• 제목/요약/키워드: abstinence

검색결과 145건 처리시간 0.022초

흡연이 치은혈류량에 미치는 영향 (Effect of Smoking on Gingival Blood Flow)

  • 오현정;박병기;신광용;한경윤;김병옥
    • Journal of Periodontal and Implant Science
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    • 제30권2호
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    • pp.471-482
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    • 2000
  • Recent studies have demonstrated that smoking may be one of the most significant risk factors in the development and progression of periodontal disease. Reports have indicated that smoking causes gingival blood flow to be decreased. However, studies on the effects of smoking on gingival blood flow have yielded contradictory results. The purpose of the present study was to determine the effect of smoking on gingival blood flow. One hundred volunteers(fifty non-smokers and fifty smokers) with good general and periodontal health, aged twenties(non-smoker : 22-29 years, mean=25.36, smoker : 23-29 years, mean=26.64) were selected. Laser Doppler flowmetry (floLAB, Moor Instruments Ltd., England) was applied to measure the gingival blood flow of interdental papilla, marginal gingiva, attached gingiva and alveolar mucosa of left and right upper lateral incisors. In smokers, following an overnight abstinence from smoking, gingival blood flow was measured before smoking, immediately after smoking, 1-, 2-, 3-, 4-, 5- and 6- hour after smoking from 9 a.m. to 3:30 p.m. The difference of blood flow in each tissue of non-smokers and that of each measuring time and each tissue of smokers were statistically analyzed by one way ANOVA and Tukey test. And the difference of blood flow between smokers and nonsmokers in each tissue was statistically analyzed by t-test. The results were as follows : 1. Mean blood flow was highest in alveolar mucosa, followed by interdental papilla, attached gingiva and marginal gingiva in both smokers and nonsmokers. There was a statistically significant difference in each tissue(p<0.05) . 2. There was no consistent result between mean blood flow before smoking in smokers and that of nonsmokers in each tissue. 3. There was a statistically significant difference between gingival blood flow at measuring time point and gingival blood flow of smokers in each tissue(p<0.05). The present study suggested that smoking could alter the gingival blood flow, thus might be partly contributed to periodontal destruction.

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한국인의 사회자본과 건강: 사회경제적 요인 및 건강 관련 생활습관을 중심으로 한 분석 (Social Capital and Health in South Korea: Considering Socio-economic Factors and Health-related Lifestyles)

  • Song, Yea-Li-A;Nam, Eun-Woo
    • 보건교육건강증진학회지
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    • 제26권5호
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    • pp.71-84
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    • 2009
  • 목적: 이 연구는 사회자본, 사회경제적 요인, 건강행동의 관계, 그리고 이 요인들이 한국인의 주관적 건강에 미치는 영향을 파악하고자 시도되었다. 방법: 통계청의 2006년 사회통계조사 원자료를 사용하여 분석하였다. 사회통계조사는 표본규모 33,000 가구내 15세 이상 가구원 약 7만명을 대상으로 수행되었다. 이 연구에서는 이 가운데에서 25세 이상 59세 이하 인구중 결혼 경험이 있는 37,928명을 추출하여 분석하였다. 사회자본, 사회경제적 요인, 건강행동의 관계, 그리고 이 요인들이 주관적 건강에 미치는 영향을 파악하고자 경로분석을 실시하였다. 결과: 교육 (0.069), 주관적 계층(0.108), 결혼(0.054), 가족관계 만족도(0.087), 기관신뢰(0.020), 시민참여(0.021), 운동(0.037), 그리고 금연(0.011)이 주관적 건강에 긍정적인 직접효과를 미치는 것으로 분석되었다. 그러나 절주 (-0.067)는 직접효과가 부정적인 것으로 나타났다. 결론: 사회자본이 건강에 긍정적 영향을 주는 것이 분명한 만큼, 건강증진사업 개발시 사회자본을 고려하여, 이의 유지 및 증진을 통해 건강수준의 긍정적인 변화를 유도하는 것이 필요하다. 특히 절주사업에서는 개인을 대상으로 하는 사업 이외에, 전반적인 사회 음주문화의 변화를 이끌어내는 사회적 문화에 대한 고려가 필요할 것으로 생각된다.

