• Journal of the Semiconductor & Display Technology
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• v.15 no.2
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• pp.61-65
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• 2016

Facial feature detection is a fundamental function in the field of computer vision such as security, bio-metrics, 3D modeling, and face recognition. There are many algorithms for the function, active shape model is one of the most popular local texture models. This paper addresses issues related to face detection, and implements an efficient extraction algorithm for extracting the facial feature points to use on iOS platform. In this paper, we extend the original ASM algorithm to improve its performance by four modifications. First, to detect a face and to initialize the shape model, we apply a face detection API provided from iOS CoreImage framework. Second, we construct a weighted local structure model for landmarks to utilize the edge points of the face contour. Third, we build a modified model definition and fitting more landmarks than the classical ASM. And last, we extend and build two-dimensional profile model for detecting faces within input images. The proposed algorithm is evaluated on experimental test set containing over 500 face images, and found to successfully extract facial feature points, clearly outperforming the original ASM.

• International Journal of Control, Automation, and Systems
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• v.4 no.5
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• pp.660-667
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• 2006

This paper presents a novel region-based snake method for vessel segmentation. According to geometric shape analysis of the vessel structure with different scale, an efficient statistical estimation of vessel branches is introduced into the energy objective function, which applies not only the vessel intensity information, but also geometric information of line-like structure in the image. The defined energy function is minimized using the gradient descent method and a new region-based speed function is obtained, which is more accurate to the vessel structure and not sensitive to the initial condition. The narrow band algorithm in the level set framework implements the proposed method, the solution of which is steady. The segmentation experiments are shown on several images. Compared with other geometric active contour models, the proposed method is more efficient and robust.

• Proceedings of the KIEE Conference
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• 2003.07d
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• pp.2798-2800
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• 2003

Active contour models(called Snakes) are methods for the image segmentation. Many researchers have developed snake algorithms and then published such as GVF, GGF snake. In this paper, we present a pre-process for GGF snake algorithm. This process removes noise so that snakes can flow smoothly. In experiment, we compared a image removed noise with a image corrupted by noise. In result, the pre-process produced a good image for GGF Snake and is necessary.

• Journal of Digital Convergence
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• v.12 no.7
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• pp.239-245
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• 2014

In this paper, a weighted value wrinkle detection method is suggested based on the analysis on the entire facial features such as face contour, face size, eyes and ears. Firstly, the main facial elements are detected with AAM method entirely from the input screen images. Such elements are mainly composed of shape-based and appearance methods. These are used for learning the facial model and for matching the face from new screen images based on the learned models. Secondly, the face and background are separated in the screen image. Four points with the biggest possibilities for wrinkling are selected from the face and high wrinkle weighted values are assigned to them. Finally, the wrinkles are detected by applying Canny edge algorithm for the interested points of weighted value. The suggested algorithm adopts various screen images for experiment. The experiments display the excellent results of face and wrinkle detection in the most of the screen images.

• Journal of Integrative Natural Science
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• v.8 no.4
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• pp.273-284
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• 2015

Chemoattractant Receptor Homologous molecule expressed on Th2 cells (CRTh2) is a chemoattractant receptor with seven transmembrane helices targeted for inflammatory diseases such as asthma and allergic rhinitis. In this study, pharmacophore based Comparative Molecular Similarity Indices Analysis (CoMSIA) were performed on the series of 2-(2-(benzylthio)-1H-benzo[d]imidazol-1-yl) acetic acids derivatives. Initially, GASP module was used for generation of pharmacophore models using five highly active compounds from the dataset. Among the generated pharmacophores, the best pharmacophore model was selected based on fitness score and was used as template for the alignment of compounds which was used for CoMSIA analysis. The best predictions were obtained utilizing steric, hydrophobic and H-bond acceptor parameters showing a $q^2$=0.559 and $r^2$=0.730. 15 test set compounds was used to investigate the predictive ability of the CoMSIA model. Contour maps suggested that presence of bulky substituents and H-bond acceptor atoms at $5^{th}$ position of benzene ring will increase the activity of the compounds. The results obtained from this study will be useful to design more potent CRTh2 antagonists.

• Journal of Integrative Natural Science
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• v.8 no.2
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• pp.89-98
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• 2015

Chemoattractant receptor homologous molecule expressed on Th2 cells (CRTh2) is a G-protein coupled receptor targeted for inflammatory diseases such as asthma, allergic rhinitis and atopic dermatitis. In this study, pharmacophore modeling and comparative molecular field analysis (CoMFA) were performed on the series of 2-(2-(benzylthio)-1H-benzo[d]imidazol-1-yl) acetic acids derivatives. Five highly active compounds were used for generation of pharmacophore models using GASP module. The best pharmacophore model was selected and used as template for the alignment of compounds which was used for CoMFA analysis. The best predictions obtained for CoMFA was $q^2=0.545$, $r^2=0.756$. The predictive ability of the model was investigated using 15 test set compounds. Contour maps suggested that presence of bulky substituents at $5^{th}$ position of benzene ring connected to suphur atoms attached to imidazol ring will increase the activity of the compounds. The results obtained from this study will be useful to design more potent CRTh2 antagonists.

