• Bulletin of the Korean Chemical Society
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• v.28 no.10
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• pp.1725-1728
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• 2007

Mast cells are key effector cells in the early phase allergic inflammation and in diverse immunological and pathological processes. In order to understand the effect on reduction of the anti-dinitrophenyl (DNP) IgE antibody-induced β-hexosaminidase release in RBL-2H3 rat mast cells, a novel series of 4-senecioyloxymethyl- 6,7-dimethoxycoumarins (SMDC) was prepared by reacting 4-chloromethyl-6,7-dimethoxycoumarin with various carboxylic acids. Compounds 8-11 with cyclic moiety such as phenyl, thiophenyl, pyridinyl, and furanyl group were found to inhibit-hexosaminidase release more potently (5.98-9.62 μM) than compounds 3- 7 and 12 with acyclic moiety (19.32-76.78 μM). Furthermore, compounds 8 and 9 inhibited IgE-induced ear swelling and significantly reduced systemic passive cutaneous anaphylaxis reaction in mice.

• Proceedings of the Korea Information Processing Society Conference
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• 2006.05a
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• pp.35-38
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• 2006

데이터 웨어하우스에서는 OLAP(On-Line Analytical Processing) 연산을 제공하기 위해 다차원 데이터를 큐브의 형태로 관리한다. 특히, 공간 차원과 같이 데이터 큐브의 차원에 개념 계층이 존재하는 경우 사용자는 특정 계층에 대한 집계 결과를 요구한다. 기조의 데이터 큐브의 구조들은 차원의 개념 계층을 지원하지 못하거나 지원하더라도 시간이나 공간적 비용에 대해 비효율적이다. 본 논문에서는 공간 데이터 웨어하우스에서 공간 개념 계층을 이용하여 효율적인 계층별 영역 집계연산을 지원하는 공간 데이터 큐브를 제안한다. 이는 개념 계층을 DAG(Directed Acyclic Graph) 형태로 표현하여 구성된 여러 개의 차원들을 공간차원의 지역성을 기준으로 연결한 구조이다. 이러한 구조를 갖는 큐브를 이용하면, 데이터 검색 시 상위 계층부터 아래 방향으로 탐색하기 때문에 각 차원에 대한 효율적인 검색이 가능하다. 특히, 공간 개념 계층에 대한 DAG를 이용하면, 공간적 지역성에 따른 영역 검색을 지원할 수 있다. 성능평가에서 개념 계층이 적용된 질의에 대한 실험을 통해 제안 기법이 기존 기법들에 비해 저장 공간 효율성 및 질의 응답 성능이 우수함을 증명한다.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.5 no.7
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• pp.1252-1273
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• 2011

In Web Service Composition (WSC) area, services selection aims at selecting an appropriate candidate from a set of functionally-equivalent services to execute the function of each task in an abstract WSC according to their different QoS values. In despite of many related works, few of previous studies consider transactional constraints in QoS-aware WSC, which guarantee reliable execution of Composite Web Service (CWS) that is composed by a number of unpredictable web services. In this paper, we propose a novel global selection-optimal approach in WSC by considering both transactional constraints and end-to-end QoS constraints. With this approach, we firstly identify building rules and the reduction method to build layer-based Directed Acyclic Graph (DAG) model which can model transactional relationships among candidate services. As such, the problem of solving global optimal QoS utility with transactional constraints in WSC can be regarded as a problem of solving single-source shortest path in DAG. After that, we present Graph-building algorithms and an optimal selection algorithm to explain the specific execution procedures. Finally, comprehensive experiments are conducted based on a real-world web service QoS dataset. The experimental results show that our approach has better performance over other competing selection approaches on success ratio and efficiency.

• Applied Chemistry for Engineering
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• v.2 no.1
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• pp.12-29
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• 1991

Stereoselective synthetic efforts for erythronolide A seco acid are reviewed from the first discovery of erythromycin A in 1952 up to the end of 1990. The synthetic strategies for construction of ten asymmetric centers embedded in an aglycone of erythramycin A have mostly been realized by the stereoselective preparation of the key fragments followed by coupling them. The synthetic methods employed for the key fragments can be classified into three categorie; a carbohydrate approach, a cyclic approach and an acyclic approach. The coupling has largely been reduced to practice by either aldol-type additions or Wittig olefinations of the key fragments.

• Proceedings of the Korea Inteligent Information System Society Conference
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• 2001.01a
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• pp.151-155
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• 2001

Mobile agent technology has been the subject of much attention in the last few years, mainly due to the proliferation of distributed software technologies combined with the distributed AI research field. In this paper, we present a design of communication networks of agents that cooperate with each other for forwarding messages to the specific mobile agent in order to make the overall system location transparent. In order to make the material accessible to general intelligent system researchers, we present the general ideas abstractly in terms of the graph theory. In particular, a proxy network is defined as a directed acyclic graph satisfying some structural conditions. In turns out that the definition ensures some kind of reliability of the network, in the sense that as long as at most one proxy agent is abnormal, there agent exists a communication path, from every proxy agent to the target agent, without passing through the abnormal proxy. As the basis for the implementation of this scheme, an appropriate initial proxy network is specified and the dynamic nature of the network is represented by a set of graph transformation rules. It is shown that those rules are sound, in the sense that all graphs created from the initial proxy network by zero or more applications of the rules are guaranteed to be proxy networks. Finally, we will discuss some implementation issues.

