• 디지털융복합연구
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• 제16권4호
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• pp.23-28
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• 2018

정치 활동이나 정책에의 참여활동에 있어서 최근에는 온라인에서 활동이 더 중요해지고 있다. 따라서 디지털정보화 수준은 온라인 환경에서의 정책에의 참여활동에도 영향을 미칠 수 있다. 본 연구에서는 장애인들의 정책 활동이 정보화 수준과 어떠한 관계를 가지고 있는지를 살펴보았다. 이를 위해 2017년 디지털정보격차실태조사 결과를 바탕으로 장애인들의 디지털정보화수준과 정책 활동 만족도 수준과의 관계를 분석하였다. 연구결과 장애인들의 유무선 정보기기 보유 및 인터넷 상시 접속가능 여부 등 디지털접근과 정책 활동 만족도 수준과는 정(+)의 관계를 가지는 것으로 나타났다. 둘째, PC이용능력 및 모바일 디지털기기 이용능력 등 디지털 정보역량수준과 소득수준도 정(+)의 관계를 가짐을 알 수 있었다. 셋째, 유선 및 모바일 인터넷 이용여부 등 디지털 정보활용 등의 수준이 높아질수록 정책 활동 만족도 수준도 정(+)의 관계로 증가한다는 것을 알 수 있었다. 이를 통해 장애인들에 대한 디지털 정보화 수준을 높일 수 있는 정부의 다양한 정보화 정책이 필요함을 시사한다.

• 한국수학교육학회지시리즈C:초등수학교육
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• 제6권2호
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• pp.75-84
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• 2002

After entering an elementary school, in fact, a number of children regard mathematics as one of very difficult subjects because of its abstractiveness. This is caused by the fact that their basic thinking power is not yet formed or they can not understand the special quality of mathematics. So this article emphasizes the need to build up the higher logical thought and a basic mathematical concept at the lower grade elementary school stage in which the loaming activity on mathematics begins in earnest, that is, at the stage before having an experience on the calculating activity using numbers. But at present the lower grade elementary school students in our country do not understand the special quality of mathematics composed of a various symbolic system and lay stress upon mathematics learning attached to the calculative activity. In order to make the right mathematical concept of the lower grade elementary school, the basic knowledge and ability as follows is sure to be formed. 1) the foundational logical manipulation activity and knowledge 2) the using ability of the sign and symbolic system At the stage on which mathematics learning activity begins, it is a very important task to make the right concept of the abstractive math and nurse the capability for finding mathematical relations covered under the sign system through the continuos loaming activity on . Through the basic logical manipulation activity and the game activity of sign for lower grade elementary school students mentioned in this article, they can not only foster the higher level logical thinking power and the foundational calculative ability but also bring up the interest on the activity of establishing a new problem solving strategy.

• 한국조리학회지
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• 제20권2호
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• pp.152-164
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• 2014

본 연구에서는 요리활동 프로그램의 교육적 가치와 효과를 인식하여 아동 요리활동 프로그램에 대한 학부모의 기대와 만족을 비교하고, 만족도에 영향을 미치는 요인을 분석하였다. 자녀에게 요리활동 프로그램을 시행하고 있거나 시행한 경험이 있는 학부모를 대상으로 총254개의 표본을 바탕으로, 대응표본 t검정, IPA분석, 회귀분석, One-way ANOVA를 시행하였고, Duncan's multiple test를 통해 사후 검증을 실시하였다. 연구결과, 요리활동 프로그램의 기대와 만족의 차이에는 '언어 표현능력 향상', '수개념 및 과학개념 발달', '내면을 표현하는 표현력 신장', '정서적 안정감과 스트레스 해소에 도움'이 유의한 차이가 있는 것으로 나타났다. 또한 요리활동 프로그램의 만족도에 영향을 미치는 요인으로 '교육내용 및 방법'이 나타났으며, 요리활동 프로그램 기관에 따른 만족도의 차이를 알아본 결과 유의한 차이가 있는 것으로 나타났다.

