• 시큐리티연구
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• 제16호
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• pp.283-304
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• 2008

정보통신 기술의 발전은 시민들을 인터넷을 통로로 그들이 원하는 정보와 공공서비스를 요구할 수 있게 되었으며, 정부는 여론을 수렴할 수 있게 됨으로써 시민들이 정부정책의 참여에 중요한 수단이 되고 있다. 따라서, 이 연구에서는 누구나가 쉽게 차여할 수 있는 정보통신 기술을 이용하여 경찰행정에의 시민참여방법으로 PCRM활용 가능성을 제안하고자 한다. 활용방안으로 크게 거시적 측면과 미시적 측면으로 구분할 수 있다. 거시적인 측면으로 첫째, 서비스 접근성과 사용편의성에 대한 고려이다. 둘째, 서비스의 쌍방성이다. 궁극적인 시민참여의 수준은 적극적인 상호참여의 수준으로 가야한다. 미시적인 측면에서는 첫째, 고객분석 및 세분화 전략을 수행해야 한다. 둘째, 정책 서비스 개발 및 홍보전략을 강화해야 한다. 셋째, 고객관리 활동 부분을 강화한다. 넷째, 총체적 고객관리를 수행해야 한다.

• Journal of mucopolysaccharidosis and rare diseases
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• 제2권2호
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• pp.43-45
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• 2016

Whole body energy balance is achieved through the coordinated regulation of energy intake and energy expenditure in various tissues including liver, muscle and adipose tissues. A positive energy imbalance by excessive energy intake or insufficient energy expenditure results in obesity and related metabolic diseases. Although there have been many obesity treatment trials aimed at the reduction of energy intake, these strategies have achieved only limited success because of their associated adverse effects. Serotonin is among those traditional pharmacological targets for anti-obesity treatment because central 5-HT functions as an anorexigenic neurotransmitter in the brain. Thus, there have been many trials aimed at increasing the activity of 5-HT in the central nervous system, and some of the developed methods are already used in the clinical setting as anti-obesity drugs. However, recent studies suggest the new functions of peripheral serotonin in energy homeostasis ranging from the endocrine regulation by gut-derived serotonin to the autocrine/paracrine regulation by adipocyte-derived serotonin. Pharmacological inhibition of 5-HT synthesis leads to inhibition of lipogenesis in epididymal white adipose tissue (WAT), induction of browning in inguinal WAT and activation of adaptive thermogenesis in brown adipose tissue (BAT). Fat specific Tph1 knock-out (Tph1 FKO) mice exhibit similar phenotypes as mice with pharmacological inhibition of 5-HT synthesis, suggesting the localized effects of 5-HT in adipose tissues. In addition, Htr3a KO mice exhibit increased energy expenditure in BAT and Htr2a KO mice exhibit the decreased lipid accumulation in WAT. These data suggest the clinical significance of the peripheral serotonergic system as a new therapeutic target for anti-obesity treatment.

• 한국융합학회논문지
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• 제12권10호
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• pp.287-294
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• 2021

본 연구는 온라인과 오프라인을 넘나드는 미용산업의 옴니채널이 소비자 행동에 미치는 영향을 알아보기 위한 미용 마케팅 비즈니스 융합연구이다. 대상은 서울거주 20-30대 남녀의 자기응답식 설문지 299부로 SPSS21.0프로그램을 활용하여 빈도분석, 탐색적 요인분석과 상관관계분석 및 다중회귀분석을 사용하였다. 연구결과 옴니채널은 소비자행동과 상관관계를 보이며 옴니채널의 하위요인은 노출성, 혜택성, 후기성, 예약성, 편의성으로 나눌수 있었다. 노출도를 제외한 옴니채널의 모든 하위요인은 소비자 행동 중 고객만족에 정(+)의 영향을 미치며 모든 옴니채널의 하위요인은 소비자행동 중 재이용의도에 정(+)의 영향을 미치는 것으로 나타났다. 고객만족은 재이용의도에 정(+)의 영향을 미치는 것으로 나타나 미용산업 옴니채널의 적극적인 활용이 미용산업활성화에 긍정적 영향을 줄 수 있을것으로 예상되는 바 마케팅전략에 대한 연구와 미용산업맞춤 플랫폼에 대한 연구가 필요함을 시사한다.

