• Title/Summary/Keyword: absorption effect

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A Study on the Absorption Mechanism of Drugs through Biomembranes

  • Lee, Chi-Ho;Kim, Heun-Jo
    • Archives of Pharmacal Research
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    • v.17 no.3
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    • pp.182-189
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    • 1994
  • The effect of lipophilicity on the mechanisms of drug absorption through biomembranes was investigated empolying HPLC system and the fluorescence technique. Human erythrocyte ghost membranes were used as a model biomembrane. A series of four parabens (methyl, ethyl, rpopyl, and butyl) and p-hydroxybenzoic acid were used as the model drugs for lipophilicities and their partition coefficients were measured in Sorensen's phosphate buffer solution (pH 5)/octanol system. Absorption amount of parabens through erythrocyte ghost membranes increased with an increase of lipophilicity resulted from the addition of methylene group to the n-alkyl chain of parabens. And the effect of parabens on the fluidity of ghost membrane also increased with an increase of their lipophilicities.

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Effect of PEO viscoelasticity on carbon dioxide absorption in aqueous PEO solution of AMP

  • Park Sang-Wook;Choi Byoung-Sik;Lee Jae-Wook
    • Korea-Australia Rheology Journal
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    • v.17 no.4
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    • pp.199-205
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    • 2005
  • Carbon dioxide was absorbed into aqueous polyethylene oxide (PEO) solution containing AMP in a flat-stirred vessel to investigate the effect of non-Newtonian rheological behavior of PEO on the rate of chemical absorption of $CO_2$, where the reaction between $CO_2$ and AMP was assumed to be a first-order reaction with respect to the molar concentration of $CO_2$ and AMP respectively. The liquid-side mass transfer coefficient, which was obtained from the dimensionless empirical equation containing the properties of viscoelasticity of the non-Newtonian liquid, was used to estimate the enhancement factor due to chemical reaction. PEO with elastic property of non-Newtonian liquid made the rate of chemical absorption of $CO_2$ accelerate compared with Newtonian liquid based on the same viscosity of the solution.

Physical and Mechanical Properties of Sawdust Board Made of Thinning Logs (II) - The Effect of Density and Additive Quantity of Powder Phenolic Resin -

  • Oh, Seung-Won
    • Journal of the Korean Wood Science and Technology
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    • v.31 no.3
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    • pp.17-23
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    • 2003
  • As a fundamental study of developing sawdust board from thinning softwood logs from three species (Pinus densiflora S. et Z., Larix leptolepis G. and Pinus koraiensis S. et Z.), this study examined the effect of board density and resin content on physical and mechanical properties of sawdust board. As the board density increase, thickness swelling, bending strength, and Brinell hardness increased while water absorption decreased. With increasing the resin content, the bending strength and hardness increased while water absorption and thickness swelling decreased. The board made of L. leptolepis was slightly low in its water absorption, and the one made of P. koraiensis was a little high in its bending strength, while there was no definite difference between each kind of trees in their hardness values.

A Practical Method to Correct the Saturation Effect in XMCD Spectra

  • Kim, J.Y.
    • Journal of Magnetics
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    • v.13 no.3
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    • pp.85-87
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    • 2008
  • I report a simple method to correct the saturation effect in absorption spectra measured in total electron yield (TEY) mode. It does not require additional measurements of the X-ray penetration depth. In order to check the reliability of the method, X-ray magnetic circular dichroism (XMCD) spectra for polycrystalline Fe were measured at two different incident angles, and then processed with the method. The two resultant XMCD spectra were identical, and their sum rule analysis produced the ratios of orbital magnetic moment to spin magnetic moment, which were very close to the well-known value.

A Study on the Absorption Enhancing Effect of Sodium 5-Methoxysalicylate(II) (Sodium 5-Methoxy Salicylate의 흡수촉진 효과에 관한 연구 (II). 흡수촉진제에 대한 반응성)

  • 김기헌
    • YAKHAK HOEJI
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    • v.30 no.2
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    • pp.96-99
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    • 1986
  • Absorption enhancing effect of 5 MSA-Na at the mucous memberanes of the rectum and duodenum was studied via in vitro sac test. There were no significant differences between two membranes. Effect of 5MSA-Na on the transfer of CMZ to the tissue was also studied via in situ loop method. There was no significant difference at the duodenum, compared to the control when CMZ was administered intravenously. Transfer of CMZ to the loop of the rectum was increased in the presence of 5MSA-Na compared to the control, which might be attributed to the enhanced permeability of the mucous memberane of the rectum.