• Bulletin of the Korean Chemical Society
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• v.31 no.5
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• pp.1355-1360
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• 2010

In order to search new inhibitors against farnesyl protein transferase (FPTase), a series of 2,3-bis-benzylidenesuccinaldehyde derivatives (1-29) were synthesized and their inhibition activities ($pI_{50}$) against FPTase were measured. From based on the reported results that the inhibitory activities of dimers 2,3-bis-benzylidenesuccinaldehydes were higher than those of monomers cinnamaldehydes, 3D-QSARs on FPTase inhibitory activities of the dimers (1-29) were studied quantitatively using comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) methods. The statistical qualities of the optimized CoMFA model II ($r^2{_{cv.}}$= 0.693 and $r^2{_{ncv.}}$= 0.974) was higher than those of the CoMSIA model II ($r^2{_{cv.}}$ = 0.484 and $r^2{_{ncv.}}$ = 0.928). The dependence of CoMFA models on chance correlations was evaluated with progressive scrambling analyses. And the inhibitory activity exhibited a strong correlation with steric factors of the substrate molecules. Therefore, from the results of graphical analyses on the contour maps and of predicted higher inhibitory active compounds, it is suggested that the structural distinctions and descriptors that contribute to inhibitory activities ($pI_{50}$) against FPTase will be able to applied new inhibitor design.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.34 no.2
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• pp.109-115
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• 2008

The comparative molecular field analyses(CoMFA) models between the substituents with changing groups($R_1{\sim}R_4$) of $3{\beta}$-hydroxy-12-oleanen-28-oic acid derivatives as substrate molecule and their inhibitory activities($pI_{50}$) against protein tyrosine phosphatase(PTP)-1B were derived and discussed quantitatively. The optimized CoMFA F1 model have best predictability and fitness($r^2_{cv.}=0.654$ and $r^2_{ncv.}=0.995$). The order of contribution ratio (%) with CoMFA fields on the inhibitory activities was a steric field(53.0%), electrostatic field(36.2%) and hydrophobic field(10.8%). From the analytical results of CoMFA contour maps, the inhibitory activities were dependent on the R4 group in substrate molecules. Particularly, the new active compounds(P1 & P2) with the inhibitory activity against melanin synthesis were expected.

• Geomechanics and Engineering
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• v.16 no.4
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• pp.435-448
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• 2018

In order to make reliable earthquake-resistant design of civil engineering structures, one of the most important considerations in a region with high seismicity is to pay attention to the local soil condition of regions. It is aimed in the current study at specifying dynamic soil characteristics of Kirikkale city center conducting the 1-D equivalent linear and non-linear site response analyses. Due to high vulnerability and seismicity of the city center of Kirikkale surrounded by active many faults, such as the North Anatolian Fault (NAF), the city of Kirikkale is classified as highly earthquake-prone city. The first effort to determine critical site response parameter is to perform the seismic hazard analyses of the region through the earthquake record catalogues. The moment magnitude of the city center is obtained as $M_w=7.0$ according to the recorded probability of exceedance of 10% in the last 50 years. Using the data from site tests, the 1-D equivalent linear (EL) and nonlinear site response analyses (NL) are performed with respect to the shear modulus reduction and damping ratio models proposed in literature. The important engineering parameters of the amplification ratio, predominant site period, peak ground acceleration (PGA) and spectral acceleration values are predicted. Except for the periods between the period of T=0.2-1.0 s, the results from the NL are obtained to be similar to the EL results. Lower spectral acceleration values are estimated in the locations of the city where the higher amplification ratio is attained or vice-versa. Construction of high-rise buildings with modal periods higher than T=1.0 s are obtained to be suitable for the city of Kirikkale. The buildings at the city center are recommended to be assessed with street survey rapid structural evaluation methods so as to mitigate seismic damages. The obtained contour maps in this study are estimated to be effective for visually characterizing the city in terms of the considered parameters.

• Journal of Applied Biological Chemistry
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• v.53 no.4
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• pp.225-231
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• 2010

To understand the inhibitory activity with changing hydroxyl substituents ($R_l-R_9$) of polyhydroxy substituted 2-phenyl-l,4-benzopyrone analogues (1-25) against tyrosinase (PDB ID: oxy-form; 1WX2), molecular docking and the three dimensional quantitative structure-activity relationships (3D-QSARs: Comparative molecular field analysis (CoMFA) & Comparative molecular similarity indices analysis (CoMSIA)) were studied quantitatively. The statistically best models were CoMFA 1 and CoMSIA 1 model from the results. The optimized CoMSIA 1 model with the sensitivity of the perturbation and the prediction produced ($dq^2'/dr_{yy'}^2$=1.009 & $q^2$=0.51l) by a progressive scrambling analysis were not dependent on chance correlation. The inhibitory activities with optimized CoMSIA 1 model were dependent upon electrostatic factor (51.4%) of substrate molecules. Contour mapping the 3D-QSAR models to the active site of tyrosinase provides new insight into the interaction between tyrosinase as receptor and 2-phenyl-l,4-benzopyrone analogues as inhibitor. Therefore, the results will he able to apply to the optimization of a new potent tyrosinase inhibitors.