• 대한임상독성학회지
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• 제6권1호
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• pp.52-56
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• 2008

Amitraz is used as farm-animal insecticide. Its side effects in humans are related to its pharmacological activity on alpha 2-adrenergic receptors. The case describes a previously healthy 46-year-old woman who intentionally ingested approximately 250mL of liquid amitraz. She presented with vomiting, altered mental status, miosis, dry mouth, hypopnea, metabolic and respiratory acidosis, hypotension, hypothermia, polyuria, metabolic acidosis, elevated serum aminotransferase and abdominal distension. Supportive treatments including mechanical ventilation, hydration, dopamine infusion, bicarbonate infusion and gastric decompression resulted in improvement. By hospital day 3, she recovered with resolution of abdominal distension. It is paramount to recognize amitraz poisoning when a pesticide-intoxicated patient presets with signs and symptoms consistent with organophosphate intoxicated patients but with greater alpha 2-adrenergic related symptoms such as decreased bowel motility and xerostomia.

• 대한의생명과학회지
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• 제21권4호
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• pp.241-247
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• 2015

Lactate and ketone bodies are considered biological markers for ketosis and several inherited metabolic disorders. In the current study, the specific ratios of lactate and ketone bodies as analytical tools for differential diagnosis of various lactic acidosis were devised. The study included a protein precipitation step following tert-butyldimethylsilyl derivatisation. Total run time was approximately 30 min including sample preparation and GS/MS analysis. The limits of detection were below 0.1 pg/mL over the targeted 4 analytes. The calibration curve was linear over the concentration range of $0.001{\sim}250{\mu}g/mL$ for pyruvate, beta-hydroxybutyrate, and acetoacetate ($R^2$ > 0.99). Inter-day accuracy and precision were 87.7~94.8% with RSD of 2.5~5.7% at 2 levels. Absolute recoveries (%) of target analytes were 87.0~98.4%. The method was validated for the quantification of lactate and ketone bodies for differentiation of lactic acidosis.

• Investigative Magnetic Resonance Imaging
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• 제21권1호
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• pp.61-64
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• 2017

A characteristic imaging finding in cases of methanol intoxication is putaminal necrosis, but its presence is usually not suspected due to its rarity. Methanol intoxication generally produces serious neurological symptoms that include visual disturbances and diminished consciousness, characteristically with metabolic acidosis. We reported the case of a 59-year-old man who was admitted to the hospital with diminished consciousness. Acute methanol intoxication was determined as the cause. Laboratory tests revealed high anion gap metabolic acidosis. Diffusion-weighted MRI indicated diffuse symmetric diffusion restriction lesions in the subcortical white matter of both cerebral hemispheres.

• Journal of Veterinary Science
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• 제22권3호
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• pp.34.1-34.7
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• 2021

Anti-lipopolysaccharide (LPS) antibody administration has the potential benefits of neutralizing and consequently controlling rumen-derived LPS during subacute ruminal acidosis. Four Holstein bulls were used in this crossover study with a 2-week wash-out period. Anti-LPS antibody (0 or 4 g) was administered once daily for 14 days. Significantly lower ruminal LPS and higher 1-h mean ruminal pH were identified in the 4 g group. However, blood metabolites, acute-phase proteins, cytokines, and hepatic transcriptomes were not different between the two groups. Therefore, anti-LPS antibody administration mitigated ruminal LPS release and pH depression without accompanying responses in acute-phase inflammation or hepatic transcriptomic expression.

• Asian-Australasian Journal of Animal Sciences
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• 제2권3호
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• pp.346-348
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• 1989

• 대한자기공명의과학회:학술대회논문집
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• 대한자기공명의과학회 2000년도 제5차 추계학술대회
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• pp.59-59
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• 2000

• 대한약리학회:학술대회논문집
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• 대한약리학회 2006년도 The 6th Congress of the Federation of Asian and Oceanian Physiological Societies
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• pp.120.2-120.2
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• 2006

• Clinical and Experimental Pediatrics
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• 제46권8호
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• pp.826-830
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• 2003

본 저자들은 출생 후 늘어지며 경구 수유를 잘 하지 못하는 증상으로 본원에서 ARCI 증후군 진단을 받고 경구용 bicarbonate, 1,25-dihydroxycholecalciferol, 비 경구 수유와 폐렴 치료를 받았으나 사망한 1례를 경험하여 이를 보고하는 바이다. 다발성 관절 구축, 신세뇨관성 산증, 담즙 정체성 간염은 ARCI 증후군의 기본적인 임상 증상이기는 하나 이들이 모두 혹은 동시에 나타나는 것은 아니므로 신생아 시기에 늘어지며 관절구축을 보이고 산증이 있는 경우 주의 깊은 추적 관찰을 통해 진단을 내리도록 해야할 것이다. 또한 이들은 성장 부진과 잦은 감염에 시달리게 되므로 일찍부터 비관 삽입 등을 통한 영양이나 감염의 증후를 잘 관찰함으로써 적절한 성장을 할 수 있도록 도와야겠다.

• 대한골관절종양학회지
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• 제13권1호
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• pp.43-47
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• 2007

Sj$\"{o}$gren 증후군은 외분비샘에 임파구 침윤으로 발생한 안구와 구강 건조를 특징적인 증세로 하는 만성적이며 서서히 진행하는 자가면역질환이나 저자들은 건조성 증세 없이 전신적 증세만을 호소하였으며 방사선 검사상 다발성 근골격계 전이로 오인되었으나 신세뇨관 산증을 동반한 일차성 Sj$\"{o}$gren 증후군으로 확진되었던 증례를 경험하였기에 보고하고자 한다.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제23권4호
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• pp.377-387
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• 2020

Purpose: To compare between sodium acetate (SA) and sodium chloride (SC) in parenteral nutrition (PN) with associated metabolic acidosis and neonatal morbidities in preterm infants. Methods: Preterm infants below 33 weeks gestational age, and with a birth weight under 1,301 g were enrolled and further stratified into two groups: i) <1,000 g, or ii) ≥1,000 g in birth weight. The subjects were randomized to receive PN containing SA or SC within the first day of life. The results of routine blood investigations for the first 6 days of PN were collated, and the neonatal outcomes were recorded upon discharge or demise. Results: Fifty-two infants entered the study, with 26 in each group: 29 infants had extremely low birth weight (ELBW). There were no significant differences in birth weight, gestation, sex, exposure to chorioamnionitis and antenatal steroids, surfactant doses and duration of mechanical ventilation between groups. The SA group had significantly higher mean pH and base excess (BE) from days 4 to 6 than the SC (mean pH, 7.36 vs. 7.34; mean BE -1.6 vs. -3.5 [p<0.01]), with a two-fold increase in the mean BE among ELBW infants. Significantly fewer on SA required additional bicarbonate (n=4 vs. 13, p=0.01). The rate of bronchopulmonary dysplasia (BPD) was approximately four-fold lower in SA than SC (n=3 vs. 11, p<0.01). No significant differences were observed in necrotizing enterocolitis, patent ductus arteriosus, retinopathy of prematurity, cholestatic jaundice, and mortality between groups. Conclusion: The use of SA in PN was associated with reduced metabolic acidosis and fewer BPD.