• Journal of Pharmaceutical Investigation
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• 제2권1호
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• pp.5-13
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• 1972

There are some repels in which they studied on the change of acid-consuming capacity of aluminium hydroxide resulted from the passing of time. However, the relationship between grain sizes(particle sizes) and the acid-consuming capacity of dried aluminium hydroxide gel was not been studied. And studies on the grain sizes of aluminium hydroxide gel qualified by pharmacopoeia of Korea has not been reported. For the purpose of studying these two problems, the author prepared two-kinds of aluminium hydroxide gel as follows : $Na_2OAl_2O_3+CO_2------{\longrightarrow}Al(OH)_3{\cdots}{\cdots}{\cdots}$sample 1 $Al_2(SO_4)_318H_2O+6NaHCO_3{\longrightarrow}Al(OH)_3{\cdots}{\cdots}{\cdots}$sample 2 Both of sample 1 and 2 are found to be amorphous by X-ray diffraction methods, and their acid-consuming capacities were determined by the method of pharmacopeia of Korea. The grain size was measured by X-ray diffraction method, the particle sizes observed by electron microscopy, and the change of acid-consuming capacity with passing of time was determined by the method of pharmacopoeia of Korea. The results of these studies are summerized as follows: 1. The grain size was linearly enlarged as the time goes by. The aluminium hydroxide gel gradually crystallized in a certain period of time. 2. The acid-consuming capacity was in exponential function, decreased as the grain size of them enlarged. 3. One particle consists of tens of grains.4. Grinding the Sample obtained in any period of testing time in mortar did not change both their grain size and their acid-consuming capacity. 5. The grain size of dried aluminium hydroxide gel ought to be micronized less than $100{\AA}$ for maintaining the ability such as consumes 250m1 of 0. 1N-HC1 solution per Is of $Al(OH)_3$ described in pharmacopoeia of Korea.

• 약학회지
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• 제8권2호
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• pp.37-44
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• 1964

The relationships involving acid-consuming capacity and X-ray powder diffraction patterns of aluminum hydroxide gel were studied. The aging of antacid efficacy of aluminum hydroxide gel has also been characterized by using X-ray powder diffraction. The acid-consuming capacity decreased with progress of crystallization from amorphous alumino gel, and it was found that aged product at 80.deg. C had crystal structure of bohmite (.alpha.-Al.sub 2/O$_{2}$(OH)$_{2}$). It was also noted that the rate of aging decreased with decreasing pH of aluminum hydroxide gel.

• 약학회지
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• 제33권2호
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• pp.111-117
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• 1989

The optimum reaction conditions for the acid consuming capacity of aluminum silicate synthesized from the reaction of sodium silicate solution and potassium aluminum sulfate solution were investigated by Box-Wilson experimental design, and the micromeritic properties were examined by the means of BET $N_2$ adsorption, Hg penetrometer and methylen blue adsorption. The chemical composition of the samples were analyzed by gravitic method. The results were found to be as follows: optimum reaction temperature $54.7^{\circ}C$, both concentrations of reactant soln 15.7%, reactants molar ratio (Al/Si) 0.5 and drying temperature $65.0^{\circ}C$. The acid consuming capacity of the sample prepared by above optimum conditions was 68 ml and the chemical composition was $Al_2O_3{\cdot}3.6SiO_2{\cdot}3H_2O$. The relationship between acid consuming capacity and micromeritic properties could not found in the range of experiments. Therefore, it is assumed that the acid consuming mechanism of aluminum silicate depends on the neutralization of $Al_2O_3$ and buffer action of $SiO_2$ in sample.

• Journal of Pharmaceutical Investigation
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• 제15권2호
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• pp.83-90
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• 1985

The effects and the optimum manufacturing conditions for the preparation of synthetic aluminum silicate which has acid-consuming power and adsorbing capacity were investigated. The results are as follows: 1. The adsorbing capacity was affected by the mixing order of the reactants, that is, the excellent ones were obtained by the method which add the sodium silicate solution to the potassium alum solution. 2. Even though preparing by the bane manufacturing condition, the acid-consuming power is superior to the adsorbing capacity. 3. According to the Box-Wilson Plan, the optimum reaction conditions are concentration of sodium silicate solution; 38% w/w, settling time; 43 hours at room temperature, drying time; 13 hours at $110^{\circ}C$.

• 약학회지
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• 제44권6호
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• pp.545-551
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• 2000

Magnesium trisilicate was prepared by reacting Magnesium sulfate solution with Sodium silicate solution in this study. The optimum synthesis conditions base on the yield of the product were established by applying Box-Wilson experimental design. It was found that the optimum synthesis conditions of Magnesium trisilicate were as follows; Reacting temperature : $57{\sim}90^{\circ}C$, Concentration of reactant solution : $19.1{\sim}20.0%$, Molar concentration ratio of two reactants : [Sod.silicate]/[Mg.sulfate] : $1.47{\sim}1.80$, Temperature of washing water : $45{\sim}48^{\circ}C$, Drying temperature : $65{\sim}82^{\circ}C$. The antacidic capacity of the five Magnesium trisilicate samples which shows the maximum antacidic efficacy was tested by pharmacopeia acid consuming capacity test. The five Magnesium trisilicate samples were identified by chemical analysis.

