• Journal of the Korean Statistical Society
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• v.4 no.2
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• pp.139-151
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• 1975

Individual effect of genes controlling quantitative traits can not ordinarily be distinguised from one another. Consequently, it is not possible to determine the mode of inheritance for single genes. By studying their combined effectsin segregating generations, however, one can gain some insight into their behavior and can make statistical inferences about their average gene action. The investigation reported herein was to extend genetic variance components and variance and covariance analyses, special attention was given to the genetic statistics from which least square estimators of genetic parameters are obtained.

• Journal of Plant Biology
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• v.18 no.4
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• pp.155-160
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• 1975

Growth responses of lettuce seeds germinated in aqueous solutions of $SO_2$ were investigated for mode of action studies of this gas. The concentration and pH of $SO_2$ solution greatly affected the growth of germinating seeds. Root growth was more sensitive to $SO_2$ than hypocotyl growth. The sensitivity of total seedling growth lay between root and hypocotyl growth. Growth inhibition of germinating seeds appeared more serioius when $SO_2$ was added during the early stage of germination.

• Archives of Pharmacal Research
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• v.27 no.6
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• pp.624-627
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• 2004

A bile acid derivative, methyl chalate （1）, was isolated from EtOAc extract of the fungus Rhizopus oryzae as a cholesterol biosynthesis inhibitor. It showed moderate inhibitory activity on cholesterol biosynthesis in human Chang liver cells. Compound 1 exhibited inhibitory effect on the later step of cholesterol biosynthesis, indicating that its action mode is different from that of statins that act on the HMG-CoA reductase.

• Toxicological Research
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• v.7 no.2
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• pp.231-238
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• 1991

The pesticide and carcinogen ethylene dibromide(EDB) is metabolized both by cytosolic GSH S-transferase and by microsomal mixed function oxygenase. Cytochrome P-450 IIE1 appears to be major enzyme to metabolize EDB.EDB is activated to a mutagen by enzymatic conjugation with glutathione (GSH). Such activation is an exception to the general mode of detoxification via GSH S-transferase action. The primary DNA adduct (>95) is S-[2-(N7-guanyl)ethyl] GSH and a minor adduct is S-[2-(N7-guanyl)ethyl]cysteine, which is excreted in the urine and may serve as a biomarker of damage.

• Proceedings of the PSK Conference
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• 2003.04a
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• pp.213.1-213.1
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• 2003

Alpha-viniferin was isolated from Carex humilis (Cyperaceae), and showed anti-inflammatory effects on carrageenin or histamine-induced paw edema in mice. To understand mode of the anti-inflammatory action. effects of alpha-viniferin on cyclooxygenase (COX)-2, iNOS, oxygen radicals and proinflammatory cytokines have been analyzed. Alpha-viniferin showed selective inhibitory effect with an IC50 value of 5 $\mu\textrm{m}$ on COX-2 activity but showed weak inhibitory effect on the synthesis of COX-2 transcript which was identified by RT-PCR. (omitted)

• Molecular & Cellular Toxicology
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• v.3 no.2
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• pp.90-97
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• 2007

8-Hydroxyquinoline is used as antibacterial agent and antioxidant based on its function inducing the chelation of ferrous ion present in host resulting in production of chelated complex. This complex being transported to cell membrane of bacteria and fungi exerts antibacterial and antifungal action. In this study, we have carried out in vitro genetic toxicity tests and microarray analysis to understand the underlying mechanisms and the mode of action of toxicity of 8-hydroxyquinoline. TA1535 and TA98 cells were treated with 8-hydroxyquinoline to test its toxicity by basic genetic toxicity test, Ames and two new in vitro micronucleus and COMET assays were applied using CHO cells and L5178Y cells, respectively. In addition, microarray analysis of differentially expressed genes in L5178Y cells in response to 8-hydroxyquinoline were analyzed using Affymatrix genechip. The result of Ames test was that 8-hydroxyquinoline treatment increased the mutations in base substitution strain TA1535 and likewise, 8-hydroxyquinoline also increased mutations in frame shift TA98. 8-Hydroxyquinoline increased micronuclei in CHO cells and DNA damage in L5178Y. 8-Hdroxyquinoline resulted in positive response in all three tests showing its ability to induce not only mutation but also DNA damage. 783 Genes were initially selected as differentially expressed genes in response to 8-hydroxyquinoline by microarray analysis and 34 genes among them were over 4 times of log fold changed. These 34 genes could be candidate biomarkers of genetic toxic action of 8-hydroxyquinoline related to induction of mutation and/or induction of micronuclei and DNA damage. Further confirmation of these candidate markers related to their biological function will be useful to understand the detailed mode of action of 8-hydroxyquinoline.

