• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제9권2호
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• pp.210-217
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• 2006

목 적: 소아 크론병의 치료방법으로 스테로이드가 주로 사용되어 왔으나 스테로이드는 부작용이 많으며 특히 소아에서는 성장지연을 초래할 수 있다. 최근 성분식이 요법이 크론병의 치료에 도입되어 몇몇 장점들이 보고되고 있다. 이에 본 연구에서는 소아 크론병의 치료로서 사용된 성분식이 요법의 임상적 효과에 대해서 평가하고자 하였다. 방 법: 2001년부터 2005년까지 서울아산병원 소아과에서 크론병으로 진단된 환아 중 성분식이 요법을 받은 환아 11명과 스테로이드 치료를 받은 환아 19명의 의무기록지를 통하여 병의 관해, 재발, 성장에 미치는 영향을 후향적으로 비교 분석하였다. 결 과: 성분식이 요법을 시작한 11명 중 10명과 스테로이드 치료를 시작한 19명 중 18명에서 1년간 치료를 지속할 수 있었다. 치료 6주 안의 관해율에 있어서는 성분식이 군과 스테로이드 군 사이의 통계학적인 유의성은 없었다. 1년간의 경과 관찰기간 중 성분식이 군의 재발률은 스테로이드 군에 비해 유의하게 낮았다. 1년 뒤의 키성장을 z-score를 사용하여 비교하였으며 성분식이 군의 delta z-score는 $0.37{\pm}0.36$, 스테로이드 군은 $0.29{\pm}0.44$였으나 유의성은 없었다. 1년 뒤의 체중의 경우, 성분식이 군의 delta z-score가 $0.64{\pm}0.60$였고 스테로이드 군은 $0.63{\pm}0.84$였으나 역시 유의성은 없었다. 결 론: 성분식이 요법은 크론병의 관해, 성장 면에서 스테로이드와 차이가 없었으나 유의하게 낮은 재발률을 보였다. 이에 소아 크론병의 1차 치료로서 성분식이 요법을 사용할 수 있을 것으로 생각되나 이에 대한 보다 많은 환자를 대상으로 한 연구가 필요하다고 생각된다.

• 지능정보연구
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• 제20권3호
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• pp.93-108
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• 2014

기업 의사 결정 지원을 위하여 거래 데이터를 다양한 관점에서 분석하고 활용하려는 노력과 관심들이 증가하고 있다. 이러한 노력들은 고객 관리나 마케팅에만 국한되는 것이 아니라 부정행위에 대한 감시와 탐지를 목적으로도 다양한 분석 방안들이 연구되고 있다. 부정행위는 기술의 발전을 악용하여 다양한 형태로 진화하고 있으며, 이에 따라 목적에 맞는 부정탐지 방안 연구와 적용을 통하여 탐지 효용의 극대화를 위한 노력의 필요성이 증가하고 있다. 이러한 연구 동향의 일환으로 본 연구에서는 대용량 거래 데이터가 저장 관리되고 있는 국내 최대 농수산물 유통 시장의 2008년부터 2010년까지 상장예외품목의 거래 가격을 분석하여 부정 탐지 규칙을 도출하였으며, 전문가 검증을 통하여 도출 된 규칙의 신뢰성을 확보하였다. 본 연구의 주요 부정거래 분석 방안으로는 정상적인 데이터들은 발생 확률이 높은 반면에 특이한 데이터들의 발생 확률은 낮다고 가정하는 통계적 접근을 통한 이상치 식별 방안을 활용하였다. 이에 따라 부정거래 분석 별로 정의 된 Z-Score 값보다 클 경우 부정거래 탐지 대상이 된다. 다만 상장예외품목 거래의 경우 취급 가능한 중도매인의 수가 제한되어 있으며, 일반적인 상장품목의 거래보다 거래량이 적기 때문에 소수의 이상치가 품목의 평균에 미치는 영향이 크다. 그 예로 다른 소수의 중도매인들이 해당 품목을 정상적인 가격에 거래하였더라도, 특정한 중도매인 한 명이 지나치게 비정상적인 가격에 거래할 경우 모든 거래들이 부정거래로 탐지 될 가능성도 있다. 이러한 문제를 해결하기 위하여 기존의 Z-Score의 개념을 활용하여 수정된 Z-Score(Self-Eliminated Z-Score)를 사용하였다. 또한 부정 유형별 탐지 규칙 관리와 활용을 위한 시스템 프로토타입(prototype) 개발을 수행하였다. 이를 통하여 실제 부정거래 탐지 업무에 적용할 수 있는 효과적인 방안을 제시하였고, 농수산 유통시장의 공정성 및 투명성 확보를 위한 관리 감독의 기능 강화가 가능할 것이다.

