• Macromolecular Research
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• 제12권1호
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• pp.71-77
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• 2004

We have synthesized various types of poly(ethylene glycol) (PEG)-ibuprofen conjugates by nucleophilic substitution of bromo-terminated PEG with ibuprofen-Cs salt. The conversion of the terminal hydroxyl groups to bromo-termini was quantitative, as was the drug conjugation process, which suggests that the present synthetic method is very useful for the preparation of PEG-based prodrugs from pharmaceuticals having carboxyl functionalities. The drug-release behavior of the prodrugs was examined in both phosphate buffer (PBS, pH 7.4) and rat plasma. From the drug-release behavior in PBS, we determined that each prodrug has high storage stability. The drug-release rate was observed to be much faster in rat plasma than in buffer solution as a result of the acceleration effect provided by enzymes present in the plasma. The drug-release rate in rat plasma depends on the degree of molecular aggregation of the prodrugs, which can be changed effectively by the nature of their spacer groups or by the use of Pluronic as the polymer carrier.

• 한국작물학회지
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• 제39권3호
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• pp.270-277
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• 1994

본 연구는 소백벼, 중원벼 등 국내 재배품종과 교배모본으로 이용되는 재래 및 도입품종을 공시하여 저장조건에 따른 종실의 휴면성의 변화를 알고자 수행 되었으며 결과를 요약하면 아래와 같다. 1. 출수후 40일 된 종실의 수확직후 및 저장기간에 따른 발아율을 조사한 결과 자포니카인 화성벼와 상풍벼, 샤레형 재래종인 자광도와 몽근샤레, 그리고 통일형 품종인 삼강벼는 성숙종자에 휴면성이 거의 없었고, 자포니카형 조생종인 소백벼와 오대벼는 약한 휴면성을, 그리고 통일형인 중원벼와 인디카형 품종인 IR-20과 IR-42는 강한 휴면성을 가지고 있었다. 2. 출수후 40일에 수확한 종실은 2$0^{\circ}C$ 항온 또는 서야 25/15$^{\circ}C$ 변온조건에 30일동안만 저장하여도 휴면성이 강한 품종을 포함한 모든 공시품종이 90%이상의 높은 발아율을 보였으나, 4$^{\circ}C$, 상대습도 40%조건에서 30일에서 180일까지 저장했을 때는 품종간 발아율 차이가 인정되었고, 휴면성이 강한 인디카형 품종인 IR-20은 180일간 저장후에도 발아율이 60%에 미치지 못하였다. 3. 성숙한 종실을 2$0^{\circ}C$ 또는 서야 20/15$^{\circ}C$ 조건에 30일 이상 180일까지 저장하면 모든 품종이 수확직후의 종실보다 발아기까지의 일수가 짧아졌으며, 4$^{\circ}C$에 저장했을때도 고온조건에서보다는 그 정도가 낮지만 저장기간이 길어질수록 발아율이 높아지고 발아일수도 빨라졌다.

• 한국구조물진단유지관리공학회 논문집
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• 제27권6호
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• pp.152-161
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• 2023

일반적으로 대용량의 수소를 저장하기 위해 사용되는 수직형 원통 용기는 강재로 제작되며, 사용 환경을 고려하여 제작된 받침 콘크리트 상부에 기초 슬래브에 선 설치된 앵커로 고정하는 방식이 사용된다. 이와 같은 방식은 지진과 같은 외력이 작용될 시 정착부에 응력이 집중될 수 있으며, 앵커 및 콘크리트 손상으로 인한 구조물의 전도 피해가 발생할 수 있다. 본 연구는 현장 조사를 통한 실제 운용중인 수직형 수소 저장용기를 특정하여 3차원 유한요소로 모델링하였고, 비 구조 요소의 내진 성능 검토에 사용되는 ICC - ES AC 156의 인공 지진 및 규모 5.0 이상의 국내 기록지진을 적용하여 거동 특성을 분석하였다. 실제 규모로 제작된 구조물을 대상으로 실험을 진행하는 것이 타당하지만 현실적 제약으로 수행하기에 어려움이 있어 해석적 접근 방식을 통하여 대상 구조물의 안전성을 검토하였다. 거동 특성의 경우 지진동에 의해 발생된 구조물의 응답 가속도는 검토되는 지진 하중 대비 평균적으로 10 배 이상 크게 증폭이 되는 것으로 나타났으며, 무게 중심이 위치되는 지점으로 전달될수록 감소되는 경향을 보였다. 취약 부위로 예상되는 하부 시스템(지지 기둥 및 앵커 정착부)의 경우 허용 응력을 만족하는 것으로 나타났지만, 정착을 위한 받침 콘크리트의 쪼갬 및 인장 강도는 허용 응력 대비 약 5 % 정도의 여유만이 있어 이에 대한 대처 방안이 요구된다. 본 논문에서 제시된 연구 결과를 바탕으로 향후 진동대 시험을 통하여 수행이 되는 수소저장 용기 제작에 필요한 설계 하중 및 조건 등의 기초자료로 활용될 수 있을 것으로 사료된다.

