• International Journal of Advanced Culture Technology
• /
• 제12권1호
• /
• pp.43-50
• /
• 2024

Patients with acute respiratory diseases, such as Middle East Respiratory Syndrome (MERS) due to COVID-19, must wear masks, protective clothing, face shields, and gloves to prevent infection during treatment and performance. Even if it is applied to disabled people, families who protect them are severely mentally tired from severe physical fatigue and stress from exposure to high-risk infectious diseases. As such, the spread of infectious diseases such as respiratory diseases has not only caused difficulties in using existing welfare and medical services but also caused various problems throughout the daily life of disabled people due to the prolonged infectious disease, and its scope is gradually expanding. Therefore, it should not be overlooked that disabled people may experience various difficulties, from the spread of infectious diseases such as respiratory diseases to isolation, diagnosis, and treatment, and it is time to actively assess the life changes felt by families caring for disabled people and consider and research to provide adequate services. According to the survey of disabled people is being conducted in the context of the spread of infectious diseases such as respiratory diseases, while research on the spread of infectious diseases such as respiratory diseases is rare for parents with disabilities. There is a need for additional investigation into the characteristics in other areas of everyday life, including the health field, which is deteriorating through prior research. Therefore, through this survey, the purpose of this study is to investigate the life changes of parents with disabilities in the context of the spread of infectious diseases such as respiratory diseases and to compare and analyze them to find out how parents were affected by each type of disability. It will be used as evidence to identify more necessary needs and problems for parents with disabilities in the spread of infectious diseases such as respiratory diseases and to provide more appropriate health care and welfare services in the future.

• 보건행정학회지
• /
• 제16권2호
• /
• pp.49-76
• /
• 2006

The aim of this study was to explore the effects of a computerized review program which was introduced in August 1, 2003, using claims data for acute respiratory infection related diseases. National Health Insurance (NHI) claims data on respiratory infection related diseases before and after the introduction, with six month intervals respectively, were used for the analysis. Clinic was the unit of observation, and clinics with only one physician whose specialty was internal medicine, pediatrics, otorhinolaryngology and family medicine and clinics with a general practitioner were selected. The final sample had 7,637 clinics in total. Indices used to measure practice pattern was prescription rates of antibiotics, prescription rates of injection drug per visit, treatment costs per claim, and total costs per claim. Changes in the number of claims for major disease categories and upcoding index for disease categories were used to measure claiming behavior. Data were analysed using descriptive analysis, t-test for indices changes before and after the introduction, analysis of variance (ANOVA) for practice pattern change for major disease categories, and multiple regression analysis to identify whether new system influenced on provider' practice patterns or not. Prescription of antibiotics, prescription rates of injection drug, treatment costs per claim, and total costs per claim decreased significantly. Results from multiple regression analysis showed that a computerized review system had effects on all the indices measuring behavior. Introduction of the new system had the spillover effects on the provider's behavior in the related disease categories in addition to the effects in the target diseases, but the magnitude of the effects were bigger among the target diseases. Rates of claims for computerized review over total claims for respiratory diseases significantly decreased after the introduction of a computerized review system and rates of claims for non target diseases increased, which was also statistically significant. Distribution of the number of claims by disease categories after the introduction of a computerized review system changed so as to increase the costs per claims. Analysis of upcoding index showed index for 'other acute lower respiratory infection (J20-22)', which was included in the review target, decreased and 'otitis media (H65, H66)', which was not included in the review target, increase. Factors affecting provider's practice patterns should be taken into consideration when policies on claims review method and behavior changes. It is critical to include strategies to decrease the variations among providers.

• Tuberculosis and Respiratory Diseases
• /
• 제79권4호
• /
• pp.307-311
• /
• 2016

Pulmonary strongyloidiasis is an uncommon presentation of Strongyloides infection, usually seen in immunocompromised hosts. The manifestations are similar to that of acute exacerbation of chronic obstructive pulmonary disease (COPD). Therefore, the diagnosis of pulmonary strongyloidiasis could be challenging in a COPD patient, unless a high index of suspicion is maintained. Here, we present a case of Strongyloides hyperinfection in a COPD patient mimicking acute exacerbation, who was on chronic steroid therapy.

• IMMUNE NETWORK
• /
• 제22권6호
• /
• pp.48.1-48.13
• /
• 2022

With the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, which are randomly mutated, the dominant strains in regions are changing globally. The development of preclinical animal models is imperative to validate vaccines and therapeutics against SARS-CoV-2 variants. The objective of this study was to develop a non-human primate (NHP) model for SARS-CoV-2 Delta variant infection. Cynomolgus macaques infected with Delta variants showed infectious viruses and viral RNA in the upper (nasal and throat) and lower respiratory (lung) tracts during the acute phase of infection. After 3 days of infection, lesions consistent with diffuse alveolar damage were observed in the lungs. For cellular immune responses, all macaques displayed transient lymphopenia and neutrophilia in the early stages of infection. SARS-CoV-2 Delta variant spike protein-specific IgM, IgG, and IgA levels were significantly increased in the plasma of these animals 14 days after infection. This new NHP Delta variant infection model can be used for comparative analysis of the difference in severity between SARS-CoV-2 variants of concern and may be useful in the efficacy evaluation of vaccines and universal therapeutic drugs for mutations.

