• Steel and Composite Structures
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• 제38권4호
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• pp.365-380
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• 2021

Although traditional steel-concrete composite beams have excellent structural characteristics, it cannot meet the requirement of quick assembly and repair in the engineering. This paper presents a study on static behavior of bolt connected steel-concrete composite beam without post-cast zone. A three-dimensional finite element model was developed with its accuracy and reliability validated by available experimental results. The analysis results show that in the normal service stage, the bolt is basically in the state of unidirectional stress with the loss of pretightening can be ignored. Parametric studies are presented to quantify the effects of the post-cast zone, size and position of splicing gap on the behavior of the beam. Based on the studies, suggested size of gap and installation order were proposed. It is also confirmed that optimized concrete slab in mid-span can reduce the requirement of construction accuracy.

• 대순사상논총
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• 제39집
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• pp.249-274
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• 2021

本文乃以韓國大巡真理會《典經》為主, 探討姜甑山的宗教醫療。姜甑山的醫療原理建立在「身心一體」的整體觀, 意即醫治疾病, 必先醫心, 也就是他所說的「大病之藥, 安心安身」。按摩是姜甑山經常運用的物理治療, 他運用按摩消除病患因氣鬱不順所導致腿部與腹部的諸多疾病 ; 而四物湯, 小柴胡湯, 木瓜, 生地黃是他常用的藥劑與藥材。道法醫療是姜氏宗教醫療的特色, 根據《典經》的記錄, 有正氣祛病, 驅除精怪, 代病與轉病, 更衣除病, 用藥於地等, 結合符咒, 藉以醫治百姓, 尤其用藥於地是他獨創的道法醫療方式。

• Smart Structures and Systems
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• 제30권3호
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• pp.273-286
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• 2022

In recent years, vision-based monitoring has received great attention. However, structural identification using vision-based displacement measurements is far less established. Especially, simultaneous identification of structural systems and unknown excitation using vision-based displacement measurements is still a challenging task since the unknown excitations do not appear directly in the observation equations. Moreover, measurement accuracy deteriorates over a wider field of view by vision-based monitoring, so, only a portion of the structure is measured instead of targeting a whole structure when using monocular vision. In this paper, the identification of structural system and excitations using vision-based displacement measurements is investigated. It is based on substructure identification approach to treat of problem of limited field of view of vision-based monitoring. For the identification of a target substructure, substructure interaction forces are treated as unknown inputs. A smoothing extended Kalman filter with unknown inputs without direct feedthrough is proposed for the simultaneous identification of substructure and unknown inputs using vision-based displacement measurements. The smoothing makes the identification robust to measurement noises. The proposed algorithm is first validated by the identification of a three-span continuous beam bridge under an impact load. Then, it is investigated by the more difficult identification of a frame and unknown wind excitation. Both examples validate the good performances of the proposed method.

• 동국한의학연구소논문집
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• 제6권1호
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• pp.1-34
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• 1997

동양의학에서 "상한론(傷寒論)"의 발전은 대체로 삼단계(三段階)의 과정을 거쳤으나 "삼강정립(三綱鼎立)"설이 대세를 이루고 있었다. 이러한 관점에 대항하여 변증논치규율(辯證論治規律)을 연구한 학파(學派)가 나타나게 되었는데 우이(尤怡)가 그 중 한사람이다. 우이(尤怡)의 생애(生涯), 저서(著書), 학술사상(學術思想) 및 후세에 미친 영향 등을 조사하고 특히 "상한론(傷寒論)"을 안법류증(按法類?)하여 육경(六經)에 따른 정치법(正治法) 권변법(權變法) 알선법(斡旋法) 구역법(救逆法) 유병법(類病法) 명변법(明辨法) 잡치법(雜治法) 등의 치법(治法)에 대하여 연구하여 보고하는 바이다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권5호
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• pp.2369-2378
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• 2012

Objectives: To assess knowledge of HPV and attitudes towards HPV vaccination among the general female population, government officials, and healthcare providers in China to assist the development of an effective national HPV vaccination program. Methods: A cross-sectional epidemiologic survey was conducted across 21 urban and rural sites in China using a short questionnaire. 763 government officials, 760 healthcare providers, and 11,681 women aged 15-59 years were included in the final analysis. Data were analyzed using standard descriptive statistics and logistic regression. Results: Knowledge of HPV among the general female population was low; only 24% had heard of HPV. Less than 20% of healthcare providers recognized sexually na$\ddot{i}$ve women as the most appropriate population for HPV vaccination. There was high acceptance of the HPV vaccine for all categories of respondents. Only 6% of women were willing to pay more than US $300 for the vaccine. Conclusions: Aggressive education is necessary to increase knowledge of HPV and its vaccine. Further proof of vaccine safety and efficacy and government subsidies combined with increased awareness could facilitate development and implementation of HPV vaccination in China.

• Journal of Ginseng Research
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• 제48권3호
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• pp.298-309
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• 2024

Background: 20(S)-ginsenoside Rh2(GRh2), an effective natural histone deacetylase inhibitor, can inhibit acute myeloid leukemia (AML) cell proliferation. Lactate regulated histone lactylation, which has different temporal dynamics from acetylation. However, whether the high level of lactylation modification that we first detected in acute promyelocytic leukemia (APL) is associated with all-trans retinoic acid (ATRA) resistance has not been reported. Furthermore, Whether GRh2 can regulate lactylation modification in ATRA-resistant APL remains unknown. Methods: Lactylation and METTL3 expression levels in ATRA-sensitive and ATRA-resistant APL cells were detected by Western blot analysis, qRT-PCR and CO-IP. Flow cytometry (FCM) and APL xenograft mouse models were used to determine the effect of METTL3 and GRh2 on ATRA-resistance. Results: Histone lactylation and METTL3 expression levels were considerably upregulated in ATRA-resistant APL cells. METTL3 was regulated by histone lactylation and direct lactylation modification. Overexpression of METTL3 promoted ATRA-resistance. GRh2 ameliorated ATRA-resistance by downregulated lactylation level and directly inhibiting METTL3. Conclusions: This study suggests that lactylation-modified METTL3 could provide a promising strategy for ameliorating ATRA-resistance in APL, and GRh2 could act as a potential lactylation-modified METTL3 inhibitor to ameliorate ATRA-resistance in APL.

