• Proceedings of the Korean Operations and Management Science Society Conference
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• 2000.10a
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• pp.325-328
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• 2000

LG 경제연구원이 발표한 보고서에 의하면, 국내 인터넷 쇼핑몰 시장이 2003년에는 1조 7000억원 규모를 상회할 것으로 예측되고 있다. 그러나 급격한 성장세를 보이고 있는 인터넷 쇼핑 시장규모에 비해 아직까지도 소비자와 관련된 연구는 많이 부족한 실정이다. 특히, 인터넷 쇼핑과 관련된 자료를 보면 소비자들은 인터넷을 통한 제품구매 시 여전히 불안감을 가지고 있는 것으로 나타나고 있음에도 불구하고 인터넷쇼핑에서의 지각된 위험에 대한 연구는 간헐적으로 이루어지고 있을 뿐이며, 이들 연구 역시 인터넷 쇼핑에서의 지각된 위험과 그 유형을 규명하는 데에만 초점을 맞추고 있어 지각된 위험수준에 따라 소비자의 구매행동이 어떻게 달라지는지에 대해서는 논의가 제대로 이루어지지 않고 있다. 따라서 본 연구에서는 지각된 위험수준에 따른 소비자의 구매행동을 브랜드와 가격 의존도로 한정시켜 이들 요인들간의 상대적 중요성 지각을 살펴볼 것이다. 본 연구에서 다룰 연구문제를 정리하면 다음과 같다. 첫째, 인터넷 쇼핑몰에서 제품 구매시 제품유형과 인터넷 쇼핑몰의 명성 그리고 인터넷 쇼핑경험의 세 변수는 소비자의 지각된 위험에 각각 어떤 영향을 미치며, 탐색재와 경험재, 인터넷 쇼핑몰 명성의 정도 그리고 인터넷 쇼핑경험의 유무에 따라 어떤 차이점이 존재하는가\ulcorner 둘째, 소비자의 지각된 위험의 수준과 브랜드와 가격의 상대적 중요성 지각과는 어떤 관계가 있는가\ulcorner 셋째, 브랜드와 가격의 상대적 중요성 지각정도에 두 매개변수인 제품 정보량과 제품 친숙도가 어떤 역할을 하는가\ulcorner 등이다.bition of severity of convulsions, decrease of seizures threshold, decrease of audiogenic seizures in rats of different strains and normalization of cerebral blood flow (measured by hydrogen test) were demonstrated in rats after i.c.v., intraperitoneally and orally administration, respectively. The antiepileptical effects by the combination of compounds from ginseng; were compared with the iuluence of Rg1, Rb1, Rc and with the well known antiepileptical drugs such as carbamazepine, valproic acid. The base for the research is obtained by using the WAG/Rij strain (Luijtelaar, Coenen, Kuznetcova), an excellent genetic model for human generalized absence epilepsy. The improving action of gensinosides was effectively demonstrated on the model of electrical kindling of amygdala of WA

• The Korean Journal of Pain
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• v.18 no.2
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• pp.118-123
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• 2005

Background: A nerve ligation injury may produce a tactile allodynia. The effects of intrathecally delivered lamotrigine on allodynia induced due to fifth and sixth lumbar spinal nerves ligation in rats, using lumbar intrathecal catheters were examined. Methods: Sprague-Dawley rats (body weight 160-180 g) were prepared by tightly ligating the fifth and sixth left lumbar spinal nerves, with the implantation of a chronic intrathecal catheter for drug administration. Mechanical allodynia and allodynic threshold were measured using von Frey filaments and the updown method, respectively. After the baseline hind paw withdrawal thresholds had been obtained, lamotrigine (10, 30, 100 and $300{\mu}g$) was administered intrathecally. Thereafter, the dose-response curves and 50% effective dose ($ED_{50}$) were obtained. Motor dysfunction was assessed by observing the righting/stepping reflex responses and abnormal weight bearing. Results: Intrathecal administration of lamotrigine produced a dose-dependent antiallodynic action ($ED_{50}=61.7{\mu}g$). Mild motor weakness was observed with $300{\mu}g$ lamotrigine, but no severe motor impairment was found. Conclusions: It is suggested that intrathecal lamotrigine could produce moderate antagonism of mechanical allodynia at the spinal level in a rat neuropathic pain model with minimal motor weakness.

