• Geotechnical Engineering
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• v.13 no.5
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• pp.75-88
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• 1997

In this study an iterative procedure for the analysis of drilled shafts was proposed on the basis of the load transfer mechanism. Special attention was given to the estimation of bearing capacity of drilled shafts which was compared with driven piles, and then with the results of pile load test. The load displacement at the pile head was calculated by load than sfer curves (t -z curves, q-z curves) by using Vljayvergiya, Castelli and hi -linear models. Bab ed on the analytical results, it is found that the behavior of drilled shafts is different from that of driven piles the smaller the skin friction mobilized at the pile-boil interface, the smaller the development of the bearing capacity. Hence the greater pile head movement is required to mobilize the same mainitride of bearing capacity. This trend is more noticeable in sand than in clay. It is also found that as the length-todiameter ratios increase, the dirtference of ultimate bearing capacity between drilled shafts and driven piles is becoming lass ger in sand, but it is minor in clay.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.19 no.2
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• pp.111-116
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• 1983

In order to furnish the fundamental data for the domestic production of magnetic compass and the prescription of standardization about it in Korea, authors made the helmholtz coil and investigated the characteristics of them. Subsequently, the damping curves of T190 and T165 compasses in the helmholtz coil were measured and analyzed the performance of those compass. The results obtained are as follows; 1. The relation between electric current (I sub I) to flow in the helmholtz coils, that the thickness of coil is 1mm, diameter 1m, winding number 117, and intensity of magnetic field is presented as follows. Vertical magnetic force: Z(Gauss)=0.34+1.506 I sub(i) Horizontal magnetic force: H(Gauss)=0.183+1.506 I sub(i) 2. Period of T190 compass is longer than T165 compass in all horizontal magnetic force. In the amplitude, the former is larger than the latter above 0.08 Gauss, but this phenomenon is opposed to that below 0.08 Gauss. 3. As the porizontal magnetic force is intensive, period of magnetic compass is short, amplitude is large, and damping degree and damping factor are small. The time elapsed to the principal points of damping curve is proportional to the -0.65 power of the horizontal magnetic force.

• Journal of Pharmaceutical Investigation
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• v.39 no.1
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• pp.65-71
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• 2009

The aim of the present study was to evaluate the bioequivalence of two domperidone maleate tablets, Motilium-$M^{(R)}$ Tablet (Janssen Korea Ltd., reference product) and $Toriem^{(R)}$ Tablet (Daewon Pharm. Co., Ltd., test product). Domperidone was extracted by liquid-liquid extraction using tert-butyl methyl ether and separated in less than 3 min on $C_{18}$ reverse-phase column using an isocratic elution. A tandem mass spectrometer, as detector, was used for quantitative analysis in positive mode by a multiple reaction monitoring mode to monitor the m/z $426.1{\rightarrow}119.1$ and the m/z $837.4{\rightarrow}158.2$ transitions for domperidone and the internal standard (roxithromycin), respectively. Calibration curves, from $0.05{\sim}50$ ng/mL of domperidone, showed correlation coefficients (r) higher than 0.9941. Intra day and inter day precision (C.V. %) for quality control were ranged from 10.04 to 16.09% and from 10.87 to 18.69%, respectively. The lower limit of quantification (LLOQ) of domperidone was 0.05 ng/mL. The method described is precise and sensitive and has been successfully applied to the study of bioequivalence of domperidone in 24 healthy Korean volunteers. Twenty-four healthy male Korean volunteers received a single dose of each medicine ($2{\times}12.72\;mg$ domperidone maleate) in a $2{\times}2$ crossover study. There was a one-week washout period between the doses. Plasma concentrations of domperidone were monitored for over a period of 24 hr after the administration. $AUC_{0-t}$ (the area under the plasma concentration-time curve) was calculated by the linear trapezoidal rule. $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{max}$) were compiled from the plasma concentration-time data. The 90% confidence intervals for the log transformed data were within acceptable range of log 0.8 to log 1.25 (e.g., $log\;0.92{\sim}log\;1.05$ for $AUC_{0-t}$, $log\;0.81{\sim}log\;1.05$ for $C_{max}$). The major parameters, $AUC_{0-t}$ and $C_{max}$ met the criteria of KFDA for bioequivalence indicating that $Toriem^{(R)}$ tablet is bioequivalent to Motilium-$M^{(R)}$ tablet.