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Effect of Inorganic Impurities on the Properties of Lean Concrete (재생골재중에 포함된 이물질이 빈배합콘크리트 물성에 미치는 영향)

  • Kim Jin-Cheol
    • Proceedings of the Korea Concrete Institute Conference
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    • 2005.05b
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    • pp.81-84
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    • 2005
  • We investigated the effect of inorganic impurities such as clay bricks and asphalt concrete in recycled aggregate on the properties of lean concrete. The optimized moisture content of lean concrete with clay bricks increased, because the absorption ratio of clay bricks is high. On the other hand, lean concrete with asphalt concrete produced an opposite result owing to low absorption ratio. The results showed that inorganic impurities did not have a significant effect on compressive .strength of lean concrete containing below 30$\%$ clay bricks and below 10$\%$ asphalt concrete.

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The Effect of Sound Reinforcement Systems on the Acoustics of a Large-Span Spaces (대공간에서 전기음향 시스템에 따른 음향특성 변화)

  • Jeong, Dae-up;Joo, Hyun-kyung;Choi, Young-Ji
    • Journal of Korean Association for Spatial Structures
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    • v.11 no.1
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    • pp.67-75
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    • 2011
  • The present work investigate the effect of sound reinforcement systems on the acoustics of a large dome stadium using a computer simulation. The acoustics of a dome stadium was predicted analyzed by varying room absorption, as well as the configuration of speakers including their directivity, installed height, and numbers. It was found that both D50 and RASTI were improved by increasing room absorption. Larger EDTs were observed according to the increase of room absorption at mid and high frequencies. On the other hand, RT did not show any significant correlation with the changes in room absorption, which might be the effect of a forced linear fitting for non -linear energy decay process. With respect to the speaker configuration, the speech intelligibility of a sound reforcement system installed at higher placed more relied upon their directivity rather than room absorption, Also, lower placing of speakers was found to be effective in decreasing RTs regardless of room absorption.

A FINITE ELEMENT STRESS ANALYSIS OF THE STRESS DISTRIBUTION AND THE SHOCK ABSORPTION IN AN OSSEOINTEGRATED IMPLANT-NATURAL TOOTH SUPPORTED FIXED PARTIAL DENTURE (골유착성 임프란트와 자연치를 이용한 고정성 국소의치에서 응력분산 및 충격흡수에 관한 유한요소법적 응력분석)

  • Jeong Chang-Mo;Lee Ho-Yong
    • The Journal of Korean Academy of Prosthodontics
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    • v.30 no.4
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    • pp.582-610
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    • 1992
  • The long-term success of any dental implant is dependent upon the optimization of stresses which occur during oral function and parafunction. Especially, it has been suggested that there is an unique set of problems associated with joining an osseointegrated implant and a natural tooth with a fixed partial denture. For this particular case, although many literatures suggest different ways to avoid high stress concentrations on the bone surrounding the implant under static and dynamic loading conditions, but few studies on the biomechanical efficacy of each assertion have been reported. The purpose of this investigation was to evaluate the efficacies of clinically suggested methods on stress distribution under static load and shock absorption under dynamic load, using two dimensional finite element method. In FEM models of osseointegrated implant-natural tooth supported fixed partial dentures, calculations were made on the stresses in surrounding bone and on the deflections of abutments and superstructure, first, to compare the difference in stress distribution effects under static load by the flexure of fastening screw or prosthesis, or intramobile connector, and second, to compare the difference in the shock absorption effects under dynamic load by intramobile connector or occlusal veneering with composite resin. The results of this analysis suggest that : 1. Under static load condition, using an implant design with fastenign screw connecting implant abutment and prosthesis or increasing the flexibility of fastening screw, or increasing the flexibility of prosthesis led to the .increase in height of peak stresses in cortical bone surrounding the implant, and has little effect on stress change in bone around the natural tooth. 2. Under static load condition, intramobile connector caused the substantial decrease in stress concentration in cortical bone surrounding the implant and the slight increase in stress in bone around the natural tooth. 3. Under dynamic load condition, both intramobile connector and composite resin veneering showed shock absorption effect on bone surrounding the implant and composite resin veneering had a greater shock absorption effect than intramobile connector.