• 한국과학예술포럼
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• 제37권3호
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• pp.113-123
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• 2019

본 연구는 영상콘텐츠 산업과 과학문화 산업의 지형 변화에서 시작되었다. 모바일 과학기술 영상 콘텐츠는 수요와 정책적 지원에 따라 성장 가능성이 예견된다. 본 연구의 목적은 과학기술 관련 모바일 영상콘텐츠 활성화를 위해 현황을 분석하여 기획 및 제작시의 시사점을 제시하는 것이다. 따라서 본 논문은 모바일 영상 중 영향력이 가장 큰 유튜브의 과학기술 채널의 영상을 사례로 하여 유형 및 스토리텔링 분석을 시도하는 융복합적 연구를 진행하였다. 연구결과 및 내용은 다음과 같다. 첫째, 과학기술 유튜브 채널 글로벌 선도그룹의 영상 콘텐츠는 과학기술의 맥락과 활동에 따라 활동형, 해설형, 비평형의 세 유형으로 범주화된다. 둘째, 언어의존성이 낮고 재매개 가능성이 높은 활동형 채널은 다시 라이프 해킹형, 소품 제작형, 파괴형, 탐구형으로 분류된다. 셋째, 활동형 채널들의 핵심 스토리텔링 전략은 일상적 소재를 전문과학기술적 방법을 통해 다루는 익숙함과 낯섦의 조화이다. 이러한 연구결과를 바탕으로 국제적 경쟁력을 가질 수 있는 킬러 콘텐츠 기획 및 제작을 기대한다.

• Molecules and Cells
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• 제42권4호
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• pp.292-300
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• 2019

Immunometabolism, defined as the interaction of metabolic pathways with the immune system, influences the pathogenesis of metabolic diseases. Metformin and carbon monoxide (CO) are two pharmacological agents known to ameliorate metabolic disorders. There are notable similarities and differences in the reported effects of metformin and CO on immunometabolism. Metformin, an anti-diabetes drug, has positive effects on metabolism and can exert anti-inflammatory and anti-cancer effects via adenosine monophosphate-activated protein kinase (AMPK)-dependent and AMPK-independent mechanisms. CO, an endogenous product of heme oxygenase-1 (HO-1), can exert anti-inflammatory and antioxidant effects at low concentration. CO can confer cytoprotection in metabolic disorders and cancer via selective activation of the protein kinase R-like endoplasmic reticulum (ER) kinase (PERK) pathway. Both metformin and CO can induce mitochondrial stress to produce a mild elevation of mitochondrial ROS (mtROS) by distinct mechanisms. Metformin inhibits complex I of the mitochondrial electron transport chain (ETC), while CO inhibits ETC complex IV. Both metformin and CO can differentially induce several protein factors, including fibroblast growth factor 21 (FGF21) and sestrin2 (SESN2), which maintain metabolic homeostasis; nuclear factor erythroid 2-related factor 2 (Nrf2), a master regulator of the antioxidant response; and REDD1, which exhibits an anticancer effect. However, metformin and CO regulate these effects via different pathways. Metformin stimulates p53- and AMPK-dependent pathways whereas CO can selectively trigger the PERK-dependent signaling pathway. Although further studies are needed to identify the mechanistic differences between metformin and CO, pharmacological application of these agents may represent useful strategies to ameliorate metabolic diseases associated with altered immunometabolism.

• 산업경영시스템학회지
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• 제42권3호
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• pp.131-141
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• 2019

Recently the business environment surrounding the financial investment industry is changing rapidly, and the demands of customers (diversity and the cycle of change etc.) are getting shorter. In this context, it can be said that companies are forced to adopt an agile management environment. In particular, non-face-to-face channels, including MTS, is adopting the agile system into the digital finance sector from a company-wide and strategic perspective. This study analyzed the effects of MTS services' environment quality on customer satisfaction and continuous intention to use for MTS users who are rapidly increasing under the agile management environment in the financial investment industry. This study surveyed the quality of service environment (accessibility, convenience, design, security), customer satisfaction, and continuous intention to use for 350 MTS users. First, accessibility, convenience, and security of MTS service environment quality had a positive effect on customer satisfaction, and design was rejected Second, customer satisfaction has a positive effect on continuous intention to use. Third, convenience and security of MTS service environment quality have positive effects on continuous intention to use, and accessibility and design were rejected. The results of this study, together with demographic analysis, are expected to provide useful implications for MTS activation studies and securities firms' strategies.