• Archives of Pharmacal Research
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• v.28 no.4
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• pp.463-468
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• 2005

The purpose of the present study was to develop a standard protocol for imidapril hydrochloride bioequivalence testing. For this reason, a specific LC-MS method was developed and validated for the determination of imidapril in human plasma. A solid-phase extraction cartridge, $Sep-pak^{R}$ C18, was used to extract imidapril and ramipril (an internal standard) from deproteinized plasma. The compounds were separated using a XTerra $MS^{R}$?C18 column ($3.5 {\mu}m, 2.1\times150 mm$) and $acetonitrile-0.1\%$ formic acid (67:33, v/v) adjusted to pH 2.4 by 2 mmol/L ammonium formic acid, as mobile phase at 0.3 mL/min. Imidapril was detected as m/z 406 at a retention time of ca. 2.3 min, and ramipril as m/z 417 at ca. 3.6 min. The described method showed acceptable specificity, linearity from 0.5 to 100 ng/mL, precision (expressed as a relative standard deviation of less than $15\%$), accuracy, and stability. The plasma concentration-versus-time curves of eight healthy male volunteers administered a single dose of imidapril (10 mg), gave an $AUC_{12hr}$ of imidapril of $121.48\pm35.81 ng mL^{-1} h$, and $C_{max} and T_{max}$ values of $32.59\pm9.76 ng/mL and 1.75\pm0.27 h$. The developed method should be useful for the determination of imidapril in plasma with sufficient sensitivity and specificity in bioequivalence study.

• Earthquakes and Structures
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• v.11 no.4
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• pp.665-680
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• 2016

This paper focuses on the study of seismic behavior of steel reinforced concrete special-shaped column-beam joints. Six specimens, which are designed according to the principle of strong-member and weak-joint core, are tested under low cyclic reversed load. Key parameters include the steel form in column section and the ratio of column limb height to thickness. The failure mode, load-displacement curves, ductility, stiffness degradations, energy dissipation capacity and shear deformation of joint core of the test subassemblies are analyzed. The results indicate that SRC special-shaped column-beam joints have good seismic behavior. All specimens failed due to the shear failure of the joint core, and the failure degree between the two sides of joint core is similar for the exterior joint but different for the corner joint. Compared to the joints with channel steel truss, the joints with solid web steel skeleton illustrate better ductility and energy dissipation capacity, but the loading capacity and stiffness are roughly close. With the increasing of the ratio of column limb height to thickness, the joints illustrate higher loading capacity and stiffness, better energy dissipation capacity, but worse ductility.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.24 no.8 s.179
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• pp.2074-2082
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• 2000

In this study, to investigate and to predict the crack growth behavior under variable amplitude loading, crack growth tests are conducted on 7075-T6 aluminum alloy. The loading wave forms are generated by normal random number generator. All wave forms have same average and RMS(root mean square) value, but different standard deviation, which is to vary the maximum load in each wave. The modified Forman's equation is used as crack growth equation. Using the retardation coefficient D defined in previous study, the load interaction effect is considered. The variability in crack growth process is described by the random variable Z which was obtained from crack growth tests under constant amplitude loading in previous work. From these, a statistical model is developed. The curves predicted by the proposed model well describe the crack growth behavior under variable amplitude loading and agree with experimental data. In addition, this model well predicts the variability in crack growth process under variable amplitude loading.

