• Korean Journal of Applied Biomechanics
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• v.23 no.2
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• pp.149-157
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• 2013

In the present study, we aimed to elucidate how muscle strength and activity are affected by movement pattern(bilateral [BLM] & unilateral movement [ULM]) and movement velocity($0^{\circ}$/s, $60^{\circ}$/s, $120^{\circ}$/s) at maximum effort, and to elucidate the relationship between a left/right asymmetry and bilateral deficit. A total of 18 healthy males participated in the study. Each participant performed maximum knee extension bilaterally and unilaterally while the EMG and moment were recorded, and then the relationships between the asymmetry and bilateral deficit were analyzed. The peak moments for the isokinetic motion at $60^{\circ}$/s and $120^{\circ}$/s and overall muscle activities of lower extremity were significantly reduced for the BLM in comparison to the ULM. And though the asymmetry in ULM were maintained during BLM at all velocities, the bilateral deficits at the velocity of $0^{\circ}\acute{y}$/s and $120^{\circ}\acute{y}$/s were significantly correlated with increased asymmetries of muscle strength in ULM. In conclusion, the reduction in the muscle strength exhibited in bilateral knee extension was shown to arise partially from a reduction in muscle activity, and left/right asymmetry was found to be associated with mechanical reduction in bilateral movement. These findings suggest that training aimed at increasing muscle strength must involve methods and strategies intended to reduce left/right asymmetry.

• Proceedings of the Korean Society of Applied Pharmacology
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• 2001.04a
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• pp.103-112
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• 2001

Bone homeostasis is maintained by a balance between activities of osteoblasts(bone forming cells) and osteoclasts (bone resorbing cells). The activities of these cells are closely regulated by multiple factors including hormones and cytokines. The cessation of estrogen at menopause disrupts the balanced regulation and is the main cause of osteoporosis in postmenopausal women. Recent molecular biological studies led to a discovery of tumor necrosis factor(TNF) and TNF receptor families genes that play critical roles in the regulation of osteoclast formation and function. RANKL (receptor activator of nuclear factor kappa B ligand; also called ODF, TRANCE, and OPGL) expressed on cells supporting osteoclast is essential for osteoclast differentiation, activation, and survival. RANK, the counter-receptor for RANKL, is expressed on progenitor and mature osteoclasts. The interaction between RANKL and RANK is requlated by a soluble decoy receptor OPG (osteoprotegerin). Gene knock out studies of these molecules showed profound effects on bone. These results prompted development of new strategies for treatment of bone diseases. Inhibition of osteoclast activity by blocking the RANKL-RANK interaction using OPG is being attempted. Research on the signaling pathways of RANK is also actively carried out. Screening natural products that inhibit the RANKL-RANK interaction or the activity of obteoclasts would be another effective means to a new drug target for bone resorbing diseases.

• Journal of Korean Library and Information Science Society
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• v.50 no.3
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• pp.117-138
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• 2019

The purpose of this study is to analyse the characteristics and limitations of community information services and to explore an activation strategies. Included in this study are as follows: (1) investigate what is an appropriate representative term through the history of terminology related to community information services, (2) examine how community information services are operated in the regional central libraries from the librarian's perspective, (3) suggest the directions of community information services. The data were collected literature studies and interview with 20 librarians in regional central libraries.

• Journal of Microbiology and Biotechnology
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• v.29 no.4
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• pp.571-576
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• 2019

Microenvironmental stress, which is naturally observed in solid tumors, has been implicated in anticancer drug resistance. This tumor-specific stress causes the degradation of topoisomerase $II{\alpha}$, rendering cells resistant to topoisomerase $II{\alpha}$-targeted anticancer agents. In addition, microenvironmental stress can induce the overexpression of 78kDa glucose regulated protein (GRP78), which can subsequently block the activation of apoptosis induced by treatment with anticancer agents. Therefore, inhibition of topoisomerase $II{\alpha}$ degradation and reduction in GRP78 expression may be effective strategies for inhibiting anticancer drug resistance. In this study, we investigated the active compound arctigenin, which inhibited microenvironmental stress-induced etoposide resistance in HT-29 cells. Arctigenin was also highly toxic to etoposide-resistant HT-29 cells, with an $IC_{50}$ value of $10{\mu}M$ for colony formation. We further showed that arctigenin inhibited the degradation of topoisomerase $II{\alpha}$ and reduced the expression of GRP78. Thus, these results suggest that arctigenin is a novel therapeutic agent that inhibits resistance to etoposide associated with microenvironmental stress conditions.

