves got from large scale direct shear test are of great importance in understanding the performance of this method. In the present study, by performing 36 large-scale direct shear tests on sandy base-soil with different fine-content of zero to 30% in both not improved and improved with gravel columns, the effect of the presence of gravel columns in the loose soils were investigated. The results were used to predict the shear stress-horizontal displacement curve of these samples using support vector machines (SVM). Variables such as the non-plastic fine content of base-soil (FC), the area replacement ratio of the gravel column (Arr), the geotextile encasement and the normal stress on the sample were effective factors in the shear stress-horizontal displacement curve of the samples. The training and testing data of the model showed higher power of SVM compared to multilayer perceptron (MLP) neural network in predicting shear stress-horizontal displacement curve. After ensuring the accuracy of the model evaluation, by introducing different samples to the model, the effect of different variables on the maximum shear stress of the samples was investigated. The results showed that by adding a gravel column and increasing the Arr, the friction angle (ϕ) and cohesion (c) of the samples increase. This increase is less in base-soil with more FC, and in a proportion of the same Arr, with increasing FC, internal friction angle and cohesion decreases.

• Steel and Composite Structures
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• v.48 no.1
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• pp.19-25
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• 2023

Due to high application of concrete structures in construction industry, however, the quality improvement is essential. One of the new ways for this purpose is adding the nanoparticles to the concrete. In this work, vibration analysis of concrete beams reinforced by graphene oxide (GO) nanoparticles based on mathematical model has been investigated. For the accuracy of the presented model, the experimental study is done for comparing the compressive strength. Since the nanoparticles can not be solved in water without any specific process, at the first, GO nanoparticles should be dispersed in water by using shaker, magnetic striker, ultrasonic devices and finally mechanical mixer. For modelling of the strucuture, sinusoidal shear deformation beam theory (SSDBT) is utilized. Mori-Tanak model model is utilized for obtaining the effective properties of the beam including agglomeration influences. Utilizing the energy method and Hamilton's principal, the motion equations are calculated. The frequency of the concrete beam is obtanied by analytical method. Three samples with 0.02% GO nanoparticles are built and its compressive strength is compared which shows a good accuracy with maximum 1.29% difference with mathematical model and other papers. The aim of this work from the theoretical study is investigating the effects of nanoparticles volume percentage and agglomeration, length and thickness of the beam on the frequency of the structure. The results show that the with enhancing the GO nanoparticles, the frequency is increased. For example, with enhancing the volume percent of GO nanoparticles from zero to 0.08%, the compressive strength is increased 48.91%. and 46.83%, respectively for two cases of with and without agglomeration.

• Journal of Veterinary Science
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• v.25 no.1
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• pp.11.1-11.16
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• 2024

Background: Canine parvoviral enteritis (CPE) is a fatal disease worldwide. The treatment of CPE is based mainly on supportive and symptomatic treatment. Antiviral addition to the treatment may result in a higher survival. Objectives: This study evaluated the effects of antiviral treatments with a standardized treatment (ST) on the clinical and inflammatory response of dogs with naturally occurring CPE. Methods: Twenty-eight dogs with CPE caused by canine parvovirus type 2 were divided randomly into treatment groups. The ST group received fluid, antibiotic, antiemetic, and deworming treatments. The antiviral treatment groups received the same ST with an additional antiviral drug, recombinant feline interferon omega (rFeIFN-ω), oseltamivir (OSEL) or famciclovir (FAM). Results: Compared to the healthy control, the tumor necrosis factor-α, interleukin-1β, interferon (IFN)-α, IFN-γ, haptoglobin, and C-reactive protein values were high (p < 0.05) on day zero. At presentation, mild lymphopenia, neutropenia, and a high neutrophil to lymphocyte (LYM) ratio (NLR) were also observed. Adding rFeIFN-ω to the ST produced the best improvement in the clinical score with a decreased NLR, while leucocytes remained low and inflammatory markers stayed high on day three. The survival rates of the groups were 85.7% in ST+IFN, 71.4% in ST+OSEL, 71.4% in ST+FAM, and 57.1% in ST groups on day seven. Conclusions: Antiviral drugs may be valuable in treating CPE to improve the clinical signs and survival. In addition, the decrease in NLR in favor of LYM may be an indicator of the early prognosis before the improvement of leukocytes, cytokines, and acute phase proteins in CPE.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.29 no.6
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• pp.369-381
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• 2017