• Clinical and Experimental Pediatrics
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• 제57권5호
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• pp.232-239
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• 2014

Purpose: Mitochondrial disease (MD) and Duchenne muscular dystrophy (DMD) are often associated with cardiomyopathy, but the myocardial variability has not been isolated to a specific characteristic. We evaluated the left ventricular (LV) mass by echocardiography to identify the general distribution and functional changes of the myocardium in patients with MD or DMD. Methods: We retrospectively evaluated the echocardiographic data of 90 children with MD and 42 with DMD. Using two-dimensional echocardiography, including time-motion (M) mode and Doppler measurements, we estimated the LV mass, ratio of early to late mitral filling velocities (E/A), ratio of early mitral filling velocity to early diastolic mitral annular velocity (E/Ea), stroke volume, and cardiac output. A "z score" was generated using the lambda-mu-sigma method to standardize the LV mass with respect to body size. Results: The LV mass-for-height z scores were significantly below normal in children with MD ($-1.02{\pm}1.52$, P<0.001) or DMD ($-0.82{\pm}1.61$, P =0.002), as were the LV mass-for-lean body-mass z scores. The body mass index (BMI)-for-age z scores were far below normal and were directly proportional to the LV mass-for-height z scores in both patients with MD (R =0.377, P<0.001) and those with DMD (R =0.330, P=0.033). The LV mass-for-height z score correlated positively with the stroke volume index (R =0.462, P<0.001) and cardiac index (R =0.358, P<0.001). Conclusion: LV myocardial atrophy is present in patients with MD and those with DMD and may be closely associated with low BMI. The insufficient LV mass for body size might indicate deterioration of systolic function in these patients.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제17권4호
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• pp.214-222
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• 2014

Purpose: The method of percutaneous endoscopic gastrostomy (PEG) tube placement can be divided into the pull and introducer techniques. We compared short-term complications and prognosis between patients who underwent the pull technique and two other types of introducer techniques, the trocar introducer technique and T-fastener gastropexy technique. Methods: Twenty-six patients who underwent PEG were enrolled in this study. We retrospectively investigated the age, sex, body weight, weight-for-age Z-score, underlying diseases, PEG indications, complications, duration of NPO (nil per os), pain control frequency, and duration of antibiotic therapy. The patients were classified into three groups according to the PEG technique. The occurrence of complications was monitored for 10 weeks after the procedure. Results: The age, sex, body weight, and weight-for-age Z-score were not significantly between the three groups. Most patients had cerebral palsy and seizure disorders. Dysphagia was the most common indication for PEG. Major complications occurred in 5 (50%), 4 (66.7%), and 0 (0%) patients in group I, II, and III, respectively (p=0.005). Further, peristomal infection requiring systemic antibiotic therapy occurred in 2 (20%), 3 (50%), and 0 (0%) patients in group I, II, and III, respectively (p=0.04). There was no significant difference between the groups with respect to minor complications, duration of NPO, pain control frequency, and duration of antibiotic therapy. Conclusion: The results indicate that the T-fastener gastropexy technique was associated with the lowest rate of major complications.

• 한국멀티미디어학회논문지
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• 제14권11호
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• pp.1365-1372
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• 2011

본 논문은 어두운 영상의 낮은 인지적인 대비를 향상하기 위해 비선형 마스킹 기법을 이용한 영상의 인지적 대비 향상 방법을 제안한다. 영상의 주요 속성인 색도의 변화를 최소화 하면서 어두운 영역의 밝기를 향상시키기 위해, 비선형 마스킹 기법 기반으로 영상에 적응적인 파라미터를 이용한 대비 향상방법을 제안하 였다. 제안하는 방법의 성능을 평가하기 위해 테스트 영상에 대해 SSR(Single-Scale Retinex), MSR(Multi-Scale Retinex), 기존의 비선형 마스킹 기법의 결과와 색도 및 채도에 대한 정량적인 평가와, z-score를 이용한 정성적 평가를 수행하였다. 결과 제안한 방법이 낮은 색도 변화와 향상된 인지적 대비를 보임을 확인하였다.