• 한국건축친환경설비학회 논문집
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• 제12권6호
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• pp.655-668
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• 2018

This paper analyzes the applicability and technology level of the green building element technology by analyzing the scorecard of the LEED Canada certified buildings. The results of this analysis will be able to evaluate the current status and level of application of green building element technology, and it will be used as a basic data to prepare for the revision of the certification standards and the establishment of strategies for the future green building activation. In this study, 1,010 LEED Canada certified buildings from 2011 to 2016 were analyzed. The results were analyzed by focusing on the status of greening by certification category and the characteristics of adoption by sub-category. The results of the study are summarized as follows. (1) EA category showed the biggest difference between the certification scores and the adoption rates than other categories, and it was confirmed that it is not easy category from the viewpoint of practical adoption. On the other hand, the ID (Innovation & Design Process) and WE were analyzed to be relatively easy to apply, with a score of over 72%. (2) In the case of Platinum class, the upper adoption rate is shown in all categories except MR. The Gold class shows the adoption rate of WE and ID in the top, and the middle rate in most categories. Silver grades showed lower rates in the three categories except WE, ID and EQ. Certified grades showed the adoption rates of the bottom except the two categories.

• 대한건축학회논문집:계획계
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• 제35권9호
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• pp.131-142
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• 2019

The purpose of this study was to find out the characteristics of housing policies and apartment designs by comparison of supplying and remodeling apartments between France and Korea. The literature review was used in Korea cases and the literature review, site investigation, and expert interviews were used in France cases. At first, by reviewing the related literatures about the apartment developments and regenerations in France and Korea, twelve remodeling cases were represented respectively in Ile de France and Seoul. As a result, in housing policy, the Korean housing market had a shortage of low-priced houses related to biased apartment developments by private sector dependence. Consequently, the living in Korea generally required the high price in low quality houses. But in France, the housing policies were very successful in housing quantity, quality, and expense. It is involved in balances between the public housing supply and the activation of a private housing market based on the government support policy. Nevertheless, in the success of the apartment as a house type, apartments in France means the social elimination because of the supply method problems and the management failures of HLM institutions. However, in Korea, the apartment implies the successful life of the middle class population because of the competitive evolutions during 40 years as a market housing. Secondly, In the characteristics of remodeling, the remodeling in Korea was for property value improvements. It mainly executed to expand the size of a house by expansion of living space. However the remodeling in France was for social mixes and connections with the surrounding area. It mostly performed by various design methods such as vertical merging houses, partial removal, reconstruction, and construction of a local community centers and mixed-use residential buildings. This study shows the simultaneously remodeling features of those two countries. These findings can be used in developing effective strategies for the public housing regenerations in Korea and other countries.

• BMB Reports
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• 제54권1호
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• pp.44-58
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• 2021

Natural killer (NK) cells, key antitumor effectors of the innate immune system, are endowed with the unique ability to spontaneously eliminate cells undergoing a neoplastic transformation. Given their broad reactivity against diverse types of cancer and close association with cancer prognosis, NK cells have gained considerable attention as a promising therapeutic target for cancer immunotherapy. NK cell-based therapies have demonstrated favorable clinical efficacies in several hematological malignancies but limited success in solid tumors, thus highlighting the need to develop new therapeutic strategies to restore and optimize anti-tumor activity while preventing tumor immune escape. The current therapeutic modalities yielding encouraging results in clinical trials include the blockade of immune checkpoint receptors to overcome the immune-evasion mechanism used by tumors and the incorporation of tumor-directed chimeric antigen receptors to enhance NK cell anti-tumor specificity and activity. These observations, together with recent advances in the understanding of NK cell activation within the tumor microenvironment, will facilitate the optimal design of NK cell-based therapy against a broad range of cancers and, more desirably, refractory cancers.

• 한국콘텐츠학회논문지
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• 제21권6호
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• pp.113-127
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• 2021

본 연구는 탈근대의 건축 공간을 고정되지 않고 지속적인 변화의 개념으로 보고, 변화하는 관계 네트워크로 건축 내 공간 요소를 이해하는 것을 목표로 한다. 연구의 목적은 관계성이라는 관점에서 렘 콜하스와 SANAA의 작품에 나타난 공간적 특성을 밝힘과 동시에 두 건축가의 공간구성 전략을 분석하는 것이다. 연구의 방법은 관계성의 대한 이론적 고찰을 통해 비고정적 관계성의 의미를 정의한 후 렘 콜하스와 SANAA의 건축적 접근방법에 대해 살펴보았다. 관계성을 공간의 프로그램, 환경, 사용자 그리고 가구와 집기로 구분하여 두 건축가의 작품 분석하였다. 결과적으로 두 건축가 모두 조직화에 의해 경직된 프로그램을 거부하고 가능성이 내재된 관계성을 건축공간 활성화 목적으로 활용하고 있다는 점에서는 유사하지만, 렘 콜하스는 사용자의 행위유발 기제의 전략을 사용하고 있는 반면, SANAA는 사용자의 자율적 행위를 담는 이완공간의 전략을 사용하고 있음을 확인할 수 있었다.