외상 환자에서 알코올 금단 증후군의 발생이 예후에 미치는 영향 (Prognosis and Clinical Outcome of Alcohol Withdrawal Syndrome in Trauma Patients)

  • 오동길;조민수;배금석;강성준
    • Journal of Trauma and Injury
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    • 제21권2호
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    • pp.115-119
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    • 2008
  • Purpose: Abrupt abstinence from alcohol in cause of chronic alcohol addiction can trigger alcohol withdrawal syndrome. The authors studied the effect of post-operative alcohol withdrawal syndrome in patients who require intensive care due to trauma. Methods: For the study group, we selected 70 patients who had undergone emergency surgery from May 2003 to March 2007 due to trauma and who had been treated with prophylactic thiamine. Data was collected retrospectively. We excluded those who extended their hospital stay for other than traumatic causes, those who died within 3 days of surgery after trauma, those who transferred to other institutions, and those who received a psychiatric diagnosis. Patient groups were determined by the existence or the non-existence of withdrawal syndrome. Age, sex, injury mechanism, mortality, complications, durations of hospital stay and intensive care, use of mechanical ventilator, and sedative use were investigated. A Chi-square test and The Mann-Whitney method were used for statistical analysis in this study. Results: Twenty-four (24) patients from the 58 who had an ISS of 16 or more showed alcohol withdrawal syndrome, and men were shown to be affected with the syndrome significantly more than women. Although ISS was higher in the group with alcohol withdrawal syndrome, statistically, the difference was not significant (P<0.08). The total hospital stay in the patient group with alcohol withdrawal syndrome was on average 10 days longer. However, the difference was not significant (P<0.054). The duration of intensive care in the patient group with alcohol withdrawal syndrome was significantly longer (P<0.029). The patients with alcohol withdrawal syndrome showed no significant difference in the duration of mechanical ventilator use (P<0.783), or in the duration of sedative use (P<0.284). Respiratory distress, pneumonia, upper airway infection, sepsis, acute renal failure, and mortality in the alcohol withdrawal syndrome group were investigated, but no statistically significant difference were noted. Conclusion: We found that the duration of intensive care in chronic alcohol abusers was longer due to the development of alcohol withdrawal syndrome. We also discovered that, when the patients overcame the symptoms of alcohol withdrawal syndrome after intensive care, no difference was found in the frequency of developing complications, the morbidity, and the mortality. Therefore, we conclude that intensive care in trauma patients who are chronic alcohol abusers decreases the incidence of complications found in patients with post-operative alcohol withdrawal syndrome and does not adversely impact the prognoses for those patients.

Four Novel Synthetic Tryptamine Analogs Induce Head-Twitch Responses and Increase 5-HTR2a in the Prefrontal Cortex in Mice

  • Abiero, Arvie;Ryu, In Soo;Botanas, Chrislean Jun;Custodio, Raly James Perez;Sayson, Leandro Val;Kim, Mikyung;Lee, Hyun Jun;Kim, Hee Jin;Seo, Joung-Wook;Cho, Min Chang;Lee, Kun Won;Yoo, Sung Yeun;Jang, Choon-Gon;Lee, Yong Sup;Cheong, Jae Hoon
    • Biomolecules & Therapeutics
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    • 제28권1호
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    • pp.83-91
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    • 2020
  • Tryptamines are monoamine alkaloids with hallucinogenic properties and are widely abused worldwide. To hasten the regulations of novel substances and predict their abuse potential, we designed and synthesized four novel synthetic tryptamine analogs: Pyrrolidino tryptamine hydrochloride (PYT HCl), Piperidino tryptamine hydrochloride (PIT HCl), N,N-dibutyl tryptamine hydrochloride (DBT HCl), and 2-Methyl tryptamine hydrochloride (2-MT HCl). Then, we evaluated their rewarding and reinforcing effects using the conditioned place preference (CPP) and self-administration (SA) paradigms. We conducted an open field test (OFT) to determine the effects of the novel compounds on locomotor activity. A head-twitch response (HTR) was also performed to characterize their hallucinogenic properties. Lastly, we examined the effects of the compounds on 5-HTR1a and 5-HTR2a in the prefrontal cortex using a quantitative real-time polymerase chain reaction (qRT-PCR) assay. None of the compounds induced CPP in mice or initiated SA in rats. PYT HCl and PIT HCl reduced the locomotor activity and elevated the 5-HTR1a mRNA levels in mice. Acute and repeated treatment with the novel tryptamines elicited HTR in mice. Furthermore, a drug challenge involving a 7-day abstinence from drug use produced higher HTR than acute and repeated treatments. Both the acute treatment and drug challenge increased the 5-HTR2a mRNA levels. Ketanserin blocked the induced HTR. Taken together, the findings suggest that PYT HCl, PIT HCl, DBT HCl, and 2-MT HCl produce hallucinogenic effects via 5-HTR2a stimulation, but may have low abuse potential.

