• 제목/요약/키워드: Yonsei University

검색결과 27,432건 처리시간 0.064초

항암화학요법을 받는 환자의 구강관리 프로토콜개발 및 적용효과 (The Development of an Oral Care Protocol for Cancer Patients Receiving Chemotherapy and its Effects)

  • 손유진;신윤정;조미영;김순호;박옥선;한수영;강영린;김연우;송수경;이선화;황인희;손병희;주은혜;김수;최혜진
    • 임상간호연구
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    • 제17권1호
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    • pp.113-122
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    • 2011

  • Purpose: This study was conducted to develop and evaluate an oral care protocol for cancer patients receiving chemotherapy. Methods: The participants in this study were cancer patients in Severance hospital in Seoul. A total of 31 patients were assigned to the experimental group, and 29 patients to the control group. Data were collected from August 1 to October 5, 2010. The protocol included definition and symptom of oral mucositis, self-check method of oral status, prophylactic method of oral mucositis (oral care, eating habits, and gargling) and management of oral mucositis. Oral Assessment Guide (OAG) was used as the measurement tool of oral mucositis in this study, Oral Care Performance Scale was used as the measurement tool of oral care performance status. Data were analyzed with a $x^2-test$ and t-test, and repeated measures ANOVA, using SPSS/WIN 18.0 program. Results: Patients in the experimental group receiving the oral care protocol had a significant difference (t=-2.938, p=.005) in the oral care performance compared to the control group. However, there was no significant difference (F=1.255, p=.274) in the oral mucositis status between two groups. Conclusion: This study showed that the oral care protocol could improve oral care performance status for the patients under chemotherapy.

  • https://doi.org/10.22650/JKCNR.2011.17.1.11 인용 PDF KSCI

Factors associated with pulmonary toxicity after myeloablative conditioning using fractionated total body irradiation

  • Byun, Hwa Kyung;Yoon, Hong In;Cho, Jaeho;Kim, Hyun Ju;Min, Yoo Hong;Lyu, Chuhl Joo;Cheong, June-Won;Kim, Jin Seok;Kim, Hyo Sun;Kim, Soo-Jeong;Yang, Andrew Jihoon;Lee, Byung Min;Lee, Won Hee;Lee, Joongyo;Ahn, Ki Jung;Suh, Chang-Ok
    • Radiation Oncology Journal
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    • 제35권3호
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    • pp.257-267
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    • 2017

  • Purpose: Pulmonary toxicities, including infectious pneumonia (IP) and idiopathic pneumonia syndrome (IPS), are serious side effects of total body irradiation (TBI) used for myeloablative conditioning. This study aimed to evaluate clinical factors associated with IP and IPS following TBI. Materials and Methods: Fifty-eight patients with hematologic malignancies who underwent TBI before allogeneic hematopoietic stem cell transplantation between 2005 and 2014 were reviewed. Most patients (91%) received 12 Gy in 1.5 Gy fractions twice a day. Pulmonary toxicities were diagnosed based on either radiographic evidence or reduced pulmonary function, and were subdivided into IP and IPS based on the presence or absence of concurrent infection. Results: Pulmonary toxicities developed in 36 patients (62%); 16 (28%) had IP and 20 (34%) had IPS. IP was significantly associated with increased treatment-related mortality (p = 0.028) and decreased survival (p = 0.039). Multivariate analysis revealed that the risk of developing IPS was significantly higher in patients who received stem cells from a matched unrelated donor than from a matched sibling donor (p = 0.021; hazard ratio [HR] = 12.67; 95% confidence interval [CI], 1.46-110.30). Combining other conditioning agents with cyclophosphamide produced a higher tendency to develop IP (p = 0.064; HR = 6.19; 95% CI, 0.90-42.56). Conclusion: IP and IPS involve different risk factors and distinct pathogeneses that should be considered when planning treatments before and after TBI.

  • https://doi.org/10.3857/roj.2017.00290 인용 PDF KSCI