• 공업화학
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• 제32권1호
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• pp.20-27
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• 2021

DTO (dimethyl ether to olefins) 반응에서 촉매의 수명 향상을 목적으로 SAPO-34 촉매의 식각 처리 효과를 연구했다. NH3 수용액은 HCl과 같은 강산 또는 NaOH와 같은 강알칼리 수용액과 비교하여 식각의 진행 정도를 제어할 수 있는 적절한 처리제였다. 따라서 NH3 수용액의 처리 농도와 시간을 변수로 하여 SAPO-34 촉매의 특성과 수명에 미치는 영향을 관찰하였다. NH3 수용액의 처리 농도 또는 시간이 증가함에 따라 SAPO-34 촉매 결정 면의 중심에서부터 침식이 진행되었으며, 점차적으로 산 점 농도와 산 세기가 감소하는 것으로 나타났다. 한편, 적절한 처리 조건에서 SAPO-34 촉매의 외부 표면적과 메조 세공 부피는 증가하는 것으로 나타났다. 처리 농도와 시간이 각각 0.05 M와 3 h일 때, 처리된 SAPO-34 촉매의 수명이 가장 우수했으며 처리 전 촉매와 비교하여 약 36% (DME 전환율 > 90% 기준)까지 크게 향상되었다. NH3 수용액을 이용한 온화한 처리과정에서 SAPO-34 촉매의 식각 진행에 대한 모형을 제안하였다.

• 한국작물학회지
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• 제67권4호
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• pp.335-341
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• 2022

기장에 있는 트리테르페노이드류인 밀리아신 성분은 각질 세포의 증식을 촉진하는 등의 특성을 가지고 있어 탈모에 효과가 있다고 알려져 있다. 이 연구에서는 기장의 기름을 추출하여 검화 반응을 거쳐 불검화물의 추출 방법을 이용하여 GC/MS로 분석하였다. 기장 기름 성분을 GC/MS의 정성분석을 통해 확인하였으며, 기장 5품종과 비교를 위한 조 2품종의 밀리아신 함량을 분석하였다. 1. 기장에서는 β-amyrine, lupeol 등의 pentacyclic triterpene 류의 성분들이 검출되었다. 2. 밀리아신 함량은 기장의 한라찰에서 370.38±0.04 ㎍/100 mg oil으로 가장 높은 함량을 나타내었다. 3. 특히 조의 품종인 삼다찰과 삼다메에서는 밀리아신 함량이 검출되지 않았다.

• 한국작물학회:학술대회논문집
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• 한국작물학회 2022년도 추계학술대회
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• pp.205-205
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• 2022

Sorghum (Sorghum bicolor L.) is a major cereal grain crop of the world and It can be cultivated under high temperature and dry condition with high adaptability to the adverse environment. It is usually eaten with rice in korea and most of domestic sorghum cultivars have been developed by pure line selection and cross breeding. In prior studies, Hybrid cultivar (F1 seed) was known to improve 30-40% in yield and resist to disease and pest than pure line varieties due to hybrid vigor. Therefore, study on the hybrid sorghum is continuously necessary. In korea, hybrid sorghum cultivar have been developed, so we need to find methods seed production technology for supply and commercialization of hybrid seed cultivar. Female inbred line(A-line) and male inbred line(R-line) are needed for hybrid seed production. This study was carried out to investigate growth characteristics and yield of hybrid sorghum according to the seedling period and planting rate between female inbred line(YSA1) and male inbred line (Sodamchal, Miryang 19). When the flowering period of two inbred groups in the process of hybrid seed production is coincides, hybrid seed production is increase. The female inbred line and male inbred lines were cultivated at Daegu in 2021. Two inbred lines were sown at intervals of 3 days and 7days and were evaluated flowering period. As a result, the flowering period of the female inbred line and male inbred lines were matched at the 7days interval. To find out optimal planting rate, two inbred lines were cultivated under different plating rate (4:2, 5:2, 6:2). Yield of YSA1/Sodamchal(F1) was the highest 130(kg/10a) in the 4:2 ratio and yield of YSA1/Miryang 19 was the highest quantity of 139(kg/10a) in the 6:2 ratio. The results of this study could be helpful for hybrid Sorghum seeds production.