금연에 대한 침술 병용 치료의 효과 및 안전성 : 체계적 검토를 위한 프로토콜 (The effectiveness and safety of acupuncture combination treatment on smoking cessation: A protocol for systematic review)

  • 최인서;성원석;조민기;김정현;박연철;김은정;백용현;김근우;서병관
    • 대한융합한의학회지
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    • 제3권1호
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    • pp.5-13
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    • 2022
  • Objectives: Smoking had a long negative impact on public health. The ingredients of a cigarette are major risk factors for several diseases. Owing to the problems about economic and quality of life, we need to ensure smoking cessation (SC). There are several approaches for SC including pharmacological therapy, nicotine replacement therapy, education, and behavioral intervention. However, due to some limitations, other alternative approaches are gaining popularity. Acupuncture has been reported to have few side effects and be more effective than some conventional treatments in several articles. However, there are no systematic reviews on the comparison of acupuncture combination treatment with other conventional monotherapies. Methods: Randomized controlled trials that used acupuncture as an adjunct treatment for SC will be searched and data will be summarized according to the predefined criteria. The primary outcome will be the abstinence rate, and secondary outcomes will be adverse events and biochemical indicators. We will use Review Manager to perform a meta-analysis, Cochrane Collaboration Risk of Bias tool for the risk of bias assessment, and the Grades of Recommendation, Assessment, Development and Evaluation approach to determine the quality of evidence. We will investigate the efficacy and safety of acupuncture combination treatment for SC with this study. Ethics and dissemination: This study will provide reliable clinical evidence on additional effect of acupuncture on smoking cessation. We will publish our results in a peer-review journal.

대학생의 폭음 관련 사회인지적 요인과 음주 정도의 관계 - 지각된 음주규준의 역할을 중심으로 (The Relationship of Alcohol Drinking and Sociocognitive Factors on Binge Drinking of College Students - Focused on of Perceived Drinking Norm)

  • 류미;이민규;신희천
    • 한국심리학회지 : 문화 및 사회문제
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    • 제16권1호
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    • pp.63-79
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    • 2010
  • 본 연구는 음주행동에 미치는 사회인지적 요인의 영향을 분석하기 위해 대학생 폭음 집단에서 음주와 음주 결과기대, 금주 자기효능감, 지각된 음주규준, 음주동기의 관계에 대해 알아보고자 하였다. 설문은 e-mail로 이루어졌으며, Wechsler(1992)의 폭음(binge drinking) 정의에 해당하는 남학생 148, 여학생 152명, 총 300명의 폭음집단을 대상으로 분석을 실시하였다. 폭음집단에서 음주정도와 음주동기, 지각된 음주규준 간의 유의미한 상관이 있었으나 비폭음집단에서는 지각된 음주규준이 음주정도와 관련이 없었다. 또한 폭음집단에서 남녀 모두 친한 친구의 음주정도를 과대추정하였으며, 지각된 동료음주 규준과의 차이가 개인의 음주정도와 유의하게 관련이 있음을 확인하였다. 하지만 보통의 대학생의 음주정도 추정과의 관련성에 있어서는 남녀에 따라 차이가 있었다. 아울러 회귀분석을 통해 알코올기대, 금주 효능감의 영향력을 통제한 후 지각된 음주규준이 음주정도에 미치는 영향력이 유의미함을 확인하였다. 또한 음주정도에 미치는 지각된 음주규준의 영향을 음주동기가 매개하는지를 검증한 결과, 지각된 음주동기는 음주규준과 음주정도를 부분 매개하는 것으로 나타났다. 이와 같은 연구결과를 토대로 본 연구의 임상적 의의와 제한점이 논의되었다.

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관상동맥질환 여성의 성기능에 관한 연구 (A Study on Sexual Function of Women with Coronary Artery Disease)

