• 제목/요약/키워드: abnormal liver function

검색결과 133건 처리시간 0.031초

간기능검사이상의 위험요인으로써 한약복용영향에 관한 단면연구 (A Cross-sectional Study between Herbal Medicine Intake and Abnormal Liver Function Test Results)

  • 박해모;신헌태;박철수;이선동
    • 대한예방한의학회지
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    • 제12권2호
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    • pp.61-72
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    • 2008
  • Objectives : The aim of this study was to evaluate effects of herbal medicine and other associated factors for abnormal liver function tests(especially total bilirubin, AST, ALT, and ${\gamma}$GT) levels in outpatients at an oriental medical clinic. Methods : A cross-sectional study based on clinical records was conducted on 504 patients at one Oriental medical clinic in Seoul, Korea. They were tested a liver function tests for screening and 497 patients ranging from the age of 4 to 74 were chosen for the study. Patients with basal liver disease or DM were excluded during the screening process. Patients were classified into case(abnormal) and control(normal) groups by normal liver function test references. Results and Conclusions : In this study, Significant correlations for abnormal total bilirubin levels was age, for abnormal AST was gender, for abnormal ALT were gender, smoking, marriage status, and job, for abnormal ${\gamma}$GT were age, gender, obesity, alcohol, smoking, marriage status, and job using the Chi-square test(p<0.05). There was no significant correlations for abnormal LFTs by using herbal medication history, and intake duration. After controlling other covariates, logistic regression analysis showed that the significant associated factors for abnormal total bilirubin levels were age(odds ratio[OR]=0.87, 95% confidence intervals [CI]=0.87-0.99). For abnormal AST levels was obesity(OR=2.45, CI=1.2-4.9), for abnormal ALT levels were age(OR=1.01, CI=0.99-1.03), male gender(OR=3.31, CI=1.62-6.76), and obesity(OR=3.71 CI=2.28-6.08). For abnormal ${\gamma}$GT levels were male gender(OR=4.83 CI=1.34-17.43), obesity(OR=3.29, CI=1.74-6.22), alcohol (OR=2.51, CI=1.19-5.28), and smoking(OR=2.29, CI=1.16-4.50). Herbal medication history was not as a risk factor for all abnormal liver function tests. Therefore, people who are male, obese, alcohol drinker and smoker will have higher liver function test levels. But intake of herbal medication or the duration of intake may not be the risk factor for abnormal liver function test results.

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비만증(肥滿症)과 간기능(肝機能) 이상(異常)을 동반(同伴)한 환자(患者) 11례(例)에 대한 임상적(臨床的) 고찰(考察) (The Clinical Study on Abnormal Liver Function Patients Caused by Obesity)

  • 임춘우;김경훈;박영준;박주한;윤보현
    • 대한한방내과학회지
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    • 제22권4호
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    • pp.547-555
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    • 2001
  • Objectives: Obesity is regarded as the aggregation of needless risk factors, for instance, cardiovascular disease, joint disease, induce cancer. We studied on interrelation between abnormal liver function and obesity. Methods: We analyzed liver function, T.Cholesterol, Triglyceride before and after lose weight treatment. The collateral condition is over 6 weeks period on obesity treatment, no liver injury and no complicated another disease on personal past history and found out abnormal impression on biochemical liver function blood test. Results: The improvement rate of LFT, compare with before treatment is 10.6% in T.Bilirubin, 11.1% in ALP, 21% in AST, 38% in ALT, 37.3% in r-GTP, 9.2% in LDH and decreased 2.7% in T.Protein, increased 2.3% in Albumin. Hyperlipidemia is 19.4% in T.Cholesterol, 42.5% in Triglyceride. Conclusions: LFT and Hyperlipidemia of abnormal liver function patients, caused by obesity, is improved to normal limit in proportion to reduce patient's weight.

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형방도적산가미방(荊防導赤散加味方) 투여로 치료한 소양인 결흉증(少陽人 結胸證)으로 변증된 간기능 수치 이상 소견을 보인 환자 증례 보고 3례 (Three Cases of Patients Who Showed Abnormal Liver Function Values in Soyangin Gyolhyungjeung Treated with Hyeongbangdojeok-san-gami)

  • 손경우;박수아;이흔주;백지영;남우진
    • 대한한방내과학회지
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    • 제37권2호
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    • pp.166-175
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    • 2016
  • Objectives: This case study reports on improvements after treating patients who had abnormal liver function values in Soyangin gyolhyungjeung with Soyangin hyeongbangdojeok-san-gami.Methods: The study was carried out with three patients who showed abnormal liver function values in Soyangin gyolhyungjeung. Liver function tests (LFT) and numerical rating scales (NRS) were used to evaluate symptoms.Results: After we treated three patients with Soyangin hyeongbangdojeok-san-gami, their symptoms and LFT results had improved considerably.Conclusions: Soyangin hyeongbangdojeok-san-gami appears to have a useful effect on abnormal liver function values in Soyangin gyolhyungjeung. Further clinical studies are needed to verify these findings.

