• Proceedings of the Korean Institute of Building Construction Conference
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• 2009.05b
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• pp.247-252
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• 2009

The LMC method of construction which have application to the road bridge is being considered the least relative importance about the watertight performance, because it focused on the durability of concrete. However, The LMC which is being expanded scope of application to the method of construction has grown importance about the watertight performance on the usability and maintenance side as well as durability. In this study, The latex concrete of two types which are different from mingled-ratio of the latex made a comparison to the compressive strength, watertight performance, dynamic wheel load resistance performance and confirmed what it has resistibility about chemical action through the chemical resistance test. The initial strength and watertight performance showed that were tendency the downward at 14 days. However, The long-term strength after 28 days showed that it has firm performance. In consequence, The initial curing of latex concrete is required to scrupulous care and attention at the site application. As a chemical resistance test result, The specimen that is steeped in sulphuric acid solution of 2% discovered the delamination phenomenon. However, it was confirmed that delamination phenomenon don't have an effect on the compressive strength. Moreover, As a dynamic wheel load resistance test result, The latex concrete was concluded to confirming the durability and running stability, because it had hardly any thickness reduction of latex concrete surface about dynamic wheel load and rarely found crack and delamination.

• Journal of the Korea institute for structural maintenance and inspection
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• v.14 no.2
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• pp.121-127
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• 2010

An experimental study of composite beam with perforated fiber reinforced polymer(FRP) plank as a permanent formwork and the tensile reinforcement was performed. A combined formwork and reinforcement system can facilitate rapid construction of concrete members since no conventional formwork is needed, which requires time consuming assembly and dismantling. In order for a smooth FRP plank to act compositely with the concrete, the surface of the FRP needs to be treated to increase its bond properties. Aggregates were bonded to the FRP plank using a commercially available epoxy and perforated web of plank. No additional flexural or shear reinforcement was provided in the beams. For comparison, two control specimens were tested. One control had no perforated hole in the web of FRP plank and the other had internal steel reinforcing bars instead of the FRP plank. The beams were loaded by central patch load to their ultimate capacity. This study demonstrates that the perforated FRP plank has the potential to serve as a permanent formwork and reinforcing for concrete beam.

• Journal of Dairy Science and Biotechnology
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• v.35 no.4
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• pp.270-285
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• 2017

Among milk proteins, caseins are not subjected to chemical changes during heat treatment of milk; however, whey proteins are partially denatured following heat treatment. The degree of whey protein denaturation by heat treatment is decreased in the order of high temperature short time (HTST) > low temperature long time (LTLT) > direct-ultra-high temperature (UHT) > indirect-UHT. As a result of heat treatment, several changes, including variations in milk nitrogen, interactions between beta-lactoglobulin and k-casein, variations in calcium sulfate and casein micelle size, and delay of milk coagulation by chymosin action, were observed. Lysine, an important essential amino acid found in milk, was partially inactivated during heat treatment. Therefore, the available amount of lysine decreased slightly (1~4% decrease) after heat treatment, However, the influence of heat treatment on the nutritional value of milk was negligible. Nutritional value and nitrogen balance did not differ significantly between UHT and LTLT in milk. In conclusion, our results showed that heat treatment of milk did not alter protein quality. Whey proteins denatured to a limited extent during the heat treatment process, and the nutritional value and protein quality were unaffected by heat treatment.

• The Korean Journal of Physiology and Pharmacology
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• v.4 no.1
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• pp.1-8
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• 2000

To investigate the contributions of intrinsic membrane properties to the spontaneous activity of medial vestibular nucleus (MVN) neurons, we assessed the effects of blocking large and small calcium-activated potassium channels by means of patch clamp recordings. Almost all the MVN neurons recorded in neonatal $(P13{\sim}P17)$ rat were shown to have either a single deep after-hyperpolarization (AHP; type A cells), or an early fast and a delayed slow AHP (type B cells). Among the recorded MVN cells, immature action potential shapes were found. Immature type A cell showed single uniform AHP and immature B cell showed a lack of the early fast AHP, and the delayed AHP was separated from the repolarization phase of the spike by a period of isopotentiality. Application of apamin and charybdotoxin (CTX), which selectively block the small and large calcium-activated potassium channels, respectively, resulted in significant changes in spontaneous firings. In both type A and type B cells, CTX (20 nM) resulted in a significant increase in spike frequency but did not induce bursting activity. By contrast, apamin (300 nM) selectively abolished the delayed slow AHP and induced bursting activity in type B cells. Apamin had no effect on the spike frequency of type A cells. These data suggest that there are differential roles of apamin and CTX sensitive potassium conductances in spontaneous firing patterns of MVN neurons, and these conductances are important in regulating the intrinsic rhythmicity and excitability.

• The Korean Journal of Physiology and Pharmacology
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• v.20 no.5
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• pp.539-545
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• 2016

Nafamostat mesilate (NM), a synthetic serine protease inhibitor, has anticoagulant and anti-inflammatory properties. The intracellular mediator and external anti-inflammatory external signal in the vascular wall have been reported to protect endothelial cells, in part due to nitric oxide (NO) production. This study was designed to examine whether NM exhibit endothelium dependent vascular relaxation through Akt/endothelial nitric oxide synthase (eNOS) activation and generation of NO. NM enhanced Akt/eNOS phosphorylation and NO production in a dose- and time-dependent manner in human umbilical vein endothelial cells (HUVECs) and aorta tissues obtained from rats treated with various concentrations of NM. NM concomitantly decreased arginase activity, which could increase the available arginine substrate for NO production. Moreover, we investigated whether NM increased NO bioavailability and decreased aortic relaxation response to an eNOS inhibitor in the aorta. These results suggest that NM increases NO generation via the Akt/eNOS signaling pathway, leading to endothelium-dependent vascular relaxation. Therefore, the vasorelaxing action of NM may contribute to the regulation of cardiovascular function.

