• Journal of Preventive Medicine and Public Health
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• v.40 no.2
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• pp.130-136
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• 2007

Objectives : Recent educational efforts have concentrated on patient's early hospital arrival after symptom onset. The purpose of this study was to evaluate the time interval between symptom onset and hospital arrival and to investigate its relation with clinical outcomes for patients with acute ischemic stroke. Methods : A prospective registry of patients with signs or symptoms of acute ischemic stroke, admitted to the OO Medical Center through emergency room, was established from September 2003 to December 2004. The interval between symptom onset and hospital arrival was recorded for each eligible patient and analyzed together with clinical characteristics, medication type, severity of neurologic deficits, and functional outcomes. Results : Based on the data of 256 patients, the median interval between symptom onset and hospital arrival was 13 hours, and 22% of patients were admitted to the hospital within 3 hours after symptom onset. Patients of not-mild initial severity and functional status showed significant differences between arrival hours of 0-3 and later than 3 in terms of their functional outcomes on discharge. Logistic regression models also showed that arrival within 3 hours was a significant factor influencing functional outcome (OR=5.6; 95% CI=2.1, 15.0), in addition to patient's initial severity, old age, cardioembolism subtype, and referral to another hospital. Conclusions : The time interval between symptom onset and hospital arrival significantly influenced treatment outcome for patients with acute ischemic stroke, even after controlling for other significant clinical characteristics. The findings provided initiatives for early hospital arrival of patients and improvement of emergency medical system.

• Kidney Research and Clinical Practice
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• v.37 no.4
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• pp.347-355
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• 2018

Background: Nephrotic syndrome (NS) is the most common glomerulopathy in children. Acute kidney injury (AKI) is a common complication of NS, caused by severe intravascular volume depletion, acute tubular necrosis, interstitial nephritis, or progression of NS. However, the incidence and risk factors of childhood-onset NS in Korea are unclear. Therefore, we studied the incidence, causes, and risk factors of AKI in hospitalized Korean patients with childhood-onset NS. Methods: We conducted a retrospective review of patients with childhood-onset NS who were admitted to our center from January 2015 to July 2017. Patients with decreased renal function or hereditary/secondary NS, as well as those admitted for management of other conditions unrelated to NS, were excluded. Results: During the study period, 65 patients with idiopathic, childhood-onset NS were hospitalized 90 times for management of NS or its complications. Of these 90 cases, 29 met the Kidney Disease Improving Global Outcomes criteria for AKI (32.2%). They developed AKI in association with infection (n = 12), NS aggravation (n = 11), dehydration (n = 3), and intravenous methylprednisolone administration (n = 3). Age ${\geq}9$ years at admission and combined use of cyclosporine and renin-angiotensin system inhibitors were risk factors for AKI. Conclusion: AKI occurred in one-third of the total hospitalizations related to childhood-onset NS, owing to infection, aggravation of NS, dehydration, and possibly high-dose methylprednisolone treatment. Age at admission and use of nephrotoxic agents were associated with AKI. As the AKI incidence is high, AKI should be considered during management of high-risk patients.

• MALSORI
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• no.46
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• pp.1-11
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• 2003

This study examines the acoustic characteristics of Korean stops of two dialects, Seoul and Kyungsang, focusing on VOT(Voice Onset Time). 8 speakers of these two dialects were asked to read 590 words which contain the stops of different places of articulation and phonation types. The results showed that overall the VOTs of Kyungsang dialect were shorter than those of Seoul dialect. This was more prominent in lenis stops than in fortis or aspirated stops. It was also shown that there were significant VOT overlapping differences between the two dialects.

• Proceedings of the Korean Vacuum Society Conference
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• 2010.08a
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• pp.60-60
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• 2010

CO2 reforming of methane (CRM) based on Ni catalysts was studied using temperature programmed reaction (TPR). The onset temperature of the CRM reaction was increased in a repeated TPR experiments. X-ray photoelectron spectroscopy (XPS) and Raman spectroscopy showed formation of graphite structures on Ni during CRM reaction, which deactivate Ni-surfaces. Attempts were made for inhibiting deactivation of Ni surfaces and reducing onset-temperature of the CRM reaction by various surface modification techniques, which will be presented in this poster.

