• Journal of Ginseng Research
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• v.43 no.3
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• pp.460-474
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• 2019

Background: Ginsenoside compound K (CK) is a promising drug candidate for rheumatoid arthritis. This study examined the impact of polymorphisms in NR1I2, adenosine triphosphate-binding cassette (ABC) transporter genes on the pharmacokinetics of CK in healthy Chinese individuals. Methods: Forty-two targeted variants in seven genes were genotyped in 54 participants using Sequenom MassARRAY system to investigate their association with major pharmacokinetic parameters of CK and its metabolite 20(S)-protopanaxadiol (PPD). Subsequently, molecular docking was simulated using the AutoDock Vina program. Results: ABCC4 rs1751034 TT and rs1189437 TT were associated with increased exposure of CK and decreased exposure of 20(S)-PPD, whereas CFTR rs4148688 heterozygous carriers had the lowest maximum concentration ($C_{max}$) of CK. The area under the curve from zero to the time of the last quantifiable concentration ($AUC_{last}$) of CK was decreased in NR1I2 rs1464602 and rs2472682 homozygous carriers, while $C_{max}$ was significantly reduced only in rs2472682. ABCC4 rs1151471 and CFTR rs2283054 influenced the pharmacokinetics of 20(S)-PPD. In addition, several variations in ABCC2, ABCC4, CFTR, and NR1I2 had minor effects on the pharmacokinetics of CK. Quality of the best homology model of multidrug resistance protein 4 (MRP4) was assessed, and the ligand interaction plot showed the mode of interaction of CK with different MRP4 residues. Conlusion: ABCC4 rs1751034 and rs1189437 affected the pharmacokinetics of both CK and 20(S)-PPD. NR1I2 rs1464602 and rs2472682 were only associated with the pharmacokinetics of CK. Thus, these hereditary variances could partly explain the interindividual differences in the pharmacokinetics of CK.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.39 no.2
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• pp.307-316
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• 2019

Development of vegetation in stream channel increases resistance to flow, resulting in increase in river stage upon flood and affecting change in stage-discharge relationship. Vegetation revealed in stream by water level reaching a peak and then declined upon flood is mostly found as prone. Taking an account of flow distribution with the number of vegetation, prone vegetation layer might be at height where discharge rate is zero (0) (Stephan and Guthnecht, 2002). However, there is a tendency that flow rate is overestimated when applying the height of river bed to flow area with no consideration of the height of vegetation layer in flow rate by float measurement. In this study, reliable flow measurement in stream with vegetation was calculated by measuring the height of vegetation layer after flood and excluding the vegetation layer-projected area from the flow area. The result showed the minimum 4.34 % to maximum 10.82 % of flow deviation depending on the scale of discharge. Accordingly, reliable velocity-area methods would be determined if vegetation layer-projected area in stream is considered in flow rate estimation using the flow area during the flood.

• Journal of IKEEE
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• v.23 no.1
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• pp.14-21
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• 2019

In this paper, we implemented an on-board miniaturization antenna operating 2.4 GHz using MZR(Mu Zero Resonator). It is must be operating under the constraint that the size of the small terminal PCB should be $78{\times}38{\times}0.8mm^3$ and the size of the system should be $63{\times}38{\times}0.8mm^3$ and the size of the radiating part should be $15{\times}38{\times}0.8mm^3$. The feeding structure uses a CPW structure for stable feeding and a feeding point at the upper left of the system board. A magnetic field coupling structure is used for coupling the feeding part and the antenna. The resonance frequency of the MZR is determined by the series inductance and capacitance of the cell, so the gap between the cells, the length of the cell, the length of the interdigital capacitor, and the spacing between the radiation part and the ground plane are analyzed. The antenna was designed and fabricated using the results. The total size of the antenna including the feed structure is $20.8{\times}9.0{\times}0.8mm^3$, and the electrical length is $0.1664{\lambda}_0{\times}0.072{\lambda}_0{\times}0.0064{\lambda}_0$. The measurement result for 10 dB bandwidth, gain and directivity are 440 MHz(18.3%), 0.4405 dB, and 2.722 dB respectively. It is confirmed that the radiation pattern has omnidirectional characteristics and it can be applied to ultra small terminal antenna.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.5
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• pp.591-598
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• 2019

