• Title/Summary/Keyword: Zn(II)

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Synthesis, Characterization and Biological Activities of 4-(p-Chlorophenyl)-1-(pyridin-2-yl)thiosemicarbazide and Its Metal Complexes

  • Hassanien, Mohammad M.;Mortada, Wael I.;Hassan, Ali M.;El-Asmy, Ahmed A.
    • Journal of the Korean Chemical Society
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    • v.56 no.6
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    • pp.679-691
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    • 2012

  • New series of metal complexes of Co(II), Ni(II), Cu(II), Zn(II), Pd(II) and Pt(II) with 4-(p-chlorophenyl)-1-(pyridin-2-yl)thiosemicarbazide (HCPTS) have been synthesized and characterized by elemental analyses, magnetic moment, spectra (IR, UV-Vis, $^1H$ NMR, mass and ESR) and thermal studies. The IR data suggest different coordination modes for HCPTS which behaves as a monobasic bidentate with all metal ions except Cu(II) and Zn(II) which acts as a monobasic tridentate. Based on the electronic and magnetic studies, Co(II), Cu(II), Pd(II) and Pt(II) complexes have square - planner, Ni(II) has mixed stereochemistry (tetrahedral + square planar), while Zn(II) is tetrahedral. Molar conductance in DMF solution indicates the non-ionic nature of the complexes. The ESR spectra of solid copper(II) complex show $g_{\parallel}$ (2.2221) > $g_{\perp}$ (2.0899) > 2.0023 indicating square-planar structure and the presence of the unpaired electron in the $d_x2_{-y}2$ orbital with significant covalent bond character. The thermal stability and degradation kinetics of the ligand and its metal complexes were studied by TGA and DTA and the kinetic parameters were calculated using Coats-Redfern and Horowitz-Metzger methods. The complexes have more antibacterial activity against some bacteria than the free ligand. However, the ligand has high anticancer activities against HCT116 (human colon carcinoma cell line) and HEPG2 (human liver hepatocellular carcinoma cell line) compared with its complexes.

  • https://doi.org/10.5012/jkcs.2012.56.6.679 인용 PDF KSCI KPUBS HTML

Cytotoxic Effects of Some Transition Metals, Nickel(II), Copper(II) and Zinc(II), with 3.6-bis(2'-pyridyl)pyridazines Complexes (몇 가지 전이금속, Ni(II), Cu(II) 및 Zn(II) 3,6-bis(2'-pyridyl)pyridazine 착 화합물들의 세포 독성효과)

  • Kwon, Byung-Mok;Lee, Chong-Ock;Choi, Sang-Un;Sung, Nack-Do
    • Applied Biological Chemistry
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    • v.49 no.1
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    • pp.21-24
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    • 2006

  • A series of cytotoxic activities $(ED_{50})$ in vitro against six human cancers (lung cancer, uterine cancer, skin cancer, brain cancer, colon cancer and adenocarcinoma) and their seventeen cell lines of 3,6-bis(2'-pyridyl)pyridazine, 1, 3,6-bis-(6'-methyl-2'-pyridyl)pyridazine, 2 and their transition metal, Ni(II), Cu(II) and Zn(II) complexes, $3{\sim}6$ were measured. Particularly, the results revealed that the cytotoxic activities against the brain cancer cell line (SNB-19) and the colon cancer cell line (SW62) of bis- [3,6-bis-(6'-methyl-2'-pyridyl)pyridazine-$k^2N^2,N^3$]chlorocopper(II)perchlorate, 4 were shown to be higher than that of the first generation anticancer agent, Cis-platin.

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Stydies on the Hexagonal Ferrites(II) The Nagnetostricton pf Ferroxplana $Co_{1-x}Zn_xZ$($BA_3Co_{2(1-x)}Zn_{2x} Fe_{24}O_{41}$)) (Hexagonal Ferrite 에 관한 연구(II) Ferroxplana $Co_{1-x}Zn_xZ$($BA_3Co_{2(1-x)}Zn_{2x} Fe_{24}O_{41}$)의 Magnetostriction)

  • 김태옥
    • Journal of the Korean Ceramic Society
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    • v.13 no.4
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    • pp.5-8
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    • 1976

  • Both oriented and non-oriented ferroxplana $Co_{1-x}Zn_xZ(Ba_3Co_{2(1-x)}Zn_{2x} Fe_{24}O_{41})$ with x=0.00, 0.45 were prepared by conventional ceramic method. The magnetostrictions of thus prepared specimens were measured by use of the three terminal capacitor device at room temperature. The magnitude of measured values was approximately five times greater than that of ZnY ferroxplana. The easy-magnetization plane at room temperature of both CoZ and Co0.55 $Zn_{0.45}$Z was their basal plane. The magentostrictions in the basal plane and the other planes showed saturated values at magnetic field intensity of about 2Koe and 4Koe, respectively. The magnetostriction constants $K_1, \; K_2, \;K_3\; and\; K_4$ for CoZ were -2.4, -10.5, -5.9 and -45.2$\times10^{-6}$ , while those for $Co_{0.55}Zn_{0.45}Z$ were +0.1, -1.2, -6.3 and -39.0$\times$10^{-6}, , respectively.

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