• 약학회지
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• 제52권4호
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• pp.316-321
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• 2008

The hepatoprotection by the methanol extract of Oenanthe javanica DC (water dropwort) (OJME) was investigated in Sprague Dawley rats with inducing liver damage by acetaminophen. After OJME administration for 1 week, the increase of hepatic lipid peroxide level by acetaminophen-induced hepatotoxicity was significantly reduced. In case of phase I microsomal enzyme systems including cytochrome P-450, aminopyrine N-demethylase and aniline hydroxylase, any significant differences between in control and in OJME-pretreated group was observed after acetaminophen treatment. However, the pretreatment of OJME maintained the hepatic glutathione level and the activity of liver cytosolic glutathione S-transferase, which was significantly decreased by the acetaminophen intoxication. Among the glutathione-generating system, glutathione reductase was more responsible for its biosynthesis rather than ${\gamma}-glutamylcystein$ synthetase. OJME itself showed the strong inhibition activity on DPPH radical generation. In conclusion, OJME administration maintains the liver glutathione pool and hepatic glutathione S-transferase activity, in addition with its high anti-oxidative capability, to show hepatoprotective effect from acetaminophen intoxication.

• IMMUNE NETWORK
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• 제10권3호
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• pp.92-98
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• 2010

Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used to relieve pain, reduce fever and inhibit inflammation. NSAIDs function mainly through inhibition of cyclooxygenase (COX). Growing evidence suggests that NSAIDs also have immunomodulatory effects on T and B cells. Here we examined the effects of NSAIDs on the antigen presenting function of dendritic cells (DCs). Methods: DCs were cultured in the presence of aspirin or ibuprofen, and then allowed to phagocytose biodegradable microspheres containing ovalbumin (OVA). After washing and fixing, the efficacy of OVA peptide presentation by DCs was evaluated using OVA-specific CD8 and CD4 T cells. Results: Aspirin and ibuprofen at high concentrations inhibited both MHC class I and class II-restricted presentation of OVA in DCs. In addition, the DCs generated in the presence of low concentrations of the drugs exhibit a profoundly suppressed capability to present MHC-restricted antigens. Aspirin and ibuprofen did not inhibit the phagocytic activity of DCs, the expression level of total MHC molecules and co-stimulatory molecules on DCs. Ibuprofen rather increased the expression level of total MHC molecules and co-stimulatory molecules on DCs. Conclusion: These results demonstrate that aspirin and ibuprofen inhibit the intracellular processing event of the phagocytosed antigen, and further suggest that prolonged administration of NSAIDs in high doses may impair the capability of DCs to present antigens in asiociation with MHC molecules.

• 대한한의학방제학회지
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• 제15권2호
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• pp.35-45
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• 2007

Objective : The purpose of this report was to provide the information activity and safety of Palmul-tang by analyzing domestic/international papers and theses about Palmul-tang, Methods: Domestic/international papers and theses related to Palmul-tang were reviewed and analyzed, These papers were then classified by year, experimental method and subject, Results: The following results were obtained in this study. 1. The study of Palmul-tang started from 1985 and was continuously increased. The study was mainly forcused on experimental model rather than clinical study. 2. As these studies were classified by subject, papers related to immune intensification were most abundant by 20 papers, Besides there were several papers related to cardiovascular activity, reproductive activity, anti-apoptotic activity and cerebral hemodynamics. 3. Among the papers related to immune intensification. the studies on recovery of fatigue were mostabundant by 10 papers and the studies of on immune cell and cytokine express were six. In addition to. several studies were associated with anti-cancer activity and anti-allergic activity. Recovery of fatigue was determined by measurement of fatigue markers in a living body such as lactate. CPK, pyruvate and triglyceride and assessment of exercise capability of animals such as swimming test. slopped plate test. Rota-rod test, and activity cage test after Palmul-tang treatment. 4. According to experimental data. it is supported that Palmul-tang has been used as Qi and Blood intensifier with immune intensification and recovery of fatigue. 5. The paper related to safety of Palmul-tang was only one paper which is studied on acute toxicity of Palmul-tang with experiment with ICR mouse. There was no study on evaluating safety by observing liver and kidney functions after Palmul-tang treatment Conclusion: Palmul-tang is being used in various ways associating with immune intensification. cardiovascular activity and reproductive activity. However. studies on efficacy and mechanism of Palmul-tang should be conducted at the molecular biology level and studies on safety of Palmul-tang need to be completed at the clinical level.

