• 대한한방소아과학회지
• /
• 제19권2호
• /
• pp.255-269
• /
• 2005

Objective : To evaluate the effect of Oriental Medical Treatment on a patient with Hypoxic Ischemic Encephalopathy followed by Cardiopulmonary Resuscitation Method : We applied various methodology of Oriental Medical Treatment including Acupuncture, Electroacupuncture, Physical treatment, Herbal Medicine, Moxibustion treatment and Western medication as well. Result: Herbal medicine was applied on the basis of the patient's history. We applied formular to remove phelgm as a pathogenic factor after Hypoxic Ischemic Encephalopathy. At the same time, considering the patient spent more than a month in ICU lacking appropriate nutrition, we used formuli on the basis of 'Deficiency of Spleen' focusing to vitalize the function of digestive system. As the condition of the patient changed, we also adapted formular accordingly. We prescribed Herbal medication to strengthen Yin and Yang equally as she got hospitalized for long time. Also we applied Acupuncture treatment and Moxibustion treatment to control Qi flow. The general condition of the patient got better with successful removal of Foley catheter and elevated Glasgow Coma scale. We used Electroacupuncture, Physical treatment and Western medication at the same to get maximized effect on relaxing the contracted muscle. According to the Modified Ashworth Scale (MAS), we have some changes in muscle spasticity but later, the effect was not that significant. Conclusion : We had a patient with Hypoxic Ischemic Encephalopathy followed by Cardiopulmonary Resuscitation. In the management of Hypoxic Ischemic Encephalopathy, Conservative treatments are the mainstream but there are not many alternatives. Therefore, We suggest that Oriental medical approach may contribute to the management of Hypoxic Ischemic Encephalopathy.

• Journal of Applied Biological Chemistry
• /
• 제42권3호
• /
• pp.140-145
• /
• 1999

Livestock manure is generally beneficial to soil and crop production when appropriate amount is applied, but excessive application may be detrimental to soil and water environments. A proper protocol of livestock waste treatment is required to manage the quality of soil and water. A trickling filter system using rice straw media was employed to treat piggery wastewater from small-scaled livestock farms as an alternative to the currently available methods. Batches of piggery wastewater were treated with this system, and the byproducts of rice straw media and trickling filtrate were applied to the soil with cultivating rye (Secale cereale L.). Objective of this research was to characterize these byproducts for the sustainable soil amendments and rye production. Both the treated straw medium and filtrate were proven to be effective organic fertilizers for rye plant development, with the enhanced but balanced absorption of nutrients. The synergistic effects of filtrate in addition to straw application did not show, but the filtrate appeared to lead to a higher water content of the plant. No specific nutrient deficiency or toxicity symptom was shown due to the salts derived from the byproducts applied. Chemical parameters of the soil quality were significantly improved with the application of straw medium either with or without the filtrate. Judging from parameters relating to the salt accumulations, such as sodium adsorption ratio (SAR), electrical conductivity (EC), exchangeable sodium percentage (ESP), potassium adsorption ratio (KAR), and residual P concentrations, the byproducts from piggery wastewater exhibited no detrimental effects on soil quality within the ranges of treatments used. In addition to the effectiveness of the rice straw trickling filter system for the small-scaled swine farms, both rice straw medium and filtrate could be recycled for the sustainable soil amendment and plant nutrition.

• 한국콘텐츠학회논문지
• /
• 제13권7호
• /
• pp.24-37
• /
• 2013

본 연구는, 픽사의 와 에 나타난 부모와 자녀 캐릭터 사이의 갈등구도를, MBTI의 유형역동이라는 관점에서 비교 분석하고자 했다. 이에, 캐릭터의 성격유형과 심리기능의 위계를 추론하고, 유형역동에 의한 갈등과 화해의 구조를 분석하였다. 작품 분석을 통해 도출된 결론은: (1) 부모의 사고기능이 자녀의 직관기능을 구속하는 구조로, '현실과 가능성의 충돌'로 은유됨. (2) 보완 역할 캐릭터의 외향적 심리기능이, 결핍 캐릭터의 미발달된 3차기능을 보완하면서, 유형발달에 기여함. (3) 에서는, 갈등주체에 의한 직접적 단방향의 보완을 이루며, (4) 에서는, 갈등주체가 아닌 거울캐릭터에 의한 간접적 쌍방향의 상호보완을 이루는 방법론의 차이를 보인다.