• 한국신재생에너지학회:학술대회논문집
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• 2005.06a
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• pp.529-533
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• 2005

A railway catenary system which supplies a train with electric power is an important system in determining the maximum speed of an electric train. However, a pantograph could be separated from a contact wire because of reciprocal action between a pantograph with constant upward force and a catenary system. The contact loss of a pantograph-catenary system is mainly affected by the dynamic characteristics of damping and wave propagation velocity of contact wire. For increasing speed of an electrical train, it is necessary to establish the techniques to identify the modal parameter of a catenary system through experiment. However, it is difficult to decouple each mode and to extract respect ive damping rat io since a catenary system has an extremely high modal density. For this reason, mode decoupling process to identify modal parameters is a principal technique in analyzing a catenary system. In this paper, the damping extract ion method for a catenary system using the continuous wavelet transform is discussed.

• Structural Engineering and Mechanics
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• v.64 no.6
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• pp.803-817
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• 2017

Structural health monitoring has increasingly been a focus within the civil engineering research community over the last few decades. With increasing application of sensor networks in large structures and infrastructure systems, effective use and development of robust algorithms to analyze large volumes of data and to extract the desired features has become a challenging problem. In this paper, we grasp some precautions and key points of the signal processing approach, wavelet, establish a relative reliable framework, and analyze three problems that require attention when applying wavelet based damage detection approach. The cases studies how to use optimal scales for extracting mode shapes and modal curvatures in a reinforced concrete beam and how to effectively identify damages using maximum curves of wavelet coefficient differences. Moreover, how to make a recognition based on the wavelet multi-resolution analysis, wavelet packet energy, and fuzzy sets is a meaningful topic that has been addressed in this work. The relative systematic work that compasses algorithms, structures and evaluation paves a way to a framework regarding effective structural health monitoring, orientation, decision and action.

• Proceedings of the KIEE Conference
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• 2000.11d
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• pp.689-693
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• 2000

In this paper, we proposed a decoupled adaptive fuzzy sliding-mode control scheme in designing the SMC of a class of fourth-order nonlinear systems. These systems are decoupled the whole system into two second-order systems such that each subsystem has a separate control target expressed in terms of a sliding surface. Then, information from the secondary target conditions the main target, which, in turn, generates a control action to make both subsystem move toward their sliding surface. respectively, and Two sets of fuzzy rule bases are utilized to represent the equivalent control input with unknown system functions of the main target, The membership functions of the THEN-part. which is used to construct a suitable equivalent control of SMC. are changed according to adaptive law, Under this design scheme, we not only maintain the distribution of membership functions over state space but also reduce considerably computing time, we apply the decoupled adaptive sliding-mode control to control a nonlinear inverted pendulum system and confirms the validity of the proposed approach.

• Bulletin of the Society of Naval Architects of Korea
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• v.20 no.1
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• pp.21-27
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• 1983

The mode superposition method(MSM) for the forced transverse vibration analysis of structures subject to Timoshenko beam analogy, which had originally been developed by Ormondroyd and McGoldrick, is reviewed to formulate it in more general form taking account of rotary inertia, dampings in separate terms of internal and external ones, and simultaneous action of exciting forces and moments. To investigate some general features of the method in practical utilizations, resonant maximum amplitudes of 4 high speed ships under concentrated sinusoidal excitation at the stern are calculated by both MSM and the finite difference method(FDM). For the FDM the hulls are discretized into 40 equal segments, and in utilization of MSM contributions of the first six modes are summed up to obtain responses up to the six-nodes resonant mode. The numerical results show that MSM gives slightly higher values, $4{\sim}10%$, than those by FDM. Since there is always uncertainty in the damping estimation of actual systems, influences of the damping magnitude on resonant amplitudes and a practical method to estimate modal damping coefficients are discussed.