• Journal of Pharmaceutical Investigation
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• 제9권4호
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• pp.23-28
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• 1979

The effect of maltitol admininstration to rat was studied on breakdown of ${\alpha}-glycoside$ linkage with intestinal mucosa or pancreatic enzymes and induction of hepatic polyol dehydrogenase activities. Maltitol was contained as 13% or 26% in diet, and was administrated to rat for 9 weeks. This report carried out that ${\alpha}-glycoside$ linkage of maltitol was not hydrolyzed with pancreatic enzymes and intestinal mucosa. Maltitol dehydrogenase was not obeserved in liver cytoplasm, and hepbtic sorbitol dehydrogenase was not induced by maltitol administsation. Also, the effect of maltitol on aging of aluminum hydroxide gel, prepared by the reaction of aluminum chloride solution with strong ammonia solution to final pH 7.0, was studied by potentiometric titration, pH and acid-consuming capacity. Gel containing 1% or 2% maltitol was lost less than 2% of their acid-consuming capacity during a 120 days aging period compared with a loss of more than for an identical gel without maltitol and gel containing 0.5% maltitol.

• Journal of Pharmaceutical Investigation
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• 제6권2호
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• pp.95-100
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• 1976

A study on the effect of the pH of precipitation on the acid consuming capacity, aging stability, physical and chemical properties of hydrous aluminum oxide prepared by the reaction of aluminum chloride and ammonium hydroxide solution was carried out by means of X-ray diffraction, IR spectra and differential thermal analysis. The results from these experiments are as follows: 1. Hydrous aluminum oxide precipitated at lower pH showed better acid consuming capacity, higher stability and more anion contained in the structure than that prepared at higher pH. 2. The hydrous aluminum oxide prepared at lower pH is amorphous and that prepared at higher pH is crystalline hydrated hydrous aluminum oxide, i.e., Bayerite and these results are conformed to Rhee's hypothesis. 3. The rate of loss of reactivity and the end-point reactivity are related to the pH of precipitation.

• 약학회지
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• 제47권1호
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• pp.5-9
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• 2003

Synthetic aluminum silicate was prepared by reacting aluminum sulfate solution with Sodium silicate solution in this study. The optimum synthesis conditions based on the yield of the product were established by applying Box-Wilson experimental design. The results were found to be as follows; Reactant temperature : 50∼72$^{\circ}C$, Concentration of two reactants : 10∼17.6％, Mole ratio of two reactants, [Sod. silicate]/[Al. sulfate) : 4.6∼5.0, Temperature of washing water : 25∼4$0^{\circ}C$, and Drying temperature of product : 50∼$65^{\circ}C$. The physical and chemical properties of synthetic aluminum silicate as medicine were investigated by means of chemical analysis, adsorption test and acid consuming capacity measurements.

• Animal Bioscience
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• 제36권3호
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• pp.461-470
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• 2023

Objective: Sweet sorghum is an important forage crop for ruminants, especially in low rainfall areas. Grapeseeds are an abundant by-product of wine-making and contain bioactive substances that can improve the antioxidant capacity of meat. We examined the effect of sweet sorghum forage with supplementary grapeseeds on carcass and meat quality in lambs. Methods: Twenty-eight Small-tailed Han lambs (body weight = 19.1±1.20 kg), aged 3 to 4 months, were penned, and fed individually. The lambs were divided into four groups (n = 7 each) and were offered one of four diets: i) sweet sorghum silage; ii) sweet sorghum silage + grapeseeds; iii) sweet sorghum hay; and iv) sweet sorghum hay + grapeseeds. The grapeseeds were added to the concentrate at 6% DM and the diets were fed for 100 d. Results: Sweet sorghum silage tended (p = 0.068) to increase hot carcass weight, while grapeseeds tended (p = 0.081) to decrease dressing percentage without affecting other carcass parameters. Lambs consuming supplementary grapeseeds increased (p<0.05) meat redness and tended to decrease (p = 0.075) concentration of methionine in meat. Lambs consuming sweet sorghum silage increased (p<0.001) water content of the meat and had a lower (p<0.05) concentration of n-6 polyunsaturated fatty acids (PUFA) and n-6:n-3 PUFA ratio than lambs consuming sweet sorghum hay. Saturated fatty acids content in meat was lowest (p<0.05) in lambs consuming sweet sorghum silage with grapeseeds. Lambs with supplementary grapeseeds tended (p<0.10) to increase eicosapentaenoic acid and docosahexaenoic acid and have a lower thrombogenic index than lambs not consuming grapeseeds. Conclusion: It was concluded that sweet sorghum with supplementary grapeseeds fed to lambs; i) improved the color of the meat to be more appetizing to the consumer; ii) tended to improve the fatty acids composition of the meat; and iii) lowered thrombogenic index of the meat.

• 약학회지
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• 제6권2호
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• pp.7-12
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• 1962

The rats of thermal ageing at elevated temperatures and heats of activation of aluminum hydroxide gel have been determined. The ageing was expressed in terms of diminution of acid consuming capacity. Although the actual rates of ageing were different by the samples, the slopes of their Arrhenius plots were the same. This may indicate similarity of ageing mechanisms and heats of activation of samples. The heat of activation was the mangitude of 30 Kcal/mole. Thus, rates of ageing of aluminum hydroxide gel may be greatly accelerated at elevated temperatures.