• BMB Reports
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• 제57권3호
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• pp.161-166
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• 2024

Aberrant DNA methylation plays a critical role in the development and progression of colorectal cancer (CRC), which has high incidence and mortality rates in Korea. Various CRC-associated methylation markers for cancer diagnosis and prognosis have been developed; however, they have not been validated for Korean patients owing to the lack of comprehensive clinical and methylome data. Here, we obtained reliable methylation profiles for 228 tumor, 103 adjacent normal, and two unmatched normal colon tissues from Korean patients with CRC using an Illumina Infinium EPIC array; the data were corrected for biological and experiment biases. A comparative methylome analysis confirmed the previous findings that hypermethylated positions in the tumor were highly enriched in CpG island and promoter, 5' untranslated, and first exon regions. However, hypomethylated positions were enriched in the open-sea regions considerably distant from CpG islands. After applying a CpG island methylator phenotype (CIMP) to the methylome data of tumor samples to stratify the CRC patients, we consolidated the previously established clinicopathological findings that the tumors with high CIMP signatures were significantly enriched in the right colon. The results showed a higher prevalence of microsatellite instability status and MLH1 methylation in tumors with high CMP signatures than in those with low or non-CIMP signatures. Therefore, our methylome analysis and dataset provide insights into applying CRC-associated methylation markers for Korean patients regarding cancer diagnosis and prognosis.

• IMMUNE NETWORK
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• 제21권2호
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• pp.14.1-14.17
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• 2021

Scrub typhus develops after the individual is bitten by a trombiculid mite infected with Orientia tsutsugamushi. Since it has been reported that pneumonia is frequently observed in patients with scrub typhus, we investigated whether intranasal (i.n.) vaccination with the outer membrane protein of O. tsutsugamushi (OMPOT) would induce a protective immunity against O. tsutsugamushi infection. It was particular interest that when mice were infected with O. tsutsugamushi, the bacteria disseminated into the lungs, causing pneumonia. The i.n. vaccination with OMPOT induced IgG responses in serum and bronchoalveolar lavage (BAL) fluid. The anti-O. tsutsugamushi IgA Abs in BAL fluid after the vaccination showed a high correlation of the protection against O. tsutsugamushi. The vaccination induced strong Ag-specific Th1 and Th17 responses in the both spleen and lungs. In conclusion, the current study demonstrated that i.n. vaccination with OMPOT elicited protective immunity against scrub typhus in mouse with O. tsutsugamushi infection causing subsequent pneumonia.

• Journal of Nutrition and Health
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• 제4권1호
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• pp.1-19
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• 1971

Nutritional anemia is an important nutritional problem affecting large population groups in most developing countries. Nutritional anemia is caused by the absence of any dietary essential involed in hemoglobin formation or by poor absorption of these dietary components. The most likely causes are lack of dietary iron, and folate, vitamin $B_{12}$ and high qualify protein. Anemia is considered to be a late mainfeastation of nutritional deficiencies, and even mild anemia is not the earilest sign of such a deficiency. Therefore, the object of therapy is to correct underlying deficiency rather than merely its manifestation. Iron deficiency anemia is generally much the most common form of anemia. And it is very prevalent particularly in pregnant women and young children, especially under five year of life. According to the rapid growth rate of infants, dietary iron should he provided for infants over three months of age in adequate amounts for the synthesis of hemoglobin required by the increasing blood volume and for the demands of newly formed cells. The principal causes of iron deficiency anemia are an inadequate dietary iron content, interference with absorption of iron from the intestine, excessive losses of iron from the body, disturbance of iron metabolism by infection, and social and cultural environments. The present study is planned to obtain informations concerning nutritional anemia through anthropometric and biochemical determinations for the assessment of nutriture in pre-school children. Determination was taken in 226 pre-school children in ruraI arae in 1968, 122 pre-school children in 1970, and 1526 hospitalized pre-school children in 1970. The results of this study are as follows; (1) According to Iowa Malnutrition Borderline (85 percentile) for weight, the proportions of underweighed pre-school boys and girls in rural area were 47.2% and 46.2% in1968, and were 36.1% and 51.8% in 1970. According to Iowa Malnutrition Borderline for height, the proportions of underheight boys and girls in rural area were 30.5% and 33.7%, and were 26.2% and 21.8% in 1970. Malnutrition scores of underweight for height values of boys and girls in rural area were 19.3 and 17.3 in 1968, and the scores of boys and girls were 15.6 and 15.5 in 1970. (2) The mean hemoglobin values of boys and girls in rural area were $11.2{\pm}1.8g/100ml\;and\;11.4{\pm}1.6g/100ml$ in 1968. In 1970, the mean values of boys and girls in rural area were $11.3{\pm}1.3g/100ml\;and\;11.7{\pm}2.4g/100ml$. The mean hemoglobin values of hospitalized boys and girls were $11.9{\pm}2.2g/100ml\;and\;11.7{\pm}2.4g/100ml$ in 1970. It is found that 92 of 215 children (42.7%) in rural area had concentrations of hemoglobin less than 11.0g/100ml in 1968. In 1970, 55 of 121 children (45.4%) in rural area and 559 of 1526 hospitalized children (36.6%) had concentrations of hemoglobin less than 11.0g/100ml. (3) The mean hematocrit levels of hospitalized boys and girls were $35{\pm}26.8%\;and\;35.4{\pm}6.4%$ in 1970. And 443 of 1334 hospitalized children (33.2%) had hematocrit values below 33%. (4) The average mean corpuscular hemoglobin concentration levels of hospitalized boys and girls were $32.4{\pm}2.2\;and\;32.3{\pm}2.2$ in 1970. And 1016 of 1352 hospitalized children (75.1%) had the mean corpuscular hemoglobin values below 34. (5) The mean iron values of young children in rural area and hospitalized children were $62.0{\pm}6.3{\mu}g/100ml\;and\;60.7{\pm}22.8{\mu}g/100ml$. The proportions of anemia cases below $50{\mu}g/100ml$ in rural area was 37.9%, and 34.3% in hospitalized children. (6) The mean total iron binding capacity of young children in rural area was $376{\pm}57.88{\mu}g/100ml,\;and\;342.2{\pm}6.15{\mu}g/100ml$ in hospitalized children. (7) The average transferrin saturation percentage of young children in rural area was $16.9{\pm}4.7%,\;and\;18.0{\pm}8.4%$ in hospitalized children. The proportions of anemia cases below 15% of young chi1dren in rural area and hospitalized children were 48.3% and 41.2%. Therefore, authors wish to recommend that the following further studies should be undertaken: (1) Standardization of simplied laboratory examination of nutritional anemia. (2) The prevalence of nutritional anemia and the requirements of iron, folate, and vitamin $B_{12}$ of pre-school children. (3) The content and absorption of iron in Korean food. (4) The pathogenesis of nutritional anemia and prevention of parasitic disease. (5) Maternal health and nutrition education.