• Tuberculosis and Respiratory Diseases
• /
• 제68권1호
• /
• pp.29-33
• /
• 2010

Strongyloides stercoralis is an intestinal nematode that is a parasite to humans. The infecting filariform larvae of S. stercoralis enters the host body via the bloodstream, passes through the lungs, penetrates the alveoli, and then ascends the airway to transit down the esophagus into the small bowel. The infection can persist for decades without causing major symptoms and can elicit eosinophilia of varying magnitudes. Of note, this infection can also develop into a disseminated, often fatal, disease (hyperinfection) in patients receiving immunosuppressive corticosteroids. A 65-year-old man who was receiving corticosteroid therapy for the treatment of spinal stenosis was admitted to the emergency room with complaints of abdominal pain and severe dyspnea. We detected many S. stercoralis larvae in the sputum and in the bronchoalveolar-lavage sample collected by bronchoscopy. Here, we report a fatal case of strongyloidiasis with acute respiratory failure and intestinal perforation. In addition, we provide a brief review of the relevant medical literature.

• Pediatric Infection and Vaccine
• /
• 제20권1호
• /
• pp.28-35
• /
• 2013

목 적 : 2000년이후human metapneumovirus (hMPV)는 하기도 호흡기 감염을 일으키는 주요 바이러스로 인식되고 있다. 급성 호흡기 감염으로 입원한 소아 환자들에서의 hMPV의 역학 및 임상적 특징, 그리고 혈액학적 특징 및 hMPV에 감염되지 않은 환자와의 비교, 중복 감염등을 통해 hMPV의 특징을 파악하고자 하였다. 방 법 : 2010년 2월부터 2012년 1월까지 급성 호흡기 증상으로 입원한 환아 1,554명의 비인두 흡인을 통해 객담 검체를 채취하여 RT-PCR을 시행 후 hMPV가 검출된 99명의 환아들의 임상 기록지를 후향적으로 검토하여 이들의 임상 증상 및 검사 소견을 분석 비교 하였다. 결 과 : 1,554명 중 1,004명(64.6%)에서 호흡기 바이러스가 검출되었다. 그 중 hMPV가 양성인 환자는 99명으로 양성 검체의 9.8%였다. hMPV에 감염된 환자의 평균 연령은 25.0개월이었으며 해마다 유행 정도는 다르나 4월부터 6월에 주로 발현하였으며 발열기간이 다른 바이러스 보다 길고 호흡기 증중을 보였으며, 천명(wheezing)이 특징적 임상 증상이었다. 진단으로 폐렴이 가장 많았지만, 12개월 이하의 연령군에서는 모세기관지염이 가장 흔하였다. 혈액학적 검사소견은 ESR (erythrocyte sedimentation rate), CRP (C-reactive protein) 모두 hMPV에 감염된 환자군에서 정상 범위 보다 상승된 소견을 보였다. hMPV의 단독 감염과 중복 감염을 비교해 보았을 때 임상증상 및 혈액 검사 소견에서 통계학적 차이를 보이지 않았다. 결론 : hMPV는 폐렴을 일으키는 주요 원인 바이러스이며 13개월 이상부터 48개월 이하의 연령에서 호발하며 평균 연령은 25개월이며 4월에서 6월까지 유행하는 양상을 보였다. 천명이 임상적 특징이며, hMPV에 대하여 우리나라에서의 보고는 점차 증가되고 있으나 아직은 생물학적, 유전학적 특징과 관련된 임상 분석이 더 필요하다.

• Pediatric Infection and Vaccine
• /
• 제10권1호
• /
• pp.114-122
• /
• 2003

본 저자들은 상기도 감염 후 발열과 배뇨곤란, 하지의 근력저하를 주소로 내원한 7세 환아에서, 급성 횡단성 척수염 증상으로 시작하여 의식 변화와 호흡부전의 급성 파종성 뇌척수염으로 진행한 1례에서 enterovirus 71을 증명하고 고용량 methylprednisolone 정주 후 증상의 호전을 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

• Journal of Trauma and Injury
• /
• 제28권1호
• /
• pp.34-38
• /
• 2015

The case of a patient with a transfusion-related acute lung injury (TRALI) to whom extracorporeal membrane oxygenation (ECMO) had been applied is reported. A 55-year-old male injured with liver laceration (grade 3) without chest injury after car accident. He received lots of blood transfusion and underwent damage control abdominal surgery. In the immediate postoperative period, he suffered from severe hypoxia and respiratory acidosis despite of vigorous management such as 100% oxygen with mechanical ventilation, high PEEP and muscle relaxant. Finally, ECMO was applied to the patients as a last resort. Aggressive treatment with ECMO improved the oxygenation and reduced the acidosis. Unfortunately, the patient died of liver failure and infection. TRALI is a part of acute respiratory distress syndrome (ARDS). The use of ECMO for TRALI induced severe hypoxemia might be a useful option for providing time to allow the injured lung to recover.

• Clinical and Experimental Pediatrics
• /
• 제65권3호
• /
• pp.150-151
• /
• 2022

• 대한간호
• /
• 제11권3호통권59호
• /
• pp.38-44
• /
• 1972

The common cold is a symptom complex caused by viral infection of the upper respiratory passages. Most precisely, the term applies to febrile, acute coryza of viral origin. In broadest sense, the common cold refers to any undifferentiated upper respirator