• Journal of Satellite, Information and Communications
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• v.11 no.3
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• pp.51-57
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• 2016

Many kinds of telemetry should be monitored to check the state of spacecraft and it leads the time consumption. However, it is very important to define the status of satellite in short time because the contact number and time of low earth orbit satellite is limited. Also, on-board fault management should be prepared for non-contact operation because of the sever space environment. In this paper, on-board and ground autonomous operation method for the safety enhancement is described. Immediate fault detection and response is possible in ground by explicit anomaly detection through satellite event and error information. Also, satellite operation assistant system is proposed for ground autonomy that collect event sequence in accordance with related telemetry and recommend or execute an appropriate action for abnormal state. Critical parameter monitoring method with checking rate, mode and threshold is developed for on-board autonomous fault management. If the value exceeds the limit, pre-defined command sequence is executed.

• Physical Therapy Korea
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• v.5 no.2
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• pp.15-22
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• 1998

Laser photobiostimulation (LPBS) is one of the recent additions to therapeutic procedures used in chronic pain management. Though widely used, a clear understanding of its mechanism of action was not disclosed. In addition, the energy density that produces maximal benefit has not yet been established. The purposes of this study were to determine the effects of LPBS on pain relief in rat and to determine treatment dosage. Eight, 8-week old female, Sprague-Dawley rats were employed. All subjects were assigned to one of four groups: a sham laser group, a 0.4 $J/cm^2$ laser group, a 2.0 $J/cm^2$ laser group, and a 6.0 $J/cm^2$ laser group. Ga-As laser (904 nm wavelength) of three different energy densities (0.4, 2.0, 6.0 $J/cm^2$) was applied on a tail acupuncture point and tail-flick latencies were measured five times pre-and post-treatment as following schedules: 30 minutes, 1 hour. 24 hours. 48 hours, and 7 days later. An increase in pain threshold was demonstrated following LPBS, employing rat tail-flick test. LPBS of 2.0 $J/cm^2$ produced hypoalgesia of rapid onset and short duration (1 hour, 24 hours) while the response to 6.0 $J/cm^2$ was delayed and lasted longer (48 hours, 7 days). LPBS of 0.4 $J/cm^2$ did not produce any hypoalgesia.

• Journal of Physiology & Pathology in Korean Medicine
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• v.32 no.1
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• pp.35-42
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• 2018

TRPA1 and TRPV1 are members of the TRP superfamily of structurally related, nonselective cation channels. TRPA1 and TRPV1 are often co-expressed in sensory neurons and play an important role in mechanical hyperalgesia and allodynia during neuropathic pain. Scutellariae Radix was reported to possess anti-inflammation properties and similar patterns of therapeutic action against different diseases. also Baicalin(a known principal constituent of Scutellaria Radix) was shown to down-regulate the mRNA expression levels of TRPV1. In this study, we observed the effects of Scutellariae Radix extract(SRE) in neuropathic pain induced SD rats via modulation of TRPV1 and TRPA1. Oral administration of a Scutellaria Radix extract(in doses of 300mg/kg, SRE(300)) showed a meaningful increase in the withdrawal threshold of mechanical allodynia and showed a meaningful decrease in the expression of c-fos compared to the control group. SRE(100) and SRE(300) showed a meaningful decrease in the expression of TRPV1 level compared to the control group. These results suggest that Scutellariae Radix extract could decrease mechanical allodynia by down-regulate the TRPV1 on the model of neuropathic pain.

• Natural Product Sciences
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• v.23 no.1
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• pp.40-45
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• 2017

Epilepsy is a brain disorder that affects millions of people worldwide. It is characterized by recurrent and unpredictable seizures that are usually controlled with antiepileptic/anticonvulsive drugs. However, most antiepileptic drugs produce various side effects such as tolerance and sedation. Thus, there is a growing interest for alternative anticonvulsive drugs, preferably from natural or herbal sources. In this study, we evaluated the anticonvulsive effects of Rehmannia glutinosa (RG). The anticonvulsive effect of RG extract was evaluated using electroshock- and chemical-induced seizure tests in mice. To identify its probable mechanism of action, the effects of RG extract on $Cl^-$ influx was measured in vitro. We found that RG extract has anticonvulsive effects against electroshock-induced seizures, as indicated by an increased seizure threshold in mice. The RG extract also decreased the percentage of seizure responses induced by the GABAergic antagonist, pentylenetetrazole. These results suggest that the anticonvulsive effects of RG extract are mediated through a GABAergic mechanism. In support of this mechanism, our in vitro test showed that RG extract increases intracellular $Cl^-$ influx. Furthermore, RG extract did not show sedative and/or muscle relaxant effects in the open-field and rota-rod tests. Altogether, these results confirm that RG extract could be a herbal anticonvulsant and a potential alternative for clinical use.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1998.11a
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• pp.178-178
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• 1998