• Journal of Gastric Cancer
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• v.24 no.2
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• pp.145-158
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• 2024

Purpose: Although smoking and alcohol consumption are known risk factors for gastric cancer (GC), studies assessing their effects on early-onset GC are limited. In this nationwide, population-based, prospective cohort study, we assessed the effects of smoking and alcohol consumption on early-onset GC in patients aged <50 years. Materials and Methods: We analyzed data of patients aged 20-39 years who underwent cancer and general health screening in the Korean National Health Screening Program between 2009 and 2012. We calculated the adjusted hazard ratios (aHR) and 95% confidence intervals (CI) for GC incidence until December 2020. Results: We enrolled 6,793,699 individuals (men:women=4,077,292:2,716,407) in this cohort. The mean duration of follow-up was 9.4 years. During follow-up, 9,893 cases of GC (men:women=6,304:3,589) were reported. Compared with the aHRs (95% CI) of never-smokers, those of former and current-smokers were 1.121 (1.044-1.205) and 1.282 (1.212-1.355), respectively. Compared with the aHRs (95% CI) of non-consumers, those of low-moderate- and high-risk alcohol consumers were 1.095 (1.046-1.146) and 1.212 (1.113-1.321), respectively. GC risk was the highest in current-smokers and high-risk alcohol consumers (1.447 [1.297-1.615]). Interestingly, alcohol consumption and smoking additively increased the GC risk in men but not in women (P_interaction=0.002). Conclusion: Smoking and alcohol consumption are significant risk factors for early-onset GC in young Koreans. Further studies are needed to investigate sex-based impact of alcohol consumption and smoking on GC incidence in young individuals.

• Journal of Korean Neurosurgical Society
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• v.52 no.3
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• pp.261-263
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• 2012

The experience of pediatric deep brain stimulation (DBS) of the globus pallidus internus (GPi) in the treatment of early-onset DYT1 generalized dystonia is still limited. Here, we report the surgical experience of bilateral GPi-DBS under general anesthesia by using microelectrode recording in a 7-year-old girl with early-onset DYT1 generalized dystonia. Excellent improvement of her dystonia without neurological complications was achieved. This case report demonstrates that GPi-DBS is an effective and safe method for the treatment of medically refractory early-onset DYT1 generalized dystonia in children.

• International Journal of Human Ecology
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• v.8 no.2
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• pp.47-60
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• 2007

While there is growing evidence regarding the subgroup-sensitive nature of risk factors among delinquent adolescents, researchers have paid little attention to the tracking of risks and needs by subgroups (e.g., gender, ethnicity, and the timing of onset for delinquency) among youth who are currently involved in the juvenile court system. Therefore, greater empirical attention directed toward subgroup-sensitive risk factors experienced by delinquent adolescents is thought to be both timely and necessary. A final convenience sample of 2167 court-involved adolescents in the US was used to specify subgroup-sensitive risks and needs. The results demonstrated that there were various levels of risks according to subgroups associated with gender, ethnicity, and onset for delinquency group. The findings of this study add to the extant literature on delinquency by demonstrating the importance of considering subgroups associated with gender, ethnicity, and the timing of onset for delinquency when practicing treatment or intervention programs with delinquent adolescents.

• The Magazine of the Society of Air-Conditioning and Refrigerating Engineers of Korea
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• v.17 no.2
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• pp.131-139
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• 1988

The thermoacoustic oscillation induced in an air column with variable cross section area is investigated theoretically and experimentally. The onset condition of the oscillation is derived by equating the acoustic power production to the power dissipation. The power production at the heater is predicted by using the efficiency factor obtained by heat transfer analysis for a single wire in a uniform cross flow and considering the interference between heater wires. The power dissipation is estimated by measuring the attenuating coefficient from the pressure decay curve. The theoretical prediction to the onset condition of the oscillation is confirmed experimentally. The effect of the variation of the column cross section area on the onset condition is presented.

• Phonetics and Speech Sciences
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• v.8 no.1
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• pp.9-17
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• 2016

The purpose of this work is to examine the voice onset times(VOTs) of the voiceless and voiced stops from the ten young male speakers of the Buckeye corpus[9]. The factors that are known to affect VOTs were also extracted, including the place of articulation, height of following vowels, location within word, presence of a preceding [s], status of the target word with respect to the content versus function word, presence of a syllabic stress, word frequency and speech rate. Findings from this work mostly agreed with those from earlier studies on English, but with some exceptions and new discoveries. We hope that this work can contribute to figuring out the nature and properties of the spontaneous speech of English.

• Phonetics and Speech Sciences
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• v.4 no.2
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• pp.33-40
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• 2012

The purpose of this paper is to investigate the voice onset time (VOT) of the English voiceless stops [p, t, k] found in the Buckeye Corpus of Conversational Speech [1]. Three young female speakers were chosen for this study and their VOT values were semi-automatically extracted along with other factors. The factors used for the analysis were place of articulation, location in word, syllabic stress, content word or not, word frequency calculated from the corpus, and the speech rate expressed in syllables per second. Results showed that, for the three places of articulation of each speaker, all the factors had a statistically significant effect on the VOT values. This paper has significance in that the materials used for the analysis were from a corpus of spontaneous natural English speech.