Influence of Prescribed Herbal and Western Medicine on Patients with Abnormal Liver Function Tests: A Retrospective Quasi-Experimental Study

  • Lee, Ah-Ram;Yim, Je-Min;Kim, Won-Il
    • 대한약침학회지
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    • 제15권1호
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    • pp.34-39
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    • 2012
  • Objectives: The aim of this study was to investigate the safety and the efficacy of Korean herbal, western and combination medicine use in patients with abnormal liver function tests. Methods: We investigated nerve disease patients with abnormal liver function tests who were treated with Korean herbal, western and combination medicine at Dong-Eui University Oriental Hospital from January 2011 to August 2011. We compared aspartic aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and total bilirubin (T-bil) levels before and after taking medicine and excluded patients who had liver-related disease when admitted. Results: AST and ALT were decreased significantly in patients who had taken herbal, western medicine. AST, ALT and ALP were decreased significantly in patients who had taken combination medicine. Compare to herbal medicine, AST, ALT and ALP were decreased significantly in patients who had taken western medicine, and ALT and ALP were decreased significantly in patients who had taken combination medicine. There were no significant differences between western and combination medicine. Conclusions: This study suggests that prescribed Korean herbal medicine, at least, does not injure liver function for patients', moreover, it was shown to be effective in patients with abnormal liver function tests.

한방비만치료가 비만환자의 간기능에 미치는 영향 증례보고 (Effects of the Obesity Therapy with Korean Herbal Medicine on Liver Function: Case Series)

  • 이지현;전우현
    • 한방비만학회지
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    • 제17권1호
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    • pp.54-60
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    • 2017
  • 비만을 주소증으로 내원하여 LFT를 시행하고, 한약 치료를 포함한 비만 치료 경과 후 다시 추적한 결과 체중 감량과 간효소 수치의 개선 경향을 보인 10예를 보고하였다. 본 연구를 토대로 한약 치료를 포함한 한방 비만치료 시 유효성과 안전성에 대한 근거를 더 확보해나갈 수 있을 것으로 생각된다.

가와사끼 병에 합병된 간기능 이상소견에 대한 임상적 및 병리조직학적 소견 (Clinical and Histopathologic Findings on the Abnormal Liver Function Complicated with Kawasaki Disease)

  • 이성철;차한;나송이;김희섭;박호진;신미경
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • 제3권1호
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    • pp.47-55
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    • 2000
  • Purpose: The aim of this research is to examine the abnormal liver function complicated with Kawasaki disease (KD) and to analyze its clinical characteristics and complications. Methods: Ninty eight cases were diagnosed as having KD, among which thirty four cases had abnormal alanine aminotransferase (ALT) (>30 IU/L). These abnormal ALT cases were evaluated in terms of age and sex distribution, major symptoms, complications, laboratory and histopathologic findings. Results: Male to female ratio was 2.4:1 and most patients (91.2%) were under 5 years of age. Cervical lymphadenopathy was observed in 3 cases (8.8%); and recurred cases were two (5.8%). Average fever duration was 8 days; average length of hospitalization was 9 days; and average recovery period was 13 days. Immediately after admission, positive CRP was observed in 31 cases (91.2%), leukocytosis (> $10,000/mm^3$) in 26 cases (76.0%), thrombocytosis (> $450,000/mm^3$) in 7 cases (20.6%), and anemia (<10 gm/dl) in 7 cases (20.6%), respectively. GB hydrops or cholecystitis were noted in 3 cases (8.8%), abnormal ECG finding in 1 case (2.9%), coronary dilatation or aneurysm in 2 cases (5.9%). Liver biopsy was done in four cases and revealed mild infiltration of lymphocytes on the portal area and mild bile duct proliferations. Conclusion: The abnormal liver function was noted in 34.7% of KD patients, and subsided all within one month. But the liver function test should be checked closely in patients of the abnormal liver function test complicated with KD despite of its good prognosis.

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항암제와 함께 옻나무 전탕추출물(치종탕)을 복용한 암환자의 간기능 검사에 대한 후향적 조사 (A Retrospective Analysis of Liver Function Test in Cancer Patients Taking Rhus Verniciflua STOKES Decoction(Chijongtang) with Anti-cancer Drugs)

  • 윤종훈;김정현;김보근;박상채
    • 대한암한의학회지
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    • 제16권2호
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    • pp.19-23
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    • 2011
  • Objectives : The aim of this study was to evaluate safety of Rhus Verniciflua STOKES as a combination therapy of Oriental and conventional cancer treatment. So, We investigated liver function test(especially total bilirubin, AST, ALT, and ALP) levels in outpatients at an oriental medical clinic, to know whether Rhus Verniciflua STOKES decotion (Chijongtang) was hepatotoxic. The outpatients were treated with Rhus Verniciflua STOKES decotion(Chijongtang) during intravenous or oral chemotherapy. Methods : We surveyed whether Chijongtang caused liver injury in patients, who visited and took Chijongtang at Hana oriental medical clinic, from March, 2008 to November 2011. We looked over all the liver function tests of those patients, done during medication. Patients who had no records of liver function tests or with basal liver disease were excluded. And patients were classified into normal and abnormal liver function groups. Results and Conclusions : 48 patients were enrolled, and their mean dosage was 300ml/day, and the mean medication period was 9.3 (2-42) months. During and after medication, there were no abnormal liver function test results at all, in the normal liver function group. and 10 out of 11 patients in the abnormal liver function group showed normal liver function test levels. Roughly speaking, according to the above results, it seems that taking Chijongtang did not cause hepatotoxicity. And it seems Chijongtang has hepatoprotective effect. But we still need more laboratory and clinical research to reach a more definitive conclusion.