• Progress in Superconductivity
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• v.1 no.2
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• pp.110-114
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• 2000

We have investigated the Josephson vortex dynamics in $Bi_2Sr_2CaCu_2O{8+\delta}$ intrinsic Josephson junctions subjected to a magnetic field parallel to $CuO_2$ planes. We investigated mesas with $40\times40{\mu}m^2$ in size and containing 6 and 20. intrinsic junctions. The zero field I-V characteristics exhibited a typical hysteretic, multi-branched nature of the intrinsic Josephson effect. At high magnetic fields (H>1.5 T), I-V characteristics showed flux flow steps. The Swihart velocity obtained from this observation was about $4.2\times10^5$ m/s, which was the lowest mode electromagnetic wave velocity of N coupled stack. The experimental I-V curves fitted well into the simple model of Cherenkov radiation including Ohmic and non-linear dissipation terms. This suggests that the dissipation mechanism of Josephson vortex be due to both Cherenkov radiation and quasiparticle tunneling current.

• Quantitative Bio-Science
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• v.36 no.1
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• pp.23-31
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• 2017

Datasets from DNA microarray experiments, which are in the form of large matrices of expression levels of genes, often have missing values. However, the existing statistical methods including the principle components analysis (PCA) and Hotelling's t-test are not directly applicable for the datasets having missing values due to the fact that they assume the observed dataset is complete in general. Many methods have been proposed in previous literature to impute the missing in the observed data. Troyanskaya et al. [1] study the k-nearest neighbor (kNN) imputation, Kim et al. [2] propose the local least squares (LLS) method and Rubin [3] propose the multiple imputation (MI) for missing values. To identify differentially expressed genes, we propose a new testing procedure when the missing exists in the observed data. The proposed procedure uses the Stouffer's z-scores and combines the test results of individual imputed samples, which are dependent to each other. We numerically show that the proposed test procedure based on MI performs better than the existing test procedures based on single imputation (SI) by comparing their ROC curves. We apply the proposed method to analyzing a public microarray data.

• International journal of steel structures
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• v.18 no.5
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• pp.1684-1698
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• 2018

Fragility functions are determined for braced steel moment frames (SMFs) with plans such as square-, T-, L-, U-, trapezoidal-, and semicircular-shaped, subjected to blast. The frames are designed for gravity and seismic loads, but not necessarily for the blast loads. The blast load is computed for a wide range of scenarios involving different parameters, viz. charge weight, standoff distance, and blast location relative to plan of the structure followed by nonlinear dynamic analysis of the frames. The members failing in rotation lead to partial collapse due to plastic mechanism formation. The probabilities of partial collapse of the SMFs, with and without bracing system, due to the blast loading are computed to plot fragility curves. The charge weight and standoff distance are taken as Gaussian random input variables. The extent of propagation of the uncertainties in the input parameters onto the response quantities and fragility of the SMFs is assessed by computing Sobol sensitivity indices. The probabilistic analysis is conducted using Monte Carlo simulations. The frames have least failure probability for blasts occurring in front of their corners or convex face. Further, the unbraced frames are observed to have higher fragility as compared to counterpart braced frames for far-off detonations.

• Journal of Korean Society of Forest Science
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• v.11 no.1
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• pp.25-32
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• 1970

Site-index curves for Pinus densiflora Sieb. et Zucc. grown in the middle part of Korea were developed from stem analysis data by a procedure of guide curve equation $Yt=K-ab^t$ (t=0, 1, 2, ${\cdots}{\cdots}$) and shown in Fig. 2. The stand density expressed as size-number criteria was calculated and the relation of number of tree per hectare and average DBH was presented in Fig. 3, in which soil fertility showed little effect. When this is compared to Reineke's density standards, the Pinus densiflora stand ranks high level of stocking density (Fig. 5). As a measure for estimating timber volume, the angle-summation technique revealed to result wider variation. Constructing hypothetical populations for appraising angle-summation technique, the significance of its application in silvicultural and ecological research are discussed.