The statistics of committing suicide in S. Korea is ranked in top with serious attempts of falling among OECD countries since 2003. The rates is slightly dropped by 5 percent point, nevertheless the falling is still high for the age of over 10 years old and this matter must be solved. Most of the case of suicides are the falling based on a trend view of falling which is serious matter and cannot be solved easily for both domestic and foreign countries. For example, the steel net of falling prevent was installed in the Golden Gate Bridge costed by 200 million-dollar. In New Zealand, the steel net of falling prevention had been removed and re-installed beccause of the high suicide rates. Canada and Australia also surrounded the bridge with steel fences to prevent suicide without consideration of the beauty of bridge. Therefore, this paper suggested a comparison study on both falling prevention systems in all countries and patent technologies. Also, it covers the blocking skills of approach in both security and limited area. This paper suggested the technical Rollinder system equipped with the mechanical apprentice to prevent effectively the falling sucides and wall passing. Before the installation of Rollinder System by 2016, there were 33 person who tried to fall in the river in Machang Bridge. However, the number of the committing suicides were dramatically reduced to zero after the installation of the system.

• Journal of The Korean Society of Clinical Toxicology
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• v.16 no.2
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• pp.68-74
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• 2018

Purpose: In 2012, a revised guideline for acute acetaminophen overdose was proposed in the UK, recommending that the treatment threshold should be lowered to 100 mcg/ml at 4 hours after ingestion without risk stratification of hepatotoxicity. However, the poison centers in some developing countries do not have laboratory resources to provide serum drug levels in time. The primary aim of the study is to evaluate the cut-off value of reported dose per kilogram to determine when N-acetylcysteine treatment is warranted under the revised guideline. Methods: Data were collected retrospectively from the toxicology registry of an urban emergency medical center between 1st January 2010 and 30th June 2017. Inclusion criteria were single acute overdose of more than 75 mg/kg in 15 hours from ingestion and over 14 years of age. Subgroups were created by 25 mg/kg increments of reported dose, then sensitivity, specificity, positive predictive value and negative predictive value were calculated for the cut-off values of 100 mg/kg, 125 mg/kg, 150 mg/kg and 175 mg/kg for toxic serum level over '100-treatment line'. Results: A total of 99 patients were enrolled in the study; 24 patients showed toxic serum levels (24.2%). Zero of 17 patients with an ingestion dose under 100 mg/kg showed toxic level (0%), and 0 of 15 under 125 mg/kg (0%), 2 of 14 under 150 mg/kg (14.3%), and 4 of 12 under 175 mg/kg (33.3%) had toxic levels. The higher the ingested dose per kilogram of weight, the higher the frequency of the toxic serum concentration on the first test (${\chi}^2$ test for trend, ${\chi}^2=22.66$, p-value<0.001) and the sensitivity of each value was 100%, 100%, 92% and 76%. Conclusion: In acute single acetaminophen intoxication, the ingestion dose of 100 mg/kg of weight will be useful in determining the need for the N-acetylcysteine antidote in the indigent laboratory environment.

• Korean Journal of Remote Sensing
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• v.35 no.2
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• pp.327-336
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• 2019

The caldera lake "Chun-ji" is located at the summit of Baekdu volcano, which is in the border of China and North Korea. Chun-ji Lake has altitude 2,189 m above sea level. The Chun-ji is freezing in the winter when the water temperature goes down to zero for a year, and it melts in the season when the water temperature goes up again. However,since it is located at a high altitude, there are many cloudy days, and it is difficult to observe with optical images. For this reason, radar images, which are less influenced by weather than optical images, are more effective for observing the ice of heaven and earth. In this study, 75 TerraSAR-X images from chun-ji area were used for analysis from 2015 to 2017, and the calculated ice area and temperature changes were analyzed. As a result, the ice of the caldera lake formed was formed in early December and slowly melted until mid-April. During this period, temperatures in the Samjiyeon area were about $-10^{\circ}C$ when ice was produced, and the temperature was about $0^{\circ}C$ in mid-April when it was thawing. Correlation coefficients between ice surface area and temperature in winter 2015 and 2016, where global ice is produced,show a high correlation of -0.82 and -0.75. In addition to the results of this study, it can be used as an indicator to monitor the volcanic activity by comparing the result of the recent volcanic activity with the result of the increase in water temperature using various imagery.

• Journal of Korean Society of Forest Science
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• v.110 no.2
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• pp.233-243
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• 2021

Considering worldwide efforts to mitigate repercussions of climate change, the South Korean government has declared to reach net zero by 2050 to achieve a carbon-neutral sustainable society. For full implementation of NDCs, the government has actively reflected its forestry sector into these strategies. Since coarse woody debris (CWD) in forests represents an enduring carbon storage, it is of particular significance to determine characteristics of changes in carbon stocks of CWD by utilizing data on dead trees monitored in permanent sample plots within national forest inventories (NFIs). In this study, therefore, both occurrence and carbon stocks of CWD were estimated in such plots using data on CWD from the 5^th, 6^th, and 7^th NFIs. Subsequently, characteristics of changes in carbon stocks over time were analyzed. Based on the analysis of 2,021 plots available for monitoring in each NFI of Gangwon Province, the volume of CWD (m³ ha^-1) was found to be 4.71 in the 5^th NFI and 4.09 in the 6^th NFI. However, the volume of CWD declined to 3.09 in the 7^th NFI. Moreover, the annual carbon stocks of CWD (ton C ha^-1) were estimated to be 0.67 in 2009, 0.64 in 2014, and 0.41 in 2019, showing a downward trend over time. This study provides a basis for future research to investigate long-term changes and estimate carbon stocks of CWD in South Korea forests.