수술후 10년 이상 장기 생존 담도폐쇄증 환장에서의 영양상태 및 임상적 특성에 관한 분석 (Clinical & Nutritional Assessments of Long-term Survivors of Biliary Atresia)

  • 전용순;김우기
    • Advances in pediatric surgery
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    • 제4권2호
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    • pp.125-130
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    • 1998
  • To assess the clinical and nutritional status of long-term survivors of biliary atresia, history taking, medical record review, physical examination (height, weight, MAC, TSF), blood tests (LFT, prothrombin time, platelet count, prealbumin, calcium) and liver needle biopsy were performed in 12 patients in whom Kasai procedure were performed more than 10 years ago at Department of Pediatric Surgery in Seoul National University Hospital. None were below the 5th percentile in height and weight. TSF was above the 75th percentile in all patients and showed good subcutaneous fat deposition. MAC was above the 5th percentile in all patients. Serum prealbumin level was abnormal in 2 patients with abnormal liver function and revealed visceral protein malnutrition. Serum calcium level was decreased below normal range in 4 patients with abnormal liver function. One patient had mild ascites. Five patients had abnormal liver function and 7 patients showed clinical manifestation of portal hypertension. Liver needle biopsy was performed in 5 patients and no cirrhotic change was observed. Although some patients who have survived for more than 10 years after Kasai procedure developed protein malnutrition and vitamin deficiencies, growth and development and nutritional status were generally satisfactory. Five patients(42%) showed normal liver function and no portal hypertension. In conclusion, Kasai procedure is satisfactory as a primary treatment in biliary atresia but significant portion of long-term survivors had abnormal liver function and portal hypertension. Continuous and careful follow-up is necessary to determine when liver transplantation may be indicated.

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남녀근로자의 복부비만에 따른 대사증후군 구성요소, 비정상 간기능 및 생활습관 비교 (Comparison of Metabolic Syndrome Components, Abnormal Liver Function, and Living Habits according to Abdominal Obesity in Male and Female Workers)

  • 박하니;이여진
    • 한국직업건강간호학회지
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    • 제22권4호
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    • pp.334-342
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    • 2013
  • Purpose: This study attempted to compare the metabolic syndrome components, liver function and heathy living habits according to abdominal obesity in male and female workers. Methods: The subjects of this study are 1,078 adult workers who visited N hospital in Incheon for health examination. The data were analyzed using t-test or $x^2$-test with the SPSS/WIN 20.0 program. Results: Prevalence of metabolic syndrome are 22.2% in male workers, and 5.2% in female workers. There were significant differences in 4 metabolic syndrome components (high blood pressure, elevated blood sugar, hypertriglyceridemia, low HDL cholesterolemia), abnormal liver function, and living habits (alcohol drinking) according to abdominal obesity in male workers. There were significant differences in 1 metabolic syndrome component (low HDL cholesterolemia), and abnormal liver function in female workers. Conclusion: It is important to manage all metabolic syndrome components and alcohol drinking in the case of male workers with abdominal obesity, and low HDL cholesterolemia in the case of female workers. Also, occupational nurses should include the relevance between abdominal obesity and liver function index when training health for workers in workplace.

한.양방 입원 환자의 비정상 간기능 검사 발생률 비교 (Comparison of Incidence of Abnormal Liver Function Test between Inpatients Who Take Traditional Korean versus Conventional Medicine)

  • 한창우
    • 대한한방내과학회지
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    • 제31권1호
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    • pp.79-83
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    • 2010
  • Herbal hepatotoxicity is a one of the most often encountered controversial issues in medical society. Some believe herbs are totally safe while others regard treatment with herbs as a very common cause of hepatotoxicity. But there are no comparative clinical hepatotoxicity studies between herbal and conventional medicines. We investigated incidence of patients with abnormal liver function who were treated with herbal or conventional medicine at Dongguk University International Hospital. Each group consisted of 300 patients, who were admitted for longer than 30 days during the year 2008. We compared albumin, total bilirubin, AST (aspartate aminotransferase), and ALT (alanine aminotransferase) levels, and excludes patients who had abnormal liver function test or liver-related disease when admitted. As a result, incidence of total bilirubin, AST, and ALT elevation in the CT (conventional treatment) group was more frequent than in the TKM (traditional Korean medicine) group (p<0.05) during admission. Albumin level also decreased more frequently in the CT group than in the TKM group (p<0.05). According to these results, herbal medicine is not more hepatotoxic than conventional medicine, and not a main cause of liver injury in inpatients.