• 한국전기전자재료학회논문지
• /
• 제30권4호
• /
• pp.229-234
• /
• 2017

In this study, we fabricated a TFT gas sensor with ZnO nanorods grown by hydrothermal synthesis. The suggested devices were compared with the conventional ZnO film-type TFTs in terms of the gas-response properties and the electrical transfer characteristics. The ZnO seed layer is formed by atomic-layer deposition (ALD), and the precursors for the nanorods are zinc nitrate hexahydrate ($Zn(NO_3)_2{\cdot}6H_2O$) and hexamethylenetetramine ($(CH_2)6N_4$). When 15 ppm of NO gas was supplied in a gas chamber at $150^{\circ}C$ to analyze the sensing capability of the suggested devices, the sensitivity (S) was 4.5, showing that the nanorod-type devices respond sensitively to the external environment. These results can be explained by X-ray photoelectron spectroscopy (XPS) analysis, which showed that the oxygen deficiency of ZnO nanorods is higher than that of ZnO film, and confirms that the ZnO nanorod-type TFTs are advantageous for the fabrication of high-performance gas sensors.

• 동의생리병리학회지
• /
• 제23권6호
• /
• pp.1292-1298
• /
• 2009

Sipjeon-Daebo-Tang (SDT) is indicated for deficiency syndrome of both gi and blood, marked by pale or sallow complexion, dizziness, lassitude, shortness of breath, dislike for talking, poor appetite, pale tongue with thin whitish fur, thready and weak pulse. Gami-Sipjeon-Daebo-Tang(GSDT) is composed of 10 herbs within SDT and Cervi Pantotrichum Cornu (CPC). CPC can noursh kidney-yang, promote the production of the essence and blood, strengthen tendons and bones. Recently SDT is known as anti-cancer drug. Especially CPC is reported to have anti-oxidative action. For these reasons, we investigated the protective effects on cell death induced by chemicals such as paraquat, hydrogen peroxide and anti-oxidative effects in C6 glioma cells. In our results, GSDT accelerated proliferation rates of C6 cells in vitro. In addition, protective effects on cell death induced by hydrogen peroxide and rotenone. In addition, SOD activities were increased by treatment with both SDT and GSDT. In conclusion, these results suggest the possibility of GSDT to protect brain cell or neuronal cell from damage induced by oxidative stress. And also suggest that related mechanisms are involved in SOD activities.

• 한국환경복원기술학회지
• /
• 제7권4호
• /
• pp.52-60
• /
• 2004

In order to analysis of the water pollution of the Anyang stream(one of the biggest branch streams of the Han River) and its main tributaries, the geological and topographical and rainfall features in its basin were investigated. To do this, the water samples were collected 23 points of the upper, mid and down of Anyang stream and its tributaries and were analyzed based on the chemical methods, Korean Biotic Index(KBI) and Saprobien systems. The Anyang stream basin has a characteristic of topographical torrential heavy rainfall like a typical rainfall feature in Korea. The concentration and the outflow rate of rainfall is very different in seasonal, and water pollution in dry season is especially severe. After 1997, although the water quality status of stream has been improved gradually, the concentration of T-N and SS at the upstream is increased due to the deficiency of facility used for collecting wastewater released from industrial factories, livestock farms and residential areas. The mainstream of the Anyang stream is classified into the 5th grade water as polysaprobic water area according to Saprobien system and the biotic index is over 2.5 in overall. Most of tributaries have 1~3 grade water limit with ${\alpha}$- and ${\beta}$-mesosaprobic except the upper and mid streams of Samsung tributary, in which pollution status is the lowest part. Though Sambong tributary is ${\alpha}$-mesosaproboic, biotic index is low because of the appearance of abundant benthos animals in farming and fishing villages.

• Toxicological Research
• /
• 제33권4호
• /
• pp.283-290
• /
• 2017

The host immune system is the first line of host defense, consisting mainly of innate and adaptive immunity. Immunity must be maintained, orchestrated, and harmonized, since overactivation of immune responses can lead to inflammation and autoimmune diseases, while immune deficiency can lead to infectious diseases. We investigated the regulation of innate and adaptive immune cell activation by Artemisia capillaris and its components (ursolic acid, hyperoside, scopoletin, and scopolin). Macrophage phagocytic activity was determined using fluorescently labeled Escherichia coli, as an indicator of innate immune activation. Concanavalin A (ConA)- and lipopolysaccharide (LPS)-induced splenocyte proliferation was analyzed as surrogate markers for cellular and humoral adaptive immunity, respectively. Neither A. capillaris water extract (WAC) nor ethanol extract (EAC) greatly inhibited macrophage phagocytic activity. In contrast, WAC suppressed ConA- and LPS-induced proliferation of primary mouse splenocytes in a dose-dependent manner. Similarly, EAC inhibited ConA- and LPS-induced splenocyte proliferation. Oral administration of WAC in mice decreased ConA- and LPS-induced splenocyte proliferation, while that of EAC suppressed LPS-induced splenocyte proliferation. Repeated administration of WAC in mice inhibited ConA- and LPS-induced splenocyte proliferation. Ursolic acid, scopoletin, and scopolin reduced ConA- and LPS-induced primary mouse splenocyte proliferation, while hyperoside did not show such activity. These results indicate that A. capillaris and its components, ursolic acid, scopoletin, and scopolin, suppress ConA- and LPS-induced adaptive immune cell activation. The results suggest that A. capillaris is useful as a regulator of adaptive immunity for diseases involving excessive immune response activation.