It has been presumed that highly nonlinear skewed waves frequently observed in a surf zone could significantly influence the transmission behaviour via a porous wave breaker due to its larger inertia force than its nonlinear counterparts of zero skewness [Cnoidal waves]. In this study, in order to confirm this perception, a numerical simulation has been implemented for 6 waves the skewness of that range from 1.02 to 1.032. A numerical simulation are based on the Tool Box called as the ihFoam that has its roots on the OpenFoam. Skewed waves are guided by the shoal of 1:30 slope, and the flow in the porous media are analyzed by adding the additional damping term into the RANS (Reynolds Averaged Navier-Stokes equation). Numerical results show that the highly nonlinear skewed waves are of higher transmitted ratio than its counterparts due to its stronger inertia force. In this study, in order to see whether or not the damping at the porous structure has an effect on the wave celerity, we also derived the dispersive relationships of Nonlinear Shallow Water Eq. [NSW] with damping at the porous structure being accounted. The newly derived dispersive relationships shows that the phase lag between the damping friction and the free surface elevation due to waves significantly influence the wave celerity.

• Korean Journal of Materials Research
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• v.10 no.3
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• pp.218-222
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• 2000

W-Ti film properties for X-ray absorber applications have been investigated with Ti composition have been investigated with Ti composition variation. W-Ti films were deposited by DC magnetron sputtering system. As the working pressure increases, film density decreases and film stress changes from compressive to tensile. The transition pressure (where the film stress in zero) and the stress gradient decrease by adding Ti into W-Ti(6.5 at.%) film shows the smallest stress gradient and transition pressure. It also shows high density ($17.7g/\textrm{cm}^3$) similar to that of pure-W ($17.8g/\textrm{cm}^3$) at the transition pressure. All the films show columnar structure, and its size decreases with increasing Ti composition. Surface roughness and thermal stability are improved by Ti-addition, resulting in a better property for X-ray absorber applications.

• Journal of Pharmaceutical Investigation
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• v.35 no.5
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• pp.323-328
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• 2005

The purpose of the present study was to evaluate the bioequivalence of two torasemide tablets, Torem tablet (Roche Korea Co., Ltd., Korea, reference drug) and Boryung Torsemide tablet (Boryung Pharmaceutical Co., Ltd., Korea, test drug), according to the guidelines of Korea Food and Drug Administration (KFDA). After adding an internal standard (furosemide) to human serum, serum samples were extracted using 5 mL of ethyl acetate. Compounds were analyzed by reverse-phase HPLC method with UV detection. This method showed linear response over the concentration range of 0.05 ug/mL with correlation coefficient of 0.999. The lower limit of quantitation using 0.5 mL of serum was 0.05 ug/mL which was sensitive enough for pharmacokinetic studies. Twenty-eight healthy male Korean volunteers received each medicine at the torasemide dose of 20 mg in a $2{\times}2$ crossover study. There was a one-week washout period between the doses. Serum concentrations of torasemide were monitored by an HPLC-UV for over a period of 12 hr after the administration. $AUC_{t}$(the area under the serum concentration-time curve from time zero to 12 hr) was calculated by the linear trapezoidal rule method. $C_{max}$ (maximum serum drug concentration) and $T_{max}$ (time to reach $C_{max}$) were compiled from the serum concentration-time data. Analysis of variance was carried out using logarithmically transformed $AUC_{t}$ and $C_{max}$. No significant sequence effect was found for all of the bioavailability parameters indicating that the crossover design was properly performed. The 90% confidence intervals of the $AUC_{t}$ ratio and the $C_{max}$ ratio for Boryung Torsemide/Torem were log 0.97-10g 1.03 and log 0.93log 1.12, respectively. These values were within the acceptable bioequivalence intervals of log 0.80-log 1.25. Thus, the criteria of the KFDA guidelines for the bioequivalence was satisfied, indicating Boryung Torsemide tablet and Torem tablet are bioequivalent.