  • 김춘심;소향숙
    • 성인간호학회지
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    • 제12권1호
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    • pp.99-111
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    • 2000
  • The purpose of this study was to identify risk factors related to sexual function of women with coronary artery disease, and to determine the predictors of sexual function. The study design, a descriptive correlational study, was done through structural questionnaire and interview. A total of 50 subjects from C University Hospital at Kwang-ju city who have undergone coronary angiography at department of cardiology were observed and interviewed from Feb. 22, 1999 to March. 23, 1999. The number of affected vessels, the level of total serum cholesterol, and the ejection fraction of 2-D echo cardiography were analyzed to evaluate the severity of coronary artery disease. And also type A behavior pattern, health behavior, Brief Index of Sexual Functioning for Women (BISF-W) were measured. The data obtained were analyzed using percentage, mean and standard deviation, t-test, ANOVA, Pearson's correlation coefficient, and stepwise multiple regression analysis via SPSS PC+. The results of this study were as follows: 1. The mean age of the subjects were 58.1 and 72.0% of those have been married over 30 years. Seventy two percentage were unemployed and monthly family income of 56.6% was less than 1,000,000 won (approximately $ 840). Eighty percent were in their postmenopausal state, and the frequency of sexual intercourse of 84.0% were two to three times per month. 2. The scores of type A behavior pattern were from 16 to 38(mean 24.94) and health behavior ranged from 21 to 43(mean 31.2). Abstinence from smoking, alcohol, and caffeine were best compliant factors and weight control and exercise were least abided ones. The result of 2D-ECHO EF showed that the half of the subjects were abnormal, and 24% had more than 240mg/dl of total serum cholesterol. The coronary angiography showed that 64% of the subjects had more than one affected vessels. 3. The predictors to explain the factor score of 'orgasm' were number of health examination, the pre- or post-menopausal state, protestant, number of coronary vessel affected, level of serum total cholesterol, and comorbid group of hypertension and diabetes, and it's total variance accounted for 52.4%. The predictors to explain the factor score of 'sexual activity' were comorbid group of hypertension and diabetes and type A behavior pattern, which accounted for 22.4% of total variance. The predictors to explain the factor score of 'sexual satisfaction' were type A behavior pattern, no religion, exercise, level of serum total cholesterol, and pre or post menopausal state, which accounted for 52.1%. The predictors to explain the factor score of 'sexual desire' were the period of marriage, type A behavior, employment or unemployment, and weight control, which accounted for 43.2%. The predictors to explain the factor score of 'external force of sexual functioning' were physical overload and exercise, which accounted for 41.1%. The predictors to explain the factor score of 'sexual activity' were family monthly income, catholics, and exercise, and which accounted for 35.4%. Above results lead us to some consensus that sexual function of women with coronary artery disease is related to various factors including vasogenic factors such as total serum cholesterol level, number of coronary vessel affected, an endocrinal factor such as menopausal state, and type A behavior pattern as a sociopshychological factor. And also health behaviors such as fitness care, overwork, weight control, and emotional tension are contributed to sexual function.

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태교 실천에 대한 일상생활 기술적 연구 (An Ethnographic Study about Taegyo Practice in Korea)

  • 김현옥
    • 대한간호학회지
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    • 제27권2호
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    • pp.411-422
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    • 1997
  • The purpose of this study is twofold : (i) to investigate how much effort the married couples are making for the good health of both the pregnant woman and her unborn child from the time of their marriage to and during the period of conception : and (ii) to comprehensive investigate socio-cultural back-grounds which affect prenatal effort. Result of this study provide a basis for the prenatal care program which will be appropriate to our culture. This study has been done by the ethnographic research method. The subjects of this study are 53 people in all consisting of 33 pregnant women and 20 husbands. In order to investigate socio-cultural factors which influence Taegyo, producers of Taegyo music were interviewed. In addition the researcher surveyed the markets of Taegyo music, participated in special courses of prenatal education, analyzed the content of the books and periodicals dealing with Taegyo, and collected the concept of Taegyo distributed by the mass media. The full-fledged study continued for eight months from February to August.1996. The data were analyzed as soon as they were collected. Spradly's(1979, 1980) developmental, sequential method of domain analysis. taxonomic analysis, componential analysis, and theme analysis in this order was adopted as the procedure of analyzing the data. To obtain the exactness of study, Sandelowski's (1986) four criteria, that is, Credibility, Fittingness, Auditability, and Confirmability were applied to all stages of data collection, data analysis, the interpretation of the result, and the description of the result. The following are the result : 1. The couples' Taegyo at the stage of preconception was related to their physical, psychological, spiritual conditions under which a healthy baby will be born. Specific methods they prefer are : "the choice of one's spouse." "physical check-up," "physical good health, " "praying, " and so on. 2. When the marriod couple have sex in order to conceive, their Taegyo was related to the imposition of their physical, psychological, and environmental conditions. Specific methods they prefer are : "having sex at specific time, " "having sex in nice place." "to purify their minds while having sex," and so on. 3. The married couples' Taegyo while they are in pregnancy was related to the imposition of their physical. psychological, emotionmental. environmental, social and spiritual conditions. Specific methods they prefer are : "listening to music. " "reading," "looking at beautiful things only," "to avoid looking at or listening to bad things." "to eat food in good shape, " "to avoid drugs," "eating Korean herbal medicine." "sexual abstinence," "to avoid dangerous places," "to keep emotional tranquility," "moderate exercises and rest." "leading a pure life." "praying." "being aware of their words and behavior." "for the couple to keep a good relationship." "interaction with their unborn child," "to support Taegyo for pregnant women," and so on. 4. The married couple put Taegyo into practice on the basis of the following principles : the principle of respecting an unborn child, the principle of forming a good disposition. the principle of top-down parental love, the principle of synergy between a pregnant woman and her unborn child, the principle of expecting a good child, the principle of forming a good habit, and the principle of acquiring a parental role. 5. The practice of Taegyo is influenced by such factors as the married couple, the supporting system, and the mass media. As the husband -and-wife factor, their information of Taegyo, the degree of importance is assigned to their characters, their time to spare, their healthiness, the age of pregnant woman, their conception plan, their religion, their belief of the Taegyo effects, and the birth of a baby in this order. The factor of the supporting system consists of her husband's support, her family support, and her neighbor's support. The mass media factors include the broadcasting media, books specialized in Taegyo, periodicals for pregnant women, booklets for advertizing powdered milk, Taegyo music of record manufacturing companies, and the teaching materials for gifted children. Among these the mass media is especially taking advantage of Taegyo as its main source of economic profits are leading the public behavior pattern to a prodigal one. Taegyo is a self-control behavior which requires practice for the following : the physical and psychological good health of the pregnant woman and her unborn child, the development of the unborn child's good character, the development of the unborn child's intelligence and talents, the expectation of the unborn child's good features. shape a good habit, the expectation of the unborn child's bright future, and the learning of a parental role, the expectation of male birth. Above all it is a type of our good cultural tradition which pursues a value higher than the one that the prenatal care does. The principles of pregnancy care inherent in the habit of Taegyo will provide us a guideline for the development of the prenatal care.