• 한국전산유체공학회지
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• 제10권3호
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• pp.9-18
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• 2005

During a hypothetical severe accident in a nuclear power plant (NPP), hydrogen is generated by the active reaction of fuel-cladding and steam in the reactor pressure vessel and released with steam into the containment. In order to mitigate hydrogen hazards possibly occurred in the NPP containment, hydrogen mitigation system (HMS) is usually adopted. The design of the next generation NPP (APR1400) designed in Korea specifies 26 passive autocatalytic recombiners and 10 igniters installed in the containment for the hydrogen mitigation. in this study, the analysis of the hydrogen and steam behavior during a total lose of feed water (TLOFW) accident in the APR1400 containment has been conducted by using the CFD code GASFLOW. During the accident, a huge amount of hot water, steam, and hydrogen is released in the in-containment refueling water storage tank (IRWST). The current design of the APR1400 includes flap-type dampers at the IRWST vents which are operated depending on the pressure difference between inside and outside of the IRWST. it was found that the flaps strongly affects the flow structure of the steam and hydrogen in the containment. The possibilities of a flame acceleration and transition from deflagration to detonation (DDT) were evaluated by using Sigma-Lambda criteria. Numerical results indicate the DDT possibility could be heavily reduced in the IRWST compartment when the flaps are installed.

• 한국안전학회지
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• 제27권4호
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• pp.13-19
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• 2012

The purpose of this study is to extract the major factors related to the deterioration mechanism of white organic light-emitting diodes(WOLED) by performing accelerated testing of temperature, voltage, time, etc., and to develop an accelerated life test(ALT) model. The measurement results of the brightness of the WOLED exhibited that their average brightness tended to increase as the operating voltage increased and that the half-life period of the brightness appeared after approximately 400 hours when the operating voltage was 20V and the ambient temperature was $85^{\circ}C$. It could be seen that although the WOLED showed comparatively the same brightness when the initial acceleration began after the operating voltage was applied to it, its brightness changed excessively after the WOLED's thermal storage had been made. In addition, it was observed that the half-life period was reduced as the ambient temperature and applied voltage increased. The strength of the WOLED which had been maintained in the range of visible light at the maximum load was reduced by the deterioration of the organic light emitting material due to the influence of the operating voltage and temperature, and the reduction of emitted light was small at low voltage and temperature. It could be seen that the failure of the WOLED during the ALT was caused by wear due to load accumulation over time, and that Weibull distribution was appropriate for the life distribution and acceleration was established between test conditions. From the WOLED analysis, it is thought that factors influencing the brightness deterioration are voltage, temperature, etc., and that comprehensive analysis considering discharge control, dielectric tangent margin, etc., would further increase the reliability.

• 한국포장학회지
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• 제26권2호
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• pp.113-118
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• 2020

Due to the rapid increase in cyber shopping mall of agricultural products, the parcel delivery service industry also increased, making it necessary to design an optimum packaging for agricultural products. And Due to the recent increase in strawberry consumption, there is also a need for a packaging system for parcel delivery service. In order to establish the criteria for optimum cushioning packaging design of strawberries, the bioyield strength of strawberries by storage time was measured through the ASABE test standards, and the peak acceleration in the resonance frequency and resonance frequency bands of strawberries was measured through the vibration test regulated in the ASTM test specifications. Tray cup pad and corrugated fiberboard box of delivery strawberries were designed using FEM theoretical analysis of contact stress and resonant frequency. In addition, an optimum packaging system was developed with a cushioning and vibration design considering the impact characteristics when distributing agricultural products. Through the performance evaluation and on-site evaluation of the optimum packaging system of strawberries for parcel delivery service, the random PSD test results of the delivery showed a 74% reduction in the acceleration level, and the actual distribution test of the delivery showed that the damage rate of strawberries was not more than 6.7%, indicating that it was possible to use the optimum packaging of strawberries for delivery.