• Journal of Pharmaceutical Investigation
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• v.23 no.3
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• pp.155-163
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• 1993

Inclusion complexation of 1,7,21,27-tetraaza[7.1.7.1]paracyclophane (CPM 55) with 2,7-dihydroxynaphthalene (2,7-DHN) or 1,3-dihydroxynaphthalene (1,3-DHN) in pD 1.17 $DCl-D_2O$ solution was investigated by $^1H$ nuclear magnetic resonance spectroscopy (NMR) using 4,4'-dimethylaminodiphenylmethane (ACM 11) as an acyclic analog of CPM 55. In CPM 55-naphthalene derivative complex, alkyl protons located in the cavity of CPM 55 were shown to be subjected to anisotropic shielding and protons of naphthalene moiety shifted remarkably to upfield. However, in ACM 11-naphthalene derivative systems, chemical shifts for protons of both DHN compounds were not significant. The remarkable chemical shift changes suggested that the naphthalene moiety of 2,7-DHN or 1,3-DHN was included in the hydrophobic cavity of CPM 55 in aqueous solution. From the continuous variation plots of induced chemical shifts of 2,7-DHN, it was found that 2,7-DHN was included in the cavity of CPM 55 at 1:1 molar stoichiometry. Both computer simulation of a inclusion complex and strong upfield chemical shift changes of 2,7-DHN protons supported the conformation of pseudoaxial inclusion as the presumed geometry of the host-guest complex.

• Environmental and Resource Economics Review
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• v.21 no.3
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• pp.493-517
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• 2012

This paper analyzes a price discovery process for gasoline among branded and independent stations in Korea using a vector error correction model (VECM) and directed acyclic graphs (DAG). Two data sets for daily prices of medium level gasoline running from April 15, 2008 to May 31, 2009 and from January 1, 2011 to December 31, 2011 are used for empirical analysis. Empirical results show that S-OIL has an exogeneity and played a important role in the flow of price information in the market in the first period. In the second period, SK energy played a key role in price discovery process in the market. The price of NH-OIL stations do not cause the price of any other stations, which implies that the entrance of new branded stations with lower gasoline price to market has no influence on gasoline prices of retail markets.

• Journal of Korea Multimedia Society
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• v.6 no.3
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• pp.549-555
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• 2003

CA is cost-effective to generate pseudorandom patterns than LFSR. Based on the effectiveness of a CA based pseudorandom pattern generator, CA have been employed successfully in several applications. Especially Nongroup CA is applied to efficient hash function generation, cryptography and image compression. In this paper we analyze the properties of TPNCA and by using basic paths in the 0-tree of a linear TPNCA we analyze the structure of the state-transition graph. Also by showing the structure of the complemented CA which have the acyclic state of the 0-tree as the complement vector is isomorphic to the structure of the original TPNCA, we reduce the time in analyzing the CA-states.

• Journal of Microbiology and Biotechnology
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• v.17 no.11
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• pp.1797-1804
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• 2007

Lycopene, an acyclic carotenoid found in tomatoes (Lycopersicon esculentum) and a number off fruits, has shown various biological properties, but its antifungal effects remain poorly understood. The current study investigated the antifungal activity of lycopene and its mode of action. Lycopene showed potent antifungal effects toward pathogenic fungi, tested in an energy-independent manner, with low hemolytic effects against human erythrocytes. To confirm the antifungal effects of lycopene, its effects on the dimorphism of Candida albicans induced by fetal bovine serum (FBS), which plays a key role in the pathogenesis of a host invasion, were investigated. The results showed that lycopene exerted potent antifungal activity on the serum-induced mycelia of C. albicans. To understand the antifungal mode of action of lycopene, the action of lycopene against fungal cell membranes was examined by FACScan analysis and glucose and trehalose-release test. The results indicated that lycopene caused significant membrane damage and inhibited the normal budding process, resulting from the destruction of membrane integrity. The present study indicates that lycopene has considerable antifungal activity, deserving further investigation for clinical applications.

• Journal of the Korea Society of Computer and Information
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• v.12 no.6
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• pp.105-113
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• 2007

A gene regulatory network is a network of genes representing how genes influence the activities of other genes. Nowadays from microarray experiments, a large number of measurements on the expression levels of genes are available. One of typical data is the so-called "steady-state model" data measuring the expression levels of other genes after knocking out a particular gene. This paper shows how to reverse engineer a parsimonious gene regulatory network, using these measurement data. Our model considers auto-regulation, which forms a cycle in a genetic network. We also model repressor and enhancer roles of genes. which are not considered in previous known methods.