• Journal of Microbiology
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• 제45권2호
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• pp.105-112
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• 2007

The objective of this study was to analyze the phylogenetic composition of bacterial community in the soil of an earth-cave (Niu Cave) using a culture-independent molecular approach. 16S rRNA genes were amplified directly from soil DNA with universally conserved and Bacteria-specific rRNA gene primers and cloned. The clone library was screened by restriction fragment length polymorphism (RFLP), and representative rRNA gene sequences were determined. A total of 115 bacterial sequence types were found in 190 analyzed clones. Phylogenetic sequence analyses revealed novel 16S rRNA gene sequence types and a high diversity of putative bacterial community. Members of these bacteria included Proteobacteria (42.6%), Acidobacteria (18.6%), Planctomycetes (9.0 %), Chloroflexi (Green nonsulfur bacteria, 7.5%), Bacteroidetes (2.1%), Gemmatimonadetes (2.7%), Nitrospirae (8.0%), Actinobacteria (High G+C Gram-positive bacteria, 6.4%) and candidate divisions (including the OP3, GN08, and SBR1093, 3.2%). Thirty-five clones were affiliated with bacteria that were related to nitrogen, sulfur, iron or manganese cycles. The comparison of the present data with the data obtained previously from caves based on 16S rRNA gene analysis revealed similarities in the bacterial community components, especially in the high abundance of Proteobacteria and Acidobacteria. Furthermore, this study provided the novel evidence for presence of Gemmatimonadetes, Nitrosomonadales, Oceanospirillales, and Rubrobacterales in a karstic hypogean environment.

• Asian Pacific Journal of Cancer Prevention
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• 제14권4호
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• pp.2525-2528
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• 2013

The Homer protein family, also known as the family of cytoplasmic scaffolding proteins, which include three subtypes (Homer1, Homer2, Homer3). Homer3 can regulate transcription and play a very important role in the differentiation and development for some tissues (e.g. muscle and nervous systems). The current studies showed that Homer3 abnormal expression changes in acute myeloid leukemia (AML). Forced expression of Homer3 in transfected K562 cells inhibited proliferation, influenced the cell cycle profile, affected apoptosis induced by $As_2O_3$ through inhibition of Bcl2 expression, and also promoted cell differentiation induced by 12-O-tetra decanoylphorbol-acetate (TPA). These results showed that Homer3 is a novel gene which plays a certain role in the occurrence and development of AML.

• Journal of the Korean Wood Science and Technology
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• 제48권6호
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• pp.869-877
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• 2020

The power consumption in the low consistency (LC) refining is an important indicator for the optimal control of the process and it is composed of the net power and the no-load power. The refining efficiency and process characterization of LC refining are directly affected by power consumption. In this paper, the effect of pulp consistency and average fiber length on the power consumption and refining efficiency were studied through the LC refining trials conducted by an experimental disc refiner. It is found that the curve of power-gap clearance can be divided into constant power section, power reduction section, and power increase section. And the no-load power and the adjustable domain of loading applied by the refining plates will increase as the increase of pulp consistency, while the increase of net power is larger than that of no-load power which makes the increasing of refining efficiency. Meanwhile, the adjustable domain of loading applied by the refining plates can be slightly improved by increasing the average fiber length, but its effect on the no-load power in the LC refining process can be neglected. The study of power consumption in LC refining is of positive significance for the proper selection of pulp properties in LC refining, in-depth exploration of refining mechanism, and energy consumption reduction in refining.

• 한국융합학회논문지
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• 제6권4호
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• pp.205-212
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• 2015

본 논문에서는 중국 최대의 온라인 쇼핑몰로 자리매김한 타오바오를 대상으로 구매후기가 구매자의 구매의사결정에 어떠한 영향을 주는지를 밝히고자 연구하였다. 본 논문에서는 구매후기 내용특성, 구매후기 제공자특성, 구매자 특성이라는 세 가지 차원을 중심으로 구매자의 구매후기 수용에 영향을 미치는 주요 선행요인들을 도출하였다. 타오바오에서 제품을 구매한 경험을 가진 구매자들을 대상으로 데이터를 수집하여 분석한 결과는 다음과 같다. 첫째, 본 연구에서 구매후기 충분성과 구매후기 선명성은 모두 고객후기 수용에 통계적으로 비유의적으로 나타났다. 둘째, 구매후기 제공자 신뢰성과 구매후기 제공자 유사성은 모두 고객후기 수용을 증가시키는 것으로 나타났다. 셋째, 구매자 특성 차원에 속하는 사전지식과 관여도는 모두 고객후기 수용을 증가시키는 것으로 밝혀졌다. 마지막으로, 고객후기 수용은 구매자의 구매의도를 상당히 증가시키는 것으로 나타났다. 본 논문은 중국시장에 진출하고자 하는 쇼핑몰 이해당사자에게 구매후기 관리의 중요성을 알리고 관리방안을 제시하고 있다.