• Korean Journal of Microbiology
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• v.25 no.4
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• pp.293-303
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• 1987

A $C_{1}$ enriched cellulase fraction was separated from culture filtrate of anaerobic Clostridium thermocellum by hydroxyapatite column chromatography. The separated fraction showed strong synergistic action with $C_{x}$ component (endo-$\beta$-1, 4-glucanase) in digestion of crystalline cellulose, similar to the other aerobic cellulolytic microorganisms. Unlike the $C_{x}$ component the $C_{1}$ enriched fraction was rapidly inactivated by oxidation at the atmospheric condition. The enzyme activity was significantly enhanced by the addition of reducing agents, especially $\beta$-mercaptoethanol, which indicates that a $C_{1}$ component has a lot of sulfhydryl groups essential for the enzyme activity. The effect of metal ions on $C_{1}$ activity was also investigated. The $C_{1}$ fraction was found to be thermally stable compare to endo-$\beta$-1,4-glucanase. Optimal temperature and pH were found to be $60^{\circ}C$ and 6.0, respectively.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.43 no.1
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• pp.62-70
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• 2007

Marine casualties of vessel are serious problems on social and national aspects, because it results in sacrifice of lives, a great lose of properties and marine pollution. According to recent statistics of marine casualties of vessel, fishing boats are more likely to be ended in the casualty, and especially, small fishing boats cause much more accidents than any other big vessels. Most of marine casualties were caused by the human factors such as poor watch keeping, inadequate manoeuvering and negligent action for engine, etc. This study is intended to provide navigator of small fishing boat with a specific information of necessary to assist both the manoeuvering and the avoidance of capsizing. The manoeuvering characteristics of ship can be adequately judged by the results of typical ship trials manoeuvres. For this purpose, the author measured the roll responses of a small fishing boat in waves using the real sea experimental measuring system, and analyzed the experimental data by the statistical and spectral analyzing methods to get the characteristics of the roll motion responses of the small boat through the wave directions and the ship's speed.

• Proceedings of the Korea Institute of Fire Science and Engineering Conference
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• 1997.11a
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• pp.130-137
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• 1997

Intumescent inorganic and organic coatings which dintr one from the other by the type of gas formers and the mechanisms of foam formation have been obtained and investigated. Inorganic intumescent coatings are the compositions based on water glass and mineral additives with different dispersity. Mineral additives contain adsorbed and absorbed water and carbonates which are destructed with the carbon dioxide and water evolution during the flame action on coating. The decreasing of mineral additives particle sizes under the mechanical milling with the fraction precipitation promotes the foam coke formation with less defects. Here the main structure of comparing compositions does not change. In organic coatings based on epoxy-polymers the polyammonium phosphate additive is used. It is the cabonization catalyst and the foam agent. The polyammonium phosphate of various dispersity employed is uniformly distributed on the polymeric matrix. The decreasing of the particle sizes leads to the increasing of the fire resistant properties of the intumescent coa-ting. The fire resistant analysis of the coating during more than an hour: the coating back side the temperature on plastic or wooden materials does not exceed 423K, and on metal-573K.

• Archives of Pharmacal Research
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• v.29 no.7
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• pp.570-576
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• 2006

Phytoestrogen biochanin A is an isoflavone derivative isolated from red clover Trifolium pratense with anticarcinogenic properties. This study examined the action of biochanin A with the carcinogen activation pathway that is mediated by the aryl hydrocarbon receptor (AhR) in MCF-7 breast carcinoma cells. Treating the cells with biochanin A alone caused the accumulation of CYP1A1 mRNA and an increase in CYP1A1-specific 7-ethoxyresorufin O-deethylase (EROD) activity in a dose dependent manner. A concomitant treatment with 7,12-dimethylbenz[a]anthracene (DMBA) and biochanin A markedly reduced the DMBA-inducible EROD activity and CYP1A1 mRNA level. In addition, the biochanin A treatment alone activated the DNA-binding capacity of the AhR for the dioxin-response element (DRE) of CYP1A1, as measured by the electrophoretic-mobility shift assay (EMSA). EMSA revealed that biochanin A reduced the level of the DMBA-inducible AhR-DRE binding complex. Furthermore, biochanin A competed with the prototypical AhR ligand, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), for binding to the AhR in an isolated rat cytosol. The biochanin A competitively inhibited the metabolic activation of DMBA, as measured by the formation of the DMBA-DNA adducts. These results suggest that biochanin A may thus be a natural ligand to bind on AhR. Therefore, biochanin A may be due to act an antagonist/agonist of the AhR pathway.

• Economic and Environmental Geology
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• v.52 no.5
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• pp.471-484
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• 2019

Liquefaction occurs by a temporal loss of sediment strength as a consequence of increased pore water pressure during the re-arrangement of unconsolidated, granular sediments. Liquefaction is dependent on the physical properties of the sediments and cause surface cracks, landslide, and the formation of soft-sediment deformation structures(SSDS). SSDS is formed by the combined action of the driving force and deformation mechanism(liquefaction, thixotropy, and fluidization) that is triggered by endogenic or exogenic triggers. So research on the SSDS can unravel syndepositional geological events. If detailed sedimentologic analysis together with surrounding geological context suggest SSDS formed by earthquakes, the SSDS provide a clue to unravel syndepositional tectonic activities and detailed paleoseismological information(> Mw 5) including earthquakes that leave no surface expression.