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단가아민 산화제 A CA 반복 유전자 다형성이 한국 알코올의존 남자환자의 행동특성과 임상양상에 미치는 영향 (The Effects of Monoamine Oxidase A CA Repeat Polymorphism on Behavioral Trait and Clinical Characteristics in Korean Male Alcoholics)

  • 이정식;양병환;이경미;김홍관;김용인;채영규
    • 생물정신의학
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    • 제7권1호
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    • pp.64-73
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    • 2000
  • 이 연구는 MAOA CA 반복 유전자다형성에 따라 알코올의존 환자에서 행동 및 성격특성 그리고 임상양상의 차이를 알아봄으로써 유전자형과 표현형과의 관계를 알아보기 위해 수행되었다. 이 연구 결과 임상양상에서 S군에 비해 L군의 임상양상이 보다 부정적인 양상을 보이고 있었다. 이는 MAOA CA 반복 유전자다형성이 음주양상을 변화시키는 역할을 할 가능성을 시사하고 있다. 그렇지만 이러한 영향이 유전자의 직접적인 인과관계로 설명하기는 어렵고 간접적이고 이차적인 영향에 따른 결과로 생각해 볼 수 있겠다. 또한, 행동특성에서 L군이 S군에 비해 전체적으로 공격성이 많았고 자기주장적 태도가 강했다. 그리고 MAOA CA 반복 유전자다형성의 대립유전자 길이가 자기주장적 태도와 상관관계가 있었으며 이러한 자기주장적 태도를 MAOA CA 반복 유전자다형성의 대립유전자 길이가 부분적으로 설명하고 있었고, 자기주장적 태도가 강한 환자의 경우 길이가 긴 대립유전자를 가질 가능성이 많았다. 공격성도 그 자체가 여러 가지 측면을 가지고 있는 복합적인 행동특성이기 때문에 전체 공격성을 어느 하나의 유전자만으로 설명할 수 있을 것으로 기대하는 것은 비현실적이다. 그렇지만 이 연구에서 자기주장적 태도는 분화된 공격성의 한 측면이어서 MAOA CA 반복 유전자다형성이 일부분이지만 설명을 할 수 있다는 것을 시사하고 있어, 연구자들은 이 연구가 향후 유전자형이 공격성 같은 표현형을 설명하는 연구들에 있어 기초자료가 될 수 있을 것으로 생각된다. 아직까지 MAOA CA 반복 유전자다형성과 MAOA 활성도와의 관계가 명확하지 않고 대사산물과의 관계도 설명이 어려운 실정이어서 향후 이에 대한 연구들이 필요하겠다.

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