• BMB Reports
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• v.52 no.2
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• pp.119-126
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• 2019

The tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) initiates the extrinsic apoptotic pathway through formation of the death-inducing signaling complex (DISC), followed by activation of effector caspases. TRAIL receptors are composed of death receptors (DR4 and DR5), decoy receptors (DcR1 and DcR2), and osteoprotegerin. Among them, only DRs activate apoptotic signaling by TRAIL. Since the levels of DR expressions are higher in cancer cells than in normal cells, TRAIL selectively activates apoptotic signaling pathway in cancer cells. However, multiple mechanisms, including down-regulation of DR expression and pro-apoptotic proteins, and up-regulation of anti-apoptotic proteins, make cancer cells TRAIL-resistant. Therefore, many researchers have investigated strategies to overcome TRAIL resistance. In this review, we focus on protein regulation in relation to extrinsic apoptotic signaling pathways via ubiquitination. The ubiquitin proteasome system (UPS) is an important process in control of protein degradation and stabilization, and regulates proliferation and apoptosis in cancer cells. The level of ubiquitination of proteins is determined by the balance of E3 ubiquitin ligases and deubiquitinases (DUBs), which determine protein stability. Regulation of the UPS may be an attractive target for enhancement of TRAIL-induced apoptosis. Our review provides insight to increasing sensitivity to TRAIL-mediated apoptosis through control of post-translational protein expression.

• Journal of Korean Society of Rural Planning
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• v.25 no.3
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• pp.89-102
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• 2019

This study was conducted to investigate priority recognition of experts and related facility operators in establishing policies for revitalizing agro-healing services. After reviewing related studies, 5 policy division and 19 detailed sector were drawn, including improving accessibility, improving promotion and information provision method, improved public relations and information provision, diversification of facility and program, financial support, and expansion of expert and specialized institutions. A questionnaire survey was conducted on agro-healing experts, agro-healing facility operators, social welfare experts, and social welfare facility operators. The AHP analysis indicated that agro-healing experts and facility operators had the highest priority in the division of expansion of expert and specialized institutions, while social welfare experts and facility operators had the highest priority in financial support. The IPA analysis was conducted to identify the priority of each policy sector. Respondents recognized above normal importance to policy divisions, but were relatively aware of the importance of improving accessibility, with overall satisfaction level appearing to be moderate. The results of this study are expected to provide useful information for establishing agro-healing policies and for establishing effective strategies.

• The Journal of Fisheries Business Administration
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• v.50 no.3
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• pp.59-71
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• 2019

In terms of coastal and marine tourism, Busan's Haeundae had the nation's representativeness, and is pushing for many kinds of related policies to revitalize the special tourism zone. Due to a drop in the number of beach users, it is inevitable for the Haeundae Special Tourist Zone to face active responses to new trends emerging in the global tourism market. Therefore, the purpose of this study is to present a tourism strategy for making the Suyeong River as a more competitive ourist resource along the zone. First, a language network analysis is conducted through interviews to understand the ideas of interest groups for the river cruise activation project. Second, the frame structure of stakeholders is used to analyze solutions by comparing the similarities and differences in recognition frames of interest groups. Third, we intend to analyze the detailed frame types of stakeholders and present new alternatives based on the structure of relationships between types.

• Journal of the Korean Society of Clothing and Textiles
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• v.42 no.6
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• pp.977-987
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• 2018

This study tests the effect of recommended product presentation on consumers' usage intentions of a website, mediated by mental simulation. Mental simulation refers to perceptual experience, a more automatic form of mental imagery, initiated by exposure to the representations of objects. This study expects that when compliments of clothes (coordination items) are vertically presented online, consumers are likely to feel as if they wear the outfits due to the activation of mental simulation. The survey was conducted on 147 women in an age group between 20 and 40 years in a panel of an online survey firm. Data are analyzed using exploratory factor analysis and bootstrapping analysis by SPSS 20.0. The results show that when compliments (vs. substitutes) of clothes are presented, participants perceive a greater mental simulation. When compliments of clothes are vertically presented (vs. horizontally presented), mental simulation is also highly driven. In addition, mental simulation mediates the effects of online product presentation on consumers' usage intentions of a website. The findings of this study contribute to marketing strategies of online retailers in terms of how product recommendation can be offered to consumers with more psychological benefits.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2014.10a
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• pp.203-204
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• 2014

Recently, to satisfy the customer's requirements for glasses such as rating of glasses or choosing, glasses industry is supporting various types and tools for making one's appearance good. In this research, we study the strategy for implementing a site for glasses to customizing a person not to distinguish whether the customer is older or younger etc. For the purpose of implementing a site for glasses, first, we suggest a differentiated methodology through analysis of glasses industry service and features of existential representative glasses sites. Through the activation of the marketing strategies, marketing in a glasses market is expected to be competitive.

• International conference on construction engineering and project management
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• 2009.05a
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• pp.1426-1432
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• 2009

Green growth is summarized as the national growth strategies to enhance the quality of life as a whole by converting not only the lifestyle but the economic and industrial structures into the low carbon and eco-friendly environments with the green growth industries with low carbon as the momentum for new growth, based on green technologies including renewable energy technologies, energy and resource efficient technologies, converging technologies related to technologies to reduce the environmental pollution. Roles of the construction industry along with other industries are very important in securing justifications for the cooperation between our government and industries for challenges to this green growth as well. The national effects of economy are very large from leading the construction industry to the green construction from the national level. Accordingly, this study suggested responsive plans for both government and companies for the activation of green construction by selecting 15 frontier green construction products and analyzing them by the type of strategy in Korea, as well as analyzing recent trends of overseas green construction.