• 동서간호학연구지
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• 제20권2호
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• pp.160-166
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• 2014

Purse: The purpose of this study was to examine the effect of a laughter therapy on mental health promoting like depression, laughing index of elderly. Methods: The study was conducted based on the non-equivalent control group pretest-posttest design. The participations included 12 older adults in the control group and 11 in the experiment group. Data was collected from October 1 to November 22, 2013. Experimental group participated in laughter therapy six times, once a week for 60 minutes of each session. Questionnaires were used to measure pretest and posttest levels of depression and laughing index. Results: At the end of six-week intervention, depression score (z=-2.95 p=.003) and laughter index score (z=-2.81 p=.005) was significantly decreased in the experimental group compared to the control group. Futhermore, there was a significant difference in the depression scores of the experiment group at the posttest, but no signigicant difference was found between the two groups. Conclusion: The study results suggest that the laughter therapy is an effective intervention to reduce the depression but helpful to enhance the laughing index. Therefore, it is expected that laughter therapy will serve as an emotional nursing intervention for elderly patients with depression.

• 한국물환경학회지
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• 제30권6호
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• pp.632-637
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• 2014

Proficiency testing by interlaboratory comparisons is used to determine the performance of individual laboratories. In order to verify the quality of acute toxicity testing with Daphnia magna, National Institute of Environmental Research in South Korea is regularly organizing interlaboratory comparisons to estimate the analytical accuracy of different laboratories. Total 58 laboratories located in South Korea took part in interlaboratory proficiency testing scheme with three proficiency testing samples. TU(Toxic Unit) values of each laboratory were determined and robust z-score was calculated in order to evaluate the proficiency levels. Based on the robust z-score classification, 74% of the participant laboratories showed a satisfactory performance (43 laboratories). The main reason of 'unsatisfactory' performance seemed to be considered that the unsuitable management of test organism incubation system and the lack of experience on the identification of the test organism condition by effect of toxicity.

• Asian-Australasian Journal of Animal Sciences
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• 제19권3호
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• pp.402-405
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• 2006

This experiment was conducted to determine the effect of dietary betaine (0, 0.125%) on performance, carcass composition, pork quality and hepatic betaine-homocysteine methyltransferase (BHMT) activity of crossbred finishing barrows. Three replicates of ten pigs were used for each treatment. The results showed that average daily gain, feed intake and feed conversion were not affected by betaine. Compared with the control group, pigs treated with betaine had a 8.17% (p<0.05) decrease in carcass fat percentage, and a 8.84% (p<0.05) reduction in 10th-rib backfat thickness, but dressing percentage, percentage lean, longissimus muscle area, and average backfat thickness were not affected. There were also no significant differences in muscle color score, marbling score, pork pH value and water loss rate between the control and betaine-treated groups. Hepatic betaine-homocysteine methyltransferase (BHMT) activity was significantly increased by 13.97% (p<0.05) when pigs were offered 0.125% betaine.

• 성인간호학회지
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• 제20권2호
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• pp.239-250
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• 2008

Purpose: The purpose of this study was to determine the effect of a 2-week somatosensory stimulation program on cognitive function and ADL of patients with brain damage. Methods: The sample consisted of two groups of patients with stroke: 10 patients with a mean age of 59.0 years who were treated with somatosensory stimulation, and 9 patients with a mean age of 51.78 years, who were not treated with somatosensory intervention. A nonequivalent control group non-synchronized design was used to assess the functional recovery after stroke. Instruments used in this study were MMSE-K for cognitive function and FIM for ADL. Results: The hypothesis 1 that "Patients with stroke who were treated with the somatosensory stimulation program will show higher MMSE-K score than that of the non-treatment group" was supported(Z = -2.390, p = .017). The hypothesis 2 that "Patients with stroke who were treated with the somatosensory stimulation program will show higher FIM score than that of the non-treatment group", however, was partially supported(social cognition: Z = -2.204, p = .045). Conclusion: Somatosensory stimulation was effective to patients with stroke in improving their cognitive function. These findings suggest that somatosensory input can be adopted to nursing intervention for functional recovery after stroke.

• The Journal of Asian Finance, Economics and Business
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• 제7권11호
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• pp.241-250
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• 2020

This study examines the relationship between the attributes of board structure and the likelihood of financial distress for the non-financial sector of an emerging market characterized by concentrated ownership and family-controlled business. The present study utilized panel logistic regression to estimate the relationship between board structure attributes and the likelihood of financial distress. We used Altman Z-Score as a proxy for firm financial distress, as this tool measures the financial distress inversely. The study finds a significant relationship between board size and the likelihood of financial distress. The results show that a one-unit increase in board size would decrease the probability of financial distress by 3.4%. Further, we observe that a greater level of board independence is associated with a lower likelihood of financial distress. A one-unit increase in board independence would decrease the probability of financial distress by 20.4%. We also find a significant positive impact of leverage on the likelihood of financial distress. The present study contributes to the body of literature on board structure attributes and likelihood of financial distress in emerging markets, like Pakistan. Furthermore, the findings would be beneficial for corporate policymakers and investors in formulating corporate financial strategy and predicting business failure.