• Journal of Bio-Environment Control
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• v.28 no.4
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• pp.311-321
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• 2019

Greenhouse farmers often use thermal screens to reduce greenhouse heating expenses during the winter, and for shade during hot, sunny days in the summer, as it is an inexpensive solution to temperature control relative to other available options. However, accurate measurements of their emitted and absorbed radiations are important for the selection of suitable screens that offer maximum performance. Material's ability to save energy is highly dependent on these properties. Limited studies have investigated the measurement of these properties under natural conditions, but they are only applicable to materials having partial porosities. In this work, we describe a new radiation balance method for determining emissive power and absorptive capacity, as well as reflectivity, transmissivity and emissivity of materials having complete and partial transparency by using pyrgeometer and net radiometer. In this study, four materials with zero porosity, were tested. The emissivity value of PE, LD-13, LD-15 and PH-20 was $0.439{\pm}0.020$, $0.460{\pm}0.010$, $0.454{\pm}0.004$, and $0.499{\pm}0.006$, respectively. All tested samples showed high emitted radiation as compared to absorbed radiation.

• Journal of Internet Computing and Services
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• v.20 no.5
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• pp.27-36
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• 2019

In this study, experiments on the improvement of the emotion classification, analysis and accuracy of EEG data were proceeded, which applied DEAP (a Database for Emotion Analysis using Physiological signals) dataset. In the experiment, total 32 of EEG channel data measured from 32 of subjects were applied. In pre-processing step, 256Hz sampling tasks of the EEG data were conducted, each wave range of the frequency (Hz); Theta, Slow-alpha, Alpha, Beta and Gamma were then extracted by using Finite Impulse Response Filter. After the extracted data were classified through Time-frequency transform, the data were purified through Independent Component Analysis to delete artifacts. The purified data were converted into CSV file format in order to conduct experiments of Machine learning algorithm and Arousal-Valence plane was used in the criteria of the emotion classification. The emotions were categorized into three-sections; 'Positive', 'Negative' and 'Neutral' meaning the tranquil (neutral) emotional condition. Data of 'Neutral' condition were classified by using Cz(Central zero) channel configured as Reference channel. To enhance the accuracy ratio, the experiment was performed by applying the attributes selected by ASC(Attribute Selected Classifier). In "Arousal" sector, the accuracy of this study's experiments was higher at "32.48%" than Koelstra's results. And the result of ASC showed higher accuracy at "8.13%" compare to the Liu's results in "Valence". In the experiment of Random Forest Classifier adapting ASC to improve accuracy, the higher accuracy rate at "2.68%" was confirmed than Total mean as the criterion compare to the existing researches.

• The Journal of the Korea Contents Association
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• v.21 no.2
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• pp.362-373
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• 2021

This study sought to explore the enhancement of the introduction of teaching and learning methods for Problem Based Learning (PBL) and the evaluation factors to evaluate them effectively through an understanding lecture in Cultural Content Planning. It was intended to incorporate a practical zero-volume education methodology of problem-oriented learning and sufficient leading learning to reflect storytelling in the entire process of completing a cultural content with culture, cultural content, and content planning. To this end, the role of teaching methods should be faithful to ensure that teamwork and cooperation can be done organically according to the educational field, practice and situation. Students who take classes were asked to meet demand, reflect it through surveys, apply real-world problems, and acquire the entire course. Learners had to cooperate with each other until planning cultural content and completing the results through classes, and they evaluated themselves and colleagues in teamwork until the last result was completed from creative ideas. The results were shared together and the students were able to investigate the necessary PBL evaluation factors for themselves, and the prior research and survey on the method of PBL evaluation was conducted to derive the factors of understanding of cultural content planning. The derived assessment elements were able to identify priorities between the assessment elements using basic statistics, word cloud analysis, and AHP analysis. The components of the assessment derived were communication skills, basic knowledge, reasoning process, expertise, and evaluation techniques. Through this article, I was able to lead the understanding of cultural content planning to problem-oriented learning classes and encourage students to be familiar and smooth.