• 대한두경부종양학회지
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• 제24권1호
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• pp.57-63
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• 2008

Background and Purpose：Nausea, vomiting and weight loss are common problems that are encountered in the course of cancer patient treatment who are receiving radiotherapy. In this study, we are aiming to analyze the effect of megestrol acetate on quality of life of head and neck cancer patients receiving radiotherapy, resulting from improvement of weight loss, appetite and nutritional status via multicenter, open-labeled, observational clinical trial. Material and Methods：A total of 270 patients from 10 medical institutes who are receiving radiotherapy or who have completed radiotherapy within 3 months, between February 2007 and February 2008, were selected as candidates for the study. Megestrol acetate suspension(megace) was given to the subjectives once a week for 4 weeks with the amount of 20ml(megestrol 800mg). Measurement of weight and questionnaire surveys were carried out three times: at the start of the study, 4 weeks after the start of the medication, and 4 weeks after the end of the medication, respectively. Results：The group who has received megace had a total number of 199, and control group was 70. The group who have received megace showed mean weight loss of 1kg in 8 weeks, compared with the weight loss of 5.5kg in control group, which showed that the medication was effective in reducing the amount of weight loss(P=0.027). The group who received megace had a tendency to report a reduced rate of decrease in the score of appetite, nausea and vomiting, and QOL score, but it did not have statistical significance(P>0.05). Conclusion：Megestrol acetate have reduced the degree of weight loss significantly, and it has a tendency to reduce the rate of decrease in appetite, aggravation of nausea and vomiting, and quality of life.

• 한국철학논집
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• 제58호
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• pp.97-137
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• 2018