• Toxicological Research
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• 제31권2호
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• pp.165-172
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• 2015

Cornus officinalis is widely distributed in Korea, and its fruit has been used to make as herbal drug for traditional medicine in Korea, Japan, and China because of its tonic, analgesic, and diuretic properties. However, the effects of C. officinalis methanol extract (COME) on melanogenesis remain poorly understood. We evaluated the melanogenic capability of COME in melan-a cells, which are immortalized mouse melanocytes. COME increased melanin synthesis in a dose-dependent manner. Treatment with $12.5{\mu}g/mL$ of COME significantly increased melanin content by 36.1% (p < 0.001) to a level even higher than that (31.6%) of 3-isobutyl-1-methyl-xanthine, a well-known pigmentation agent. COME also upregulated tyrosinase activity and its messenger RNA and protein expression. In addition, COME upregulated the expression of tyrosinase-related proteins 1 and 2 and microphthalmia-associated transcription factor-M messenger RNA expression. These results imply that COME may be appropriate for development as a natural product to treat hair graying.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2012년도 제43회 하계 정기 학술대회 초록집
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• pp.220-220
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• 2012

The supercapacitors with extraordinarily high capability for energy storage are attracting growing attention for their potential applications in portable electronic equipments, hybrid vehicles, cellular devices, and so on. The nanostructuring of the electrode surface can provide large surface area and consequently easy diffusion of ions in the capacitors. In addition, compared to two-dimensional nanostructures, the three-dimensional (3D) nano-architecture is expected to lead to significant enhancement of mechanical and electrical properties such as capacitance per unit area of the electrode. Polyaniline (PANi) is known as promising electrode material for supercapacitors due to its desirable properties such as high electro activity, high doping level and environmental stability. In this context, we fabricated well-ordered 3D PANi nanostructures on 3D polystyrene (PS) nanospheres which was arrayed by layer-by-layer stacking method. The height of the PANi nanostructures could be controlled by the number of PS layers stacked. 3D PANi hollow nanospheres were also fabricated by dissolving inner PS nanospheres, which resulted in further enhancement of the surface area and capacitance of the electrode.

• 한국조경학회지
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• 제32권3호
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• pp.43-50
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• 2004

This study looked into the water quality improvement effect of reed (Phragmites communis), bur reed (Sparaganium stoloniferum), Alisma canaliculatum, and Hydrocharis dubia in order to develop native hydrophytes suitable to natural-type wetlands for ecological restoration. The result confirms that the concentration of wastewater was lowered in most plants indicating a possibility in wastewater treatment. Among four species, reed (Phragmites communis) and bur reed (Sparaganium stoloniferum) were most effective in removing a majority of contaminants. Considering that reed (Phragmites communis) is a species that has been used most often among hydrophytes, bur reed (Sparaganium stoloniferum), which is a native species in Korea, showed equivalent level of outstanding effect. In the physiological and growing activity and its relations to water quality improvement effect, each species appeared differently. Reed (Phragmites communis) and bur reed (Sparaganium stoloniferum) were best also in physiological and growing activity. In the case of Hydrocharis dubia, growth was strong in polluted water environment but its physiological activity was poor, indicating that it was under stress. The growth and physiological activity of Alisma canaliculatum were also poor, indicating that it too is being stressed. However, measuring organic contents in the plants of each species shows that the organic contents of Alisma canaliculatum was high. Alisma canaliculatum is a species effective in removing pollutants in water, although it is under stress. A unique phenomenon in removing water pollution with plants is that each species removed different pollutants. In the case of Alisma canaliculatum, which was relatively poor in removing pollution, it was remarkable in reducing nitrogen and phosphorus. Hydrocharis dubia was also effective in eliminating floating matter.

• 예술인문사회 융합 멀티미디어 논문지
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• 제6권6호
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• pp.395-402
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• 2016

과학기술의 발전과 수요의 변화로 인해 기업들은 빠른 환경변화에 직면하고 있다. 기업들은 이러한 환경변화에 대응하기 위해 공급망의 역량을 강화하기 위해서 노력하고 있다. 개선과정에서는 공급망의 참여자들 간의 협력적인 관계가 중요하며, 기업들은 내부적 활동을 다른 조직들에게 외주를 지고 프로세스 상에서의 낭비를 제거하기 위해 노력하고 있으며, 결과적으로 공급망은 지속적으로 간결하고 효과적인 상태가 되어간다. 본 연구는 외부 위험 하에서 낭비수준의 정도가 공급망 성과에 미치는 영향을 확인하고자 한다. 본 연구의 결과는 낭비 수준이 공급망 성과에 음의 영향을 미치고 있음을 보여준다. 또한 공급망 성과에 대한 낭비수준의 영향을 조직이 직면한 위험상황에 따라서 다르게 나타나고 있음을 보여준다. 즉 낭비의 수준이 높을수록 위험은 낭비수준과 공급망 성과 사이에서 조절효과가 있다. 이는 공급망 성과를 개선하기 위해서 내부적 효율성을 강화하는 것이 중요하지만, 외부적 위험을 적절히 관리하는 것이 우선적으로 선행되어야 함을 시사한다.