We reported that the hexane fraction of Torilis Fructus have an anti-inflammatory and analgesic effect. Therefore, in order to isolate the active compound, the hexan fraction of Torilis Fructus was chromatographed on silica gel column. The subfraction of hexane fraction was crystallized as colorless stout needles. The chemical structure of this compound was verified to be torilin through m.p., UV, IR, GC-MS, and NMR spectral data. In pharmacological tests, torilin exhibited strong anticarrageenan activity at the dose of 90 and 270 mg/kg, p.o. in rats, and it had inhibitory effect on the vascular permeability at the dose of 30 and 90 mg/kg, p.o. in mice. Torilin showed potent inhibition of leucocyte emigration in CMC-pouch at the dose of 3 and 9 mg/rat, s.c. Torilin have the analgesic effect at the dose of 30, 90 and 270 mg/kg, p.o. in both of the acetic acid- and phenyl-p-benzoquinone-induced writhing syndrome. It also increased the pain threshold at the dose of 30, 90 and 270 mg/kg, p.o. in the tail pressure method and the Randall-Selitto method. Torilin did not show a hypothermic action at the dose of 30 and 90 mg/kg, p.o. in mice. The acute toxicity of torilin was very weak: the LD$\_$50/ value was more than 5000 mg/kg, p.o. and 2000 mg/kg, Lp. in mice. From the above mentioned results, it was suggested that torilin had potent anti-inflammatory and analgesic activities in animals.

• The Korean Journal of Physiology and Pharmacology
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• v.3 no.1
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• pp.35-45
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• 1999

Excitatory amino acid (EAA) and substance P (SP) have been known to be primary candidates for nociceptive neurotransmitter in the spinal cord, and calcium ions are implicated in processing of the sensory informations mediated by EAA and SP in the spinal cord. In this study, we examined how $Ca^{2+}$ modified the responses of dorsal horn neurons to single or combined iontophoretical application of EAA and SP in the rat. All the LT cells tested responded to kainate, whereas about 55% of low threshold (LT) cells responded to iontophoretically applied NMDA. NMDA and kainate excited almost all wide dynamic range (WDR) cells. These NMDA- and kainate-induced WDR cell responses were augmented by iontophoretically applied EGTA, but suppressed by $Ca^{2+},\;Mn^{2+},$ verapamil and ${\omega}-conotoxin$ EVTA, effect of verapamil being more prominent and well sustained. $Ca^{2+}$ and $Mn^{2+}$ antagonized the augmenting effect of EGTA. On the other hand, prolonged spinal application of EGTA suppressed the response of WDR cell to NMDA. SP had triple effects on the spontaneous activity as well as NMDA-induced responses of WDR cells: excitation, inhibition and no change. EGTA augmented, but $Ca^{2+},\;Mn^{2+}$ and verapamil suppressed the increase in the NMDA-induced responses and spontaneous activities of WDR cells following iontophoretical application of SP. These results suggest that in the spinal cord, sensory informations mediated by single or combined action of EAA and SP can be modified by the change in calcium ion concentration.

• Journal of the Institute of Electronics Engineers of Korea CI
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• v.48 no.5
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• pp.42-48
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• 2011

Agent acts for specification purpose, which is common element of CGF (Computer Generated Forces). When basic agent acts as planned, the advanced intelligence agent can do more than this. It can follow predefined actions along appointed script to achieve purpose or lay another plans when it is difficult to achieve. In other words, it can amend plan again or make new plan in order to achieve goals. When plan fails, agent amends oneself, possibly decreases target level to achieve easily. In doing so, the agent calculates a quantitative value for changing plans in realtime, and choose appropriate alternative plans when the threshold value reaches an limit. In this paper, we propose an military system in which the planned action can be modified according to the level of achievement and alternative plans can be generated accordingly.

• The Journal of Korea Institute of Information, Electronics, and Communication Technology
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• v.9 no.1
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• pp.75-81
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• 2016

The main characters play leading roles in novels. In the previous studies, they recognize the main characters in a novel mainly based on dictionaries that built beforehand. In English, names begin with upper cases and are used with some words. In this paper, we propose a recognition method for main characters name in Korean novels by using predicates, rules and weights. We first recognize candidates for the characters name by predicates and propose some rules to exclude candidates that cannot be characters. We assign importances for candidates, considering weights that given by the number of candidates appeared in a sentence. Finally, if the importance of the character is more than a threshold, we decide that the character is one of main characters. The results from the experiments for 300 novels show that an average accuracy is 85.97%. The main characters name may be used to grasp relationships among characters, character's action and tendency.