• 의학교육논단
• /
• 제9권2호
• /
• pp.1-12
• /
• 2007

Purpose: The aim of this study is to identify the elements of success in curriculum reformation using focus group interview and faculty survey. Methods: We analyzed the 105 questionnaires that were collected horn 450 faculties in Yonsei University College of Medicine from September 1 to September 12, 2005. The interview of focus group was conducted to 105 faculty and students using 10 interview questions from July 25 to August 29, 2005. The data of focus group interview and faculty survey were analyzed by content analysis. frequency and percentile. Results : 66.7% of faculty have pointed out that it is right a direction of new curriculum but there are some problems in curriculum management. The most frequently addressed problem in the new curriculum is as follows : ability of self-directed learning(15.3%). deficiency of faculty understanding(10.5%). The faculty comments on the improvement areas of new curriculum such as curriculum revision (8.6%). efficiency of curriculum management (6.7%), reward and incentive system of education(6.7%). The focus groups pointed out the important factors of curriculum reformation such as horizontal and vertical integrity between subjects, improvement of student achievement test, enhancement of self-directed learning. responsibility and authorities of course director. Conclusions : It should be concluded. to succeed curriculum reformation, which the purpose of curriculum reformation announces obviously and management group should effort continuously so that professors may understand the new curriculum. The course directors have to responsibility and authorities operating the subjects and the university should develop the students' evaluation system and faculty performance appraisal system.

• 동의생리병리학회지
• /
• 제33권3호
• /
• pp.163-168
• /
• 2019

In order to enhance the 8 principle pattern diagnosis rate comparing with diagnostic method by self-report questionnaire on cold/heat pattern in the clinical practice, a new diagnostic method using form-color-pulse-symptom (FCPS) system is proposed. FCPS system is composed of outputs of cold/heat pattern through the calculation process of contribution degree to the cold, heat pattern and qi, blood, yin, yang deficiency patterns, based on analysis of 16 mechanisms of disease calculated by diagnostic system of oriental medicine (DSOM) first. And second component is an output of differentiated 8 principle patterns in detail through binding and calculating process with digital informations of pulse, color, form, constitution obtained by computerized measurement system. Putting together above two processes consecutively, cold-heat complex or true/false cold/heat patterns and personalized characters of cold/heat patterns of each patient can be subdivided through a computation method of determining each pattern. In conclusion, 8 principle pattern identification can be performed more accurately using FCPS system than existent self report questionnaire method. These hypothetic proposal is needed to be proven by clinical trial for the future and then the accurate numbers used in each calculational function should be revised properly.

• Clinical and Experimental Pediatrics
• /
• 제62권6호
• /
• pp.224-234
• /
• 2019

Purpose: Pompe disease (PD) is an autosomal recessive disorder caused by a deficiency of acid alpha-glucosidase resulting from pathogenic GAA variants. This study describes the clinical features, genotypes, changes before and after enzyme replacement therapy (ERT), and long-term outcomes in patients with infantile-onset PD (IOPD) and late-onset PD (LOPD) at a tertiary medical center. Methods: The medical records of 5 Korean patients (2 male, 3 female patients) diagnosed with PD between 2002 and 2013 at Samsung Medical Center in Seoul, Republic of Korea were retrospectively reviewed for data, including clinical and genetic characteristics at diagnosis and clinical course after ERT. Results: Common initial symptoms included hypotonia, cyanosis, and tachycardia in patients with IOPD and limb girdle weakness in patients with LOPD. Electrocardiography at diagnosis revealed hypertrophic cardiomyopathy in all patients with IOPD who showed a stable disease course during a median follow-up period of 10 years. Patients with LOPD showed improved hepatomegaly and liver transaminase level after ERT. Conclusion: As ERT is effective for treatment of PD, early identification of this disease is very important. Thus, patients with IOPD should be considered candidates for clinical trials of new drugs in the future.