본 논문은 '한국철학사연구회'의 발족 30주년을 맞이하여, 그 학술지인 "한국철학논집"의 논문 분류와 연구회의 대표적인 학자 두 명의 논문 주제와 특징을 분석한 것이다. "한국철학논집"은 1991년 제1집을 부터 2017년 11월 현재까지 총 제55집까지 발간했고, 총 582편의 논문을 소개했다. 582편 가운데 297편의 논문이 한국철학을, 174편의 논문이 중국철학을 다루었다. 한국철학 논문 가운데 198편, 중국철학 논문 가운데 125편이 성리학을 주제로 한 연구이다. 한국철학자 가운데는 정약용이, 중철학자 가운데는 주희에 대한 연구가 가장 많았다. "한국철학논집"에 참여한 필자는 모두 203명에 이르는데 이 가운데 이상익이 28편, 최영성이 23편을 게재하였다. 이상익의 논문 28편에 기초해보면 이상익은 철두철미한 성리학자이다. 그의 연구는 성리학의 성리설과 경세론을 두 축으로 한다. 한편으로는 자신의 성리설을 정립하고 여타 성리설을 비평하고 있으며, 또 자신의 경세이론을 정립하고 여타 경세 이론을 비평하고 있다. 그리고 현대 사회의 여러 문제에 대한 이론적 제안을 하고 있다. 최영성의 논문 23편에 기초해보면 최영성은 한국유학사상사 분야의 최고 연구자이다. 그의 연구는 그간의 한국유학사상사에 있어 잘못된 인식이나 서술을 바로 잡고, 미진하게 개진된 부분을 계발하는 데 집중되어 있다. 또한 사상사의 연구에만 그치는 것이 아니라 사상사를 접근하는 철학적 토대 정립을 위해 최치원의 철학 사상을 깊이 연구하고 있기도 하다. "한국철학논집"과 게재된 논문은 명실상부하며 양적, 질적인 발전을 해왔다. 그러나 "한국철학논집"과 '한국철학사연구회'의 지속적인 발전과 훌륭한 학자를 배출하기 위해서는 성균관대학교 한국철학과의 소생이 반드시 필요하다.

• 한국강구조학회 논문집
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• 제16권2호통권69호
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• pp.191-200
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• 2004

본 연구에서는 보강판을 직교이방성 판으로 해석하는 경우 보강판의 제원에 따라 정확도에 큰 차이를 보이는 단점을 해결하기 위하여, 개단면 리브를 갖는 보강판에 대하여 직교이방성 강성을 보정하는 방법을 제안하였다. 여러 가지 보강판에 대하여 등방성 및 직교이방성 판 요소로 모델링하여 해석하고 최대 처짐을 비교한 결과, 특정 강성비를 중심으로 이보다 강성비가 작아질수록 직교이방성 판이 더 작은 처짐을, 이보다 커질수록 더 큰 처짐을 나타내어 정확도의 향상을 위해서는 강성비에 따른 직교이방성 강성 수정이 이루어져야 함을 알 수 있었다. 거동 분석을 토대로, 직교이방성 판의 처짐식과 판만의 처짐과 관련한 처짐 비율을 이용하는 두 가지 강성 수정 방법을 제안하였으며, 두 경우 모두 오차율 및 오차율의 분포폭이 크게 감소하여 정확도가 크게 향상되지만, 처짐 비율의 방법이 처짐식을 이용한 방법보다 사용성 및 안정성 측면에서 더 적절한 것으로 나타났다. 또한, 개단면 리브를 갖는 보강판을 직교이방성 판으로 해석하는 경우, 본 연구에서 제안한 강성 수정 방법을 사용하여 보강판의 직교이방성 휨강성을 보정하게 되면, 상당한 정확성의 증가로 보강판에 대한 간편하고 타당한 결과를 얻을 수 있을 것으로 판단된다.

• 대한임상검사과학회지
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• 제37권1호
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• pp.1-7
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• 2005

The purpose of this study was to verify (i) a consistent calibration verification for the assessment of method linearity and (ii) calibration agreement with calibration settings. We validated calibration verification through method linearity with different lot number of individual calibrators that span the working range for 9 tests except salicylate with control sample in test. We evaluated that it covered broad analyte range to assay from near zero to the top of the measuring range with 5 or 6 points every three times for 10 analytes in TDM test. Target values were plotted on X-axis with assigned or observed values on the Y-axis. Working range were as follows. Calibration verification of the measuring range (maximum to minimum values) has been validated asetaminophen 0.1 to $304.6_{\mu}g/mL$, salicylate 0 to $1005_{\mu}g/mL$, valproic acid 3.2 to $154.19_{\mu}g/mL$, digoxin 0.17 to 5.65 ng/mL, vancomycine 1.3 to $80.51_{\mu}g/mL$, carbarmazepine 0.1 to $22.3_{\mu}g/mL$, phenytonin 0.6 to $40.21_{\mu}g/mL$, theophyline 0.2 to $40.21_{\mu}g/mL$, primidone 0 to $24.07_{\mu}g/mL$, phenobarbital 0.6 to $60.0_{\mu}g/mL$. Drawing a straight line through five or six points of these data showed good linearity. We are sure that it is important to assess the calibration verification of a test method to ascertain the lowest and highest test results that are reliable.