• Journal of the Korean Chemical Society
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• v.59 no.5
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• pp.387-396
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• 2015

The DFT and ab initio calculations have been performed to elucidate hydrogen interaction of HOOO-(H₂O)_n (n=1~5) clusters. The optimized geometries, harmonic vibrational frequencies, and binding energies are predicted at various levels of theory. The trans conformer of HOOO monomer is predicted to be thermodynamically more stable than cis form at the CCSD(T) level of theory. For HOOO-(H₂O)_n clusters, the geometries are optimized at B3LYP/aug-cc-pVTZ and CAM-B3LYP/aug-cc-pVTZ levels of theory. The binding energy of HOOO-H₂O cluster is predicted to be 6.05 kcal/mol at the MP2//CAM-B3LYP/ aug-cc-pVTZ level of theory after zero-point vibrational energy (ZPVE) and basis set superposition error (BSSE) correction. The average binding energy per H₂O is increased according to adding a H₂O moiety in HOOO-(H₂O)_n clusters up to 7.2 kcal/mol for n=5.

• Journal of the Korean earth science society
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• v.36 no.6
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• pp.501-511
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• 2015

This study suggests a method of alleviating global warming by the increase of the Earth surface albedo through Artificial Sea ice Increasing (ASI) over the Available Freezing Areas (AFA). The method is developed based on the fact that the large sea surface area in or near the Arctic and the Antarctic has no ice even though both water and air temperatures are below zero and the artificial sea ice generation is thus available. The mean energy of $0.85Wm^{-2}$, which was suspected of adding to the earth by the global warming effect was calculated to offset at once when the sea ice area about $4.09{\times}10^6km^2$ was additionally increased. In addition, three techniques for producing ice plates on the sea surface (using ships, installation apparatus, and floating matter such as Green Cell Foam) for ASI were proposed. According to the result of simple analysis using the energy balance model, when ASI was maximally operated only for 3 months (September, October, and November) over AFA, it is expected that the annual mean temperature of earth surface would be decreased about $0.11^{\circ}C$ in the following year. On the other hand, in case of generating the artificial sea ice in all four seasons, a risk of triggering snowball earth was detected.

• Journal of the Korean earth science society
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• v.34 no.7
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• pp.626-632
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• 2013

In this study the GPS Precipitable Water Vapor (PWV) was derived and evaluated by a radiosode measure during the winter intensive observation in Gangneung site from January 5 till February 29 in 2012. Bernise 5.0 software was used to derive the GPS data. GPS-derived PWV from Zero difference (GANG) and Single difference (GANG and DAEJ) was high variance in time and about 5 times the PWV of radiosonde. GPS post-processing has been performed from two additional IGS site (Xian Dao, Ibaraki-ken) in order to correct the absolute troposphere errors. As a result, the mean bias error (MBE) and root mean square error (RMSE) and correlation compared with radiosonde measure were 0.67 mm, 6.40 mm, and 0.93, respectively. In order to correct the relative troposphere errors from the altitudinal difference between the two GPS receivers, we calculated the GPS-derived PWV by adding the data of GPS that was installed in Gangneung-Wonju University near the Gangwon Regional Meteorological Administration. In the end, the improved result showed that MBE, RMSE and correlation in comparison with radiosonde measures were 0.61 mm, 5.79 mm, and 0.93, respectively.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.6 no.2
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• pp.67-75
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• 1986

This paper introduces the nonlinear Stream Function Wave Theory for design waves efficiently to compute the wave energy and energy transport quantities and to analyze the effects of nonlinearities on them. The Stream Function Wave Theory was developed by Dean for case of the observed waves with assymmetric wave profiles and of the design waves with symmetric theoretical wave profiles. Dalrymple later improved the computational procedure by adding two Lagrangian constraints so that more efficient convergence of the iterative numerical method to a specified wave height and to a zero mean free surface displacement resulted. And the Stream Function coefficients are computed numerically by the improved Marquardt algorithm developed for this study. As the result of this study the effects of nonlinearities on the wave quantities of the average potential energy density, the average kinetic energy density result in overestimation by linear wave theory compared to the Stream Function Wave Theory and increase monotonically with decreasing $L^*/L_O$ and with increasing $H/H_B$. The effects of nonlinearities on the group velocity and the wavelength quantities result in underestimation by linear wave theory and increase monotonically with increasing $H/H_B$. Finally the effect of nonlinearity on the average total energy flux results in overestimation for shallow water waves and underestimation for deep water waves by linear wave theory.