• Smart Structures and Systems
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• 제2권2호
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• pp.115-126
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• 2006

The Terra-Scope system is an affordable 4-D down-hole seismic monitoring system based on independent, microprocessor-controlled sensor Pods. The Pods are nominally 50 mm in diameter, and about 120 mm long. They are expected to cost approximately $6000 each. An internal 16-bit, extremely low power MCU controls all aspects of instrumentation, eight programmable gain amplifiers, and local signal storage. Each Pod measures 3-D acceleration, tilt, azimuth, temperature, and other parametric variables such as pore water pressure and pH. Each Pod communicates over a standard digital bus (RS-485) through a completely web-based GUI interface, and has a power consumption of less than 400 mW. Three-dimensional acceleration is measured by pure digital force-balance MEMS-based accelerometers. These accelerometers have a dynamic range of more than 115 dB and a frequency response from DC to 1000 Hz with a noise floor of less than $30ng_{rms}/{\surd}Hz$. Accelerations above 0.2 g are measured by a second set of MEMS-based accelerometers, giving a full 160 dB dynamic range. This paper describes the system design and the cooperative shared-time scheduler implemented for this project. Restraints accounted for include multiple data streams, integration of multiple free agents, interaction with the asynchronous world, and hardened time stamping of accelerometer data. The prototype of the device is currently undergoing evaluation. The first array will be installed in the spring of 2006.

• 한국컴퓨터정보학회논문지
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• 제27권2호
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• pp.61-69
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• 2022

배달산업이 COVID-19 상황과 함께 요식업을 중심으로 크게 성장함에 따라 배달업 종사자가 크게 증가했다. 그와 함께 개인형 모빌리티(Personal Mobility: PM)를 활용한 새로운 배달 형태가 등장했으며, 이륜차 혹은 PM 관련 사고는 꾸준히 증가하고 있다. 본 연구는 안전 배달 모니터링 환경을 구축하기 위해 PM의 주행 분석 장치의 제작한다. 이를 위해 주행 분석 장치와 장치에서 수집된 데이터를 클라우드 서버를 통해 처리하는 시스템을 구성했으며, 이 시스템을 통해 PM의 운전상황에서 운전 중 발생할 수 있는 특수한 상황(가/감속, 과속방지턱 통과)을 인식하고 기록하고자 한다. 그 결과 장치 내 측정 센서(IMU)에서 수집한 각속도, 가속도, 지자기 값을 통해 운행 여부 및 인도 주행 여부, 경사로 주행 여부를 판단해 낼 수 있었다. 이 기술은 기존의 영상기반 기록장치보다 약 1600배 이상의 주행 정보 저장 효율을 달성할 수 있었다.

• Nuclear Engineering and Technology
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• 제56권7호
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• pp.2595-2609
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• 2024

This paper introduces a base isolation system-tuned mass damper inerter (BIS-TMDI) hybrid system to the AP1000 nuclear power plant (NPP), which reduces seismic damage potential of the NPP structure. The effects of fluid-structure interaction (FSI) caused by the passive containment cooling system water storage tank (PCCWST) on NPP's seismic performance are investigated. The FSI of water tank theoretical model is considered based on the Housner's model, and a series of time history analyses are performed to prove the rationality of the proposed model. Three single-objective optimization strategies are employed to minimize the relative displacement variance and absolute acceleration variance of the upper structure, as well as the filtered energy index (FEI). Furthermore, a multi-objective optimization strategy considering all these three indexes is proposed to obtain optimal parameters of vibration control. The influence of vibration control strategies on the relative deformation and acceleration of the upper structure is explored with various water level ratios. The analytical results indicate that the proposed BIS-TMDI strategy has significantly reduced the NPP structure's seismic response. The effectiveness of the vibration control strategy is influenced by the water level ratio, emphasizing the significance of designing an appropriate water level ratio to reduce NPP structure's seismic response.

• 한국정밀공학회지
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• 제25권4호
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• pp.134-139
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• 2008

A spirally arrayed nano-pattern is designed as a model pattern for the next generation optical storage media. The pattern consists off types of embossed rectangular dot, which are 50nm, 100nm, 150nm and 200nm in length and 50nm in width. The height of the dot is designed to be 50nm. The pitch of the spiral track of the pattern is 100nm. A ER(Electron resist) master for this pattern is fabricated by e-beam lithography process. The ER is first spin-coated to be 50nm thick on a Si wafer and then the model pattern is written on the coated ER layer by e-beam. After developing this pattern written wafer in the solution, a ER pattern master is fabricated. The most conventional e-beam machine can write patterns in orthogonal way, so we made our own pattern generator which can write the pattern in circular or spiral way. This program generates the patterns to be compatible with the e-beam machine from Raith(Raith 150). To fabricate 50nm pattern master precisely, a series of experiments were done including the design compensation for the pattern size, optimization of the dose, acceleration voltage, aperture size and developing. Through these experiments, we conclude that the higher accelerating voltages and smaller aperture size are better for mastering the nano pattern which is in order of 50nm. With the optimized e-beam lithography process, a spiral arrayed 50nm pattern master adopting PMMA resist was fabricated to have dimensional accuracy over 95% compared to the designed. Using this pattern master, a metal pattern stamp will be fabricated by Ni electro plating for injection molding of the patterned plastic substrate.