• The Transactions of the Korea Information Processing Society
• /
• v.6 no.5
• /
• pp.1332-1341
• /
• 1999

Rapid expansion of network and increment of computer system access cause computer security to be an important issue. Hence, the researches in intrusion detection system(IDS)are active to reduce the risk from hackers. Considering IDS, we propose a new IDS model(DABIDS : Distributed Agent Based Intelligent intrusion Detection System) based on distributed intrusion detecting agents. The DABIDS dynamically collects intrusion behavior knowledge from each agents when some doubtable behaviors of users are detected and make new agents codes using intrusion scenario data base, and broadcast the detector codes to the distributed intrusion detecting agent of all node. This DABIDS can efficiently solve the problem to reduce the overhead for training detecting agent for intrusion behavior patterns.

• Proceedings of the KSRS Conference
• /
• 2003.11a
• /
• pp.949-951
• /
• 2003

To improve the reusability and interoperability of GIS components, we propose the registration/retrieval agents, which can search the locating of users' frequently used components in not only the GIS domain but also other spatial information technologies such as GPS, ITS, RS and FM. The registration/retrieval agents increase the reusability through the GIS component based development under distributed GIS components environment and enables the rapid setting of application on the web. Moreover, users can understand easily the information of GIS component and have the effective investment, timeliness and reliability while they have less maintenance effort by agent. In order to design and implement this system on web, HTML and ASP (Active Serve Page), and JAVA were used. In addition, the performance of this system was verified through comparing others, which are similar to.

• Archives of Pharmacal Research
• /
• v.24 no.6
• /
• pp.473-484
• /
• 2001

There is clearly a need for novel breast cancer chemopreventive agents with enhanced potency and specificity with tittle or no side effects. To this end, several new chemical moieties have been synthesized or isolated from natural sources. In this reviewal we have described some agents currently in use or under development for treatment or prevention of breast cancer, as well as our own strategies for the discovery of natural product modulators of estrogen biosynthesis and function. In particulars bioassay-guided fractionation of active plant extracts is a unique method for identifying agents with novel mechanisms of action, some of which should be useful for prevention of human cancer. Further, with the advent of combinatorial chemistry and high throughput screening, even greater progress may now be expected with natural product leads.

• Journal of Pharmaceutical Investigation
• /
• v.18 no.2
• /
• pp.69-81
• /
• 1988

We studied on the synthesis of chloromethylated polystyrene as a precursor of optically active polymers for direct resolution of optical isomers. Changing the degree of crosslinking and the kind of crosslinking agents, several polystyrene resin matrices were synthesized. The matrices were chloromethylated with methylal and chlorosulfonic acid as chloromethylating agents. The effects of solvents of various dielectric constants on the chloromethylation were quantitavely examined. We also synthesized chloromethylated polystyrene of macroreticular type that retained large surface area and good physical stability. The differences between the macroreticular type and macroporous type were investigated.

• The Journal of Pediatrics of Korean Medicine
• /
• v.22 no.3
• /
• pp.63-73
• /
• 2008

Objectives : The purpose of this study is to analyze the baby moisturizers and give information about basis of herbal moisturizer. Methods : We selected 243 goods by searching with keywords as "baby moisturizer" at 6 major web search engines, 12 web shopping malls in Korea. 10 items were evaluated under three evaluation criteria such as type of product, ingredient and function of goods. Results : Study resulted that the most type of moisturizers were lotion type. 80% of the products contained medical agents. Ingredients of medical agents were herbal medicine, aroma oil, vitamin and extract. The moisturizer for atopic dermatitis contained ceramide about half. The ingredient of herbal medicine existed usually as excipients, not as active ingredient. Conclusion : It is necessary to study and develop new products contained herbal medicine as active ingredient based on the oriental medical theory.

• Journal of Microbiology and Biotechnology
• /
• v.11 no.6
• /
• pp.1102-1105
• /
• 2001

In order to find therapeutic agents for porcine pneumonia, we screened far antibacterial activities of methanol extracts of 81 higher plants against four pathogenic microorganisms of Heamophilus parasuis, Pasteurella multocida, Actinobacillus pleuropneumonia, and Bordetella bronchiseptica, and found the bark of Cinnamomi cortex showed potent activities. Since this was inexpensive, we purified active compounds from it. The structures of the final active fractions were obtained through an activity-guided fractionation and their antibacterial activities are reported here.

• Proceedings of the Polymer Society of Korea Conference
• /
• 2006.10a
• /
• pp.354-354
• /
• 2006

Alginic acid-silica hydrogel films was prepared for testing as protective coating materials for PTFE OD membranes. Unprotected hydrophobic membranes are subject to wet-out when contacted by surface-active agents. Films were characterised using SEM, XRD, DSC, mechanical strength measurements, and water-swelling measurements. In OD trials using coated membranes, no wet-out occurred over the 15 h duration of three consecutive 5 h OD trials using orange oil-water mixtures. In the case of detergent solutions, the coating afforded protection to the membrane for 4-5 h. In a separate trial, no wet-out occurred when the coated side of the membrane was placed in contact with 1.2 wt % orange oil for 72 hours.

• Journal of the Korean Electrochemical Society
• /
• v.10 no.1
• /
• pp.43-47
• /
• 2007

Electrochemical rectification at electrode chemically modified with redox active agents isolated at monolayer level was considered. Formulation of the rising part of linear sweep voltammogram at steady and rotating disc electrode was introduced.

• Journal of Physiology & Pathology in Korean Medicine
• /
• v.19 no.2
• /
• pp.441-445
• /
• 2005

Tripterygium regelii has been used as an oriental medicine, especially antiparasitic, anti-inflammatory and detoxifying agents in East asia. During our research to develop new antitumor agents from natural products, MeOH ext. and CH2Cl2 ext. of Tripterygium regelii showed the potent antitumor activity. In order to purify active compounds from Tripterygium regelii, activity-guided fractionation was carried out. Silica gel and RP-18 column chromatography for the active fraction led to the isolation of two compounds and their antitumor activities were studied. Those two compounds didn't show potent antitumor activity against human tumor cell lines. The structure of two compounds were determined by $^1H-NMR$, $^{13}C-NMR$, DEPT, $^1H-^{13}C$ COSY and IR spectrum. Compound I and Compound II were turned out to be Celastrol, and ${\beta}-sitosteryl-3-o-{\beta}-D-glucopyranoside$ respectively.

• Bulletin of the Korean Chemical Society
• /
• v.22 no.11
• /
• pp.1243-1247
• /
• 2001

The water-soluble poly(aminoaryloxy-methylamino phosphazene) has been synthesized and investigated as a polymeric carrier species for the covalent attachment of biologically active agents. The cyclic trimeric model systems were utilized for the synthesis of polymeric analogues containing bioactive side groups. The sodium salt of 4-acetamidophenol was first allowed to react with (NPCl2)3 or (NPCl2)n and was then treated with excess methylamine to yield derivatives of type [NP(NHCH3)x(OArNHCOCH3)y]3 or [NP(NHCH3)x(OArNHCOCH3)y]n. The 4-acetamido groups were then hydrolyzed to 4-aminophenoxy units with potassium tert-butoxide. Coupling reactions between amino group and N-acetylglycine was accomplished with the use of dicyclohexylcarbodiimide. Their properties and structural characterization are discussed.