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Influence of Prescribed Herbal and Western Medicine on Patients with Abnormal Liver Function Tests: A Retrospective Quasi-Experimental Study

  • Lee, Ah-Ram (Department of Oriental Internal Medicine, Dong-Eui University College of Oriental Medicine) ;
  • Yim, Je-Min (Department of Oriental Internal Medicine, Dong-Eui University College of Oriental Medicine) ;
  • Kim, Won-Il (Department of Oriental Internal Medicine, Dong-Eui University College of Oriental Medicine)
  • Received : 2012.01.20
  • Accepted : 2012.03.12
  • Published : 2012.03.31

Abstract

Objectives: The aim of this study was to investigate the safety and the efficacy of Korean herbal, western and combination medicine use in patients with abnormal liver function tests. Methods: We investigated nerve disease patients with abnormal liver function tests who were treated with Korean herbal, western and combination medicine at Dong-Eui University Oriental Hospital from January 2011 to August 2011. We compared aspartic aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and total bilirubin (T-bil) levels before and after taking medicine and excluded patients who had liver-related disease when admitted. Results: AST and ALT were decreased significantly in patients who had taken herbal, western medicine. AST, ALT and ALP were decreased significantly in patients who had taken combination medicine. Compare to herbal medicine, AST, ALT and ALP were decreased significantly in patients who had taken western medicine, and ALT and ALP were decreased significantly in patients who had taken combination medicine. There were no significant differences between western and combination medicine. Conclusions: This study suggests that prescribed Korean herbal medicine, at least, does not injure liver function for patients', moreover, it was shown to be effective in patients with abnormal liver function tests.

Keywords

References

  1. Lee DS, Back JT, Kim JS, Jeung SJ, Lee HK, Ahn BM, et al. A case of toxic hepatitis caused by the Chinese diet food. Korean J Med. 2003;65(3):689-692.
  2. Kim BU. An Impact of Saeng-Gan-Geon-Bi-Tang on the Metabolism and Reproduction of the Liver and Bowels. J Korean Oriental Med. 1982;22(1):32-57.
  3. Kim YS, Cho JH, Mun SG, Cho GH, Bae HS, Lee GS. An Impact of Long-term Administration of Herbal Medicine on the Injury of Liver. Kyung Hee Medicine. 1999;15(1):71-6.
  4. Park SJ, Lee HM, Kang YK, Jeon SY, Kim JW. A case study of herbal-medicine-induced liver injury improved with Taeumjowe-tang. J of Sasang Constitutional Medicine. 2010; 22(2);135-142.
  5. Choi HS, Jeong TY. One case of drug-induced liver injury treated with Saenggangeonbi-tang. Korean J Orient Int Med. 2004;25(4):207-211.
  6. Han CW, Kim SY, Min KS, Lee JH, Lee SH, Youn YS. Incidence of liver function test abnormality among patients hospitalized in an oriental hospital. J Korean Oriental Med. 2010;31(2):109-113.
  7. Yun YJ, Shin BC, Lee MS, Cho SI, Park JH, Lee HJ. Systematic review of the cause of drug-induced liver injuries in Korean literature. J Korean Oriental Med. 2009;30(2):30-45.
  8. Kim DJ. A preliminary multicenter study for the detection of toxic hepatitis induced by various plant preparations and healthy foods and the development of nationwide reporting system of toxic hepatitis. National Institute of Toxicological Research. 2003:12.
  9. Lee JH, Ryu IY, Yun SJ, Shin WH, Lee JS, Choi YH, et al. Seventeen cases with herbal medicine-induced Hepatitis. Korean J Gastroenterol. 1998;32(1):69-74.
  10. Wai CT, Tan BH, Chan CL, Sutedja DS, Lee YM, Khor C, et al. Drug-induced liver injury at an Asian center: a prospective study. Liver International. 2007;27(4):465-474. https://doi.org/10.1111/j.1478-3231.2007.01461.x
  11. Rhee SH, Park JS, Yeo HS, Choi YK, Jun CY, Park CH, et al. Relationship between herb-medicine and liver damage. Korean J Orient Int Med. 2006;27(3):572-578.
  12. Paeck EK, Park JH, Park JH, Yoon YJ, Jeong SK, Lee HJ, et al. Influence of taking medicine for a period of time on the liver function and improvement of the developmental disordered children. Korean J Oriental Physiology & Pathology. 2006;20(2):494-497.
  13. Lesley Rees, Andrew Weil. Imbuse orthodox medicine with the value of complemetary medicine. British Medical Journal. 2001:119-120.
  14. Pittler MH, Ernt E. Systematic Review: hepatotoxic events associated with herbal medicinal products. Aliment Pharmacol Ther. 2003;18(5):451-471. https://doi.org/10.1046/j.1365-2036.2003.01689.x
  15. Ichiro Shimisu. Effect of Sho-saiko-to, a Japanese Herbal Medicine on Hepatic Fibrosis in Rat. Hepatology. 1999;29(1): 149-160. https://doi.org/10.1002/hep.510290108
  16. Department of Internal Medicine, Medical College, Seoul National University. Clinical Internal Medicine 1st ed. Korea Medical Book Publisher. 2004:468-512.
  17. Chun WJ, Yoon BG, Kim NI, Lee G, Yang CH, Lee CW, et al. A clinical study of patients with acute liver injury caused by herbal medication in Gyeongju area. Korean J Med. 2002;62(2):141-150.
  18. Yun YJ, Shin BC, Lee MS, Cho SI, Park JH, Lee HJ. Systematic review of the cause of drug-induced liver injuries in Korean literature. J Korean Oriental Med. 2009;30(2):30-45.
  19. Kim YJ. Interpretation of liver function tests. Korean J Gastroenterol. 2008;51(4):219-224.
  20. Yun YJ, Park EK, Park JH, Jeong SK, Park HM, Lee SD, et al. Safety of prescribed Korean herbal medicine on liver function: prospective multi-center pilot study. Korean J Oriental Physiology & Pathology. 2009;23(3):715-722.