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GREEN TEA AND ITS CATECHINS AS DIETARY AND PHARMACOLOGICAL MEANS OF LOWERING CHOLESTEROL ABSORPTION

  • Koo Sung I;Noh Sang K.;Loest Helena B;Wang Shu
    • Proceedings of the Korean Society of Food Science and Nutrition Conference
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    • 2001.12a
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    • pp.74-87
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    • 2001
  • Evidence shows that the serum level of cholesterol (CH) is decreased with increasing green tea (GT) consumption. This presentation summarizes our recent findings on the effect of GT extract on intestinal absorption of [$^{14}C$-labeled CH and phosphatidylcholine (PC). Ovariectomized (OX) adult rats were infused intraduodenally with lipid emulsions containing radiolabeled lipids [$^{14}C$-CH or $^{14}C$-phosphatidylcholine (PC)] in the presence of GT extract or catechins to determine the rates and amounts of CH absorption and the intestinal hydrolysis and lymphatic output of PC. During lipid infusion, lymph was collected hourly for 8 h. The lymphatic absorption of $^14C$-CH was drastically lowered by infusion of GT extract at two dosage levels (GTl =5.4 mg catechins/h and GT2 = 15.1mg catechins/h). The cumulative lymphatic absorptions of $^{14}C$-CH in rats infused with GT1 and GT2 were 20.7$\pm$4.3 and $4.8{\pm}4.1{\%}$ dose, respectively, whereas the absorption of $^{14}C$-CH in rats infused with no GT extract (GT0) was $36.3{\pm}1.1{\%}$ dose. GT extracts also significantly lowered the absorption of-tocopherol (TP) in a dose dependent manner ($29.6{\pm}4.9{\%}$ dose in GT0, $20.8{\pm}5.8{\%}$ dose in GTl, and $7.9{\pm}5.4{\%}$ dose in GT2 groups). Both (+)-catechin and EGCG significantly lowered the lymphatic outputs of $^{14}C$-radioactivity after intraduodenal $^{14}C$-PC infusion. A significantly higher amount of $^{14}C$-PC remained unhydrolyzed in the intestinal lumen of the EGCG rats ($22.8{\%}$) compared with the (+)-catechin ($15.8\%$) and control groups ($11.9\%$). GT extracts, (+)-catechin, and EGCG significantly reduced the absorption of TP. The inhibitory effect of GT extract and catechins on lipid absorption may be mediated in part through the inhibition of pancreatic PLAz. The findings provide the first direct evidence that green tea and catechins have a profound inhibitory effect on the intestinal absorption of CH in OX rats. Results suggest that green tea and catechins may be used as a dietary or pharmacological means of lowering cholesterol absorption.

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Performance Analysis of Micro-turbine CHP System with Absorption Chiller (흡수식 칠러를 장착한 마이크로터빈 구동 열병합시스템의 성능 해석)

  • Yun, Rin;Han, Seung-Dong
    • Proceedings of the SAREK Conference
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    • 2007.11a
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    • pp.540-545
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    • 2007
  • The performance of microturbine CHP system equipped with an absorption chiller was analyzed by modelling of a microturbine and an absorption chiller. The microturbine having recuperator was simulated by the Brayton cycle model. The mass flow rate and available heat energy of the exhaust gas from the microtubune were simulated, and this results were utilized as input values for the generator of the absorption chiller. The absorption chiller is a single-effect air cooled type having solution heat exchanger. When heat input to the generator increased, the heat transfer rate and UA of the heat exchangers of the absorption chiller proportionally increased. Besides, the COP of the absorption chiller increased with increase of the heat input to the generator under the sufficient size of the evaporator condition. When the capacity of the CHP system increased from 30 to 60 kW, the mass flow rate of the LiBr for the absorption chiller increased by two times, and UA values for evaporator and condenser were increased by 3.9 and 3.4 times, respectively, under the same COP condition.

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